Application of effervescent tube - electrolyte effervescent tablets

 Electrolyte effervescent tablets are a convenient, quick solution for replenishing fluids and electrolytes, especially suitable for people with busy lifestyles and those who need a quick recovery. The effervescent tube plays a vital role in electrolyte effervescent tablets. Its design and function allow users to conveniently replenish the required water and electrolytes at any time and anywhere.

144mm*29mm effervescent tube packaging

caps for effervescent tube

First of all, the portability of effervescent tubes is one of its very big advantages. Thanks to its compact, lightweight design, users can easily slip it into their pocket or bag and take it with them at any time. This allows users to conveniently replenish water and electrolytes during outdoor activities, sports competitions or travel, ensuring that the body maintains adequate levels and electrolyte balance.

Secondly, the effervescent tube has a built-in desiccant, and the material is made of raw materials with very good barrier properties and has good moisture-proof performance. This means that even in humid environments, the effervescent electrolyte tablets maintain their quality and effectiveness, ensuring users get optimal rehydration when they need it.

In addition, the effervescent tube adopts a coil spring design to compress the tablets and prevent the medicine from being damaged during transportation. This design ensures that every effervescent tablet received by users is intact, thereby ensuring product quality and reliability.

Therefore, the effervescent tube plays a key role in electrolyte effervescent tablets. Its portability, moisture-proof performance and drug protection function allow users to obtain the required water and electrolyte supplements anytime and anywhere, providing convenience and guarantee for health and vitality.

Requirements for the moisture content of the desiccant in the effervescent tube

 Effervescent tube is a kind of medicine packaging container with excellent moisture-proof performance. On the one hand, its moisture-proof function is realized through strict sealing. On the other hand, silica gel and molecular sieve desiccant are placed inside the package to absorb the internal moisture.

144mm*29mm effervescent tube packaging

For the moisture content of the two desiccants, effervescent tubes also have relevant regulations. In YBB00172004-2015 "Quality Standard for Oral Solid Pharmaceutical Low Density Polyethylene Moisture-Proof Combination Caps", the requirements for the moisture content of the desiccant are as follows:

caps for effervescent tube

In an environment where the relative humidity of silica gel does not exceed 75%, quickly take out the bottle cap from the closed packaging bag, and take out 5-7g of desiccant from the bottle cap, put it in a weighing bottle (W1) with constant weight, and weigh it. Weight (W2), placed in an oven at 180°C ± 10°C (the total time from opening the bottle cap to the time when the desiccant is placed in the oven should not exceed 5 minutes) to constant weight (weighing as W3), calculated by the following formula, containing water The rate must not exceed 4.8%.

Macromolecular sieve In an environment where the relative humidity does not exceed 75%, quickly take out an appropriate amount of the bottle cap from the closed package, take out the desiccant in the bottle cap with tweezers, and place it in a constant weight crucible W0 (add 8-10g to each crucible). ), accurately weighed W1, placed in a high-temperature furnace at 950°C (the total time from opening the cap packaging bag to placing the desiccant in the high-temperature furnace should not exceed 5 minutes), drying for one hour, taking out the crucible, and accurately weighing after cooling. Determine W2, and calculate according to the following formula, and the moisture content should not exceed 4.8%.

The above are the requirements of the effervescent tube for the moisture content of the desiccant. A qualified desiccant is the basis for ensuring its internal moisture-proof performance and is also an important factor to ensure the stability of the effervescent tablet.

Vitamin C effervescent tube highlights differentiation

 Vitamin C effervescent tablets are a common vitamin supplement that is very popular among young people. There are many manufacturers of vitamin C effervescent tablets on the market, and the phenomenon of product homogeneity is serious. In this context, the effervescent tube has become the key for pharmaceutical companies to break through the bottleneck of product development.

effervescent tablet tubes

Product competition is not only the competition of the product itself, but also the competition of the entire company and the competition of brands. When vitamin C effervescent tablets have similar taste and safety, the difference in packaging becomes a direct manifestation of product differentiation. Even two products with the same common name will have different market performance due to differences in packaging.

The effervescent tube is a special pharmaceutical packaging for vitamin C effervescent tablets. The effervescent tablet contains a disintegrant and is easily deteriorated by moisture. In order to ensure the dryness of the tablet, a desiccant made of silica gel and molecular sieve is placed inside the effervescent tube . Different from ordinary medicine bottles, the desiccant is stored on the top of the lid to prevent children from accidentally ingesting. The spiral spring on the lid can protect the tablet from damage due to various external forces.

In order to highlight the differentiation of brands and distinguish competing products, some pharmaceutical companies will use the color, logo, slogan, etc. of the effervescent tube to reflect it. For example, use different caps for different flavors of effervescent tablets, and add eye-catching slogans on the external label. In short, differentiation is a weapon for companies to break homogeneity. Only when there are differences can there be a market, and only then can they gain a place in the competition among the strong players.

How Can Plastic Vitamin Tube Keep Dry Environment

 Plastic vitamin tube is used in vitamin tablet packaging due to its dry environment. There are silical-gel desiccant and large molecular sieve desiccant in plastic vatimin tube. However, silica-gel desiccant is the only one through FDA and healthy for human.

 

spiral desiccant closure

 

Silica-gel desiccant in vitamin tube is a highly active adsorbent material, which belongs to amorphous material. Silic-gel desiccant of vitamin tube cap insoluble in water, non-toxic and tasteless, chemically stable. According to diameter, silica can be divided into macroporous silica gel, coarse - hole silica gel, type B silicone, fine - hole silica gel. Silica can reuse through rebirth. The main ingredient of silica-gel desiccant is Sio2, for more translucent amorphous, composed of natural mineral processed granular or bead, usually after treatment with sulfuric acid to form, its hard, non-toxic, tasteless, non-corrosive, good chemical stability and thermal stability.

plastic vitamin C tube

 

Silica-gel desiccant of vitamin tube covers many hydroxyl groups with strong hydrophilicity, at the same time, the surface of silica gel desiccant has many small holes that are not visible to the naked eye, so that its surface area is greatly increased, and the properties of silica gel desiccant decide to become a good desiccant.Desiccant moisture environment as temperature of the shelf life is most suitable for 20 ~ 32 ℃, humidity was 60% ~ 60%, it can reduce the environmental relative humidity to 40%.

Xinfuda as a China major pharmaceutical packaging manufacturer with DMF, which can offer excellent desiccant packaging for vitamin tablets. Plastic vitamin tube adopted silica-gel desiccant to keep dry and the spring on the cap can prevent tablets damaging.

Covid-19 Vaccine Science carries out clinical effectiveness evaluation

 On April 13, April 27, and May 13, following the inactivated vaccine developed by Wuhan Research Institute, Beijing Kexing Zhongwei Biotechnology Co., Ltd., Beijing Institute of Biological Products, Chinese Academy of Medical Sciences Medical Biology The new inactivated vaccines developed by the Institute have successively obtained clinical trial approvals.

vitamin c tube

'After the vaccine enters the clinical trial stage, it is necessary for the drug regulatory department to strengthen the supervision of the clinical trial process, scientifically carry out clinical safety and effectiveness evaluation, supervise the applicant to perform the main responsibility, and strengthen the safety information reporting and risk management in the clinical trial process.' According to Wang Haixue, head of the Clinical Trial Management Office, in order to ensure the quality of clinical trials and protect the rights and interests of subjects, the Center for Drug Evaluation formally issued the "Regarding Strengthening the Clinical Trial of New Coronary Pneumonia Vaccines" The Notice on Trial Safety Information Report and Risk Management clarifies the applicant’s main responsibility for clinical trials, requires the applicant to carry out clinical trials in strict accordance with the clinical trial management specifications and the requirements of clinical trial approval documents, establish a complete pharmacovigilance system, and formulate a complete Risk control measures, strengthen the quality control of clinical research samples, timely report the phased progress of clinical trials, set up a data security monitoring committee, conduct risk communication in a timely manner, and recommend long-term safety observations for subjects.

desiccant cap

'The Clinical Trial Management Office communicates with applicants daily to master vaccine clinical trial progress, case enrollment status and safety information. At the same time, it strengthens communication among vaccine review indication teams, conducts risk analysis and assessment, and establishes an efficient According to incomplete statistics, according to incomplete statistics, according to incomplete statistics, according to incomplete statistics, except for the daily report of clinical trial progress and safety information, according to Wang Haixue, only one new crown vaccine research and development institution/company is taken as an example. In addition, the Center for Drug Evaluation also conducted 14 special communications with the applicant.

COP  vials

In order to strengthen the applicant's timely and dynamic risk monitoring and evaluation of safety information, the Clinical Trial Management Office of the Center for Drug Evaluation also drafted a report form that summarizes clinical research progress and safety information, and determined a clear, unified and standardized safety information report. Applicants are required to report the number of participants in clinical trials and the status of SAE and SUSAR on a daily basis for the content and format of the trial; and it is recommended to submit phase I and II clinical trial data as soon as possible, in order to timely evaluate vaccine early clinical trial data, and accelerate the promotion and support of vaccine follow-up Development of clinical research.

At the same time, the Center for Drug Evaluation is actively discussing with domestic and foreign experts and industry R&D personnel on the basic conditions for the approval of the new crown vaccine for marketing and the phase III clinical protection efficacy trial design and implementation strategies, in order to reach consensus and obtain relevant information. With the support of all parties, we will make every effort to promote the early listing of the new crown vaccine.

How Can Plastic Vitamin Tube Keep Dry Environment

Plastic vitamin tube is used in vitamin tablet packaging due to its dry environment. There are silical-gel desiccant and large molecular sieve desiccant in plastic vatimin tube. However, silica-gel desiccant is the only one through FDA and healthy for human.

spiral desiccant closure

Silica-gel desiccant in vitamin tube is a highly active adsorbent material, which belongs to amorphous material. Silic-gel desiccant of vitamin tube cap insoluble in water, non-toxic and tasteless, chemically stable. According to diameter, silica can be divided into macroporous silica gel, coarse - hole silica gel, type B silicone, fine - hole silica gel. Silica can reuse through rebirth. The main ingredient of silica-gel desiccant is Sio2, for more translucent amorphous, composed of natural mineral processed granular or bead, usually after treatment with sulfuric acid to form, its hard, non-toxic, tasteless, non-corrosive, good chemical stability and thermal stability.

plastic vitamin C tube

Silica-gel desiccant of vitamin tube covers many hydroxyl groups with strong hydrophilicity, at the same time, the surface of silica gel desiccant has many small holes that are not visible to the naked eye, so that its surface area is greatly increased, and the properties of silica gel desiccant decide to become a good desiccant.Desiccant moisture environment as temperature of the shelf life is most suitable for 20 ~ 32 ℃, humidity was 60% ~ 60%, it can reduce the environmental relative humidity to 40%.

Xinfuda as a China major pharmaceutical packaging manufacturer with DMF, which can offer excellent desiccant packaging for vitamin tablets. Plastic vitamin tube adopted silica-gel desiccant to keep dry and the spring on the cap can prevent tablets damaging.

How to Choose Vitamin C Tubes

Vitamin C tubes belongs to a special pharmaceutical packaging in the international, which has strong professionalism. The sealed fitting of bottle body and cap is important for avoiding vitamin C tablets wetting. It is the key step for vitamin C tablet manufacturer to choose suitable packaging. Except sealing, there are also some points need to pay attention.

 

 

effervescent packaging 

 

First, surface: Color uniform, no damage, no oil, good match.

Second, the moisture content of the drying agent:lower than 4.8%.

Third, anti-fall: desiccant must not be dropped

Fourth, board: moisture content below 6%, no fluorescence reaction, heavy metal less than 5 parts per million.

Fifth, dissolution: heavy metals, oxides and non-volatile substances.

Sixth, microorganisms: bacteria less than 1000, mould yeast less than 100, escherichia coli may not be detected.

Seventh, abnormal toxicity should not be detected.

 

 

 

144mm plastic vitamin c tube

 

VC tablets tube has an important part is that spiral desiccant cap, spiral desiccant cap is the international univerisal cap for effervescent tablets, the structure has high requirement for mould design, even some countries can not volum production. The spiral in the cap can buffer the impact of the transport process, thus protecting fragile effervescent tablets will not be damaged.

The selection of high-quality vitamin C tubes will also need to analyze the strength, equipment and comprehensive quality of the manufacturers, and the high quality of the enterprise products will be stable, which will help your products to be more smooth in the competition.

Notes on preparation and packaging of effervescent tablets

Effervescent tablet tube generally mainly applies in the effervescent piece's packing to rise to moistureproof with the function that prevent damage, effervescent piece early when packing pays most attention to the dry sex of sealing of packing. Another design of the effervescent bottle is the spiral spring on the platform, which prevents the effervescent from being damaged in transit.

plastic tube for effervescent tablets

Notes for preparation and packaging of effervescent tablets:

1. During granulation, acid and alkali should not be prepared together with the main drug, because the general acid or alkali will affect the stability of the drug, which may lead to unqualified degradation products.
2. Disintegration degree is not more than 5 minutes according to the pharmacopoeia, which is relatively easy to achieve. Our internal control standard is 90 seconds. Granulation is made with a low viscosity binder and a high concentration of ethanol (such as anhydrous ethanol), so that it dries quickly, the particles are loose and disintegrate easily. But pay attention to the crispness, the pharmacopoeia does not exceed 1%. (however, special applications for effervescent tablets seem to be allowed, with appropriate relaxation.) Finally, acid and base are added as excipients.
3. pay attention to the prepared particles do not store too long, and control the humidity.
4. pressing also need to control the humidity, in order to prevent water absorption.
5. As for the packaging, you can choose the double aluminum packaging that is impervious to water and oxygen, or the packaging of high-density polyethylene bottle or PP plastic bottle to ensure its stability.

white cardboard lead content of glucose tablets packaging standard and determination method

After taking the cardboard in the glucose tablets packaging, weigh 1g into the crucible, carefully carbonize it, then transfer it to the high temperature furnace for 550 degrees, remove the crucible, and then add a small amount of nitric acid-perchloric acid solution after cooling. 1), heat with a small heat, do not make dry, you must add a little nitric acid-perchloric acid solution (4:1), so repeated treatment until there is no carbon particles in the residue, wait a little cold, add 50ml hydrochloric acid solution (1 -12 After dissolving the residue), according to the atomic absorption spectrophotometry (Chinese Pharmacopoeia 2015 edition general rule 0406), the lead content shall not exceed 0.0005%.

glocose tablets packaging

The atomic absorption spectrophotometric method is a metal element and a part of non-metal elements in an atomic state, and is a combined analysis method for quantitatively analyzing the absorption intensity of a characteristic electromagnetic radiation by an atom in a vapor. Atomic absorption spectrophotometry follows the absorption law of spectrophotometry. Generally, the content of the element to be tested in the test sample is calculated by comparing the absorbance of the reference solution and the test solution.

Vitamin c tube for tablets.

Contact us

email: pharma-pack@fudaplastic.com

tell: +86 15731938681

Desiccant packaging oxide and non-volatile standards and testing methods

Desiccant packaging easy oxide detection method: precise measurement of water for test solution 20ml, precision addition of potassium permanganate titration solution (0.002mol / L) 20ml and dilute sulfuric acid 1ml, boil for 3 minutes, rapid cooling, adding potassium iodide 0.21g, Place in the dark for 5 minutes, titrate with sodium thiosulfate titration solution (0.01mol / L), titrate to near the end point, add 5 drops of starch indicator solution, continue titration until colorless, receive the blank solution with the same operation, both consumption The difference between sodium thiosulfate titration solution (0.01mol/L) should not exceed 1.5ml.

vitamin c tube

Desiccant packaging non-volatiles detection method: respectively, precision water, 65% ethanol, n-hexane test solution and blank solution 50ml each placed in a constant weight evaporating dish. The water bath is evaporated to dryness and dried at 105 °C for 2 hours. After cooling, it is accurately weighed. The difference between the non-volatile residue of water and the blank residue of the test solution shall not exceed 12.0 mg; the difference between the 65% ethanol non-volatile residue and its blank residue shall not exceed 50mg; the difference between the n-hexane non-volatile residue and its blank page residue should not exceed 200mg.

contact us

email: pharma-pack@fudaplastic.com

tell: + 86 15731938681

Plastic tube with lid for effervescent tablets

One of the key elements you must consider when creating your private label effervescent tablets, is it’s packaging. Your effervescent manufacturers packaging must not only be attractive to your target market, but it must also be functional for transportation and storage of your private label effervescent product. 

plastic tube with lid for effervescent tablets

Your effervescent manufacturers retail packaging should be user-friendly and convenient for your customers. The effervescent tube packaging with desiccant cap services at Xinfuda have been designed to create efficient, high quality, cost effective packaging to help save your business time and money while protecting the integrity of the product within.

effervescent packaging

When private labeling effervescent tablets, the plastic tube with lid is first and foremost designed to protect your investment. We use the highest quality effervescent manufacturers packaging materials to ensure that your product is never compromised.

84mm tube for vitamin tablets

The plastic tubes used during packaging are made to protect your branded effervescent products from light, moisture, breakage and more. They are made of polypropylene (PP) and are designed with extreme intricacy and care. These are user-friendly with appealing designs and can come in a variety of sizes.

cap with finger notch

Our plastic tube with lid for effervescent tablet have passed various quality checks such as overall migration, specific migration of heavy metals.These also comply with major EU/EC norms for plastic packaging materials that come in contact with food. We can provide various services such as shrink sleeving, heat transfer labeling as well as offset printing.

Tube Closure

Tube closures are made from low density polyethylene (LDPE). Those are compatible with our tubes. Thanks to the construction and usage of silicagel, it ensures excellent tightness to keep adequate humidity.

spiral desiccant closure

How to choose vitamin C tube?

Vitamin C tube belongs to a special packaging in the international, which has strong professionalism. The sealed fitting of bottle body and cap is important for avoiding vitamin C tablets wetting. It is the key step for vitamin C tablet manufacturer to choose suitable packaging. Except sealing, there are also some points need to pay attention.

effervescent packaging 

First, surface: Color uniform, no damage, no oil, good match.

Second, the moisture content of the drying agent:lower than 4.8%.

Third, anti-fall: desiccant must not be dropped

Fourth, board: moisture content below 6%, no fluorescence reaction, heavy metal less than 5 parts per million.

Fifth, dissolution: heavy metals, oxides and non-volatile substances.

Sixth, microorganisms: bacteria less than 1000, mould yeast less than 100, escherichia coli may not be detected.

Seventh, abnormal toxicity should not be detected.

144mm plastic vitamin c tube

VC tablets tube has an important part is that spiral desiccant cap, spiral desiccant cap is the international univerisal cap for effervescent tablets, the structure has high requirement for mould design, even some countries can not volum production. The spiral in the cap can buffer the impact of the transport process, thus protecting fragile effervescent tablets will not be damaged.

The selection of high-quality vitamin C tube will also need to analyze the strength, equipment and comprehensive quality of the manufacturers, and the high quality of the enterprise products will be stable, which will help your products to be more smooth in the competition.