Characteristics of biological drugs and requirements for packaging

 Biopharmaceuticals refer to a class of products used for prevention, treatment and diagnosis that are manufactured from organisms, biological tissues, cells, body fluids, etc., using the research results of microbiology, biology, medicine, biochemistry, etc., and comprehensively utilizing the scientific principles and methods of microbiology, chemistry, biochemistry, biotechnology, pharmacy, etc. Its characteristics can be explained from the following aspects:

Polymer Vial 2ml 5ml 10ml for cell and gene therapies

1. Pharmacological properties

Strong activity: As natural active substances or their analogues existing in the body, biopharmaceuticals usually have high pharmacological activity.

Low toxicity and side effects: Compared with some chemical drugs, biopharmaceuticals usually have less toxicity and side effects, and have higher nutritional value for the human body under specific conditions.

Strong targeting: Biopharmaceuticals can play a role in specific diseases or pathological processes, such as vaccines can stimulate the human immune system to produce a protective response to specific pathogens.

2. Physical and chemical properties

Low content and high impurities: The content of biopharmaceuticals in organisms is usually low, and various impurities are easily mixed in the extraction process, resulting in complex processes.

Complex structure: The composition structure of biopharmaceuticals is complex and has a strict spatial structure, which is the basis for their biological activity.

Small effective dose: Due to the high activity of biological drugs, their effective dose is usually small, and there are strict requirements for the effectiveness and safety of the products.

RTU(ready to use) 2ml COP vial

III. Drug types and efficacy

Vaccines: used to prevent specific diseases, by stimulating the human immune system to produce a protective response to pathogens.

Antibody drugs: can specifically recognize and bind to specific molecules on pathogens or abnormal cells, thereby blocking their functions or marking them for the immune system to clear. This type of drug is widely used in cancer treatment and autoimmune diseases.

Recombinant protein: a protein expressed in cells or microorganisms using genetic engineering technology, used to treat certain genetic diseases or supplement proteins lacking in the body.

In addition, biological drugs also have anti-inflammatory, antiviral, immunomodulatory, cell repair and analgesic effects and functions.

100ml polymer vial

IV. Requirements for packaging of biological drugs

Biological drugs are different from ordinary chemical drugs and are very sensitive to the storage environment, so the requirements for packaging are also very strict. In addition to the requirements for sealing and material barrier properties of ordinary packaging, biological drugs generally need to be stored in low temperature or even liquid nitrogen environment. In addition, protein drugs also require packaging materials to have very low adsorption to ensure drug dosage and reduce overfilling costs. COP vials are special packaging made of cycloolefin polymer raw materials. They have high transparency and strong barrier properties and can withstand low temperatures of -196°C. Due to the hydrophobic properties of the material itself, the adhesion between the drug and the packaging material is effectively reduced, thereby reducing the risk of drug loss and interaction.

In summary, biological drugs have the characteristics of strong pharmacological properties, complex physical and chemical properties, diverse drug types and significant efficacy. COP vials have the characteristics of transparency, low temperature resistance, and low protein adsorption, making them a good packaging form for biological drugs.

HDPE moisture-proof combination bottle caps that meet FDA USP standards

 In today's pharmaceutical packaging field, ensuring the safety and effectiveness of drugs is crucial. As a key part, packaging materials including bottle caps must meet strict standards to ensure drug quality and patient health, and require compliance with FDA USP standards for high-density polyethylene moisture-proof combination bottle caps.

50ml desiccant bottle with CRC

USP standards ensure the quality of drug packaging

The United States Pharmacopeia (USP) is a globally recognized pharmaceutical quality standard setting agency. Its regulations on plastic packaging systems, especially Chapter <661>, detail the selection, performance requirements and test methods of plastic materials. These standards apply not only to the packaging of the main drug, but also to auxiliary materials such as bottle caps.

Advantages of high-density polyethylene moisture-proof combination bottle caps

High-density polyethylene (HDPE) is widely selected for bottle cap manufacturing in pharmaceutical packaging due to its excellent moisture resistance, chemical stability and biocompatibility. According to USP standards, HDPE bottle caps can effectively protect drugs from external contamination and moisture intrusion, ensuring long-term storage and stability of drugs.

Guarantee of meeting strict standards

According to the requirements of USP <661> chapter, HDPE bottle caps must pass a variety of tests, including but not limited to physical properties, chemical stability, and compatibility tests after contact with drugs. These tests ensure that the bottle caps will not release harmful substances during use, ensuring the safety and purity of the drugs.

Choosing high-density polyethylene moisture-proof combination bottle caps is not only an investment in drug quality, but also a responsibility for patient health and safety. These bottle caps can not only effectively protect drugs, but also reduce the risks of drugs during transportation and storage, providing more confidence and protection for medical institutions and patients.

Differences in the design of oral liquid bottle caps for glass bottles and plastic bottles

 In the packaging design of oral liquids, the selection of medicinal bottle caps is crucial. Especially for oral liquid screw caps with child protection function, there are certain differences in the internal design between glass bottles and plastic bottles.

 

28mm child resistant cap for liquid

Background and risks of oral liquids

As a pharmaceutical preparation with good taste, oral liquids are extracted from Chinese herbal decoctions, and additives such as flavoring agents and antibacterial agents are added, and are sealed in bottles in a sterile or semi-sterile form. However, because of its taste close to that of beverages, it is easy for children to mistake it for ordinary drinks, and there is a risk of accidental ingestion. The physiological characteristics of children determine that they have low tolerance for drugs, and excessive consumption may bring serious consequences and even endanger life.

60ml HDPE dry syrup bottle

Design of water-based screw caps

In order to reduce the risk of accidental ingestion of oral liquids, water-based screw caps with child protection function are often used. This cap adopts an inner and outer double-layer structure design, and the inner and outer caps are connected by a card slot. When opening the cap, it is necessary to press down the outer cap and rotate it at the same time to drive the inner cap to rotate together and complete the opening action. This design can effectively prevent children from opening the package at will in a short time, reducing the risk of accidental ingestion.

Differences between glass bottles and plastic bottles

Although the water-based screw-on caps are used in both glass bottles and plastic bottles, there are certain differences in their internal designs. It is mainly reflected in the gasket inside the cap. The gasket of the glass bottle cap is relatively thicker, while that of the plastic bottle is relatively thinner. This difference is mainly determined by the different materials of the bottles. Glass bottles are relatively more brittle, and the increase in the thickness of the gasket can enhance its performance in sealing and pressure resistance, ensuring that the liquid is not easy to leak. Since the material of plastic bottles is relatively soft, the gasket of the cap can be relatively thin, which can ensure the sealing and reduce the production cost at the same time.

The design difference between the oral liquid bottle caps in glass bottles and plastic bottles is mainly reflected in the thickness of the gasket, which is determined according to the material of the bottle body and aims to ensure the good sealing of the bottle. Through reasonable design and selection, the water-based screw-on cap can effectively reduce the risk of accidental ingestion of oral liquid and ensure the safety of children's medication.

Dosing Cups vs. Oral Syringes: Which Is Better for Acetaminophen Suspension Drops?

 When it comes to administering acetaminophen suspension drops to children, accuracy and ease of use are essential. Acetaminophen is a commonly used over-the-counter medication to relieve fever and pain, especially in young children, but improper dosing can lead to underdosing (ineffective treatment) or overdosing (potential toxicity). Two common tools for measuring and delivering liquid medications are dosing cups and oral dosing syringes. Let's explore the benefits, drawbacks, and best practices for each when it comes to acetaminophen suspension drops.

PET amber bottle

What Are Acetaminophen Suspension Drops?

Acetaminophen suspension drops are a concentrated liquid form of the medication. They are often prescribed for infants and young children because they are easy to swallow and can be accurately dosed according to a child's weight and age. Proper dosing is crucial since the drops are more concentrated than standard liquid acetaminophen formulations.

When to Choose a Dosing Cup vs. an Oral Dosing Syringe

Selecting the right tool for administering acetaminophen suspension drops—or any liquid medication—depends on factors like the patient’s age, the required dosage, and ease of use. Here's a breakdown of when to use a dosing cup and when an oral dosing syringe is the better choice:

When to Use a Dosing Cup

For Older Children and Adults

Reason: Older children and adults can drink directly from a cup without assistance.

dosing cup 20ml

When to Use an Oral Dosing Syringe

For Infants and Toddlers

Reason: Infants and young children cannot drink from a cup, and syringes allow for slow, controlled administration.

5ml oral dosing pipette

Bottom Line

Use oral dosing syringes for precision, small doses, and younger patients.

Opt for dosing cups for larger doses or when administering to cooperative, older children and adults.

Choosing the right tool ensures safe and effective medication delivery, tailored to the specific needs of the patient.

Differences in the design of oral liquid bottle caps for glass bottles and plastic bottles

 In the packaging design of oral liquids, the selection of medicinal bottle caps is crucial. Especially for oral liquid screw caps with child protection function, there are certain differences in the internal design between glass bottles and plastic bottles.

 

28mm child resistant cap for liquid

Background and risks of oral liquids

As a pharmaceutical preparation with good taste, oral liquids are extracted from Chinese herbal decoctions, and additives such as flavoring agents and antibacterial agents are added, and are sealed in bottles in a sterile or semi-sterile form. However, because of its taste close to that of beverages, it is easy for children to mistake it for ordinary drinks, and there is a risk of accidental ingestion. The physiological characteristics of children determine that they have low tolerance for drugs, and excessive consumption may bring serious consequences and even endanger life.

60ml HDPE dry syrup bottle

Design of water-based screw caps

In order to reduce the risk of accidental ingestion of oral liquids, water-based screw caps with child protection function are often used. This cap adopts an inner and outer double-layer structure design, and the inner and outer caps are connected by a card slot. When opening the cap, it is necessary to press down the outer cap and rotate it at the same time to drive the inner cap to rotate together and complete the opening action. This design can effectively prevent children from opening the package at will in a short time, reducing the risk of accidental ingestion.

Differences between glass bottles and plastic bottles

Although the water-based screw-on caps are used in both glass bottles and plastic bottles, there are certain differences in their internal designs. It is mainly reflected in the gasket inside the cap. The gasket of the glass bottle cap is relatively thicker, while that of the plastic bottle is relatively thinner. This difference is mainly determined by the different materials of the bottles. Glass bottles are relatively more brittle, and the increase in the thickness of the gasket can enhance its performance in sealing and pressure resistance, ensuring that the liquid is not easy to leak. Since the material of plastic bottles is relatively soft, the gasket of the cap can be relatively thin, which can ensure the sealing and reduce the production cost at the same time.

The design difference between the oral liquid bottle caps in glass bottles and plastic bottles is mainly reflected in the thickness of the gasket, which is determined according to the material of the bottle body and aims to ensure the good sealing of the bottle. Through reasonable design and selection, the water-based screw-on cap can effectively reduce the risk of accidental ingestion of oral liquid and ensure the safety of children's medication.

Advantages and usage guidelines of oral drug delivery devices

 Oral drug delivery device is a special drug delivery device suitable for some drugs that require high accuracy, such as psychotropic drugs. Here is a detailed guide on the benefits of oral dosing syringe and how to use it correctly.

5ml oral dosing pipette

10ml oral dosing syringe

1. Main advantages

Oral dosing syringes are designed to improve convenience and accuracy of drug administration. Its intuitive scale system allows for more precise dosage control, reducing the possibility of medication errors. In addition, the device is constructed and operated with patient comfort in mind and can significantly reduce the discomfort of medication ingestion, especially when used by children or people with reduced mobility. The use of this device also simplifies the care process and improves the overall efficiency of medication management.

2. Correct usage steps

To ensure the safety and effectiveness of medications, it is critical to use the oral applicator correctly. First, confirm the patient's body posture and emotional state. It is recommended that the patient adopt a sitting or semi-sitting position so that the medicine can be swallowed smoothly. Next, open the oral applicator package, draw the medication into the device according to your doctor's instructions or the drug package insert, and watch the scale carefully to ensure the dose is accurate. Finally, place the tip of the device into the patient's mouth and push the plunger until the medication is fully released.

1ml dosing syringe

3. Precautions for use

Although oral dosing syringes offer many advantages in medication administration, there are some limitations to their use. For example, the device may not work well in patients who cannot cooperate. 

Understanding the patient's specific needs and conditions is critical to selecting and using the appropriate applicator.

In short, as a convenient, safe and accurate drug delivery tool, the oral applicator provides an effective solution for the management of various oral liquid preparations. With the continuous advancement of medical technology, oral applicators are expected to be applied and promoted in more fields.

Special design of oral dosing syringe

 Oral administration is a common method of drug administration in drug therapy. The drug will be absorbed through the gastric mucosa, but it is difficult for people with limited mobility or children to administer the drug orally. As a drug delivery device, the oral drug delivery device has a special design, which makes drug delivery convenient and accurate, and has become the choice of many patients.

5ml oral dosing pipette

1. Easy to use: Oral drug delivery devices-dosing syringe are usually made of plastic materials with appropriate hardness and softness to facilitate users to operate and control the flow of drugs. Their design usually includes a syringe-style barrel with a fixed syringe nozzle for accurate measurement and distribution of drug doses.

2. Capacity and scale: The capacity of the oral drug delivery device can vary according to needs, generally between 1 ml and 10 ml. Oral dosing syringes usually have scales for accurate measurement and distribution of drug doses, making drug delivery more accurate and convenient.

3. Drug delivery plug: This drug delivery device usually comes with a drug delivery plug. When taking the medicine, put the plug into the mouth of the medicine bottle and use the syringe nozzle to take out the medicine to avoid leakage.

4. Cleaning and reuse: This syringe can usually be cleaned and reused. The specific frequency of use and cleaning method should be operated according to the manufacturer's recommendations and relevant hygiene requirements. It is necessary to pay attention to timely and thorough cleaning and disinfection after use to avoid cross infection or drug residues.

10ml oral dosing syringe

In short, oral dosing syringes are a common and practical medical tool that can help people administer drugs in the correct dosage and reduce the risk of misuse and waste of drugs. When using, you should carefully read and follow the relevant instructions and doctor's advice to ensure the correct method and dosage of administration to ensure the safety and efficacy of the drug.