The structure and function of the effervescent tube cap

 The advantages and disadvantages of the pharmaceutical packaging and the functional design are very important for the storage of medicines. The effervescent tube is a special type of medicine packaging. Its bottle cap is composed of a desiccant, a coil spring and an anti-theft ring. Each design is large. useful.

sprial cap

Desiccant: In order to prevent the medicine from absorbing moisture and deteriorating, a desiccant is placed inside the medicine packaging. Commonly used desiccants include quicklime, magnesium chloride, calcium chloride, phosphorus pentoxide, molecular sieves, etc. Unlike other packaging, the desiccant of the effervescent tube is placed in the small medicine bin on the top of the bottle cap. This design reduces the contact between the desiccant and the medicine, and also reduces the risk of children ingesting the desiccant by mistake.

Coil spring: The effervescent tablet has a large dosage form and is easily damaged by various external forces during transportation. The spiral spring on the bottle cap is soft and can compress the tablets to prevent the effervescent tablet from breaking during transportation and handling, and it protects the integrity of the medicine.

Anti-theft ring: The design of the anti-theft ring on the cap of the effervescent tube is derived from the beverage bottle. When the cap is unscrewed, the anti-theft ring will fall off and stay on the bottle. We can judge whether the medicine has been opened according to the state of the anti-theft ring.

The special design of the effervescent tube cap is the result of the ever-changing market demand, and it is also the embodiment of the packaging manufacturer's continuous innovation and innovation in the production process. With the increase of various kinds of medicines, there will be more and more new medicines, and the design of medicine packaging will also show a diversified development trend.

Several factors of damp inside the effervescent tube

 Effervescent tablets are a kind of solid beverage, which will disintegrate quickly when exposed to water. Therefore, the moisture-proof performance of the effervescent tube is stricter. If the inside of the package is damp and the tablet disintegrates, it is mostly related to these factors.

effervescent tablet tube

Moisture-proof is the basic requirement for the pharmaceutical packaging of medicines, especially for some solid medicines. Once the inside of the packaging gets damp, it will easily lead to deterioration or failure of the medicine. If the patient takes the deteriorated medicine by mistake, it will endanger the health of the body. If the inside of the effervescent tube is damp, first consider whether the tightness of the packaging is qualified. The tightness of the effervescent tube mainly depends on the precision of the mold and the control of each production link. Packaging materials generally have moisture barrier properties, which can block the intrusion of external water molecules. However, if the seal is not tight, it is easy to cause water vapor to penetrate into the packaging and make the medicines damp and deteriorate.

On the other hand, also consider the amount of desiccant. The desiccant inside the effervescent tube is mainly a mixture of silica gel and molecular sieve. The drying performance of the desiccant itself is almost the same. If the packaging is well-sealed, the interior of the effervescent tube is still damp, which may be due to dryness. The dosage of the agent is not enough to completely absorb the moisture of the medicine itself, so you can consider increasing the dosage of the desiccant.

In addition, the moisture inside the effervescent tube is also related to the external storage environment. If the external environment is too humid, it is easy to get moisture inside the package. Therefore, when storing the product, choose a dry and ventilated place as much as possible.

The above is the analysis of several main reasons for the internal dampness of the effervescent tube. High-quality packaging is the basic requirement for drug storage. When purchasing effervescent tubes, pharmaceutical companies should pay attention to the product quality while paying attention to the impact of the external storage environment on the drugs.

Xinfuda successfully passed the ISO15378 quality management system certification

 On March 23-25, 2021, the SGS certification body conducted a certification audit on the ISO15378 quality management system of Shijiazhuang Xinfuda Pharmaceutical Packaging Co., Ltd. After three days of comprehensive review, the experts of the audit team agreed that: Xinfuda met the requirements of the ISO15378:2017 international standard for pharmaceutical packaging materials and successfully passed the on-site audit.

workshop

ISO15378 certification is a special requirement for the application of the ISO9001 quality management system in pharmaceutical packaging materials, and it is also an internationally accepted authoritative certification for pharmaceutical packaging materials. Published by the International Organization for Standardization (ISO), based on the basic principles of pharmaceutical GMP, and with reference to the ISO9001 quality management system framework and quality management principles, it is formulated, including management requirements (quality management system), hardware requirements (plants, production sites, equipment, etc.) , Procurement and use of raw materials/packaging materials, sanitation and quality control during product manufacturing, personnel sanitation management, product inspection, handling of abnormal quality, product complaints and recalls, etc.

ISO15378:2017 certification is another certification of Xinfuda after ISO9001:2008 certification and EU CE certification. It means that the company has reached international standards in terms of quality management, drug raw material risk control, etc., and will be more international Customers provide high-standard and professional services. In the future, Xinfuda will continue to base itself on product quality, strictly implement ISO15378 standards, and promote the high-quality development of the pharmaceutical packaging industry.

Vitamin C effervescent tube highlights differentiation

 Vitamin C effervescent tablets are a common vitamin supplement that is very popular among young people. There are many manufacturers of vitamin C effervescent tablets on the market, and the phenomenon of product homogeneity is serious. In this context, the effervescent tube has become the key for pharmaceutical companies to break through the bottleneck of product development.

effervescent tablet tubes

Product competition is not only the competition of the product itself, but also the competition of the entire company and the competition of brands. When vitamin C effervescent tablets have similar taste and safety, the difference in packaging becomes a direct manifestation of product differentiation. Even two products with the same common name will have different market performance due to differences in packaging.

The effervescent tube is a special pharmaceutical packaging for vitamin C effervescent tablets. The effervescent tablet contains a disintegrant and is easily deteriorated by moisture. In order to ensure the dryness of the tablet, a desiccant made of silica gel and molecular sieve is placed inside the effervescent tube . Different from ordinary medicine bottles, the desiccant is stored on the top of the lid to prevent children from accidentally ingesting. The spiral spring on the lid can protect the tablet from damage due to various external forces.

In order to highlight the differentiation of brands and distinguish competing products, some pharmaceutical companies will use the color, logo, slogan, etc. of the effervescent tube to reflect it. For example, use different caps for different flavors of effervescent tablets, and add eye-catching slogans on the external label. In short, differentiation is a weapon for companies to break homogeneity. Only when there are differences can there be a market, and only then can they gain a place in the competition among the strong players.

List of Drugs Applicable to COP Vial

 The development of science and technology has allowed more excellent properties of polymer materials to be continuously explored. COP vials are a typical representative of new materials used in the field of pharmaceutical packaging. Thanks to its many excellent properties, the COP bottle is suitable for anti-cancer, anti-tumor, rheumatic, protein and other high value-added drugs.

5ml and 100ml COP vial

The COP bottle has high transparency, low birefringence, low water absorption, high rigidity, high heat resistance, low protein adsorption, and good water vapor airtightness. It can be stored in liquid nitrogen and meets FDA standards. According to incomplete statistics, the list of drugs applicable to COP bottles is as follows:

Avastin (bevacizumab), Herceptin (trastuzumab for injection), adalimumab (Humira), palivizumab alias palizolizumab, anthrax (disease) , Combined with chlorambucil, belimumab, treatment of systemic lupus erythematosus, alemtuzumab, certuzumab, trastuzumab, trensuzumab <antineoplastic drugs>, diabetes, rani Buzumab injection, opdivo, pertuzumab, golimumab, panitumumab, primimab, erbitux, infliximab, rituximab ( Rituxan), Etanercept, Bepoetin Alfada, Interferon β-1b, Rituximab <Anti-tumor Drug>, Interferon β-1a, Nurasta, Aflibercept, Gonadotropin Hormones, Anakinra <Interleukin Receptor Blocking Drugs>, Peaspartase Injection.

The above is a list of medicines known in the market that are suitable for COP bottle packaging. With the continuous advancement of technology in the pharmaceutical industry, more new drugs will continue to come out, and the application range of COP bottles will become more common.

Humanized design of eye drop bottle

 Eye drop bottle is a special pharmaceutical packaging for eye drops. With the continuous changes in market demand, on the basis of satisfying functional design, humanized design has gradually become an important way for eye drop bottle manufacturers to improve their product competitiveness.

eye dropper bottle

Humanized design is a design that pays attention to the needs of human nature. From the perspective of consumers, humanized design starts from the perspective of ergonomics to make products conform to people's daily use habits. Eye drops directly contact the eyes, which is a high-risk route of administration. The humanized design of the eye drops bottle can increase the comfort and convenience of the route of administration.

The humanized design of the eye drop bottle is first reflected in the selection of materials. The eye drops generally need to be squeezed gently by hand when administering, so the material of the bottle should not be too hard, which is not conducive to the export of the liquid. Among many plastic materials, low-density polyethylene with good flexibility has become the best choice for eye drop bottle materials.

The humanized design of the eye drop bottle is also reflected in the volume of its packaging. Generally, the eye drop needs to be used up within four weeks after it is opened and cannot be used after it expires. Therefore, the packaging capacity of the eye drop bottle is mostly 5ml or 10ml, and the specific capacity will be calculated according to the method of use of the liquid medicine to avoid waste due to excessive amount of liquid medicine due to expiration.

The humanized eye drop bottle design not only improves the market competitiveness of the product, but also the key for enterprises to win in the fierce market competition. As humanized products are gradually being favored by the market, the production and design of humanized products has become every An important direction for an enterprise in product design.

Prevent children from opening the bottle to create a safe growth environment for children

Child safety is a common concern of society, and it is also a very important topic. Children playing on the road, sticking their heads out of the window, riding in the shopping cart, etc. are all dangerous. Among the many potential safety hazards, accidental ingestion of drugs has attracted more and more people’s attention. Prevent children from opening the bottle slowly. Into people's field of vision.

child proof bottle

The child is in the growth and development period and is full of curiosity about everything. It is easy to be attracted by the colorful pills. In addition, the parents' negligence and the loopholes in the drug packaging design can easily lead to the accidental ingestion of the drug by the child, resulting in irreversible consequences . For adults, one antihypertensive drug can control blood pressure, and two tablets may cause low blood pressure. Even if children take a small dose, they will have toxic side effects and even life-threatening.

On the one hand, preventing children from accidentally ingesting medicines requires parents to attach great importance to them and put medicines in places out of reach of children. On the other hand, it is necessary to increase the difficulty for children to open the package and reduce the probability of accidental eating. The design of preventing children from opening the bottle well realizes this function. The highlight is mainly reflected in the bottle cap. Ordinary bottle caps generally adopt a single-layer structure, while the child-proof bottle cap adopts an internal and external double-layer structure design. The interior is connected by a card slot. If the bottle is opened, it needs to be pressed down and rotated at the same time. The bottle cap can only be opened. This opening method involves force in two directions. It is difficult for children who are still in the developmental stage. It is generally difficult to open in a short time, which effectively reduces the risk of accidentally ingesting drugs.

As the society continues to pay attention to the problem of children’s accidental ingestion of drugs, many pharmaceutical companies have also begun to take this issue as the focus of medicine drug packaging choices. Some anti-hypertensive, hypoglycemic, and cardiovascular drugs have gradually cited anti-children’s opening bottles. The packaging method not only protects the safety of children, but also improves the overall image of the brand.

Prevent children from opening bottles to help pharmaceutical companies break through

 Recently, the State Food and Drug Administration passed the priority review and approval procedure and conditionally approved the listing of the Class 1 innovative drug vometinib mesylate (trade name: Ivesa) declared by Shanghai Ailisi Pharmaceutical Technology Co., Ltd., which is also The second domestically produced Class 1 new chemical drug approved for marketing this year.

The drug is the third representative EGFR kinase inhibitor, and is an innovative drug independently researched and developed by my country with independent intellectual property rights. Applicable to the disease progression during or after treatment with previous epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), and the presence of locally advanced or metastatic non-small cell lung cancer with positive EGFR T790M mutation confirmed by testing ( NSCLC) treatment of adult patients.

The launch of this drug will bring new choices for lung cancer patients, and competition in the lung cancer drug market will also become more intense. Innovation is the foundation of enterprise development. Pharmaceutical companies must continue to innovate and develop new drugs that meet market needs if they want to survive in the ever-changing market. In addition, pharmaceutical packaging also needs continuous innovation. At present, some anti-cancer drugs, high blood pressure and other drugs mostly use the special packaging method of preventing children from opening the bottle, in order to find a breakthrough in the fierce market competition.

child proof bottle

The main function of the child-proof bottle is to prevent children from opening the pharmaceutical packaging and accidentally ingesting drugs. The United States has implemented the Poison Prevention Packaging Act (PPPA) as early as 1970, requiring certain products that are potentially threatening to children to use child-proof packaging. More and more developed countries are implementing it. With the continuous innovation of medicines and people's attention to the problem of children's accidental ingestion of medicines, child-proof bottles will be applied to more medicine packaging, to a certain extent, to help companies establish a good brand image and improve product competitiveness.

Biological drug packaging-COP injection vials

 The full name of biopharmaceutical biotech drugs, broadly refers to all kinds of bioactive substances based on biomass and their synthetic analogues, as well as drugs made by modern biotechnology. Narrow sense refers to the use of organisms, biological tissues, cells and their components to comprehensively apply the principles and technical methods of chemistry, biology and medicine to prevent, diagnose, treat and rehabilitate health products. DNA recombination technology or other protein or nucleic acid drugs developed by modern biotechnology.

COP injection vials

Biotechnology drugs are important carriers of the bio-economy. It can treat diseases, biotechnology drugs including cell pellets, recombinant protein drugs, antibodies, vaccines and oligonucleotide drugs, etc., mainly for the prevention and treatment of cancer, cardiovascular diseases, infectious diseases, asthma, diabetes, genetic diseases, cardiovascular and cerebrovascular diseases. Difficult diseases such as rheumatoid arthritis have been widely used in clinical practice, bringing revolutionary changes to the pharmaceutical industry.

Since biopharmaceuticals are naturally occurring proteins or polypeptides of human beings, the amount is small and the activity is strong, and the amount of the biopharmaceuticals is extremely small, which has a significant effect, and relatively less side effects, lower toxicity, and higher safety. Biotechnology active protein or peptide drugs are unstable, apt to be degraded, easily inactivated, and easily damaged by microbial contamination and enzymatic hydrolysis.

In view of the above various strict storage conditions, biopharmaceuticals require low adsorption, no reaction with metal ions, low temperature resistance (liquid nitrogen environment), high temperature resistance, and some drugs belong to interferon alkaline, so COP (cycloolefin) Polymers) are the main packaging materials for biopharmaceuticals. Since the 13th Five-Year Plan, the state has advocated vigorous development of biopharmaceutical original research drugs and generic drugs. COP as a mainstream packaging material for biopharmaceuticals in foreign countries is still in its infancy in the country. With the continuous improvement of biopharmaceutical technology, COP will be the mainstream. Packaging materials, enter the pharmaceutical packaging market.

Eye drop bottle requirements for appearance

The main function of medicine packaging is to protect the safety of medicines, and the appearance of the packaging often determines a person's first impression and whether it will produce purchase behavior. The eye drop bottle is a special package for eye drops. Its shape is small and easy to carry. For its appearance, there are also relevant standards in the industry.

eye dropper bottle

Details determine success or failure, especially for eye drop bottles. With the prevalence of electronic products, the number of people with eye diseases such as eye fatigue and dry eyes has increased sharply, and the sales of eye drops have also increased. For some mild symptoms of eye discomfort, most people choose to go to the pharmacy to buy drugs for relief. The appearance of the eye drop bottle is the first step for consumers to understand the product. The buyer’s buying behavior has a direct impact, which greatly compromises the brand image.

According to the YBB20072012 "Low Density Polyethylene Medical Eye Drop Bottle" standard, the appearance of the bottle should meet the following requirements: Take an appropriate amount of this product, and look at it directly at a distance of 60cm in bright natural light. The thickness should be uniform, the surface should be smooth, the color should be uniform, there should be no bumps, the inner wall of the bottle should be smooth, and there should be no easily falling off. The threads of the bottle mouth and cap are clear and smooth.

The significance of the eye drop bottle is to make it convenient for consumers to use, to ensure the efficacy of eye drops, and to facilitate logistics and transportation. The appearance inspection is only one aspect of the various inspection standards. Good packaging must not go wrong in all aspects of material, processing technology, sterilization, etc. Each process must be interlocked and strict quality standards can be produced to produce high-quality eye drop bottles.

Comparison of safety items of eye drop bottles at home and abroad

 With the rapid increase in the demand for eye use, eye drops have become a must-have item for many people. As a high-risk route of administration, eye drops have very strict pharmaceutocal packaging requirements. There are differences in the standards for eye drop bottles at home and abroad. The differences in safety items are mainly reflected in clarity, burning residue, N-ethane non-volatile matter, easy to oxidize, and eye irritation test.

eye dropper bottle

Compared with foreign pharmacopoeias, some items in the YBB standard have higher requirements, such as heavy metals, n-ethane nonvolatiles, ultraviolet absorbance, etc., adding biological test items such as microbial limit, sterility, abnormal toxicity, and eye irritation tests. According to the relevant requirements of the 2015 edition of the Chinese Pharmacopoeia, eye drops should be sterile products. Through these items, the degree of microbial contamination of the drug packaging materials can be checked. In addition, the preclinical safety evaluation of ophthalmic drugs must first evaluate the ocular irritation; therefore, in order to investigate the toxicity introduced during the production process, it is necessary to detect the ocular irritation.

In the ignition residue inspection items, the YBB standard stipulates different limit requirements based on the two types of sunscreen and no sunscreen, which is more reasonable than the United States Pharmacopoeia. In terms of easy oxide detection, the content specified in the YBB standard shall not exceed 1.5ml, which is too loose compared with the 0.5ml regulation in the European Pharmacopoeia.

Although there are certain differences in individual test items, there is no doubt about the degree of attention paid to the quality of eye drop bottles at home and abroad, and there is room for improvement in the improvement of standards.

Eye drop bottle purchase to control these points

 Eye drops are common drugs for the treatment of eye diseases. As packaging materials for direct contact with drugs, the quality of eye drops bottles is the focus of attention of pharmaceutical companies. At present, there are many types of pharmaceutical packaging materials. How to choose high-quality and suitable eye drop bottles has become the key to many pharmaceutical companies to improve their product competitiveness.

5ml eye dropper bottle

The eye drop bottle is composed of a bottle cap, a bottle body and a bottle mouth. Due to the high reusability, the torque of the bottle cap will directly affect the tightness of the package. Pharmaceutical companies should fully consider this factor when choosing eye drop bottles. . According to the regulations of "Low Density Polyethylene Medical Eye Drop Bottle", when the bottle cap is twisted at 55-80Ncm, the bottle mouth and cap should match properly, and the teeth should not be slippery.

Secondly, consider the tightness of the eye drop bottle. The detection method is as follows: take a few of this product, first open the bottle, and then tighten the cap (use a force wrench to tighten the bottle and cap with a torque of 55-80Ncm, and place it in Add a baffle to the container with an air extraction device, immerse it with water, and vacuum to a vacuum of 20kPa and maintain it for 2 minutes. There should be no water or bubbling in the bottle.

Eye drops are in direct contact with the eyes, which is a high-risk route of administration. Under certain conditions, plastic packaging will migrate some of the substances contained in it to the contents, which may trigger a reaction to the contents. Therefore, the eye drops bottle Non-volatiles detection is very important. Detection method: Precisely measure 50.0ml each of the test solution and the blank solution and place them in an evaporating dish with constant weight. After evaporating to dryness in a water bath, dry to constant weight at 105°C. The difference between the two should not exceed 5.0mg.

In summary, the quality of eye drop bottles is related to the effectiveness and safety of drugs. Cap torque, tightness, and non-volatile detection are several factors that pharmaceutical companies should focus on when choosing packaging. A powerful means to control packaging quality to ensure drug safety and improve product competitiveness.

How to test the safety of child-proof bottles

 With the development of the pharmaceutical industry, a variety of new preparations emerge in an endless stream, and the safety of pharmaceutical packaging has also received more and more attention. Among them, whether children can effectively prevent children from opening the packaging and accidentally eating drugs has become a problem that pharmaceutical companies need to consider. The emergence of the open bottle successfully solved this problem.

45ml plastic medicine bottle with crc

The child-proof bottle is a special packaging with protective function. Its characteristics are mainly reflected in the bottle cap. The bottle cap is composed of an inner and outer double layer structure and is connected by a card slot. Only rotating the outer cap cannot open the package. It needs to be downwards. The bottle cap can be opened by rotating the bottle while pressing. The child is still in the developmental stage and has poor physical coordination. It is difficult to open the package, which effectively reduces the risk of accidental eating.

The child-proof packaging regulations are aimed at children younger than 5 years old, so how to test the safety of child-proof bottles? The United States Code of Federal Regulations requires that 50 children be divided into three age groups and asked to open the child-proof packaging to be tested. The test time is 10 minutes. If a child fails to open the package within the first 5 minutes, then the package will receive a certificate and the test will continue for 5 minutes. If a child opens the package within the first 5 minutes or within the next 5 minutes, then the package fails the child. To pass the test, no less than 85% of children must be unable to open the package in the first 5 minutes, and no less than 80% of children cannot open the package in the next 5 minutes. If the results of multiple tests are inconsistent, you need to change to another wave, and the number of children to be tested should not exceed 200.

Child safety is a matter of great concern to the country and every family. The use of child-proof bottles for medicines is an effective measure to reduce the accidental consumption of medicines by children, and it is also the joint responsibility of pharmaceutical companies and pharmaceutical packaging companies.

How to test the safety of child-proof bottles

 With the development of the pharmaceutical industry, a variety of new preparations emerge in an endless stream, and the safety of pharmaceutical packaging has also received more and more attention. Among them, whether children can effectively prevent children from opening the packaging and accidentally eating drugs has become a problem that pharmaceutical companies need to consider. The emergence of the open bottle successfully solved this problem.

45ml plastic medicine bottle with crc

The child-proof bottle is a special packaging with protective function. Its characteristics are mainly reflected in the bottle cap. The bottle cap is composed of an inner and outer double layer structure and is connected by a card slot. Only rotating the outer cap cannot open the package. It needs to be downwards. The bottle cap can be opened by rotating the bottle while pressing. The child is still in the developmental stage and has poor physical coordination. It is difficult to open the package, which effectively reduces the risk of accidental eating.

The child-proof packaging regulations are aimed at children younger than 5 years old, so how to test the safety of child-proof bottles? The United States Code of Federal Regulations requires that 50 children be divided into three age groups and asked to open the child-proof packaging to be tested. The test time is 10 minutes. If a child fails to open the package within the first 5 minutes, then the package will receive a certificate and the test will continue for 5 minutes. If a child opens the package within the first 5 minutes or within the next 5 minutes, then the package fails the child. To pass the test, no less than 85% of children must be unable to open the package in the first 5 minutes, and no less than 80% of children cannot open the package in the next 5 minutes. If the results of multiple tests are inconsistent, you need to change to another wave, and the number of children to be tested should not exceed 200.

Child safety is a matter of great concern to the country and every family. The use of child-proof bottles for medicines is an effective measure to reduce the accidental consumption of medicines by children, and it is also the joint responsibility of pharmaceutical companies and pharmaceutical packaging companies.

How Can Plastic Vitamin Tube Keep Dry Environment

 Plastic vitamin tube is used in vitamin tablet packaging due to its dry environment. There are silical-gel desiccant and large molecular sieve desiccant in plastic vatimin tube. However, silica-gel desiccant is the only one through FDA and healthy for human.

 

spiral desiccant closure

 

Silica-gel desiccant in vitamin tube is a highly active adsorbent material, which belongs to amorphous material. Silic-gel desiccant of vitamin tube cap insoluble in water, non-toxic and tasteless, chemically stable. According to diameter, silica can be divided into macroporous silica gel, coarse - hole silica gel, type B silicone, fine - hole silica gel. Silica can reuse through rebirth. The main ingredient of silica-gel desiccant is Sio2, for more translucent amorphous, composed of natural mineral processed granular or bead, usually after treatment with sulfuric acid to form, its hard, non-toxic, tasteless, non-corrosive, good chemical stability and thermal stability.

plastic vitamin C tube

 

Silica-gel desiccant of vitamin tube covers many hydroxyl groups with strong hydrophilicity, at the same time, the surface of silica gel desiccant has many small holes that are not visible to the naked eye, so that its surface area is greatly increased, and the properties of silica gel desiccant decide to become a good desiccant.Desiccant moisture environment as temperature of the shelf life is most suitable for 20 ~ 32 ℃, humidity was 60% ~ 60%, it can reduce the environmental relative humidity to 40%.

Xinfuda as a China major pharmaceutical packaging manufacturer with DMF, which can offer excellent desiccant packaging for vitamin tablets. Plastic vitamin tube adopted silica-gel desiccant to keep dry and the spring on the cap can prevent tablets damaging.

How to test the safety of child-proof bottles

 With the development of the pharmaceutical industry, a variety of new preparations emerge in an endless stream, and the safety of pharmaceutical packaging has also received more and more attention. Among them, whether children can effectively prevent children from opening the packaging and accidentally eating drugs has become a problem that pharmaceutical companies need to consider. The emergence of the open bottle successfully solved this problem.

45ml plastic medicine bottle with crc

The child-proof bottle is a special packaging with protective function. Its characteristics are mainly reflected in the bottle cap. The bottle cap is composed of an inner and outer double layer structure and is connected by a card slot. Only rotating the outer cap cannot open the package. It needs to be downwards. The bottle cap can be opened by rotating the bottle while pressing. The child is still in the developmental stage and has poor physical coordination. It is difficult to open the package, which effectively reduces the risk of accidental eating.

The child-proof packaging regulations are aimed at children younger than 5 years old, so how to test the safety of child-proof bottles? The United States Code of Federal Regulations requires that 50 children be divided into three age groups and asked to open the child-proof packaging to be tested. The test time is 10 minutes. If a child fails to open the package within the first 5 minutes, then the package will receive a certificate and the test will continue for 5 minutes. If a child opens the package within the first 5 minutes or within the next 5 minutes, then the package fails the child. To pass the test, no less than 85% of children must be unable to open the package in the first 5 minutes, and no less than 80% of children cannot open the package in the next 5 minutes. If the results of multiple tests are inconsistent, you need to change to another wave, and the number of children to be tested should not exceed 200.

Child safety is a matter of great concern to the country and every family. The use of child-proof bottles for medicines is an effective measure to reduce the accidental consumption of medicines by children, and it is also the joint responsibility of pharmaceutical companies and pharmaceutical packaging companies.

Viewing the special design of effervescent tube from the importance of medicine moisture prevention

 As a necessary product in our lives, medicine is mainly used to prevent, treat and diagnose various diseases. Because of its direct action on the human body, the safety and effectiveness of medicines are crucial. It is a common choice of many pharmaceutical companies to prevent the deterioration of medicines from moisture absorption through the design of moisture-proof packaging. The common effervescent tube makes good use of this function of packaging.

144mm eff tablet tube

Drugs are prone to deliquescence by absorbing water, especially for effervescent tablets. To achieve the function of moisture-proof, packaging materials are required to have high moisture resistance and low water vapor transmission rate, which can effectively prevent the intrusion of external water vapor and prevent the medicine from being damp.

desiccant cap

In addition, the moisture resistance inside the effervescent tube must also be considered. After the drug is taken, some water vapor may enter the package through the cap during the opening process. Therefore, most of the effervescent tubes are fully considered in the design. When it comes to the importance of moisture-proofing for medicines, a moisture-proof cover is used in the design of the effervescent tube. The moisture-proof cap is a new design that combines the desiccant and the bottle cap into one. There is a small medicine storehouse on the top of the bottle cap to store silica gel and molecular sieve, which can absorb the moisture in the effervescent tube and keep the medicine dry. This design saves space and avoids the risk of children accidentally ingesting the desiccant, and is suitable for test strips and tablet packaging with larger dosage forms.

The special moisture-proof cover design of the effervescent tube is an inevitable trend for pharmaceutical packaging companies to adapt to the changing market needs. We will wait and see what innovative designs for pharmaceutical packaging in the future.

Eye drop bottle purchase to control these points

 Eye drops are common drugs for the treatment of eye diseases. As packaging materials for direct contact with drugs, the quality of eye drops bottles is the focus of attention of pharmaceutical companies. At present, there are many types of pharmaceutical packaging materials. How to choose high-quality and suitable eye drop bottles has become the key to many pharmaceutical companies to improve their product competitiveness.

5ml eye dropper bottle

The eye drop bottle is composed of a bottle cap, a bottle body and a bottle mouth. Due to the high reusability, the torque of the bottle cap will directly affect the tightness of the package. Pharmaceutical companies should fully consider this factor when choosing eye drop bottles. . According to the regulations of "Low Density Polyethylene Medical Eye Drop Bottle", when the bottle cap is twisted at 55-80Ncm, the bottle mouth and cap should match properly, and the teeth should not be slippery.

Secondly, consider the tightness of the eye drop bottle. The detection method is as follows: take a few of this product, first open the bottle, and then tighten the cap (use a force wrench to tighten the bottle and cap with a torque of 55-80Ncm, and place it in Add a baffle to the container with an air extraction device, immerse it with water, and vacuum to a vacuum of 20kPa and maintain it for 2 minutes. There should be no water or bubbling in the bottle.

Eye drops are in direct contact with the eyes, which is a high-risk route of administration. Under certain conditions, plastic packaging will migrate some of the substances contained in it to the contents, which may trigger a reaction to the contents. Therefore, the eye drops bottle Non-volatiles detection is very important. Detection method: Precisely measure 50.0ml each of the test solution and the blank solution and place them in an evaporating dish with constant weight. After evaporating to dryness in a water bath, dry to constant weight at 105°C. The difference between the two should not exceed 5.0mg.

In summary, the quality of eye drop bottles is related to the effectiveness and safety of drugs. Cap torque, tightness, and non-volatile detection are several factors that pharmaceutical companies should focus on when choosing packaging. A powerful means to control packaging quality to ensure drug safety and improve product competitiveness.

Eye drop bottle purchase to control these points

 Eye drops are common drugs for the treatment of eye diseases. As packaging materials for direct contact with drugs, the quality of eye drops bottles is the focus of attention of pharmaceutical companies. At present, there are many types of pharmaceutical packaging materials. How to choose high-quality and suitable eye drop bottles has become the key to many pharmaceutical companies to improve their product competitiveness.

5ml eye dropper bottle

The eye drop bottle is composed of a bottle cap, a bottle body and a bottle mouth. Due to the high reusability, the torque of the bottle cap will directly affect the tightness of the package. Pharmaceutical companies should fully consider this factor when choosing eye drop bottles. . According to the regulations of "Low Density Polyethylene Medical Eye Drop Bottle", when the bottle cap is twisted at 55-80Ncm, the bottle mouth and cap should match properly, and the teeth should not be slippery.

Secondly, consider the tightness of the eye drop bottle. The detection method is as follows: take a few of this product, first open the bottle, and then tighten the cap (use a force wrench to tighten the bottle and cap with a torque of 55-80Ncm, and place it in Add a baffle to the container with an air extraction device, immerse it with water, and vacuum to a vacuum of 20kPa and maintain it for 2 minutes. There should be no water or bubbling in the bottle.

Eye drops are in direct contact with the eyes, which is a high-risk route of administration. Under certain conditions, plastic packaging will migrate some of the substances contained in it to the contents, which may trigger a reaction to the contents. Therefore, the eye drops bottle Non-volatiles detection is very important. Detection method: Precisely measure 50.0ml each of the test solution and the blank solution and place them in an evaporating dish with constant weight. After evaporating to dryness in a water bath, dry to constant weight at 105°C. The difference between the two should not exceed 5.0mg.

In summary, the quality of eye drop bottles is related to the effectiveness and safety of drugs. Cap torque, tightness, and non-volatile detection are several factors that pharmaceutical companies should focus on when choosing packaging. A powerful means to control packaging quality to ensure drug safety and improve product competitiveness.

Viewing the special design of effervescent tube from the importance of medicine moisture prevention

 As a necessary product in our lives, medicine is mainly used to prevent, treat and diagnose various diseases. Because of its direct action on the human body, the safety and effectiveness of medicines are crucial. It is a common choice of many pharmaceutical companies to prevent the deterioration of medicines from moisture absorption through the design of moisture-proof packaging. The common effervescent tube makes good use of this function of packaging.

144mm eff tablet tube

Drugs are prone to deliquescence by absorbing water, especially for effervescent tablets. To achieve the function of moisture-proof, packaging materials are required to have high moisture resistance and low water vapor transmission rate, which can effectively prevent the intrusion of external water vapor and prevent the medicine from being damp.

desiccant cap

In addition, the moisture resistance inside the effervescent tube must also be considered. After the drug is taken, some water vapor may enter the package through the cap during the opening process. Therefore, most of the effervescent tubes are fully considered in the design. When it comes to the importance of moisture-proofing for medicines, a moisture-proof cover is used in the design of the effervescent tube. The moisture-proof cap is a new design that combines the desiccant and the bottle cap into one. There is a small medicine storehouse on the top of the bottle cap to store silica gel and molecular sieve, which can absorb the moisture in the effervescent tube and keep the medicine dry. This design saves space and avoids the risk of children accidentally ingesting the desiccant, and is suitable for test strips and tablet packaging with larger dosage forms.

The special moisture-proof cover design of the effervescent tube is an inevitable trend for pharmaceutical packaging companies to adapt to the changing market needs. We will wait and see what innovative designs for pharmaceutical packaging in the future.