Pharmaceutical high-density polyethylene bottles need to meet these characteristics

 As a common polymer material, high-density polyethylene is often processed into high-density polyethylene bottles, which are used in all aspects of our daily life, such as shampoo, hand sanitizer, detergent, beverage bottles, etc., among which pharmaceutical packaging It is also one of its applications.

child proof bottle

Medicine is a special item, and its quality is related to the health of patients. Therefore, high-density polyethylene bottles also need to be strictly controlled to meet safety requirements in quality. Safety mainly depends on packaging materials. High-density polyethylene is one of the common materials for pharmaceutical packaging. It is non-toxic, tasteless, resistant to most acids and alkalis, light in weight, and easy to transport. This material has been included in the national pharmaceutical packaging materials. And the container registration certificate quality standard, its detection method, experiment, sterility, easy oxidizing, etc. have clear regulations, which can ensure the safety and stability of the drug.

In addition, the high-density polyethylene bottle should also consider the convenience of patients, which needs to be considered from the design of its appearance. At present, the shapes of medicine bottles include square, oval, round, etc. Among them, round high-density polyethylene bottles are more commonly used than other shapes. This is mainly because the circular design is not only in line with people’s aesthetics. It also caters to the principles of human mechanics and meets the needs of patients for easy grasping.

Hygiene, safety and convenient use are the two basic requirements of medicinal high-density polyethylene bottles. They seem to be simple. Behind it requires manufacturers of pharmaceutical packaging materials to repeatedly modify the appearance design, strictly control product quality management, and constantly pursue higher quality. Medicine packaging.

Prevent children from opening bottles to help pharmaceutical companies break through

 Recently, the State Food and Drug Administration passed the priority review and approval procedure and conditionally approved the listing of the Class 1 innovative drug vometinib mesylate (trade name: Ivesa) declared by Shanghai Ailisi Pharmaceutical Technology Co., Ltd., which is also The second domestically produced Class 1 new chemical drug approved for marketing this year.

The drug is the third representative EGFR kinase inhibitor, and is an innovative drug independently researched and developed by my country with independent intellectual property rights. Applicable to the disease progression during or after treatment with previous epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), and the presence of locally advanced or metastatic non-small cell lung cancer with positive EGFR T790M mutation confirmed by testing ( NSCLC) treatment of adult patients.

The launch of this drug will bring new choices for lung cancer patients, and competition in the lung cancer drug market will also become more intense. Innovation is the foundation of enterprise development. Pharmaceutical companies must continue to innovate and develop new drugs that meet market needs if they want to survive in the ever-changing market. In addition, pharmaceutical packaging also needs continuous innovation. At present, some anti-cancer drugs, high blood pressure and other drugs mostly use the special packaging method of preventing children from opening the bottle, in order to find a breakthrough in the fierce market competition.

child proof bottle

The main function of the child-proof bottle is to prevent children from opening the pharmaceutical packaging and accidentally ingesting drugs. The United States has implemented the Poison Prevention Packaging Act (PPPA) as early as 1970, requiring certain products that are potentially threatening to children to use child-proof packaging. More and more developed countries are implementing it. With the continuous innovation of medicines and people's attention to the problem of children's accidental ingestion of medicines, child-proof bottles will be applied to more medicine packaging, to a certain extent, to help companies establish a good brand image and improve product competitiveness.

How to test the safety of child-proof bottles

 With the development of the pharmaceutical industry, a variety of new preparations emerge in an endless stream, and the safety of pharmaceutical packaging has also received more and more attention. Among them, whether children can effectively prevent children from opening the packaging and accidentally eating drugs has become a problem that pharmaceutical companies need to consider. The emergence of the open bottle successfully solved this problem.

45ml plastic medicine bottle with crc

The child-proof bottle is a special packaging with protective function. Its characteristics are mainly reflected in the bottle cap. The bottle cap is composed of an inner and outer double layer structure and is connected by a card slot. Only rotating the outer cap cannot open the package. It needs to be downwards. The bottle cap can be opened by rotating the bottle while pressing. The child is still in the developmental stage and has poor physical coordination. It is difficult to open the package, which effectively reduces the risk of accidental eating.

The child-proof packaging regulations are aimed at children younger than 5 years old, so how to test the safety of child-proof bottles? The United States Code of Federal Regulations requires that 50 children be divided into three age groups and asked to open the child-proof packaging to be tested. The test time is 10 minutes. If a child fails to open the package within the first 5 minutes, then the package will receive a certificate and the test will continue for 5 minutes. If a child opens the package within the first 5 minutes or within the next 5 minutes, then the package fails the child. To pass the test, no less than 85% of children must be unable to open the package in the first 5 minutes, and no less than 80% of children cannot open the package in the next 5 minutes. If the results of multiple tests are inconsistent, you need to change to another wave, and the number of children to be tested should not exceed 200.

Child safety is a matter of great concern to the country and every family. The use of child-proof bottles for medicines is an effective measure to reduce the accidental consumption of medicines by children, and it is also the joint responsibility of pharmaceutical companies and pharmaceutical packaging companies.

How to test the safety of child-proof bottles

 With the development of the pharmaceutical industry, a variety of new preparations emerge in an endless stream, and the safety of pharmaceutical packaging has also received more and more attention. Among them, whether children can effectively prevent children from opening the packaging and accidentally eating drugs has become a problem that pharmaceutical companies need to consider. The emergence of the open bottle successfully solved this problem.

45ml plastic medicine bottle with crc

The child-proof bottle is a special packaging with protective function. Its characteristics are mainly reflected in the bottle cap. The bottle cap is composed of an inner and outer double layer structure and is connected by a card slot. Only rotating the outer cap cannot open the package. It needs to be downwards. The bottle cap can be opened by rotating the bottle while pressing. The child is still in the developmental stage and has poor physical coordination. It is difficult to open the package, which effectively reduces the risk of accidental eating.

The child-proof packaging regulations are aimed at children younger than 5 years old, so how to test the safety of child-proof bottles? The United States Code of Federal Regulations requires that 50 children be divided into three age groups and asked to open the child-proof packaging to be tested. The test time is 10 minutes. If a child fails to open the package within the first 5 minutes, then the package will receive a certificate and the test will continue for 5 minutes. If a child opens the package within the first 5 minutes or within the next 5 minutes, then the package fails the child. To pass the test, no less than 85% of children must be unable to open the package in the first 5 minutes, and no less than 80% of children cannot open the package in the next 5 minutes. If the results of multiple tests are inconsistent, you need to change to another wave, and the number of children to be tested should not exceed 200.

Child safety is a matter of great concern to the country and every family. The use of child-proof bottles for medicines is an effective measure to reduce the accidental consumption of medicines by children, and it is also the joint responsibility of pharmaceutical companies and pharmaceutical packaging companies.

A compatibility test between a pharmaceutical bottle and a drug

Pharmaceutical packaging bottles are commonly used in the packaging of tablets, capsules, injections, eye drops and the like. Commonly used materials are high density polyethylene, low density polyethylene, polypropylene, polyester, and the like. Drug compatibility focuses on the penetration of water vapor, the infiltration of oxygen; the penetration of moisture and volatile drugs: the transfer of fat-soluble drugs and bacteriostatic agents to plastics: the adsorption of plastics on drugs: the role of solvents and plastics: The influence of additives in plastics, decomposition products during processing on drugs, and problems such as particles and sealing.
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 The establishment of the compatibility test method, when inspecting the pharmaceutical packaging materials, three batches of packaging materials should be used to carry out the compatibility test on the batch of drugs to be packaged; when inspecting the drugs, three batches of drugs should be used. The compatibility test is carried out after packaging a batch of materials or containers in the package.
[caption id="" align="alignnone" width="1000"] effervescent tablet tubes[/caption]
When conducting a compatibility test between a pharmaceutical bottle and a drug, the test method can be established by referring to the quality standard of the drug and the packaging material or container.