Three criteria for effervescent tube selection

 The effervescent tube is a special packaging made of polypropylene in a straight barrel. Today, when the health of the whole people is popularized, we have three more important standard choices when choosing to purchase effervescent tubes, that is:

144mm*29mm effervescent tube packaging

caps for effervescent tube

1. Qualification of effervescent tube manufacturer

In addition to the business qualification requirements of enterprises in China, there are also some requirements for pharmaceutical packaging materials, and it is also necessary to register with the drug supervision and management department and obtain the "Drug Packaging Material Registration Certificate" before production. If the drug needs to be exported to foreign countries, it needs to go through foreign filing, such as EU certification, US DMF filing, etc. And Xinfuda is a company with complete formalities and qualifications.

2. The strength of effervescent tube manufacturers

Manufacturer qualification is the basic requirement for pharmaceutical packaging material manufacturers, followed by strength, such as whether the production equipment is advanced, whether the production process is mature, whether it has a high-standard clean workshop, whether the production scale can meet the needs of pharmaceutical companies, etc. The side reflects the strength of the manufacturer, and a strong manufacturer is more secure in product quality control and post-service.

3. Product quality of effervescent tube

The quality of effervescent tubes is a point that pharmaceutical companies need to pay special attention to. While meeting the requirements of national standards, they must also meet the characteristics of the drug. Cost-effective packaging is the constant pursuit of pharmaceutical companies. On the basis of meeting the above conditions, consider the cost-effectiveness of effervescent tubes.

Of course, when pharmaceutical companies choose effervescent tube suppliers, they generally put product quality and cost-effectiveness first. However, no matter which factor is considered first, the qualification and strength of the manufacturer are still important factors that cannot be ignored.

Factors Affecting Moisture Resistance of Effervescent Tablet Tubes

 Effervescent tablet is a new type of preparation, which originated from abroad and has been widely used in China in recent years. Due to the complex and difficult production process and high production cost, this dosage form has very strict requirements on packaging. Then as an effervescent tube as a special packaging for effervescent tablets, in order to prevent the medicine from being damp, denatured, and invalidated, a desiccant is usually placed in the bottle.

144mm*29mm effervescent tube packaging

caps for effervescent tube

But we also need to pay attention to the fact that the desiccant in the effervescent tube is sealed by white cardboard. There are certain requirements for the thickness and moisture content of the cardboard. If the cardboard is too thick, it will enhance the barrier effect on the desiccant and affect its moisture resistance. If the moisture content is too high, the desiccant will apply more moisture absorption performance to the cardboard, reducing the overall moisture resistance of the packaging internal environment. The quality requirements for effervescent tubes are in accordance with the national standard YBB00172004-2015 "Oral Solid Medicinal Low-density Polyethylene Moisture-proof Composite Bottle Caps", in which the requirements for cardboard are as follows: the moisture content is less than 6%, the The lead shall not exceed 0.0005%, and the drug contact surface shall be inspected under the ultraviolet lamp with a wavelength of 365mm and 254mm, and there shall be no flake fluorescence. The thickness is recognized in the industry as 0.46-0.55mm pure high-quality wood pulp white cardboard.

To sum up, the whiteboard must strictly meet the standard requirements, so as to ensure the moisture-proof performance of the desiccant, and then ensure the overall moisture-proof function of the effervescent tablet tube, and protect the health of users.

Analysis of the causes of moisture inside the effervescent tube

 Effervescent tablets are a kind of pharmaceutical dosage forms containing disintegrants. There are many kinds of them, such as aspirin effervescent tablets for antipyretic and analgesic, Chinese patent medicine Jinlian Qingre effervescent tablets, multi-dimensional effervescent tablets for supplementing vitamins or trace elements, etc. As a special item, it has very strict requirements on packaging effervescent tubes. If it gets wet, it will easily lead to deterioration of medicines, affect the efficacy of medicines and even human health. In order to avoid this situation, we can avoid the effervescent tube from getting damp from the following aspects:

144mm*29mm effervescent tube packaging

caps for effervescent tube

1. Sealing: If the inside of the effervescent tube is damp, first consider whether the sealing of the effervescent tube is qualified. The factors affecting the sealing performance mainly depend on the precision of the mold and the strict control of each production link. The material of the effervescent tube generally has moisture resistance, which can block the external water molecules, but if the seal is not tight, it is easy to cause water vapor to enter the inside of the effervescent tube, causing the medicine to be damp and deteriorate.

2. Dosage of desiccant: The desiccant of the effervescent tube is mainly a mixture of silica gel and molecular sieve. If the inside of the effervescent tube is still damp when the overall sealing is good, it may be because the amount of desiccant is not enough to completely To absorb the moisture of the medicine itself, consider increasing the amount of desiccant.

3. External environment: The moisture inside the effervescent tube is also related to the external environment. If the storage environment is too humid, it is easy to get damp inside the effervescent tube, so try to choose a dry and ventilated place during storage.

If we encounter moisture in the effervescent tube later, we can try to analyze these aspects to avoid this situation and ensure our stability during drug storage.

what's in the cap of effervescent tablet tubes

 We often drink effervescent vitamin c tablets to improve our health, do you care of the cap of the tube, there is a small conntainer in the cap, so what's in it? The effervescent tablet can react with moisture of air,so the effervescent tube must have desiccant to control the environment of bottle inside. In generally, desiccant use silica gel or molecular sieve.

effervescent tablet tubes

First,i will introduce the silica gel and molecular sieve.

Silica gel

Silica gel is an amorphous and porous form of silicon dioxide (silica), consisting of an irregular tridimensional framework of alternating silicon and oxygen atoms with nanometer-scale voids and pores. The voids may contain water or some other liquids, or may be filled by gas or vacuum.Silica xerogel with an average pore size of 2.4 nanometers has a strong affinity for water molecules and is widely used as a desiccant. Silica gel's high specific surface area (around 800 m2/g) allows it to adsorb water readily, making it useful as a desiccant (drying agent). 

Silica gel is silicon dioxide (SiO2). It is a naturally occurring mineral that is purified and processed into either granular or beaded form. As a desiccant, it has an average pore size of 24 angstroms and has a strong affinity for moisture molecules. The silica gel will pull in moisture at temperatures up to 220°F (105°C). As temperature goes above 100°F, the rate of moisture pickup will slow down but the silica gel will still work.

Silica gel performs best at room temperatures (70° to 90°F) and high humidity (60 to 90% RH) and will drop the relative humidity in a container down to around 40% RH. In the United States, silica gel is commonly used in food and pharmaceutical applications as only silica gel has been approved by the FDA for direct contact with these items.

As with clay, silica gel, with its wide range of pore sizes, has the capability of adsorbing compounds other than water. The relative order of adsorbability is: water, ammonia, alcohols, aromatics, diolefins, olefins and paraffins. When the potential for multicomponent adsorption is present, expect the more strongly adsorbed compounds, such as water, to displace the more weakly held ones.

desiccant cap

Molecular sieve

molecular sieve is a material with pores (very small holes) of uniform size. Molecular sieves are synthetic porous crystalline aluminosilicates which have been engineered to have a very strong affinity for specifically sized molecules. The definitive feature of the molecular sieve structure, as compared to other desiccant medias, is the uniformity of the pore size openings.

There is no pore size distribution with molecular sieves, as part of the manufacturing process the pore size on the molecular sieve particles can be controlled. The most commonly used pore size is 4 angstroms (4A) although 3 angstroms (3A), 5 angstroms (5A) and 10 angstroms (13X) are available. This distinctive feature allows for the selection of a molecular sieve product which can adsorb water vapor yet exclude most other molecules such as volatile organic compounds (VOCs) which may or may not be present in the package.

The selective adsorption characteristics of molecular sieves can be useful when it is necessary to dry a package or environment without removing other desirable compounds within the system. Molecular sieve can trap water vapor to temperatures well past 225°C in some cases, and due to its high affinity for water vapor, molecular sieve is able to bring the relative humidity (RH) in environments down to as low as 1% RH.

In Europe molecular sieve is used in pharmaceutical applications. In the United States it is often the desiccant of choice for pharmaceuticals and bio-chemicals and/or reagents. Although molecular sieve is sligthtly higher in cost per unit due to its extremely large range of adsorptive capabilities and high capacity at low relative humiddity it is often the best value.

Notes on preparation and packaging of effervescent tablets

Effervescent tablet tube generally mainly applies in the effervescent piece's packing to rise to moistureproof with the function that prevent damage, effervescent piece early when packing pays most attention to the dry sex of sealing of packing. Another design of the effervescent bottle is the spiral spring on the platform, which prevents the effervescent from being damaged in transit.

plastic tube for effervescent tablets

Notes for preparation and packaging of effervescent tablets:

1. During granulation, acid and alkali should not be prepared together with the main drug, because the general acid or alkali will affect the stability of the drug, which may lead to unqualified degradation products.
2. Disintegration degree is not more than 5 minutes according to the pharmacopoeia, which is relatively easy to achieve. Our internal control standard is 90 seconds. Granulation is made with a low viscosity binder and a high concentration of ethanol (such as anhydrous ethanol), so that it dries quickly, the particles are loose and disintegrate easily. But pay attention to the crispness, the pharmacopoeia does not exceed 1%. (however, special applications for effervescent tablets seem to be allowed, with appropriate relaxation.) Finally, acid and base are added as excipients.
3. pay attention to the prepared particles do not store too long, and control the humidity.
4. pressing also need to control the humidity, in order to prevent water absorption.
5. As for the packaging, you can choose the double aluminum packaging that is impervious to water and oxygen, or the packaging of high-density polyethylene bottle or PP plastic bottle to ensure its stability.

Effervescent Packaging Manufacturer

There is no doubt that Xinfuda can offer customers what you need in pharmaceutical packaging area. Xinfuda is the pioneer packaging manufacture in northern China. High quality, strong supply capacity and shorten shipping cycle can meet your all demand. Effervescent packaging is one set in our products.

   

effervvescent packaging

Effervescent packaging has two series which are effervescent tablets tubes and test strip packaging. The main is that Xinfuda moisture proof tamper closures, which can perform well in storing capsules and tablets that need dry condition. Of course, we also introduce the desiccant shelf, component of effervescent packaging and characteristics of effervescent tablets bottles. Effervescent packaging has five sizes include 84mm, 96mm, 99mm, 133mm, 144mm.

effervescent tablet tube with vitamin

    These can give you more choose to match your products. The raw material is PP. All the products meet the DMF and produce in CGMP standard .Xinfuda will be your reliable partners in packaging. 

CONTACT US

+86-311-6902-4816

+86-157-3193-8681

sales@fudaplastic.com

Rm 1531, Tower A, Hebei Normal University Science Park, No. 269 Jianshe South Street, Shijiazhuang City, Hebei Province, China. 050000

plastic tube for tablets

Plastic tube with desiccant cap for tablets and pills to keep supplement effective, effervescent pills tube is an important packaging for suppleent.

effervescent packaging

Drug producers can achieve higher attention and customer loyalty thanks to photorealistic printing and a wide range of design options. Patients profit from easy handling, while manufacturers can optimize their supply chain while ensuring the highest process safety.  If a customer wants the tubes to be child-resistant, we also have a solution to offer.

effervescent tablet tube

Pain killers and other pharmaceutical agents can be easily digested and consumed in liquid form. Moreover, patients particularly appreciate the easy handling of effervescent tubes. Equipped with a convenience closure like the FOG from Sanner, the tubes remain tightly closed at all times, while the tablets are protected against light and moisture with a long shelf life. In contrast to blisters, for instance, the drugs remain inside their package, which in turn is not damaged during transport.

Effervescent Tablet Bottle With Spring Cap

The effervescent tablet bottle with spring cap need control the humidity of the tube,so the effervescent tube use the desiccant, the desiccant common is silica gel or molecular sieve.I will introduce the silica gel and molecular sieve.

effervescent tablet bottle with spring cap

First.the silica gel. Silica gel is an amorphous and porous form of silicon dioxide (silica), consisting of an irregular tridimensional framework of alternating silicon and oxygen atoms with nanometer-scale voids and pores. The voids may contain water or some other liquids, or may be filled by gas or vacuum.Silica xerogel with average pore size of 2.4 nanometers has a strong affinity for water molecules is widely used as a desiccant.The silica gel is often filled in the cap of the effervescent tube,the silica gel can absorb any humidity that might cause spoilage of the pharmaceutical.

spiral desiccannt cap

Second,the molecular sieve. A molecular sieve is a material with pores (very small holes) of uniform size. These pore diameters are similar in size to small molecules, and thus large molecules cannot enter or be adsorbed, while smaller molecules can. As a mixture of molecules migrate through the stationary bed of porous, semi-solid substance referred to as a sieve (or matrix), the components of highest molecular weight (which are unable to pass into the molecular pores) leave the bed first, followed by successively smaller molecules.Some molecular sieves are used as desiccants (some examples include activated charcoal and silica gel).

Effervescent Tablet Bottle With Spring Cap

The effervescent tablet bottle with spring cap need control the humidity of the tube,so the effervescent tube use the desiccant, the desiccant common is silica gel or molecular sieve.I will introduce the silica gel and molecular sieve.

effervescent tablet bottle with spring cap

First.the silica gel. Silica gel is an amorphous and porous form of silicon dioxide (silica), consisting of an irregular tridimensional framework of alternating silicon and oxygen atoms with nanometer-scale voids and pores. The voids may contain water or some other liquids, or may be filled by gas or vacuum.Silica xerogel with average pore size of 2.4 nanometers has a strong affinity for water molecules is widely used as a desiccant.The silica gel is often filled in the cap of the effervescent tube,the silica gel can absorb any humidity that might cause spoilage of the pharmaceutical.

spiral desiccannt cap

Second,the molecular sieve. A molecular sieve is a material with pores (very small holes) of uniform size. These pore diameters are similar in size to small molecules, and thus large molecules cannot enter or be adsorbed, while smaller molecules can. As a mixture of molecules migrate through the stationary bed of porous, semi-solid substance referred to as a sieve (or matrix), the components of highest molecular weight (which are unable to pass into the molecular pores) leave the bed first, followed by successively smaller molecules.Some molecular sieves are used as desiccants (some examples include activated charcoal and silica gel).