How to Protect Child Resistant Bottles from Moisture

 As people pay more and more attention to the incidents of children accidentally ingesting medicines, child-proof medicine bottles are applied to more and more medicines to better protect children's safety. Among all pharmaceutical dosage forms, solid drugs have relatively high requirements for moisture-proof performance, so how can this kind of packaging be moisture-proof?

50ml pharma desiccant bottle

The child-resistant bottle adopts a special double-layer structure design, which is opened by pressing down and rotating. The moisture-proof function of the packaging is to prevent the intrusion of external water vapor on the one hand, and to maintain the stability of the internal environment of the bottle on the other hand. The bottle body of this kind of packaging is generally made of polyethylene or polypropylene material. These materials themselves have very good barrier properties. As packaging materials, they can block the invasion of external water vapor and impurities.

desiccant cap

effervescent tube cap

Of course, in addition to preventing the entry of external water vapor, the drug itself will also contain some water molecules during the production process, so it is also necessary to maintain the stability of the internal environment. A desiccant bag will be placed inside the package to absorb moisture. There are also some manufacturers who have made special designs, using the small medicine compartment on the top of the cover to store the desiccant. This kind of cover integrates the functions of moisture-proof and child-proof, and the overall appearance is more beautiful.

The moisture-proof function of the child-proof bottle is very important for solid medicines. It is related to whether your medicines can be well stored within the validity period without deterioration or failure.

How to prevent moisture in child resistant packaging

 With the concern of children's drug poisoning incidents, many drugs have chosen child-safe packaging with protective functions, such as some tablets, capsules or liquid preparations. For solid preparations, moisture resistance is an essential function of packaging. So, how does this packaging prevent moisture?

28 410 child resistant cap

desiccant cap with crc

child resistant cap

Child-resistant packaging is packaging that is difficult for children under 52 months to open (or access to the contents) within a reasonable amount of time, but which is properly used by adults under 70 years of age (including 70 years of age). This kind of package increases the difficulty of opening through the special design of the lid, in order to prevent children from opening the package at will and accidentally eating the medicine. This kind of packaging is essentially a medicinal plastic bottle, and the internal moisture resistance is mainly achieved in two ways:

One is to pack the desiccant in a non-woven bag, then place it inside the bottle, and store it directly with the medicine. With the continuous update and iteration of packaging, a cover with moisture-proof function gradually appeared. It utilizes the space at the top of the lid and stores the desiccant in the small medicine compartment on the top of the lid, which not only realizes the moisture-proof function, but also prevents the direct contact between the medicine and the desiccant.

At present, this kind of packaging with both moisture-proof and child-proof functions has been applied to more and more medicines, and has played a very important role in protecting children's safety and preventing them from eating medicines by mistake.

Factors Affecting the Forming of Effervescent Tubes-Back Pressure

 In the production process of effervescent tubes, the control of various parameters is the key to ensure the quality of the finished product. This effervescent packaging container is produced by an injection molding process, in which back pressure is also one of the main factors affecting its molding.

144mm*29mm effervescent tablet tube supplier

Injection back pressure refers to the pressure that the screw needs to overcome when the screw is reversed and withdrawn to store the material. The back pressure has a great influence on the melt temperature. The increase of the back pressure makes the material in the screw groove denser, prolongs the heating process of the material in the screw, and improves the plasticization quality of the effervescent tube. The use of high back pressure is conducive to the dispersion of the pigment and the melting of the plastic, but at the same time, it prolongs the retraction time of the screw, reduces the length of the plastic fiber, and increases the pressure of the injection molding machine. Therefore, the back pressure should be lower, generally not more than the injection molding machine. 20% of the pressure.

Back pressure is required for uniform heat melting, especially where the particles are still not melted by shear heat. Mechanical and appearance uniformity, uniform dispersion of color masterbatch (toner) and filler (glass fiber). The air brought in by the removed material is discharged towards the feed port. A uniform melt temperature gradient axis is produced, especially when the effective screw metering length is shortened. Reduce the fluctuation of residual buffer melt from mold to mold due to air trapping during pressurization.

To sum up, back pressure is also an important factor affecting the forming quality of effervescent tubes, and proper setting of back pressure parameters can ensure the quality of the finished product.

Molnupiravir for moisture-proof packaging of drugs two requirements

 Molnupiravir is an antiviral drug that inhibits the replication of certain RNA viruses. For the treatment of COVID-19 in people infected with SARS-CoV-2. It belongs to a small molecule drug and is in the form of capsules. What are the requirements of this drug for moisture-proof packaging of drugs?

50ml desiccant bottle

40ml desiccant bottle

medicine cap

Capsules refer to capsules made of special film-forming materials (such as gelatin, cellulose, polysaccharides, etc.), into which the contents (such as powdered and liquid medicines, etc.) or doses are loaded for easy swallowing. Medicines in capsules are generally powders or granules that are irritating to the esophagus and gastric mucosa, or have bad taste, are easily volatile, are easily decomposed by saliva in the oral cavity, and are easily inhaled into the trachea. These medicines are packed into capsules, which not only protect the medicinal properties of the medicines from being destroyed, but also protect the digestive organs and respiratory tract. Removing the capsule shell may result in drug loss, drug waste, and reduced efficacy. In addition, some drugs need to be dissolved and absorbed in the intestine, and the capsule protects the drug from being destroyed by stomach acid.

Molnupiravir's requirements for moisture-proof packaging of pharmaceuticals are mainly moisture-proof and airtight. These drugs are very sensitive to water molecules, and are prone to adhesion and deliquescence after being exposed to moisture, and their efficacy is greatly reduced, and sometimes there are toxic and side effects. In order to maintain the stability of the internal environment of the packaging, a desiccant will be included in the moisture-proof packaging of medicines to absorb moisture. There are also strict requirements for indicators such as the water absorption rate of the desiccant. In terms of sealing, it is mainly the ability of the bottle mouth and the bottle cap to cooperate, and to ensure the accuracy of the size, in order to better ensure the good sealing of the package.

The above are the two requirements of Molnupiravir for moisture-proof packaging of drugs, which are also two very important aspects to maintain drug stability and safety. Pharmaceutical companies should pay attention when choosing packaging.

DMF List

Molnupiravir for moisture-proof packaging of drugs two requirements

Molnupiravir is an antiviral drug that inhibits the replication of certain RNA viruses. For the treatment of COVID-19 in people infected with SARS-CoV-2. It belongs to a small molecule drug and is in the form of capsules. What are the requirements of this drug for moisture-proof packaging of drugs?

50ml desiccant bottle

40ml desiccant bottle

medicine cap

Capsules refer to capsules made of special film-forming materials (such as gelatin, cellulose, polysaccharides, etc.), into which the contents (such as powdered and liquid medicines, etc.) or doses are loaded for easy swallowing. Medicines in capsules are generally powders or granules that are irritating to the esophagus and gastric mucosa, or have bad taste, are easily volatile, are easily decomposed by saliva in the oral cavity, and are easily inhaled into the trachea. These medicines are packed into capsules, which not only protect the medicinal properties of the medicines from being destroyed, but also protect the digestive organs and respiratory tract. Removing the capsule shell may result in drug loss, drug waste, and reduced efficacy. In addition, some drugs need to be dissolved and absorbed in the intestine, and the capsule protects the drug from being destroyed by stomach acid.

Molnupiravir's requirements for moisture-proof packaging of pharmaceuticals are mainly moisture-proof and airtight. These drugs are very sensitive to water molecules, and are prone to adhesion and deliquescence after being exposed to moisture, and their efficacy is greatly reduced, and sometimes there are toxic and side effects. In order to maintain the stability of the internal environment of the packaging, a desiccant will be included in the moisture-proof packaging of medicines to absorb moisture. There are also strict requirements for indicators such as the water absorption rate of the desiccant. In terms of sealing, it is mainly the ability of the bottle mouth and the bottle cap to cooperate, and to ensure the accuracy of the size, in order to better ensure the good sealing of the package.

The above are the two requirements of Molnupiravir for moisture-proof packaging of drugs, which are also two very important aspects to maintain drug stability and safety. Pharmaceutical companies should pay attention when choosing packaging.

DMF List

Test standard of desiccant cap

 

desiccant caps for pharma bottles

The following is the test standard for pharmaceutical desiccant caps:

1. Appearance

According to the quality requirements of plastic products, combined with the actual sample description, in line with the purpose of fully reflecting the quality of the product.

2. Identification

In order to effectively control the quality of the product and strengthen the monitoring of the formula and set the project, we refer to the YBB00172004-2015 method, select the infrared spectrum and density test, the index is consistent with YBB00112002-2015

3. Residue on ignition

The purpose of this test is to control the inorganic impurities in the plastic. We followed the 0.1% standard for YBB00172004-2015 and the 3.0% standard for the cover with sunscreen.

4. Desiccant Moisture Content Desiccant is a highly absorbent material that may absorb water during production. In order to ensure the quality of the product, it is necessary to control the moisture content of the desiccant to ensure the quality of the product before use.

5. Saturating agent saturated moisture absorption rate 

The desiccant capacity of the desiccant is an important indicator to check the quality of the desiccant. The saturated moisture absorption rate of different desiccants is different. To achieve the saturation of moisture absorption, it is taken out to constant weight after 8 days.

6. Short-term moisture absorption rate of desiccant

The short-term moisture absorption capacity of desiccant is also an important indicator to examine the quality of desiccant, simulating the hygroscopicity of the product during use.

7. Drop resistance

This product is a combination and should consider the combined performance of the product.

8. Physical and chemical properties of cardboard

According to the requirements of YBB00172004-2015, the physical and chemical indicators of cardboard have been established.

9. Dissolution test

Easy Oxide This item is designed to control the impurities in the water-soluble extract of the product that may affect the safety and effectiveness of the drug. Method YBB00172004-2015, the indicator is still no more than 1.0ml.

Heavy metals To control the total amount of heavy metals, set this item. . The method of the Pharmacopoeia of the People's Republic of China is adopted, and the indicator is one in a million

Non-volatile methods and indicators are fully based on the requirements of YBB00172004-2015.

10. Microbiological limits The method of the Pharmacopoeia of the People's Republic of China shall be adopted and shall comply with the regulations.

11. Abnormal toxicity The method of the Pharmacopoeia of the People's Republic of China is adopted and should comply with the regulations.

Desiccant packaging prevent moisture entering bottle

There are six sources of moisture in pharmaceutical packaging containers. First, the body and the cap material have a certain amount of water, and secondly, the water in the medicine and the desiccant packaging material is evaporated during the production process and storage, and third, the moisture contained in the drug itself; fourth, the packaging material of the packaged product itself contains moisture, released during storage. Fifth, the moisture contained in the air in the packaging bag after the packaging container is sealed. Sixth, after sealing, the water molecules in the outside atmosphere penetrate into the product during transportation and storage.

desiccant packaging

Desiccant

The desiccant physically adsorbs water molecules in its own structure, or chemically absorbs water molecules and changes its chemical structure to become another substance. Affect the number of water molecules in the effervescent bottle:

First, the size of the packaging container (dry space), the humidity requirements of the packaged product (ie, the relative humidity of the predetermined control)

Second,the water content of the product itself

Third,the properties of the packaging materials used in the product (especially moisture permeability)

desiccant cap

Fourth, the degree of sealing of the product packaging,

Fifth, the temperature and humidity of the environment when the product is packaged, the shelf life of the product, the environment and climatic conditions for product transportation and storage, etc.

Moisture-proof bottle feature

Moisture-proof bottles are now widely used in the field of food and medicinal plastic bottles, and plastic bottles are used to hold nutritious tablets or solid medicines. The moisture-proof bottle is widely used inseparable from its unique design. It is generally used to store effervescent tablets, and it is also used to fill the foot film. It is composed of barrels with different specifications and moisture-proof caps.


moisture proof bottle
The effervescent tablet container is characterized by the design of the lid, which is composed of a silica gel, a spiral ring and a small medicine silo. The silica gel plays a role of adsorbing moisture in the inside, which can prevent the drug from damaging after absorbing moisture. The spiral ring plays a role in protecting the tablet medicine here, and can prevent the tablet from being damaged due to shaking during the transportation process, and the small drug warehouse mainly It is used to hold silica gel desiccant to prevent children from eating and protecting.