Effervescent Tube Manufacturers: Revolutionizing Packaging Solutions with Innovation and Convenience

 Introduction:

Effervescent tablets have gained popularity in recent years, offering a convenient and efficient way to consume various medications, dietary supplements, and personal care products. Behind these effervescent tablets lies a crucial component-effervescent tube. In this article, we will explore the world of effervescent tube manufacturers, highlighting their innovative solutions and contributions to the growing demand for effervescent products.

144mm*29mm effervescent tube packaging

1. Understanding Effervescent Tubes:

Effervescent tubes are specially designed containers that house effervescent tablets. These tubes are typically made from high-quality plastic materials, ensuring product integrity and safety. They come in various sizes and shapes, often featuring airtight caps to maintain the tablets' freshness and prevent moisture or air exposure.

caps for effervescent tube

2. Advanced Manufacturing Processes:

Effervescent tube manufacturers employ advanced manufacturing processes to produce high-quality tubes. These processes include injection molding, blow molding, and extrusion techniques. By leveraging state-of-the-art machinery and technologies, manufacturers can ensure precise dimensions, consistent quality, and efficient production rates.

3. Customization and Branding:

Effervescent tube manufacturers understand the importance of branding and customization in today's competitive market. They offer a range of options for branding and labeling, allowing companies to showcase their logo, product information, and unique design elements on the tubes. Customization options include color variations, embossing, and even special finishes to enhance the overall aesthetics and brand recognition.

4. Focus on Sustainability:

In recent years, there has been a growing emphasis on sustainability and eco-friendly packaging solutions. Effervescent tube manufacturers are actively addressing this concern by adopting sustainable practices. They prioritize the use of recyclable materials and employ energy-efficient manufacturing processes. Some manufacturers even offer biodegradable or compostable tube options, ensuring minimal environmental impact.

5. Quality Control and Compliance:

Effervescent tube manufacturers adhere to stringent quality control measures and industry standards to ensure the safety and efficacy of their products. They conduct thorough testing, including checks for leakage, tamper resistance, and compatibility with various effervescent formulations. Compliance with regulations, such as FDA guidelines, is paramount to guarantee consumer trust and confidence.

6. Collaboration and Innovation:

Effervescent tube manufacturers actively collaborate with pharmaceutical companies, dietary supplement producers, and personal care brands to develop innovative packaging solutions. This collaboration ensures that the tubes are designed to meet specific product requirements, such as moisture protection, extended shelf life, and ease of use. Manufacturers continuously invest in research and development to stay at the forefront of packaging innovation.

Conclusion:

Effervescent tube manufacturers play a vital role in the success and growth of the effervescent tablet industry. Through advanced manufacturing processes, customization options, sustainability initiatives, and a focus on quality control, these manufacturers provide innovative packaging solutions that meet the evolving needs of consumers and businesses alike. As demand for effervescent products continues to rise, the collaboration between manufacturers and industry stakeholders will drive further advancements in this exciting field.

The role of the anti-theft ring on the cap of the effervescent tube

 The main function of effervescent tablets is to enhance the body's resistance, and to prevent and treat various acute and chronic infectious diseases, or other diseases. When it comes to health problems, pharmaceutical packaging manufacturers will pay special attention to it. One is the anti-theft ring on the cap of the effervescent tube.

144mm*29mm effervescent tube packaging

caps for effervescent tube

Because if the effervescent tube used up is stolen by someone, it will produce various adverse consequences after being put into fake and shoddy products and eaten by people by mistake. Therefore, in order to prevent counterfeit and shoddy products from flooding the market and ensure that the quality of the contents is not maliciously damaged, most of the current bottle caps have adopted an anti-theft structure.

The anti-theft ring is processed by cutting the ring, and the injection molding process can achieve "the anti-theft ring integrally formed with the bottle cap body" through the mold mechanism, but the cost of the mold is relatively high. The anti-theft ring on the cap of the effervescent tube is set at the neck of the bottle, and the anti-theft ring will be stuck when the moisture-proof cover is closed, and when it is opened again, the anti-theft ring will automatically fall off, which has a very good anti-theft effect.

Xinfuda is a packaging company aiming at functional packaging and overall solution provider. In the future, the overall design of the effervescent tube will not only be reflected on the bottle cap, but more functional designs will be continuously excavated to adapt to continuous changes. market demand.

Introduction of desiccant in effervescent tube

 We know that the packaging of effervescent tablets—the effervescent tube has very high requirements for moisture-proof performance, because due to the characteristics of effervescent tablets, it will cause disintegration and deterioration after being exposed to moisture. Today, I would like to share with you the desiccants that play an important role and their characteristics.

144mm*29mm effervescent tube packaging

caps for effervescent tube

The main material of the desiccant used in the effervescent tube is silica gel and molecular sieve. Among them, silica gel is a highly active adsorption material, with a very fine pore network structure inside, which can be used to absorb water and retain water, and it is an extremely suitable desiccant at room temperature, while it can desiccate the environment at high temperature. Humidity is reduced to the point where it does not affect the medicine.

Molecular sieve desiccant is a synthetic product. It has regular and uniform pores in its crystal structure. The pore diameter is on the order of molecular size. To be sieved, it is called molecular sieve. Its material can absorb water vapor and other gases at the same time. And the moisture absorption effect is fast.

The desiccant in the packaging of effervescent tablets is generally a mixture of silica gel and molecular sieve in equal proportions. Silica gel has strong moisture absorption capacity and molecular sieve has a fast moisture absorption speed. After the two are mixed, they can achieve a good moisture absorption effect and ensure the stability of effervescent tablets.

Three criteria for effervescent tube selection

 The effervescent tube is a special packaging made of polypropylene in a straight barrel. Today, when the health of the whole people is popularized, we have three more important standard choices when choosing to purchase effervescent tubes, that is:

144mm*29mm effervescent tube packaging

caps for effervescent tube

1. Qualification of effervescent tube manufacturer

In addition to the business qualification requirements of enterprises in China, there are also some requirements for pharmaceutical packaging materials, and it is also necessary to register with the drug supervision and management department and obtain the "Drug Packaging Material Registration Certificate" before production. If the drug needs to be exported to foreign countries, it needs to go through foreign filing, such as EU certification, US DMF filing, etc. And Xinfuda is a company with complete formalities and qualifications.

2. The strength of effervescent tube manufacturers

Manufacturer qualification is the basic requirement for pharmaceutical packaging material manufacturers, followed by strength, such as whether the production equipment is advanced, whether the production process is mature, whether it has a high-standard clean workshop, whether the production scale can meet the needs of pharmaceutical companies, etc. The side reflects the strength of the manufacturer, and a strong manufacturer is more secure in product quality control and post-service.

3. Product quality of effervescent tube

The quality of effervescent tubes is a point that pharmaceutical companies need to pay special attention to. While meeting the requirements of national standards, they must also meet the characteristics of the drug. Cost-effective packaging is the constant pursuit of pharmaceutical companies. On the basis of meeting the above conditions, consider the cost-effectiveness of effervescent tubes.

Of course, when pharmaceutical companies choose effervescent tube suppliers, they generally put product quality and cost-effectiveness first. However, no matter which factor is considered first, the qualification and strength of the manufacturer are still important factors that cannot be ignored.

Factors Affecting Moisture Resistance of Effervescent Tablet Tubes

 Effervescent tablet is a new type of preparation, which originated from abroad and has been widely used in China in recent years. Due to the complex and difficult production process and high production cost, this dosage form has very strict requirements on packaging. Then as an effervescent tube as a special packaging for effervescent tablets, in order to prevent the medicine from being damp, denatured, and invalidated, a desiccant is usually placed in the bottle.

144mm*29mm effervescent tube packaging

caps for effervescent tube

But we also need to pay attention to the fact that the desiccant in the effervescent tube is sealed by white cardboard. There are certain requirements for the thickness and moisture content of the cardboard. If the cardboard is too thick, it will enhance the barrier effect on the desiccant and affect its moisture resistance. If the moisture content is too high, the desiccant will apply more moisture absorption performance to the cardboard, reducing the overall moisture resistance of the packaging internal environment. The quality requirements for effervescent tubes are in accordance with the national standard YBB00172004-2015 "Oral Solid Medicinal Low-density Polyethylene Moisture-proof Composite Bottle Caps", in which the requirements for cardboard are as follows: the moisture content is less than 6%, the The lead shall not exceed 0.0005%, and the drug contact surface shall be inspected under the ultraviolet lamp with a wavelength of 365mm and 254mm, and there shall be no flake fluorescence. The thickness is recognized in the industry as 0.46-0.55mm pure high-quality wood pulp white cardboard.

To sum up, the whiteboard must strictly meet the standard requirements, so as to ensure the moisture-proof performance of the desiccant, and then ensure the overall moisture-proof function of the effervescent tablet tube, and protect the health of users.

Analysis of the causes of moisture inside the effervescent tube

 Effervescent tablets are a kind of pharmaceutical dosage forms containing disintegrants. There are many kinds of them, such as aspirin effervescent tablets for antipyretic and analgesic, Chinese patent medicine Jinlian Qingre effervescent tablets, multi-dimensional effervescent tablets for supplementing vitamins or trace elements, etc. As a special item, it has very strict requirements on packaging effervescent tubes. If it gets wet, it will easily lead to deterioration of medicines, affect the efficacy of medicines and even human health. In order to avoid this situation, we can avoid the effervescent tube from getting damp from the following aspects:

144mm*29mm effervescent tube packaging

caps for effervescent tube

1. Sealing: If the inside of the effervescent tube is damp, first consider whether the sealing of the effervescent tube is qualified. The factors affecting the sealing performance mainly depend on the precision of the mold and the strict control of each production link. The material of the effervescent tube generally has moisture resistance, which can block the external water molecules, but if the seal is not tight, it is easy to cause water vapor to enter the inside of the effervescent tube, causing the medicine to be damp and deteriorate.

2. Dosage of desiccant: The desiccant of the effervescent tube is mainly a mixture of silica gel and molecular sieve. If the inside of the effervescent tube is still damp when the overall sealing is good, it may be because the amount of desiccant is not enough to completely To absorb the moisture of the medicine itself, consider increasing the amount of desiccant.

3. External environment: The moisture inside the effervescent tube is also related to the external environment. If the storage environment is too humid, it is easy to get damp inside the effervescent tube, so try to choose a dry and ventilated place during storage.

If we encounter moisture in the effervescent tube later, we can try to analyze these aspects to avoid this situation and ensure our stability during drug storage.

Factors Affecting Moisture Resistance of Effervescent Tablet Tubes

 Effervescent tablet is a new type of preparation, which originated from abroad and has been widely used in China in recent years. Due to the complex and difficult production process and high production cost, this dosage form has very strict requirements on packaging. Then as an effervescent tube as a special packaging for effervescent tablets, in order to prevent the medicine from being damp, denatured, and invalidated, a desiccant is usually placed in the bottle.

144mm*29mm effervescent tube packaging

caps for effervescent tube

But we also need to pay attention to the fact that the desiccant in the effervescent tube is sealed by white cardboard. There are certain requirements for the thickness and moisture content of the cardboard. If the cardboard is too thick, it will enhance the barrier effect on the desiccant and affect its moisture resistance. If the moisture content is too high, the desiccant will apply more moisture absorption performance to the cardboard, reducing the overall moisture resistance of the packaging internal environment. The quality requirements for effervescent tubes are in accordance with the national standard YBB00172004-2015 "Oral Solid Medicinal Low-density Polyethylene Moisture-proof Composite Bottle Caps", in which the requirements for cardboard are as follows: the moisture content is less than 6%, the The lead shall not exceed 0.0005%, and the drug contact surface shall be inspected under the ultraviolet lamp with a wavelength of 365mm and 254mm, and there shall be no flake fluorescence. The thickness is recognized in the industry as 0.46-0.55mm pure high-quality wood pulp white cardboard.

To sum up, the whiteboard must strictly meet the standard requirements, so as to ensure the moisture-proof performance of the desiccant, and then ensure the overall moisture-proof function of the effervescent tablet tube, and protect the health of users.

Factors Affecting Moisture Resistance of Effervescent Tablet Tubes

 Effervescent tablet is a new type of preparation, which originated from abroad and has been widely used in China in recent years. Due to the complex and difficult production process and high production cost, this dosage form has very strict requirements on packaging. Then as an effervescent tube as a special packaging for effervescent tablets, in order to prevent the medicine from being damp, denatured, and invalidated, a desiccant is usually placed in the bottle.

144mm*29mm effervescent tube packaging

caps for effervescent tube

But we also need to pay attention to the fact that the desiccant in the effervescent tube is sealed by white cardboard. There are certain requirements for the thickness and moisture content of the cardboard. If the cardboard is too thick, it will enhance the barrier effect on the desiccant and affect its moisture resistance. If the moisture content is too high, the desiccant will apply more moisture absorption performance to the cardboard, reducing the overall moisture resistance of the packaging internal environment. The quality requirements for effervescent tubes are in accordance with the national standard YBB00172004-2015 "Oral Solid Medicinal Low-density Polyethylene Moisture-proof Composite Bottle Caps", in which the requirements for cardboard are as follows: the moisture content is less than 6%, the The lead shall not exceed 0.0005%, and the drug contact surface shall be inspected under the ultraviolet lamp with a wavelength of 365mm and 254mm, and there shall be no flake fluorescence. The thickness is recognized in the industry as 0.46-0.55mm pure high-quality wood pulp white cardboard.

To sum up, the whiteboard must strictly meet the standard requirements, so as to ensure the moisture-proof performance of the desiccant, and then ensure the overall moisture-proof function of the effervescent tablet tube, and protect the health of users.

Microbial Limit Testing of Effervescent Tube Caps

 Effervescent tube is a kind of packaging form with special structure design. It consists of two parts: a cover and a tube body. It is mostly used for tablets, capsules and other drugs that need moisture-proof preservation. In the quality standard of packaging, the microbial limit is an important test item.

144mm*29mm effervescent tube packaging

caps for effervescent tube

The quality standard for effervescent tube caps is based on the "YBB00172004-2015" standard for oral solid medicinal low-density polyethylene moisture-proof combined bottle caps. The standard has a detailed description of the detection method of microbial limit, as follows:

Take a few pieces of this product, in a sterile environment, slightly dampen a sterile cotton swab with sodium chloride injection, wipe the bottle cap, wipe each bottle cap with 2 cotton swabs, and cut each cotton swab immediately after wiping (or Burn off), put it into a test tube containing 10ml of sodium chloride injection, shake and mix well, and then get the test solution. Take the test solution for membrane filtration and check according to the law (General Rules 1105 and 1106 of the Chinese Pharmacopoeia 2015 Edition). The cover cannot be detected.

The above is the microbial limit test of the lid of the effervescent tube. The main purpose of controlling this indicator is to prevent the microorganisms in the package from contaminating the drug and bringing the risk of medication to the patient.

Two types of caps for effervescent tubes

 Effervescent tube is a kind of packaging with very good moisture-proof performance, which is mainly used to hold dosage forms such as VC effervescent tablets and chewable tablets. This packaging consists of a cap and a tube body. Depending on the properties of the drug, there are two different types of caps for effervescent tubes: spring caps and non-spring caps.

144mm*29mm effervescent tube packaging

caps for effervescent tube

Spring cover: This is a specially designed cover, which consists of four parts: desiccant, cardboard, coil spring, and anti-theft ring. There is a small medicine compartment on the top of the cover to store the desiccant, avoiding the direct contact between the medicine and the desiccant. touch. The spring is processed from soft LDPE raw materials, and its main function is to compress the tablet to avoid affecting the integrity of the drug due to various external forces during transportation. The anti-theft ring plays a vigilant role, and the cover will automatically fall off when it is opened. Spring caps are mainly used for drugs in larger dosage forms such as VC effervescent tubes.

Non-spring cover: The main difference with the spring cover is that it has no spring, but it also has the function of moisture resistance. Generally, vitamin chewable tablets and small-dose candy pressed tablets will choose this type of cap, and some VC effervescent tablet manufacturers will also use this type of cap.

The above are two types of effervescent tube caps, which meet the storage needs of different medicines and cater to market needs. In the future, with the continuous emergence of new drugs, the packaging will also be more diversified.

Extractable matter testing of caps for effervescent tubes

 As an important part of the packaging, the cap of the effervescent tube is of great significance to the overall sealing and moisture resistance of the packaging. In addition, as the material in direct contact with the drug, the dissolution test must be carried out to ensure that the material does not contain ingredients that affect the safety and stability of the drug.

144mm*29mm effervescent tube packaging

caps for effervescent tube

In China, the standard implemented for effervescent tube caps is YBB00172004-2015 "Quality Standard for Oral Solid Medicinal Low Density Polyethylene Moisture-Proof Combination Caps". The dissolution test in the standard mainly includes three items: easy oxides, nonvolatiles and heavy metals Detection:

Accurately measure 20ml of water test solution for easy oxide, accurately add 20ml of potassium permanganate titration solution (0.002mol/L) and 1ml of dilute sulfuric acid, boil for 3 minutes, cool rapidly, add 0.1g of potassium iodide, and place in a dark place for 5 minutes. Titrate with sodium thiosulfate titration solution (0.01mol/L), when the titration is near the end point, add 5 drops of starch indicator solution, continue to titrate until it is colorless, and take another water blank solution and operate in the same way, both of which consume sodium thiosulfate titration solution. (0.01mo/L) The difference should not exceed 1.5ml.

Non-volatile matter Precisely measure 50ml of water, 65% ethanol, n-hexane test solution and blank solution, respectively, and place them in an evaporating dish with constant weight, evaporate to dryness in a water bath, and dry at 105 °C for 2 hours. The difference between the non-volatile residue of the test solution and the residue of the blank solution should not exceed 12.0 mg: the difference between the non-volatile residue of 65% ethanol and the residue of the blank solution should not exceed 50.0 mg: the difference between the non-volatile residue of n-hexane and the residue of the blank solution should not exceed 50.0 mg. 200.0 mg·

Heavy metals: Precisely measure 20ml of water as test solution, add 2ml of acetate buffer (pH3.5), and check according to the law (the first method of Chinese Pharmacopoeia 2015 edition general rule 0821), and the heavy metal content shall not exceed one millionth.

The dissolution test of effervescent tube caps is an important test item to ensure the quality of packaging. Xinfuda has been engaged in drug packaging for 20 years, and its products have passed ISO15378 certification, US DMF filing and other certifications. If you are choosing packaging for drugs, Welcome to contact us.

What are the characteristics of the cap of the effervescent tube

 The cap of the effervescent tube is composed of bottle cap skeleton, desiccant, cardboard, and coil spring. It uses the space at the top of the lid to store silica gel and molecular sieve. Silica gel can effectively control the number of water molecules for a long time. Absorbs water molecules, so that the internal moisture can be absorbed and the drug will not get wet.

caps for effervescent tube

Effervescent tablet is a kind of tablet medicine containing disintegrant. It disintegrates instantly when put into water, releasing a large amount of carbon dioxide gas. It has very strict requirements on the moisture-proof performance of the effervescent tube, and its cover not only plays an important role in moisture-proof. It also protects the integrity of the effervescent tablet very well.

144mm*29mm effervescent tube packaging

There is a helical spring on the cap, which is made of soft LDPE material, which can compress the tablet and prevent the drug from breaking due to the impact of various external forces during transportation.

In a word, the cap of the effervescent tube is different from the ordinary bottle cap. It not only isolates the outside world from contact with the inside of the package, but also has the functions of moisture-proof and drug integrity protection. It is a cap with its own characteristics.

Requirements for short-term moisture absorption rate of desiccant for effervescent tubes

 Effervescent tube is a kind of drug storage container with very good moisture-proof performance. The performance of the desiccant directly affects the moisture-proof function of the packaging, so what are the requirements for the short-term moisture absorption rate of the desiccant?

144mm*29mm effervescent tube packaging

The desiccant of the effervescent tube is mostly silica gel, molecular sieve or a mixture of the two in equal proportions. According to the requirements of China YBB00172004-2015 "Quality Standard for Oral Solid Medicinal Low Density Polyethylene Moisture-Proof Combination Caps", the short-term moisture absorption rate of the desiccant is required. as follows:

caps for effervescent tube

In an environment where the relative humidity is less than 60%, take 5 finished bottle caps from the same packaging bag, accurately weigh W0, and put the caps into a constant temperature with a temperature of 25°C±2°C and a relative humidity of 60%±5%. In the constant humidity box, take it out after 1 hour, weigh W1, carefully remove the cardboard, and take out the desiccant that has absorbed moisture: wipe the cardboard and bottle cap clean, and weigh W2 together. Calculated according to the following formula, the short-term moisture absorption rate of silica gel, macromolecular sieve, silica gel: macromolecular sieve (4:6) mixed desiccant shall not exceed 3%, 4.5%, and 3.5%, respectively.

The short-term moisture absorption rate of the desiccant is an important indicator to measure the moisture-proof effect of the packaging in a short time. It is related to whether the moisture-proof function of the packaging can be well exerted, and plays an important role in the stability of the drug during the storage period.

Factors Affecting the Forming of Effervescent Tubes-Back Pressure

 In the production process of effervescent tubes, the control of various parameters is the key to ensure the quality of the finished product. This effervescent packaging container is produced by an injection molding process, in which back pressure is also one of the main factors affecting its molding.

144mm*29mm effervescent tablet tube supplier

Injection back pressure refers to the pressure that the screw needs to overcome when the screw is reversed and withdrawn to store the material. The back pressure has a great influence on the melt temperature. The increase of the back pressure makes the material in the screw groove denser, prolongs the heating process of the material in the screw, and improves the plasticization quality of the effervescent tube. The use of high back pressure is conducive to the dispersion of the pigment and the melting of the plastic, but at the same time, it prolongs the retraction time of the screw, reduces the length of the plastic fiber, and increases the pressure of the injection molding machine. Therefore, the back pressure should be lower, generally not more than the injection molding machine. 20% of the pressure.

Back pressure is required for uniform heat melting, especially where the particles are still not melted by shear heat. Mechanical and appearance uniformity, uniform dispersion of color masterbatch (toner) and filler (glass fiber). The air brought in by the removed material is discharged towards the feed port. A uniform melt temperature gradient axis is produced, especially when the effective screw metering length is shortened. Reduce the fluctuation of residual buffer melt from mold to mold due to air trapping during pressurization.

To sum up, back pressure is also an important factor affecting the forming quality of effervescent tubes, and proper setting of back pressure parameters can ensure the quality of the finished product.

What are the characteristics of the cap of the effervescent tube

 The cap of the effervescent tube is composed of bottle cap skeleton, desiccant, cardboard, and coil spring. It uses the space at the top of the lid to store silica gel and molecular sieve. Silica gel can effectively control the number of water molecules for a long time. Absorbs water molecules, so that the internal moisture can be absorbed and the drug will not get wet.

caps for effervescent tube

Effervescent tablet is a kind of tablet medicine containing disintegrant. It disintegrates instantly when put into water, releasing a large amount of carbon dioxide gas. It has very strict requirements on the moisture-proof performance of the effervescent tube, and its cover not only plays an important role in moisture-proof. It also protects the integrity of the effervescent tablet very well.

144mm*29mm effervescent tube packaging

There is a helical spring on the cap, which is made of soft LDPE material, which can compress the tablet and prevent the drug from breaking due to the impact of various external forces during transportation.

In a word, the cap of the effervescent tube is different from the ordinary bottle cap. It not only isolates the outside world from contact with the inside of the package, but also has the functions of moisture-proof and drug integrity protection. It is a cap with its own characteristics.

Requirements for the moisture content of the desiccant in the effervescent tube

 Effervescent tube is a kind of medicine packaging container with excellent moisture-proof performance. On the one hand, its moisture-proof function is realized through strict sealing. On the other hand, silica gel and molecular sieve desiccant are placed inside the package to absorb the internal moisture.

144mm*29mm effervescent tube packaging

For the moisture content of the two desiccants, effervescent tubes also have relevant regulations. In YBB00172004-2015 "Quality Standard for Oral Solid Pharmaceutical Low Density Polyethylene Moisture-Proof Combination Caps", the requirements for the moisture content of the desiccant are as follows:

caps for effervescent tube

In an environment where the relative humidity of silica gel does not exceed 75%, quickly take out the bottle cap from the closed packaging bag, and take out 5-7g of desiccant from the bottle cap, put it in a weighing bottle (W1) with constant weight, and weigh it. Weight (W2), placed in an oven at 180°C ± 10°C (the total time from opening the bottle cap to the time when the desiccant is placed in the oven should not exceed 5 minutes) to constant weight (weighing as W3), calculated by the following formula, containing water The rate must not exceed 4.8%.

Macromolecular sieve In an environment where the relative humidity does not exceed 75%, quickly take out an appropriate amount of the bottle cap from the closed package, take out the desiccant in the bottle cap with tweezers, and place it in a constant weight crucible W0 (add 8-10g to each crucible). ), accurately weighed W1, placed in a high-temperature furnace at 950°C (the total time from opening the cap packaging bag to placing the desiccant in the high-temperature furnace should not exceed 5 minutes), drying for one hour, taking out the crucible, and accurately weighing after cooling. Determine W2, and calculate according to the following formula, and the moisture content should not exceed 4.8%.

The above are the requirements of the effervescent tube for the moisture content of the desiccant. A qualified desiccant is the basis for ensuring its internal moisture-proof performance and is also an important factor to ensure the stability of the effervescent tablet.

How the effervescent tube control moisture-proof function

 As the main packaging form of vitamin C effervescent tablets, the moisture-proof function of effervescent tubes is a point that pharmaceutical companies pay great attention to when choosing packaging. So, how can this kind of packaging control its moisture-proof function?

144mm effervescent tube packaging

The moisture-proof function of packaging is mainly controlled in two aspects, one is to block the invasion of external water molecules, and the other is to maintain the stability of the internal environment of the packaging. Judging from the material of the body of the effervescent tube, polypropylene is the main raw material. This raw material itself has good barrier properties, which can block the invasion of external water molecules and exert the moisture-proof function of the outside of the packaging.

The packaging or tablet itself will carry a certain amount of water molecules during the manufacturing process, so the internal moisture protection is also important. From the internal structure of the package, the lid of the effervescent tube is composed of a bottle cap skeleton, cardboard, coil spring, anti-theft ring and desiccant. The desiccant is stored in a small medicine warehouse, which is composed of an equal proportion mixture of silica gel and molecular sieve. It can absorb the internal water molecules and maintain the stability of the internal environment, thereby ensuring the stability of vitamin C effervescent tablets within the validity period.

Therefore, the moisture-proof function of the effervescent tube is mainly performed in two aspects: external moisture-proof and internal moisture-proof. The raw material assumes the function of external moisture-proof, and the internal desiccant plays the important role of internal moisture-proof. The moisture-proof function of the packaging can be well played.