Effervescent tube water vapor transmission rate test

 In the field of pharmaceutical packaging, effervescent tubes play a critical role in protecting moisture-sensitive medications such as vitamin C effervescent tablets, certain tablets, and capsules. Among the various performance indicators, the water vapor transmission rate (WVTR) is a key metric used to assess the moisture barrier properties of effervescent tubes. The accuracy and standardization of WVTR testing methods directly affect the quality and safety of the medications. Let's take a closer look at this crucial testing process.

cap for effervescent tube

I. Significance of Testing: A Critical Line of Defense for Drug Quality

The stability and efficacy of medications are closely tied to their storage conditions, with humidity being one of the most critical factors. As the "protective outerwear" of pharmaceuticals, effervescent tubes must have excellent moisture barrier performance. If the water vapor transmission rate is too high, external moisture can silently seep in and cause the drug to absorb moisture. This not only alters the physical form of the medication—such as causing effervescent tablets to clump or tablets to deform—but can also affect its chemical properties, reducing efficacy and potentially generating harmful impurities that pose health risks to patients. Therefore, accurately testing the WVTR of effervescent tubes is a vital prerequisite for ensuring drug quality and safe, effective medication use.

II. Testing Standards: The Foundation of Standardized Procedures

According to the authoritative Chinese standard "Oral Solid Pharmaceutical Polypropylene Bottles" (YBB00112002-2015), the WVTR testing process for effervescent tubes follows a clearly defined and standardized procedure. Specifically, the test must use Method 3 (2) from "Water Vapor Transmission Rate Testing Method" (YBB00092003-2015). During testing, environmental conditions must be strictly controlled, with temperature maintained at 25°C ± 2°C and relative humidity at 95% ± 5%. Only under these standardized conditions can the resulting WVTR values be accurate and comparable, truly reflecting the moisture barrier performance of the tubes. According to the regulations, the WVTR of effervescent tubes must not exceed 100 mg/24h·L, which serves as a key benchmark for determining whether the tubes meet quality standards.

III. Key Testing Considerations: Ensuring Accuracy and Reliability

In actual testing, many details can impact the accuracy of the results. First, sample selection is crucial. Since factors like material type, thickness, and structure can all affect WVTR, it's essential to select samples with the same material, thickness, and structure. This minimizes errors caused by sample differences and ensures the test accurately reflects the true performance of the effervescent tubes. For example, different materials have different molecular structures and thus vary greatly in their ability to block water vapor; similarly, variations in thickness can influence how easily water vapor penetrates.

effervescent tube

Second, the stability of the testing environment must not be overlooked. Fluctuations in temperature and humidity can affect the diffusion rate of water vapor, thereby skewing test results. In conditions with higher temperatures or unstable humidity, water vapor molecules become more active, potentially increasing the amount that passes through the tube and causing deviations in the results. Thus, testing must be conducted in a stable environment with precisely controlled temperature and humidity. Laboratories must be equipped with high-precision environmental control systems to continuously monitor and adjust conditions, ensuring the entire testing process stays within the required standards.

WVTR testing for effervescent tubes is a vital step in safeguarding the quality and safety of medications. By strictly adhering to testing standards and paying close attention to key details during testing, accurate and reliable results can be obtained, allowing for the selection of high-performance tubes that effectively protect medications during storage and transport—ultimately safeguarding patient health.

Effervescent tablet packaging for nutraceutical applications

 Effervescent tablet packaging for nutraceutical applications requires careful consideration of factors like moisture control, convenience, and maintaining product efficacy. Here’s an overview of key aspects:

effervescent tablet packaging

1. Moisture Barrier

Effervescent tablets are highly sensitive to moisture because they dissolve when exposed to humidity. To preserve their integrity:

Desiccant Materials: Packaging often includes silica gel or molecular sieve desiccants inside the container to absorb any moisture.

2. Primary Packaging Types

Tubes: Common for effervescent tablets, these tubes are moisture-proof and feature desiccant stoppers to keep the contents dry.

Blister Packs: Each tablet is sealed in its own compartment, preventing contact with air until use.

Stick Packs: Single-serve packaging where each tablet is packed individually, providing ease of use and portability.

3. Secondary Packaging

Secondary packaging, such as boxes or cartons, is often used for branding, labeling, and ensuring the protection of the product during transportation.

4. Tamper-Evident Seals: Seals or shrink bands around the tube or bottle ensure that consumers know if the product has been tampered with.

5. Sustainability

As sustainability becomes more important, the use of recyclable or biodegradable materials is gaining traction, along with efforts to reduce the overall packaging footprint.

6. Labeling and Branding

Since nutraceuticals are often marketed as wellness or dietary supplements, the packaging design should convey a sense of health and vitality. 

Application of effervescent tablet packaging in arginine effervescent tablets

 The application of effervescent tablet packaging in arginine effervescent tablets is a key technology. It not only provides excellent protection performance, but also brings convenient and efficient use experience to users. This special packaging design provides a good environment for transportation and storage, and ensures the integrity and efficacy of the tablets.

144mm*29mm effervescent tube packaging

caps for effervescent tube

First, the effervescent tube is made of polyethylene, which has excellent moisture resistance and barrier properties, and can effectively prevent moisture and oxygen from entering the tube, thereby maintaining the stability and effectiveness of the drug. In addition, a desiccant compartment is provided on the top of the tube cover, which can absorb moisture in the tube and further maintain the stability of the drug environment. This design ensures that the drug is not affected by moisture and oxidation during transportation and storage, and maintains the stability and durability of the drug efficacy.

Secondly, a spiral spring is also used inside the effervescent tube to compress the tablet to prevent the tablet from breaking or deforming due to violent shaking during transportation. This design takes into account the stability and integrity of the drug, ensuring that users can obtain a complete and effective dose of the drug when opening the package, and improving the user's experience and trust.

As a high-quality pre-workout sports nutrition supplement, the packaging design of arginine effervescent tablets not only meets the protection needs of the drug, but also provides users with a convenient way of use. The use of effervescent tablets can effectively increase the level of nitric oxide in the body, dilate blood vessels, and promote the supply of oxygen and nutrients to muscles, thereby improving sports performance, improving blood circulation, and reducing sports fatigue. This innovative packaging design provides important support for the health and sports performance of users, and demonstrates the outstanding application and innovative achievements of modern medical technology in the field of sports nutrition.

Choose this way for high-quality effervescent tablet packaging

 A high-quality packaging is of great significance to the safety and stability of medicines during storage. Vitamin effervescent tablets are common nutritional supplements in our lives. Its dosage form is thick and large. So how should we choose high-quality effervescent tablet packaging? ? There are 4 points to note:

effervescent tablet packaging

caps for effervescent tube

1. Packaging materials: Packaging materials are the first thing we need to consider, as they are related to the overall quality of effervescent tablet packaging. Generally, the tube is made of polypropylene and the lid is made of low-density polyethylene. The combination of the harder polypropylene and the soft low-density polyethylene can achieve better sealing and provide more stable protection for the effervescent tablets. When choosing, we must consider whether the material manufacturer and the pharmaceutical packaging material company have a good material management system to ensure that packaging materials are well stored.

2. Special design: Different from ordinary plastic bottles, effervescent tubes are packaged in straight barrels. The diameter of the bottle is generally slightly larger than the diameter of the effervescent tablets. There is a desiccant bin on the top of the cap, which can store desiccant and maintain the inside. environmental stability. Due to the large dosage form, in order to prevent damage during transportation, there will be a soft coil spring on the cap, which can compress the tablet and protect the integrity of the tablet. Of course, there are also caps without springs. . Here we need to consider the special design of the cover based on the actual situation, including the type and amount of desiccant.

144mm*29mm effervescent tube packaging

3. Specification selection: There are many specifications for effervescent tablet packaging, the common ones are 84mm/96mm/99mm/133mm/144mm, etc. The size here is calculated based on the height of the tube. When selecting specifications, we need to choose the packaging of corresponding specifications according to the diameter and thickness of the film. If there are special needs, we can also make exclusive customizations.

4. Manufacturer strength: The above is considered from the perspective of products. On the other hand, we must also start from the strength of pharmaceutical packaging material manufacturers and comprehensively consider factors such as production scale, equipment, quality management, and services. These are related to Whether the product can be delivered on schedule, product quality control, etc.

How to choose the packaging of high-quality effervescent tablets? It can be easily done by examining factors such as packaging materials, special design, specification selection, and manufacturer’s strength. Have you learned it?

How to ensure the sealing of effervescent tablet packaging

 Sealing is the basic function of pharmaceutical packaging, and it is also a prerequisite for ensuring drug safety. Effervescent tablet packaging, as the special packaging for vitamin effervescent tablets, also has strict requirements on airtightness. In order to ensure this performance, it is usually necessary to control from various aspects such as material selection, sealing technology, packaging design, and production process control.

144mm*29mm effervescent tube packaging

caps for effervescent tube

1. Material selection: Effervescent tablet packaging usually uses materials with good sealing properties, such as polyethylene, polypropylene, etc. These materials have high sealing performance and can effectively prevent the entry of oxygen and moisture, thereby maintaining the stability and efficacy of the effervescent tablet.

2. One-time seal: Effervescent tablet packaging usually adopts one-time seal, that is, once the seal is completed, it cannot be reopened or resealed. This design can prevent the package from being opened illegally or maliciously, ensuring the safety and integrity of the product.

3. Packaging Design: Packaging is usually designed with sealing performance in mind. For example, the caliber of the bottle and the design of the cap can ensure a complete seal and exclude the outside air. In addition, some packages are equipped with security seals or anti-counterfeiting devices to improve airtightness and product security.

4. Strict production and quality control: In the production process of effervescent tablet packaging, strict production control and quality inspection are required. Manufacturers will formulate standard operating procedures and use high-quality equipment and processes to ensure the sealing performance of each package. Quality control personnel will test and sample the seal to ensure that the product meets the standard requirements.

Through the above methods, the sealing performance of the effervescent tablet packaging can be effectively guaranteed, ensuring the stability, safety and efficacy of the product.

How to ensure the sealing of effervescent tablet packaging

Sealing is the basic function of pharmaceutical packaging, and it is also a prerequisite for ensuring drug safety. Effervescent tablet packaging, as the special packaging for vitamin effervescent tablets, also has strict requirements on airtightness. In order to ensure this performance, it is usually necessary to control from various aspects such as material selection, sealing technology, packaging design, and production process control.

144mm*29mm effervescent tube packaging

caps for effervescent tube

1. Material selection: Effervescent tablet packaging usually uses materials with good sealing properties, such as polyethylene, polypropylene, etc. These materials have high sealing performance and can effectively prevent the entry of oxygen and moisture, thereby maintaining the stability and efficacy of the effervescent tablet.

2. One-time seal: Effervescent tablet packaging usually adopts one-time seal, that is, once the seal is completed, it cannot be reopened or resealed. This design can prevent the package from being opened illegally or maliciously, ensuring the safety and integrity of the product.

3. Packaging Design: Packaging is usually designed with sealing performance in mind. For example, the caliber of the bottle and the design of the cap can ensure a complete seal and exclude the outside air. In addition, some packages are equipped with security seals or anti-counterfeiting devices to improve airtightness and product security.

4. Strict production and quality control: In the production process of effervescent tablet packaging, strict production control and quality inspection are required. Manufacturers will formulate standard operating procedures and use high-quality equipment and processes to ensure the sealing performance of each package. Quality control personnel will test and sample the seal to ensure that the product meets the standard requirements.

Through the above methods, the sealing performance of the effervescent tablet packaging can be effectively guaranteed, ensuring the stability, safety and efficacy of the product. 

The role of the anti-theft ring on the cap of the effervescent tube

 The main function of effervescent tablets is to enhance the body's resistance, and to prevent and treat various acute and chronic infectious diseases, or other diseases. When it comes to health problems, pharmaceutical packaging manufacturers will pay special attention to it. One is the anti-theft ring on the cap of the effervescent tube.

144mm*29mm effervescent tube packaging

caps for effervescent tube

Because if the effervescent tube used up is stolen by someone, it will produce various adverse consequences after being put into fake and shoddy products and eaten by people by mistake. Therefore, in order to prevent counterfeit and shoddy products from flooding the market and ensure that the quality of the contents is not maliciously damaged, most of the current bottle caps have adopted an anti-theft structure.

The anti-theft ring is processed by cutting the ring, and the injection molding process can achieve "the anti-theft ring integrally formed with the bottle cap body" through the mold mechanism, but the cost of the mold is relatively high. The anti-theft ring on the cap of the effervescent tube is set at the neck of the bottle, and the anti-theft ring will be stuck when the moisture-proof cover is closed, and when it is opened again, the anti-theft ring will automatically fall off, which has a very good anti-theft effect.

Xinfuda is a packaging company aiming at functional packaging and overall solution provider. In the future, the overall design of the effervescent tube will not only be reflected on the bottle cap, but more functional designs will be continuously excavated to adapt to continuous changes. market demand.

The role of the anti-theft ring on the cap of the effervescent tube

 The main function of effervescent tablets is to enhance the body's resistance, and to prevent and treat various acute and chronic infectious diseases, or other diseases. When it comes to health problems, pharmaceutical packaging manufacturers will pay special attention to it. One is the anti-theft ring on the cap of the effervescent tube.

144mm*29mm effervescent tube packaging

caps for effervescent tube

Because if the effervescent tube used up is stolen by someone, it will produce various adverse consequences after being put into fake and shoddy products and eaten by people by mistake. Therefore, in order to prevent counterfeit and shoddy products from flooding the market and ensure that the quality of the contents is not maliciously damaged, most of the current bottle caps have adopted an anti-theft structure.

The anti-theft ring is processed by cutting the ring, and the injection molding process can achieve "the anti-theft ring integrally formed with the bottle cap body" through the mold mechanism, but the cost of the mold is relatively high. The anti-theft ring on the cap of the effervescent tube is set at the neck of the bottle, and the anti-theft ring will be stuck when the moisture-proof cover is closed, and when it is opened again, the anti-theft ring will automatically fall off, which has a very good anti-theft effect.

Xinfuda is a packaging company aiming at functional packaging and overall solution provider. In the future, the overall design of the effervescent tube will not only be reflected on the bottle cap, but more functional designs will be continuously excavated to adapt to continuous changes. market demand.

Introduction of desiccant in effervescent tube

 We know that the packaging of effervescent tablets—the effervescent tube has very high requirements for moisture-proof performance, because due to the characteristics of effervescent tablets, it will cause disintegration and deterioration after being exposed to moisture. Today, I would like to share with you the desiccants that play an important role and their characteristics.

144mm*29mm effervescent tube packaging

caps for effervescent tube

The main material of the desiccant used in the effervescent tube is silica gel and molecular sieve. Among them, silica gel is a highly active adsorption material, with a very fine pore network structure inside, which can be used to absorb water and retain water, and it is an extremely suitable desiccant at room temperature, while it can desiccate the environment at high temperature. Humidity is reduced to the point where it does not affect the medicine.

Molecular sieve desiccant is a synthetic product. It has regular and uniform pores in its crystal structure. The pore diameter is on the order of molecular size. To be sieved, it is called molecular sieve. Its material can absorb water vapor and other gases at the same time. And the moisture absorption effect is fast.

The desiccant in the packaging of effervescent tablets is generally a mixture of silica gel and molecular sieve in equal proportions. Silica gel has strong moisture absorption capacity and molecular sieve has a fast moisture absorption speed. After the two are mixed, they can achieve a good moisture absorption effect and ensure the stability of effervescent tablets.

Three criteria for effervescent tube selection

 The effervescent tube is a special packaging made of polypropylene in a straight barrel. Today, when the health of the whole people is popularized, we have three more important standard choices when choosing to purchase effervescent tubes, that is:

144mm*29mm effervescent tube packaging

caps for effervescent tube

1. Qualification of effervescent tube manufacturer

In addition to the business qualification requirements of enterprises in China, there are also some requirements for pharmaceutical packaging materials, and it is also necessary to register with the drug supervision and management department and obtain the "Drug Packaging Material Registration Certificate" before production. If the drug needs to be exported to foreign countries, it needs to go through foreign filing, such as EU certification, US DMF filing, etc. And Xinfuda is a company with complete formalities and qualifications.

2. The strength of effervescent tube manufacturers

Manufacturer qualification is the basic requirement for pharmaceutical packaging material manufacturers, followed by strength, such as whether the production equipment is advanced, whether the production process is mature, whether it has a high-standard clean workshop, whether the production scale can meet the needs of pharmaceutical companies, etc. The side reflects the strength of the manufacturer, and a strong manufacturer is more secure in product quality control and post-service.

3. Product quality of effervescent tube

The quality of effervescent tubes is a point that pharmaceutical companies need to pay special attention to. While meeting the requirements of national standards, they must also meet the characteristics of the drug. Cost-effective packaging is the constant pursuit of pharmaceutical companies. On the basis of meeting the above conditions, consider the cost-effectiveness of effervescent tubes.

Of course, when pharmaceutical companies choose effervescent tube suppliers, they generally put product quality and cost-effectiveness first. However, no matter which factor is considered first, the qualification and strength of the manufacturer are still important factors that cannot be ignored.

Effect of desiccant in effervescent tube on effervescent tablet

Today, with the health awareness of the whole people, we always keep some medicines or health care products at home, such as effervescent tablets. A desiccant is usually placed in the bottle. Will the desiccant in the bottle affect the effervescent tablet?

144mm*29mm effervescent tube packaging

caps for effervescent tube

First of all, we need to clarify one thing that effervescent tablets are tablets containing effervescent disintegrants, which have high requirements for the moisture-proof performance of the packaging. The effervescent tablet tube is a special package used to store this kind of tablet. A desiccant is usually placed inside the package to absorb moisture. The material of the desiccant itself is silica gel, molecular sieve and a mixture of the two materials for customers to choose. It is non-toxic, harmless and highly hygroscopic.

And the difference of the effervescent tablet tube is mainly reflected in the bottle cap, and the cap of the effervescent tablet tube is provided with a small medicine compartment, which contains a desiccant. It can achieve zero contact between the desiccant and the medicine without contacting the medicine, and by the way, it can prevent children from eating the desiccant by mistake. And there are relevant regulations to regulate desiccants, such as the "Pharmaceutical Packaging Material Registration Certificate" has clear regulations.

So to sum up, unless the desiccant in the effervescent tube breaks and comes into contact with the drug to cause secondary pollution, the desiccant in the effervescent tube will not affect the effervescent tablet.

Factors Affecting Moisture Resistance of Effervescent Tablet Tubes

 Effervescent tablet is a new type of preparation, which originated from abroad and has been widely used in China in recent years. Due to the complex and difficult production process and high production cost, this dosage form has very strict requirements on packaging. Then as an effervescent tube as a special packaging for effervescent tablets, in order to prevent the medicine from being damp, denatured, and invalidated, a desiccant is usually placed in the bottle.

144mm*29mm effervescent tube packaging

caps for effervescent tube

But we also need to pay attention to the fact that the desiccant in the effervescent tube is sealed by white cardboard. There are certain requirements for the thickness and moisture content of the cardboard. If the cardboard is too thick, it will enhance the barrier effect on the desiccant and affect its moisture resistance. If the moisture content is too high, the desiccant will apply more moisture absorption performance to the cardboard, reducing the overall moisture resistance of the packaging internal environment. The quality requirements for effervescent tubes are in accordance with the national standard YBB00172004-2015 "Oral Solid Medicinal Low-density Polyethylene Moisture-proof Composite Bottle Caps", in which the requirements for cardboard are as follows: the moisture content is less than 6%, the The lead shall not exceed 0.0005%, and the drug contact surface shall be inspected under the ultraviolet lamp with a wavelength of 365mm and 254mm, and there shall be no flake fluorescence. The thickness is recognized in the industry as 0.46-0.55mm pure high-quality wood pulp white cardboard.

To sum up, the whiteboard must strictly meet the standard requirements, so as to ensure the moisture-proof performance of the desiccant, and then ensure the overall moisture-proof function of the effervescent tablet tube, and protect the health of users.

Analysis of the causes of moisture inside the effervescent tube

 Effervescent tablets are a kind of pharmaceutical dosage forms containing disintegrants. There are many kinds of them, such as aspirin effervescent tablets for antipyretic and analgesic, Chinese patent medicine Jinlian Qingre effervescent tablets, multi-dimensional effervescent tablets for supplementing vitamins or trace elements, etc. As a special item, it has very strict requirements on packaging effervescent tubes. If it gets wet, it will easily lead to deterioration of medicines, affect the efficacy of medicines and even human health. In order to avoid this situation, we can avoid the effervescent tube from getting damp from the following aspects:

144mm*29mm effervescent tube packaging

caps for effervescent tube

1. Sealing: If the inside of the effervescent tube is damp, first consider whether the sealing of the effervescent tube is qualified. The factors affecting the sealing performance mainly depend on the precision of the mold and the strict control of each production link. The material of the effervescent tube generally has moisture resistance, which can block the external water molecules, but if the seal is not tight, it is easy to cause water vapor to enter the inside of the effervescent tube, causing the medicine to be damp and deteriorate.

2. Dosage of desiccant: The desiccant of the effervescent tube is mainly a mixture of silica gel and molecular sieve. If the inside of the effervescent tube is still damp when the overall sealing is good, it may be because the amount of desiccant is not enough to completely To absorb the moisture of the medicine itself, consider increasing the amount of desiccant.

3. External environment: The moisture inside the effervescent tube is also related to the external environment. If the storage environment is too humid, it is easy to get damp inside the effervescent tube, so try to choose a dry and ventilated place during storage.

If we encounter moisture in the effervescent tube later, we can try to analyze these aspects to avoid this situation and ensure our stability during drug storage.

Effervesent Tablet Tubes: FAQ Guide

 Effervescent table tubes is popular in pharmaceutcial packaging, this guide main contain more detials and questions you want to know.

144mm*29mm effervescent tube packaging

caps for effervescent tube

1. what is packaging requirement fo effervescent tablet?

   Moisture
   

2. what is effervescent tablet tube?
   

3. what is application of the effervescent tube?

   
   

4. what is standard size for effervescet tablet tube?

   There are 144mm*29mm and...

5. what is material of effervescent tube?

   PP and PE

6. what is inside the cap of effervescent vitamin c tablets?

   There are silica gel desiccant
   

7. How long is the shelf life of the desiccant of the effervescent tube?

    If the effervescent tube is not opened, the theoretical data of the internal desiccant shelf life experiment is two years
   

8. How to test the tightness of effervescent tubes?

9. Production environment requirements for effervescent tubes?

10. Do effervescent tubes maufacturer provide printing and labeling services?

    Screen printing and flexographic printing

11. What information should be included on the label of an effervescent tube?

    Label of effervescent tube contain more information
    

12. What is the desiccant for effervescent lids?

    Silica gel

Factors Affecting Moisture Resistance of Effervescent Tablet Tubes

 Effervescent tablet is a new type of preparation, which originated from abroad and has been widely used in China in recent years. Due to the complex and difficult production process and high production cost, this dosage form has very strict requirements on packaging. Then as an effervescent tube as a special packaging for effervescent tablets, in order to prevent the medicine from being damp, denatured, and invalidated, a desiccant is usually placed in the bottle.

144mm*29mm effervescent tube packaging

caps for effervescent tube

But we also need to pay attention to the fact that the desiccant in the effervescent tube is sealed by white cardboard. There are certain requirements for the thickness and moisture content of the cardboard. If the cardboard is too thick, it will enhance the barrier effect on the desiccant and affect its moisture resistance. If the moisture content is too high, the desiccant will apply more moisture absorption performance to the cardboard, reducing the overall moisture resistance of the packaging internal environment. The quality requirements for effervescent tubes are in accordance with the national standard YBB00172004-2015 "Oral Solid Medicinal Low-density Polyethylene Moisture-proof Composite Bottle Caps", in which the requirements for cardboard are as follows: the moisture content is less than 6%, the The lead shall not exceed 0.0005%, and the drug contact surface shall be inspected under the ultraviolet lamp with a wavelength of 365mm and 254mm, and there shall be no flake fluorescence. The thickness is recognized in the industry as 0.46-0.55mm pure high-quality wood pulp white cardboard.

To sum up, the whiteboard must strictly meet the standard requirements, so as to ensure the moisture-proof performance of the desiccant, and then ensure the overall moisture-proof function of the effervescent tablet tube, and protect the health of users.

Extractable matter testing of caps for effervescent tubes

 As an important part of the packaging, the cap of the effervescent tube is of great significance to the overall sealing and moisture resistance of the packaging. In addition, as the material in direct contact with the drug, the dissolution test must be carried out to ensure that the material does not contain ingredients that affect the safety and stability of the drug.

144mm*29mm effervescent tube packaging

caps for effervescent tube

In China, the standard implemented for effervescent tube caps is YBB00172004-2015 "Quality Standard for Oral Solid Medicinal Low Density Polyethylene Moisture-Proof Combination Caps". The dissolution test in the standard mainly includes three items: easy oxides, nonvolatiles and heavy metals Detection:

Accurately measure 20ml of water test solution for easy oxide, accurately add 20ml of potassium permanganate titration solution (0.002mol/L) and 1ml of dilute sulfuric acid, boil for 3 minutes, cool rapidly, add 0.1g of potassium iodide, and place in a dark place for 5 minutes. Titrate with sodium thiosulfate titration solution (0.01mol/L), when the titration is near the end point, add 5 drops of starch indicator solution, continue to titrate until it is colorless, and take another water blank solution and operate in the same way, both of which consume sodium thiosulfate titration solution. (0.01mo/L) The difference should not exceed 1.5ml.

Non-volatile matter Precisely measure 50ml of water, 65% ethanol, n-hexane test solution and blank solution, respectively, and place them in an evaporating dish with constant weight, evaporate to dryness in a water bath, and dry at 105 °C for 2 hours. The difference between the non-volatile residue of the test solution and the residue of the blank solution should not exceed 12.0 mg: the difference between the non-volatile residue of 65% ethanol and the residue of the blank solution should not exceed 50.0 mg: the difference between the non-volatile residue of n-hexane and the residue of the blank solution should not exceed 50.0 mg. 200.0 mg·

Heavy metals: Precisely measure 20ml of water as test solution, add 2ml of acetate buffer (pH3.5), and check according to the law (the first method of Chinese Pharmacopoeia 2015 edition general rule 0821), and the heavy metal content shall not exceed one millionth.

The dissolution test of effervescent tube caps is an important test item to ensure the quality of packaging. Xinfuda has been engaged in drug packaging for 20 years, and its products have passed ISO15378 certification, US DMF filing and other certifications. If you are choosing packaging for drugs, Welcome to contact us.