Effervescent Tablet Tube Test Specification

 The concept of the inspection result exceeding standard management was introduced for the first time, which means that the test result is beyond the legal standard and the enterprise internal control standard. Excessive inspection results do not necessarily mean that the sample inspection is not qualified. How can the effervescent tablet tube manufacturer be implemented?

effervescent packaging

First, the operating procedures for the establishment of inspection results exceeding the limits of the investigation within the company. Laboratory investigation was carried out according to the regulations to confirm whether it was laboratory bias. If it is not the laboratory deviation, the R & D, technology and production personnel should be organized to investigate the production process. It can also be interpreted as two categories: laboratory bias and non laboratory bias.

133*29mm vitamin tablet tube

The laboratory deviation shall investigate any deviation of the test results caused by the factors related to the inspection process,A laboratory survey should be carried out by the professional personnel. The non laboratory deviation refers to the deviation of the test results caused by any other factors except the deviation of the laboratory. The above deviation analysis also standardizes the concrete implementation of the inspection results exceeding the standard for effervescent tablet tube factory. 

Vitamin C effervescent tube highlights differentiation

 Vitamin C effervescent tablets are a common vitamin supplement that is very popular among young people. There are many manufacturers of vitamin C effervescent tablets on the market, and the phenomenon of product homogeneity is serious. In this context, the effervescent tube has become the key for pharmaceutical companies to break through the bottleneck of product development.

effervescent tablet tubes

Product competition is not only the competition of the product itself, but also the competition of the entire company and the competition of brands. When vitamin C effervescent tablets have similar taste and safety, the difference in packaging becomes a direct manifestation of product differentiation. Even two products with the same common name will have different market performance due to differences in packaging.

The effervescent tube is a special pharmaceutical packaging for vitamin C effervescent tablets. The effervescent tablet contains a disintegrant and is easily deteriorated by moisture. In order to ensure the dryness of the tablet, a desiccant made of silica gel and molecular sieve is placed inside the effervescent tube . Different from ordinary medicine bottles, the desiccant is stored on the top of the lid to prevent children from accidentally ingesting. The spiral spring on the lid can protect the tablet from damage due to various external forces.

In order to highlight the differentiation of brands and distinguish competing products, some pharmaceutical companies will use the color, logo, slogan, etc. of the effervescent tube to reflect it. For example, use different caps for different flavors of effervescent tablets, and add eye-catching slogans on the external label. In short, differentiation is a weapon for companies to break homogeneity. Only when there are differences can there be a market, and only then can they gain a place in the competition among the strong players.

How Can Plastic Vitamin Tube Keep Dry Environment

 Plastic vitamin tube is used in vitamin tablet packaging due to its dry environment. There are silical-gel desiccant and large molecular sieve desiccant in plastic vatimin tube. However, silica-gel desiccant is the only one through FDA and healthy for human.

 

spiral desiccant closure

 

Silica-gel desiccant in vitamin tube is a highly active adsorbent material, which belongs to amorphous material. Silic-gel desiccant of vitamin tube cap insoluble in water, non-toxic and tasteless, chemically stable. According to diameter, silica can be divided into macroporous silica gel, coarse - hole silica gel, type B silicone, fine - hole silica gel. Silica can reuse through rebirth. The main ingredient of silica-gel desiccant is Sio2, for more translucent amorphous, composed of natural mineral processed granular or bead, usually after treatment with sulfuric acid to form, its hard, non-toxic, tasteless, non-corrosive, good chemical stability and thermal stability.

plastic vitamin C tube

 

Silica-gel desiccant of vitamin tube covers many hydroxyl groups with strong hydrophilicity, at the same time, the surface of silica gel desiccant has many small holes that are not visible to the naked eye, so that its surface area is greatly increased, and the properties of silica gel desiccant decide to become a good desiccant.Desiccant moisture environment as temperature of the shelf life is most suitable for 20 ~ 32 ℃, humidity was 60% ~ 60%, it can reduce the environmental relative humidity to 40%.

Xinfuda as a China major pharmaceutical packaging manufacturer with DMF, which can offer excellent desiccant packaging for vitamin tablets. Plastic vitamin tube adopted silica-gel desiccant to keep dry and the spring on the cap can prevent tablets damaging.

How Can Plastic Vitamin Tube Keep Dry Environment

Plastic vitamin tube is used in vitamin tablet packaging due to its dry environment. There are silical-gel desiccant and large molecular sieve desiccant in plastic vatimin tube. However, silica-gel desiccant is the only one through FDA and healthy for human.

spiral desiccant closure

Silica-gel desiccant in vitamin tube is a highly active adsorbent material, which belongs to amorphous material. Silic-gel desiccant of vitamin tube cap insoluble in water, non-toxic and tasteless, chemically stable. According to diameter, silica can be divided into macroporous silica gel, coarse - hole silica gel, type B silicone, fine - hole silica gel. Silica can reuse through rebirth. The main ingredient of silica-gel desiccant is Sio2, for more translucent amorphous, composed of natural mineral processed granular or bead, usually after treatment with sulfuric acid to form, its hard, non-toxic, tasteless, non-corrosive, good chemical stability and thermal stability.

plastic vitamin C tube

Silica-gel desiccant of vitamin tube covers many hydroxyl groups with strong hydrophilicity, at the same time, the surface of silica gel desiccant has many small holes that are not visible to the naked eye, so that its surface area is greatly increased, and the properties of silica gel desiccant decide to become a good desiccant.Desiccant moisture environment as temperature of the shelf life is most suitable for 20 ~ 32 ℃, humidity was 60% ~ 60%, it can reduce the environmental relative humidity to 40%.

Xinfuda as a China major pharmaceutical packaging manufacturer with DMF, which can offer excellent desiccant packaging for vitamin tablets. Plastic vitamin tube adopted silica-gel desiccant to keep dry and the spring on the cap can prevent tablets damaging.

Pharmaceutical Packaging Compatibility Test-Migration Test

The extraction solvent used in the extraction test of the pharmaceutical packaging compatibility test is only similar to the preparation in terms of polarity, pH value and ionic strength, because it is not the actual prescription of the preparation, and the characteristics of the active ingredients or some auxiliary materials in the preparation , So that the interaction between the extraction solvent, the real preparation and the packaging material may be different, that is, the extractables obtained in the extraction test are inconsistent with the extracts obtained in the real preparation migration test.

pharma desiccant bottle
In addition, although some components in the packaging materials can be obtained in the extraction test, they will not migrate into the preparation in the migration test and stability test; but the extractable may be degraded or other Components react, and these degradation products or reaction products can migrate into the formulation. Therefore, based on the extraction test, the real preparation should still be used for migration test.

empty vitamin c tubes
Migration tests are used to monitor substances that migrate from the packaging material and enter the formulation. Usually through accelerated or long-term stability tests (note that the preparation should be in full contact with the packaging material) to increase the corresponding detection target compound (derived from the understanding of the packaging component material composition or the extractable information obtained by the extraction test) to obtain the drug The information of the extract contained in it includes the type and content level of the extract.

In addition, if the packaging material is composed of different layers of materials (3-layer and 5-layer co-extruded film bags), it is not only necessary to evaluate the possibility of the innermost component migrating into the drug, but also the middle and outer components should be considered. Possibilities in drugs; At the same time, it must also be proved that the ink or adhesive in the outer layer will not migrate into the drug. Semipermeable material packaging should be researched on the outer layer of ink or adhesive will not migrate into the drug.