The principle of autoclavable sterilization of plastic vaccine vial

 Plastic vaccine vials are containers for inactivated animal vaccines, and sterility is the basic requirement for packaging. Among the sterilization methods, autoclavable sterilization is a commonly used sterilization method for this type of packaging.

100ml PP transparent vial

High temperature and high pressure sterilization can not only kill general bacteria, fungi and other microorganisms, but also kill spores and spores. It is a relatively reliable and widely used physical sterilization method. It is mainly used for the sterilization of high temperature resistant items, such as culture medium, metal equipment, glass, enamel, dressing, rubber and some drugs. When sterilizing, put the plastic vaccine bottle to be sterilized in the pressure cooker, the steam does not overflow when heating, and the temperature in the pressure cooker increases with the increase of steam pressure. Under the steam pressure of 103.4kPa (1.05kg/cm2), the temperature can reach 121.3℃ and maintain for 15~30 minutes, which can achieve the purpose of sterilization.

250ml plastic vaccine bottle

Common types of high pressure steam sterilizers include lower exhaust pressure steam sterilizers and pulse vacuum pressure steam sterilizers. The difference between the two is mainly reflected in the sterilization temperature, pressure and time, and the sterilization effect There is not much difference.
The common materials of plastic vaccine bottles include polyethylene and polypropylene. The bottles that are sterilized by high temperature and high pressure are generally polypropylene. Because compared with polyethylene, this material has good high temperature resistance. Features, can meet the temperature requirements of this sterilization method.

Precautions for ethylene oxide sterilization of plastic vaccine bottles

 Ethylene oxide is a kind of sterilizing agent, which is suitable for the sterilization of items that cannot be soaked with disinfectant, dry heat, pressure, steam and other chemical gases. It is also a common sterilization method for plastic vaccine bottles. However, ethylene oxide is flammable and explosive, so the following points need to be paid attention to during the sterilization process:

100ml PP transparent vial

1. The ethylene oxide sterilizer must be placed in a well-ventilated place. Do not place it near the fire source. In order to facilitate maintenance and regular maintenance, 51cm of space should be reserved on each side (including the top) of the ethylene oxide sterilizer. Special exhaust ducts should be installed and completely isolated from other exhaust ducts in the sterilization site.
2. Items to be sterilized must be thoroughly cleaned. Note that they cannot be cleaned with saline. There should be no water droplets or too much water on the sterilized items to avoid dilution and hydrolysis of ethylene oxide. If the packaging material is changed, it should be verified to ensure the reliability of the sterilization of the sterilized items.

250ml PE vaccine bottle with rubber stopper

3. There should be gaps on the top, bottom, left and right of the loaded items in the sterilization cabinet (the sterilized items cannot touch the cabinet wall), and the items should be placed in a metal mesh basket or on a metal net rack; the amount of items loaded should not exceed the total volume of the cabinet 80% of it.
4. Sterilization treatment: It should be carried out in accordance with the operating instructions of the manufacturer of the ethylene oxide sterilizer; select the appropriate sterilization parameters according to the type, packaging, loading volume and method of the plastic vaccine bottle.
The above points should be paid attention to when the plastic vaccine bottle is sterilized by ethylene oxide. In addition, in order to ensure the safety and effectiveness of the sterilization, the ethylene oxide sterilization equipment must be regularly cleaned, repaired and debugged in accordance with the manufacturer's requirements.

Principles of Cobalt 60 Irradiation Sterilization of Plastic Vaccine Bottles

 Plastic vaccine bottles are the main packaging of inactivated animal vaccines. Vaccines are different from ordinary items. They have strict requirements on packaging. Among them, sterility is a very important point. In the way of sterilization, this kind of packaging will choose cobalt 60 irradiation sterilization.

250ml plastic vaccine bottle

Cobalt 60 irradiation sterilization is the use of 60Coγ-ray irradiation, which acts on microorganisms, directly or indirectly destroys the nucleus of microorganisms, thereby killing microorganisms and playing a role of disinfection and sterilization. It is a kind of radiation sterilization technology. The gamma rays produced by the radioactive isotope cobalt 60 irradiate packaged food. In the process of energy transfer and transfer, it produces powerful physical and biological effects to achieve the purpose of killing insects and sterilization.
Cobalt 60 irradiation sterilization has the advantages of strong penetration, uniform, thorough and rapid sterilization, no pollution to the environment, low cost and low energy consumption. The plastic vaccine bottle sterilized by this method can achieve a good sterilization effect without There will be drug residues. In my country, a national standard has been formed for cobalt 60 sterilization technology. The current implementation is the GB10252-2009 "Radiation Protection and Safety Specifications for Gamma Irradiation Devices" standard, which is a relatively mature sterilization method.

100ml PP transparent vial

Cobalt 60 irradiation sterilization is only one of the many sterilization methods for plastic vaccine bottles. Others include high temperature and high pressure sterilization and ethylene oxide sterilization. The specific sterilization method to choose depends on the requirements and requirements of the veterinary drug manufacturer. Depending on the characteristics of the vaccine.

Introduction of two caps for effervescent tablet packaging

 Effervescent tablet packaging is a packaging containing vitamin effervescent tablets or chewable tablets and other dosage forms. It has good moisture resistance. According to the different packaging requirements of pharmaceutical companies, this packaging contains two types of bottle caps.

caps for effervescent tube

Spring cap: This bottle cap is characterized by a spiral spring on the cap, this spring is made of LDPE raw materials, can play a role in compressing the tablets, and avoid being broken due to various external forces during transportation. It also reduces unnecessary losses for pharmaceutical companies. The LDPE material has good flexibility. The use of this material as a coil spring will neither crush the fragmentation agent due to the too hard texture, nor cause the medicine to be poorly fixed due to the too soft texture and too small pressure. It can give full play to the spring design. The advantages. In addition, this kind of bottle cap also has a feature that it has a desiccant. Unlike ordinary medicine bottles, the effervescent tablet packaging puts the desiccant on the cap, saving space, and is a cap with moisture-proof function. .

effervescent tablet tube 84mm

Non-spring cap: This kind of bottle cap is different from the spring cap. There is no spring on the cap, but it also has a moisture-proof function. Generally, vitamin chewable tablets and small-dose candy tablets will choose this kind of cap, and some vitamin C effervescent tablet manufacturers will also use this kind of bottle cap.

The above are the two types of caps and their characteristics for effervescent tablet packaging. These two different types of caps meet the differentiated needs of pharmaceutical companies for packaging, and are also a manifestation of the continuous development and diversification of pharmaceutical packaging.

Application of Twin neck bottle in Fluorescent Leak Detector

 Two neck bottle is a new type of packaging container. It consists of two mouths of a volumetric flask and a metering bottle. It is mainly used for the packaging of disinfectants, pesticides, herbicides and other solutions that need to be diluted. Fluorescent leak detector is one of them.

twin neck bottle

 

Fluorescent leak detector is a special detection solvent. It uses the principle of emitting bright yellow and green light under the irradiation of ultraviolet/blue leak detection lamps. It is used for various types of boilers, heaters, pumps, sprinkler systems, storage tanks, pipelines, etc. Fluid leakage in the system is detected. When in use, you only need to add fluorescent agent in a certain proportion to the system. After the system runs for 20 minutes, put on special glasses and illuminate the outside of the system with a leak detection lamp. The leak will show yellow fluorescence.

1000ml twin neck bottle

This kind of solvent generally needs to be diluted according to a certain proportion when in use. In order to save the intermediate operation process, the fluorescent leak detector is mostly packaged in a double-necked bottle with a metering bottle. When in use, open the cap of the measuring bottle with graduations, squeeze the bottle body with both hands lightly, the fluorescent leak detector will enter the upper measuring bottle through the tube, squeeze it to the required measurement to stop, and then set the small The fluorescent leak detector in the measuring bottle is poured into the system to complete the operation.
The double-mouth bottle has a unique design and has a metering function that ordinary bottles do not have. It is more convenient and faster to use. It is a good storage container. With the rapid development of various new processing technologies, the functions of double-neck bottles will also continue to improve, serving more products and enterprises.

Test method for puncture force of COP bottle rubber stopper aluminum cap

 COP bottle is a new type of packaging, mainly used in high protein, anti-tumor or PH value greater than 9. Most of these drugs are injection preparations, so the bottle cap of this kind of packaging is a rubber stopper aluminum cap. In order to ensure ease of use, this type of bottle cap is generally subjected to a puncture force test.

COP vial

COP bottle is a plastic packaging bottle made of COP as raw material and processed by injection stretch blowing technology. The COP raw material has good physical and chemical stability, not only has high transparency, but does not peel off in the compatibility test with medicines, is not easy to change color after radiation, and has excellent low protein adsorption and chemical barrier properties. It is especially suitable for some packaging requirements. High protein drugs.

The puncture force test of the aluminum cap of the COP bottle rubber stopper mainly refers to the test of its built-in butyl rubber stopper. Since the rubber stopper is in direct contact with the medicine, the country has issued relevant standards to require its quality. According to the second method of YBB00322004-2015, the force required to pierce the bottle stopper must not exceed 10N. Test method: Take 10 injection bottles equipped with rubber stoppers, add water of nominal capacity, install the pretreated rubber stoppers to be tested, add aluminum caps or aluminum-plastic combination caps, and seal them. Place an injection needle on the material testing machine and fix it, put the injection bottle into the material testing machine, open the aluminum cap or aluminum-plastic combination cap, leak out the rubber stopper marked part, the puncture device performs vertical puncture at a speed of 200mm/min, and record the glue The maximum force applied by the plug puncture. Replace an injection needle and repeat the above steps until all the rubber plugs are punctured once.

Whether the rubber stopper of the COP bottle cap is easy to puncture will affect the safety and convenience of medical staff in extracting injection preparations, and it is also the basic requirement for the packaging of medicines.

Vaccine diluent requirements for vaccine bottles

 Vaccine diluent refers to the reagent used to dilute the vaccine. Depending on the type of vaccine, there are different types of diluents, but plastic vaccine bottles are used in the packaging. Its requirements for packaging are mainly reflected in the following aspects:

250ml PE plastic vaccine bottle

1. Sealability: The vaccine diluent is mainly used to dilute the vaccine, which is related to the immune effect of the vaccine. Therefore, the plastic vaccine bottle must ensure good airtightness, so as to ensure that the diluent is in a good storage environment and improve the immune effect.
2. Barrier property: The barrier property of the bottle refers to its ability to block the invasion of external microorganisms. The packaging material of the diluent is generally polyethylene or polypropylene, which are non-toxic and tasteless, and have good barrier properties. Can isolate the pollution of the external environment.
3. Compatibility: The diluent is generally acid or salt, and the packaging material needs to be compatible with this type of solution to ensure that the contents will not deteriorate due to the reaction between the solution and the material during storage.
Commonly used diluents in animal vaccines include physiological saline, phosphate buffer, aluminum glue saline, and special diluents specially formulated according to the characteristics of the vaccine itself. Although the types are different, the requirements for injection vials are uniform. Yes, proper packaging can ensure that the solution is in a good storage condition and improve the immune effect of the vaccine.

Cap characteristics of plastic vaccine bottles

 Plastic vaccine bottles are the main packaging of inactivated veterinary vaccines. Vaccines are a special solution and have high requirements for packaging. What are the characteristics of the bottle cap as an important part of the bottle?

250ml plastic vaccine bottle

Plastic vaccine bottle caps generally use rubber stopper aluminum caps, which are composed of rubber stoppers and aluminum caps. The aluminum cap has good hygiene, will not rust, is easy to open, and does not require auxiliary tools to open, and is not easy to hurt the user. After opening, the bottle cap is obviously destructive and can effectively prevent theft. In addition, the aluminum cover also has the characteristics of good cushioning, shock resistance, heat insulation, moisture resistance, chemical corrosion resistance, etc., non-toxic, non-absorbent, non-dust, and has very good anti-pollution properties. The internal cleanliness, chemical stability, air tightness, and biological performance of the butyl rubber stopper are very good. The rubber stopper coated with the film can effectively reduce the absorption, adsorption, leaching and permeation between the rubber stopper and the drug, and improve the drug Long-term stability; at the same time, the mechanical lubricity of the rubber plug is also well improved, which greatly reduces the increase in the number of insoluble particles in the liquid medicine caused by the silicone oil.

10ml PP injection vial

The aluminum cover of the rubber plug made by the combination of the aluminum cover and the rubber stopper has been exerted to a large extent in terms of airtightness, anti-pollution properties, and chemical stability, and can maintain a good storage state of the vaccine. Large-capacity injection bottles, oral liquid bottles, etc. have selected this kind of good bottle cap.
In addition, the choice of plastic vaccine bottle aluminum caps has a unique advantage, that is, embossing, milling, etc. can be embossed on the aluminum cap to meet the brand promotion needs of pharmaceutical companies.

The special function of the tablet medicine bottle-prevent children opening

 Medicines are substances used to prevent, treat and diagnose diseases. Almost every family prepares some commonly used medicines. The tablet medicine bottle is the packaging of solid medicines such as tablets and capsules. In addition to the medicine storage function, this kind of packaging also has a special function, that is, the function of preventing children from opening.

45ml plastic medicine bottle with crc

Child safety has always been a major event affecting hundreds of millions of parents. In addition to the common accidental injuries in our lives, seemingly unimportant drug packaging has also become an important cause of hidden dangers to children's safety. Children are still in the growth and development stage and are full of curiosity about various things. They are easily attracted by pills of different colors, causing accidental ingestion and causing serious consequences.

100ml tablet bottle with crc

The anti-child opening function of the tablet medicine bottle can prevent children from opening the bottle at will, and protect the safety of children. Cardiovascular and cerebrovascular medicines, psychotropic medicines and other medicines are all selected with packaging with this function. The child-proof opening function is realized through a special bottle cap design. The bottle cap adopts an inner and outer double-layer structure, which is connected by a card slot. If you want to open the bottle cap, you need to press the outer cap and drive the inner cap at the same time. It can be opened only by rotating. This opening method involves applying force in two directions. It is difficult for children who are still in the developmental stage. It can prevent children from opening at will and avoid accidental ingestion of medicines.

With the continuous improvement of people's safety awareness, some patients will also pay attention to whether the tablet bottle has the function of preventing children from opening when buying medicines, and the application range of this kind of pharmaceutical packaging will become wider and wider.

Sealing test of syringe for grease

 The syringe for grease is a special packaging container, generally used in the packaging of dairy cow mastitis, pet nutrition ointment and other drugs, and can also be used as the packaging of grease. Tightness is the basic requirement for the packaging of medicines, and the same is true for greases. So, how to check the tightness of the package?

10ml gel syringe

Grease is made of mineral oil (or synthetic lubricating oil) and thickening agent. It is a grease-like semi-solid. It is mainly used in the friction part of machinery to play the role of lubrication and sealing, such as mixers, valves, Electrical connectors, switch devices, automatic ignition components and other equipment are also used on metal surfaces to fill gaps and prevent rust.

15ml dosing syringe

When choosing the packaging of the grease syringe, the manufacturer will pay more attention to the sealing of the packaging. This is because once there is a leakage, it will affect the use of the contents and also affect the brand image of the manufacturer. The sealing of the package can be tested according to the following standards: take an appropriate amount of the plastic veterinary syringe, inject half of the water into the syringe, insert the piston into the plastic gel syringe, remove the protective cap, remove the residual air, and then block with the protective cap, and pass the push rod Apply an axial pressure of 30N on the push rod rubber plug inside the syringe and keep it for 30 seconds. There should be no leakage at the seal of the protective cap and the seal of the piston.
The above detection methods are China's requirements for the sealing test of grease syringe. Of course, different countries may have slightly different test methods for package sealing, but the purpose is to ensure the quality of the package and the stability of the lubricant.

Three advantages of pet nutrition ointment syringe

 Pets play an important role in our lives. When choosing supplies or medicines for pets, in addition to considering their own effects, packaging is also a very important aspect. As a new type of packaging, pet nutrition ointment syringe has many advantages and has won the favor of many pet owners.

15ml syringe for pet feeding

1. Easy to use: The pet nutrition ointment syringe is composed of a tube sleeve, a push rod, a piston, a protective cap, and a positioning ring. Open the protective cap during use and push the push rod to administer medicine. It is more convenient to use.
2. Scientific feeding: While pets accompany us, they also bring us a lot of joy. Pet owners also regard them as a member of the family and give them considerate care. If the dosage is not properly controlled when feeding the nutrient cream, it will easily cause pets to eat too much, resulting in overnutrition and affecting the health of pets. This special package is printed with a scale on the push rod. When using the positioning ring, turn the positioning ring to a suitable scale, which can make the feeding amount more accurate and realize the scientific feeding of the pet.

paste syringe

3. Reducing residues: There are currently two ways of packaging pet nutrition cream: hose and syringe. The hose packaging is prone to residues, leading to waste. The syringe uses the pressure of the push rod to greatly reduce the residual nutrient paste and avoid waste.
These advantages of pet nutrition ointment syringes are the points that pet owners value more. Choosing this kind of packaged nutrition ointment will also have a greater advantage in the market, which will help shape the corporate brand image.

The importance of the choice of eye drop bottles to enterprises

 With the rapid development of technology and the changes in people's lifestyles, more and more eye diseases are caused by overuse of the eyes, so that the market demand for ophthalmic drugs continues to grow, and market competition is becoming more intense. While paying attention to the effect of drug treatment, pharmaceutical companies can seek market breakthroughs in eye drop bottles.

5ml eye dropper bottle

At present, most of the market share of ophthalmic drugs is controlled by international giants such as Novartis, Santian, Bayer and Allergan. Although the ophthalmic drug market accounts for a small proportion of the retail market, with the intensification of aging and long-term overuse of eyes, the ophthalmic drug market will show a trend of "small areas and big development". In June 2021, Hengrui Pharmaceuticals, one of China’s largest pharmaceutical companies, announced that its subsidiary Chengdu Shengdi Pharmaceutical Co., Ltd. received the “Notice of Drug Clinical Trial Approval” approved and issued by the National Medical Products Administration, and approved the development of an HR19034 eye drop. A phase III clinical trial for the prevention and control of the progression of myopia in children. The active ingredients of the product mainly interact with the receptors of the sclera, choroid and retina to inhibit the growth of the eye axis, thereby delaying the progression of myopia. At present, no similar products at home and abroad have been approved for listing. This drug will surely stir up the ophthalmic drug market after it goes on the market, triggering more intense market competition.

10ml plastic eye dropper vial

The competition in the ophthalmic drug market tests not only the brand strength and influence, but also the patient's medication experience. Commonly used ophthalmic drugs are basically the same in efficacy, but eye drops are high-risk medications. The softness of the eye drop bottle and the amount of dripping from the bottle will affect the patient's drug delivery experience.

On the whole, pharmaceutical companies want to gain a share in the ophthalmic drug market. In addition to strictly controlling the quality of drugs, the choice of eye drop bottles is also crucial. Good packaging will play a role in improving the competitiveness of the product market. Important role.

How long can the vaccine be stored after opening the plastic vaccine bottle?

 Animal vaccines are the main way to prevent animal diseases, and the quality of vaccines is related to the final immune effect. During the immunization process, we will encounter the situation that the vaccine cannot be used up. If the plastic vaccine bottle is opened, how long can the vaccine be stored?

50ml pp injection vial

Animal vaccines are generally divided into inactivated vaccines and attenuated live vaccines. These two vaccines have their own characteristics and are also different in packaging. Among them, plastic vaccine bottles generally contain inactivated vaccines. Inactivated vaccines are vaccines made by using physical or chemical methods to treat microorganisms so that they lose their infectivity or toxicity and maintain good immunogenicity. It has the characteristics of safety, no return to ancestors, no return to strength, and easy storage and transportation. This kind of vaccine is generally a liquid preparation, containing adjuvants, fire extinguishing agents and stabilizers. Freezing may affect the stability of the vaccine, causing the antigen and adjuvant to be stratified, affecting the immune effect, so it is generally stored at 2-8°C in the dark , Strictly prevent freezing.
The capacity of inactivated vaccines is generally relatively large, and sometimes it may not be used up once after opening. In order to avoid waste, some farms choose to save the vaccine again and use it next time. In fact, this approach is wrong. After the vaccine is opened, its environment has changed. It must be vaccinated as soon as possible. If the vaccine is not used up, try to use it up on the same day. If it is not used up, it should be discarded.
Immunization is a complex physiological reaction process, which must be operated in strict accordance with regulations. After the plastic vaccine bottle is opened, the vaccine has a limited shelf life. If an animal is injected with a vaccine stored for a long time after opening, it will not only affect the immune effect, but even endanger the health of the animal and cause unnecessary losses to the farm.