2023年8月2日星期三

COP vials can be used to store exosomes

 COP vial is a kind of high-end drug packaging, which has the characteristics of low temperature resistance, low protein adsorption, good chemical stability, etc. It is widely used in anti-tumor drugs, protein drugs, and cell drugs. In addition, it can also be used to store exosomes.


Requirements for COP vials for cell-based drugs

RTU(ready to use) 2ml COP vial

Application of COP vial in high pH value drug

5ml COP vial


Application of COP vial in high pH value drug

100ml COP injection vial


Exosomes refer to small membrane vesicles (30-150nm) that contain complex RNA and proteins. Today, they specifically refer to disc-shaped vesicles with a diameter of 40-100nm. Exosome extraction can be extracted from a variety of body fluids, such as human blood, urine, semen, and saliva, and can also be extracted from a variety of cell cultures. Exosomes can transfer proteins and genetic information between adjacent and distant cells, so many biotech companies hope to use them to deliver therapeutic drugs to hard-to-reach cells, delivering many types of molecules (including nucleic acids). In addition, exosomes can pass through the cell membrane and are not easy to cause immune reactions, so they have unique advantages in the delivery of genes, anti-tumor drugs and other drugs in vivo.

Exosomes need to be stored at low temperature, so there are strict requirements on the low temperature resistance of the packaging. The CZ Vial is made of cyclic olefin polymer, which can withstand a low temperature of minus 196°C to ensure a good active state of exosomes.

In short, as a kind of packaging with excellent performance, the polymer vial  is also being used in a wider range of applications, including some drugs with high pH value. Its good chemical stability can ensure the storage stability of such drugs.

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