COP bottle with low protein adsorption

 High-end drugs have always been the focus of research and development in the medical field. With the support of various national policies, the research and development of innovative drugs in my country is on the rise. However, the packaging of high-end drugs has always been a concern in the industry. Material properties such as polypropylene and polyethylene are not suitable for high-end drugs, but those with high transparency, corrosion resistance, good storage performance, easy disinfection and sterilization, and low price Due to the shortcomings of protein adsorption, glass bottles greatly reduce the capacity of high-end drugs. Is there a material that combines the advantages of glass bottles with the properties of low protein adsorption?

In fact, a material with low protein adsorption properties is gradually becoming the exclusive packaging for biological products and anti-tumor drugs, that is, COP vials. COP raw material is developed and produced by Japan Zeon Company, used for medical optical components and high-end pharmaceutical packaging materials, with high transparency, excellent low protein adsorption, low birefringence, good water vapor air tightness, and compatibility with pharmaceuticals. It has the advantages of no peeling off, no discoloration after radiation, high temperature sterilization, etc. It can also be used as a container for biological products and organic solutions that need to be frozen.

5ml COP vial

100ML COP bottle

DMF check

COP vials are mainly used for high value-added drugs, such as lymphocyte antigens, hormone drugs, anesthesia drugs, drugs with a pH value greater than 9, and projects with accurate dosage requirements. Although the price of COP bottle is slightly higher than that of glass bottle, the drugs in its application field generally have higher prices, and the low protein adsorption characteristics of COP can greatly improve the use value of drugs and save some pharmaceutical costs for pharmaceutical companies. Said that it is more suitable for high-end drugs to choose COP bottles.

Everything is constantly developing and changing. Pharmaceutical companies must learn to look at problems with a developmental perspective. They should not only see the high price of COP bottles, but also pay attention to the value brought by their application in the market. At present, some domestic pharmaceutical companies have been at the forefront of the industry. For example, a certain original research drug of CSPC and the COP bottle produced by Xinfuda have passed the CDE related review in 2018 (registration number: B20180001378), Mass production of the drug is just around the corner. It is believed that with the continuous deepening of innovative drug research and development in my country, the market of COP bottles will also usher in a rapid development.

Dosage of desiccant for effervescent tube cap

 Effervescent tablet is a special dosage form containing effervescent disintegrant. This drug has high requirements on the moisture resistance of the effervescent tube, and a desiccant is placed inside to absorb moisture. The dosage of desiccant is related to the stability of the drug, how to determine its dosage?

caps for effervescent tube

144mm*29mm eff tablet tube supplier

desiccant cap

DMF check

The desiccant inside the effervescent tube is mainly silica gel, molecular sieve or an equal proportion mixture of the two. The amount of desiccant is a very critical point in the application of desiccant. If the amount of desiccant is too small, it will not have an effective moisture-proof effect, and the product will be easily damaged by moisture; if the amount of desiccant is too much, it will cause waste, Uneconomical.

Water vapor transmission rate (g/m2·day) refers to the gram weight of water vapor permeating the test material after a test time of 24 hours in a static environment under a stable temperature and humidity condition. Before starting to calculate the amount of desiccant, we must set a target humidity, which is the higher humidity allowed in the package. Generally speaking, ordinary products can be safely stored in a humidity environment below 50%, and there are many products that require lower humidity, such as 20% environment. The lower the target humidity setting, the more desiccant is required to keep the package dry. Combined with the water vapor transmission rate of the barrier packaging, the amount of desiccant can be calculated through a special formula.

The amount of desiccant in the effervescent tube is an important factor affecting the overall moisture resistance of the package. When choosing a package, pharmaceutical companies should not only consider its quality, but also the amount of desiccant to avoid moisture deterioration of the drug.

How to Use a Plastic Syringe to Feed a Horse

 Horse deworming medicine is one of the commonly used drugs in horse farms. Its dosage form is generally paste. In order to facilitate administration, plastic syringes are selected on the packaging. The horses are huge, how to feed the horses?

60ml horse paste syringe

Many people may think that deworming horses is a trivial matter, but the fact is that all horses carry internal parasites more or less. It may have been infected with parasites, and the consequences can be serious if not treated in time. Feeding deworming medicine to horses can be done as follows:
Step 1: Weigh the horse, you can use a soft ruler to calculate the approximate weight of the horse.
Step 2: Adjust the scale of the deworming medicine: The dosage of the deworming medicine is determined according to the body weight, and the deworming medicine we buy is generally larger than the dosage of a horse. According to the estimated weight, we find the prefilled syringe plunger The scale on the top is fixed (if the deworming medicine is fed less, it will not work, it is recommended that you use a little more than the standard dosage).
Step 3: Inject the deworming medicine deep into the horse's mouth and push the push rod for administration.
Step 4: Raise the horse's head and let the horse swallow the deworming medicine.
Plastic veterinary syringes are a very convenient package to use, if you find that your horse doesn't like medication and tends to shy away from syringes, coat the outside with applesauce or other food they like to make it easier for the horse to accept.

List of Drugs Applicable to COP Vials

 With the development of science and technology, the excellent properties of more polymer materials have been continuously explored. COP vial is a typical representative of new materials used in the field of pharmaceutical packaging.

5 ml COP vial

DMF list

COP vial is suitable for anti-cancer, anti-tumor, rheumatic, protein and other high value-added drugs.

COP vial has high transparency, low birefringence, low water absorption, high rigidity, high heat resistance, low protein adsorption, good water vapor airtightness, can be stored in liquid nitrogen, and meets FDA standards. According to incomplete statistics, the list of medicines suitable for COP vials is as follows:

Avastin (bevacizumab), Herceptin (trastuzumab for injection), adalimumab (Humira), Palivizumab alias Palivizumab, Anthrax (disease) , combined with chlorambucil, belimumab, treatment of systemic lupus erythematosus, alemtuzumab, certolizumab, trastuzumab, transtuzumab <anti-tumor drug>, diabetes, rani Bulimumab Injection, Opdivo, Pertuzumab, Golimumab, Panitumumab, Primumab, Erbitux, Infliximab, Rituximab ( Rituxan), etanercept, darbepoetin alfa, interferon beta-1b, rituximab <anti-tumor drug>, interferon beta-1a, nulasta, aflibercept, gonadotropin Hormones, anakinra <interleukin receptor blocker>, and pegaspargase injection.

The above is a list of known drugs suitable for COP vial packaging on the market. With the continuous advancement of technology in the pharmaceutical industry, more new drugs will continue to come out, and the scope of application of COP vials will be more common.