Why do chronic disease drugs use tablet vials

 With the aging of the global population, the number of people with high blood pressure and diabetes has increased sharply, and the market demand for drugs for chronic diseases such as blood pressure and blood sugar has surged. Most of these drugs are tablets, and medicine tablet bottles are often used in the packaging.

150ml HDPE supplement bottle

Chronic disease refers to the general term for diseases that do not constitute infection and have long-term accumulation of disease form damage. According to a survey by the World Health Organization, 60% of the causes of chronic diseases depend on the individual’s lifestyle, and are also related to factors such as genetics, medical conditions, social conditions, and climate. In lifestyle, irrational diet, insufficient physical activity, tobacco use and harmful use of alcohol are the four major risk factors for chronic diseases. Chronic diseases mainly cause damage to important organs such as the brain, heart, and kidneys, which can easily cause disability, affect labor ability and quality of life, and medical expenses are extremely expensive, which increases the economic burden of society and families.

Hypertension and diabetes are globally recognized multiple diseases, and the superimposed prevalence is high. If they are not prevented in time, they will cause economic and life harm. With the improvement of people's living standards, the patients with these two diseases are showing a younger trend. Patients with chronic diseases generally need to take medicine for a long time, so the dosage form of this kind of medicine is mainly convenient to take tablets, and most of the packaging options are tablet vials. Such a large packaging capacity can reduce the number of times patients purchase medicines. On the other hand, this type of packaging is more friendly to the elderly and easy to open.

Chronic disease drugs are one aspect of the application of tablet medicine bottles. In addition, this kind of pharmaceutical packaging is light in weight, not fragile, and convenient to transport. It is also widely used in health care products, lozenges, capsules and other medicines.

Vitamin C effervescent tube highlights differentiation

 Vitamin C effervescent tablets are a common vitamin supplement that is very popular among young people. There are many manufacturers of vitamin C effervescent tablets on the market, and the phenomenon of product homogeneity is serious. In this context, the effervescent tube has become the key for pharmaceutical companies to break through the bottleneck of product development.

effervescent tablet tubes

Product competition is not only the competition of the product itself, but also the competition of the entire company and the competition of brands. When vitamin C effervescent tablets have similar taste and safety, the difference in packaging becomes a direct manifestation of product differentiation. Even two products with the same common name will have different market performance due to differences in packaging.

The effervescent tube is a special pharmaceutical packaging for vitamin C effervescent tablets. The effervescent tablet contains a disintegrant and is easily deteriorated by moisture. In order to ensure the dryness of the tablet, a desiccant made of silica gel and molecular sieve is placed inside the effervescent tube . Different from ordinary medicine bottles, the desiccant is stored on the top of the lid to prevent children from accidentally ingesting. The spiral spring on the lid can protect the tablet from damage due to various external forces.

In order to highlight the differentiation of brands and distinguish competing products, some pharmaceutical companies will use the color, logo, slogan, etc. of the effervescent tube to reflect it. For example, use different caps for different flavors of effervescent tablets, and add eye-catching slogans on the external label. In short, differentiation is a weapon for companies to break homogeneity. Only when there are differences can there be a market, and only then can they gain a place in the competition among the strong players.

Pharmaceutical high-density polyethylene bottles need to meet these characteristics

 As a common polymer material, high-density polyethylene is often processed into high-density polyethylene bottles, which are used in all aspects of our daily life, such as shampoo, hand sanitizer, detergent, beverage bottles, etc., among which pharmaceutical packaging It is also one of its applications.

child proof bottle

Medicine is a special item, and its quality is related to the health of patients. Therefore, high-density polyethylene bottles also need to be strictly controlled to meet safety requirements in quality. Safety mainly depends on packaging materials. High-density polyethylene is one of the common materials for pharmaceutical packaging. It is non-toxic, tasteless, resistant to most acids and alkalis, light in weight, and easy to transport. This material has been included in the national pharmaceutical packaging materials. And the container registration certificate quality standard, its detection method, experiment, sterility, easy oxidizing, etc. have clear regulations, which can ensure the safety and stability of the drug.

In addition, the high-density polyethylene bottle should also consider the convenience of patients, which needs to be considered from the design of its appearance. At present, the shapes of medicine bottles include square, oval, round, etc. Among them, round high-density polyethylene bottles are more commonly used than other shapes. This is mainly because the circular design is not only in line with people’s aesthetics. It also caters to the principles of human mechanics and meets the needs of patients for easy grasping.

Hygiene, safety and convenient use are the two basic requirements of medicinal high-density polyethylene bottles. They seem to be simple. Behind it requires manufacturers of pharmaceutical packaging materials to repeatedly modify the appearance design, strictly control product quality management, and constantly pursue higher quality. Medicine packaging.

Prevent children from opening the bottle to create a safe growth environment for children

Child safety is a common concern of society, and it is also a very important topic. Children playing on the road, sticking their heads out of the window, riding in the shopping cart, etc. are all dangerous. Among the many potential safety hazards, accidental ingestion of drugs has attracted more and more people’s attention. Prevent children from opening the bottle slowly. Into people's field of vision.

child proof bottle

The child is in the growth and development period and is full of curiosity about everything. It is easy to be attracted by the colorful pills. In addition, the parents' negligence and the loopholes in the drug packaging design can easily lead to the accidental ingestion of the drug by the child, resulting in irreversible consequences . For adults, one antihypertensive drug can control blood pressure, and two tablets may cause low blood pressure. Even if children take a small dose, they will have toxic side effects and even life-threatening.

On the one hand, preventing children from accidentally ingesting medicines requires parents to attach great importance to them and put medicines in places out of reach of children. On the other hand, it is necessary to increase the difficulty for children to open the package and reduce the probability of accidental eating. The design of preventing children from opening the bottle well realizes this function. The highlight is mainly reflected in the bottle cap. Ordinary bottle caps generally adopt a single-layer structure, while the child-proof bottle cap adopts an internal and external double-layer structure design. The interior is connected by a card slot. If the bottle is opened, it needs to be pressed down and rotated at the same time. The bottle cap can only be opened. This opening method involves force in two directions. It is difficult for children who are still in the developmental stage. It is generally difficult to open in a short time, which effectively reduces the risk of accidentally ingesting drugs.

As the society continues to pay attention to the problem of children’s accidental ingestion of drugs, many pharmaceutical companies have also begun to take this issue as the focus of medicine drug packaging choices. Some anti-hypertensive, hypoglycemic, and cardiovascular drugs have gradually cited anti-children’s opening bottles. The packaging method not only protects the safety of children, but also improves the overall image of the brand.

What factors should be considered in the packaging design of effervescent tablets

 Effervescent tablets are very common in life, such as vitamin C effervescent tablets are mostly used to enhance human immunity. The effervescent tube is a special packaging for effervescent tablets. To meet the storage requirements of the tablets, the effervescent tube should be designed with full consideration of the characteristics of the dosage form, packaging capacity, and consumer needs.

84mm*29mm effervescent tablet tube

The bottle body and desiccant cap material of effervescent tablets contain a certain amount of moisture. In addition to the penetration of external water molecules during transportation and storage after sealing, the tablets are easily decomposed by moisture, which will cause the medicine to deteriorate. To ensure that the tablet is in a good packaging environment, the effervescent tube should be designed with moisture-proof function as the focus of research.

Effervescent tablets are a kind of ready-to-use solid beverages, and many people carry them with them. Therefore, the effervescent tube should be designed with the capacity of the package in mind. It should be based on the diameter and thickness of the tablet dosage form, combined with the fact that consumers often carry it The characteristics of the bottle determine the capacity of the bottle to better meet the market demand.

On the other hand, due to the characteristics of the dosage form, the hardness of the effervescent tablet should not be too large, and the diameter of the tablet is generally larger, which increases the difficulty of compaction. It is easy to break the effervescent tablet due to collision during logistics and handling. In order to buffer the pressure of the bottle itself and fix the tablets, a soft coil spring is usually placed on the cap of the effervescent tube to absorb shock and avoid shattering.

In fact, no matter how the pharmaceutical packaging is designed, it is inseparable from a fundamental purpose to meet the special properties of drugs and consumer demand. Of course, with the continuous changes in market demand, the effervescent tube will also be upgraded in design.

Comparison of safety items of eye drop bottles at home and abroad

 With the rapid increase in the demand for eye use, eye drops have become a must-have item for many people. As a high-risk route of administration, eye drops have very strict pharmaceutocal packaging requirements. There are differences in the standards for eye drop bottles at home and abroad. The differences in safety items are mainly reflected in clarity, burning residue, N-ethane non-volatile matter, easy to oxidize, and eye irritation test.

eye dropper bottle

Compared with foreign pharmacopoeias, some items in the YBB standard have higher requirements, such as heavy metals, n-ethane nonvolatiles, ultraviolet absorbance, etc., adding biological test items such as microbial limit, sterility, abnormal toxicity, and eye irritation tests. According to the relevant requirements of the 2015 edition of the Chinese Pharmacopoeia, eye drops should be sterile products. Through these items, the degree of microbial contamination of the drug packaging materials can be checked. In addition, the preclinical safety evaluation of ophthalmic drugs must first evaluate the ocular irritation; therefore, in order to investigate the toxicity introduced during the production process, it is necessary to detect the ocular irritation.

In the ignition residue inspection items, the YBB standard stipulates different limit requirements based on the two types of sunscreen and no sunscreen, which is more reasonable than the United States Pharmacopoeia. In terms of easy oxide detection, the content specified in the YBB standard shall not exceed 1.5ml, which is too loose compared with the 0.5ml regulation in the European Pharmacopoeia.

Although there are certain differences in individual test items, there is no doubt about the degree of attention paid to the quality of eye drop bottles at home and abroad, and there is room for improvement in the improvement of standards.

How to test the safety of child-proof bottles

 With the development of the pharmaceutical industry, a variety of new preparations emerge in an endless stream, and the safety of pharmaceutical packaging has also received more and more attention. Among them, whether children can effectively prevent children from opening the packaging and accidentally eating drugs has become a problem that pharmaceutical companies need to consider. The emergence of the open bottle successfully solved this problem.

45ml plastic medicine bottle with crc

The child-proof bottle is a special packaging with protective function. Its characteristics are mainly reflected in the bottle cap. The bottle cap is composed of an inner and outer double layer structure and is connected by a card slot. Only rotating the outer cap cannot open the package. It needs to be downwards. The bottle cap can be opened by rotating the bottle while pressing. The child is still in the developmental stage and has poor physical coordination. It is difficult to open the package, which effectively reduces the risk of accidental eating.

The child-proof packaging regulations are aimed at children younger than 5 years old, so how to test the safety of child-proof bottles? The United States Code of Federal Regulations requires that 50 children be divided into three age groups and asked to open the child-proof packaging to be tested. The test time is 10 minutes. If a child fails to open the package within the first 5 minutes, then the package will receive a certificate and the test will continue for 5 minutes. If a child opens the package within the first 5 minutes or within the next 5 minutes, then the package fails the child. To pass the test, no less than 85% of children must be unable to open the package in the first 5 minutes, and no less than 80% of children cannot open the package in the next 5 minutes. If the results of multiple tests are inconsistent, you need to change to another wave, and the number of children to be tested should not exceed 200.

Child safety is a matter of great concern to the country and every family. The use of child-proof bottles for medicines is an effective measure to reduce the accidental consumption of medicines by children, and it is also the joint responsibility of pharmaceutical companies and pharmaceutical packaging companies.

How Can Plastic Vitamin Tube Keep Dry Environment

 Plastic vitamin tube is used in vitamin tablet packaging due to its dry environment. There are silical-gel desiccant and large molecular sieve desiccant in plastic vatimin tube. However, silica-gel desiccant is the only one through FDA and healthy for human.

 

spiral desiccant closure

 

Silica-gel desiccant in vitamin tube is a highly active adsorbent material, which belongs to amorphous material. Silic-gel desiccant of vitamin tube cap insoluble in water, non-toxic and tasteless, chemically stable. According to diameter, silica can be divided into macroporous silica gel, coarse - hole silica gel, type B silicone, fine - hole silica gel. Silica can reuse through rebirth. The main ingredient of silica-gel desiccant is Sio2, for more translucent amorphous, composed of natural mineral processed granular or bead, usually after treatment with sulfuric acid to form, its hard, non-toxic, tasteless, non-corrosive, good chemical stability and thermal stability.

plastic vitamin C tube

 

Silica-gel desiccant of vitamin tube covers many hydroxyl groups with strong hydrophilicity, at the same time, the surface of silica gel desiccant has many small holes that are not visible to the naked eye, so that its surface area is greatly increased, and the properties of silica gel desiccant decide to become a good desiccant.Desiccant moisture environment as temperature of the shelf life is most suitable for 20 ~ 32 ℃, humidity was 60% ~ 60%, it can reduce the environmental relative humidity to 40%.

Xinfuda as a China major pharmaceutical packaging manufacturer with DMF, which can offer excellent desiccant packaging for vitamin tablets. Plastic vitamin tube adopted silica-gel desiccant to keep dry and the spring on the cap can prevent tablets damaging.

How to test the safety of child-proof bottles

 With the development of the pharmaceutical industry, a variety of new preparations emerge in an endless stream, and the safety of pharmaceutical packaging has also received more and more attention. Among them, whether children can effectively prevent children from opening the packaging and accidentally eating drugs has become a problem that pharmaceutical companies need to consider. The emergence of the open bottle successfully solved this problem.

45ml plastic medicine bottle with crc

The child-proof bottle is a special packaging with protective function. Its characteristics are mainly reflected in the bottle cap. The bottle cap is composed of an inner and outer double layer structure and is connected by a card slot. Only rotating the outer cap cannot open the package. It needs to be downwards. The bottle cap can be opened by rotating the bottle while pressing. The child is still in the developmental stage and has poor physical coordination. It is difficult to open the package, which effectively reduces the risk of accidental eating.

The child-proof packaging regulations are aimed at children younger than 5 years old, so how to test the safety of child-proof bottles? The United States Code of Federal Regulations requires that 50 children be divided into three age groups and asked to open the child-proof packaging to be tested. The test time is 10 minutes. If a child fails to open the package within the first 5 minutes, then the package will receive a certificate and the test will continue for 5 minutes. If a child opens the package within the first 5 minutes or within the next 5 minutes, then the package fails the child. To pass the test, no less than 85% of children must be unable to open the package in the first 5 minutes, and no less than 80% of children cannot open the package in the next 5 minutes. If the results of multiple tests are inconsistent, you need to change to another wave, and the number of children to be tested should not exceed 200.

Child safety is a matter of great concern to the country and every family. The use of child-proof bottles for medicines is an effective measure to reduce the accidental consumption of medicines by children, and it is also the joint responsibility of pharmaceutical companies and pharmaceutical packaging companies.

Viewing the special design of effervescent tube from the importance of medicine moisture prevention

 As a necessary product in our lives, medicine is mainly used to prevent, treat and diagnose various diseases. Because of its direct action on the human body, the safety and effectiveness of medicines are crucial. It is a common choice of many pharmaceutical companies to prevent the deterioration of medicines from moisture absorption through the design of moisture-proof packaging. The common effervescent tube makes good use of this function of packaging.

144mm eff tablet tube

Drugs are prone to deliquescence by absorbing water, especially for effervescent tablets. To achieve the function of moisture-proof, packaging materials are required to have high moisture resistance and low water vapor transmission rate, which can effectively prevent the intrusion of external water vapor and prevent the medicine from being damp.

desiccant cap

In addition, the moisture resistance inside the effervescent tube must also be considered. After the drug is taken, some water vapor may enter the package through the cap during the opening process. Therefore, most of the effervescent tubes are fully considered in the design. When it comes to the importance of moisture-proofing for medicines, a moisture-proof cover is used in the design of the effervescent tube. The moisture-proof cap is a new design that combines the desiccant and the bottle cap into one. There is a small medicine storehouse on the top of the bottle cap to store silica gel and molecular sieve, which can absorb the moisture in the effervescent tube and keep the medicine dry. This design saves space and avoids the risk of children accidentally ingesting the desiccant, and is suitable for test strips and tablet packaging with larger dosage forms.

The special moisture-proof cover design of the effervescent tube is an inevitable trend for pharmaceutical packaging companies to adapt to the changing market needs. We will wait and see what innovative designs for pharmaceutical packaging in the future.

Basic requirements for pharmaceutical packaging

 Pharmaceutical packaging is a container used to store medicines, with different materials and shapes. The main function is to protect medicines in circulation and maintain the safety of medicines within the validity period. The quality of the packaging is related to the efficacy of the medicine and will have a direct impact on the patient's condition. So what should pharmaceutical companies pay attention to when it comes to pharmaceutical packaging?

eye dropper bottle

1. The choice of pharmaceutical packaging should be based on the in-depth knowledge of pharmaceutical companies on medicines. Only by combining the characteristics of medicines to choose the right packaging can better protect the quality of medicines and maintain good efficacy.

2. Make sure that the pharmaceutical packaging complies with the relevant regulations of the national and professional standards.

3. Under normal storage and transportation conditions, medical packaging must ensure that qualified drugs do not deteriorate within the validity period.

effervescent tablet tube

4. Medical packaging (including transportation packaging) must be sealed, sealed, sealed, or used with anti-theft caps, bottle cap sleeves, etc. The label must be affixed and adhered firmly, and must not be put into the bottle together with the drug; any damaged seal, label, packaging container, etc. shall not be shipped or sold.

5. The transport packaging of various drugs must meet the requirements of their physical and chemical properties. All medicines that are afraid of freezing and heat are shipped to different regions in different seasons, and corresponding measures to prevent cold or heat must be taken.

child proof bottle

6. The storage and transportation pictorial signs of drug transport packaging, and the packaging signs of dangerous goods, etc., must comply with national standards and relevant regulations.

Pharmaceutical packaging is nothing trivial. When pharmaceutical companies do a good job in drug research and development, only by choosing qualified and high-quality packaging can they better protect drugs and contribute to human health.

Eye drop bottle purchase to control these points

 Eye drops are common drugs for the treatment of eye diseases. As packaging materials for direct contact with drugs, the quality of eye drops bottles is the focus of attention of pharmaceutical companies. At present, there are many types of pharmaceutical packaging materials. How to choose high-quality and suitable eye drop bottles has become the key to many pharmaceutical companies to improve their product competitiveness.

5ml eye dropper bottle

The eye drop bottle is composed of a bottle cap, a bottle body and a bottle mouth. Due to the high reusability, the torque of the bottle cap will directly affect the tightness of the package. Pharmaceutical companies should fully consider this factor when choosing eye drop bottles. . According to the regulations of "Low Density Polyethylene Medical Eye Drop Bottle", when the bottle cap is twisted at 55-80Ncm, the bottle mouth and cap should match properly, and the teeth should not be slippery.

Secondly, consider the tightness of the eye drop bottle. The detection method is as follows: take a few of this product, first open the bottle, and then tighten the cap (use a force wrench to tighten the bottle and cap with a torque of 55-80Ncm, and place it in Add a baffle to the container with an air extraction device, immerse it with water, and vacuum to a vacuum of 20kPa and maintain it for 2 minutes. There should be no water or bubbling in the bottle.

Eye drops are in direct contact with the eyes, which is a high-risk route of administration. Under certain conditions, plastic packaging will migrate some of the substances contained in it to the contents, which may trigger a reaction to the contents. Therefore, the eye drops bottle Non-volatiles detection is very important. Detection method: Precisely measure 50.0ml each of the test solution and the blank solution and place them in an evaporating dish with constant weight. After evaporating to dryness in a water bath, dry to constant weight at 105°C. The difference between the two should not exceed 5.0mg.

In summary, the quality of eye drop bottles is related to the effectiveness and safety of drugs. Cap torque, tightness, and non-volatile detection are several factors that pharmaceutical companies should focus on when choosing packaging. A powerful means to control packaging quality to ensure drug safety and improve product competitiveness.

Viewing the special design of effervescent tube from the importance of medicine moisture prevention

 As a necessary product in our lives, medicine is mainly used to prevent, treat and diagnose various diseases. Because of its direct action on the human body, the safety and effectiveness of medicines are crucial. It is a common choice of many pharmaceutical companies to prevent the deterioration of medicines from moisture absorption through the design of moisture-proof packaging. The common effervescent tube makes good use of this function of packaging.

144mm eff tablet tube

Drugs are prone to deliquescence by absorbing water, especially for effervescent tablets. To achieve the function of moisture-proof, packaging materials are required to have high moisture resistance and low water vapor transmission rate, which can effectively prevent the intrusion of external water vapor and prevent the medicine from being damp.

desiccant cap

In addition, the moisture resistance inside the effervescent tube must also be considered. After the drug is taken, some water vapor may enter the package through the cap during the opening process. Therefore, most of the effervescent tubes are fully considered in the design. When it comes to the importance of moisture-proofing for medicines, a moisture-proof cover is used in the design of the effervescent tube. The moisture-proof cap is a new design that combines the desiccant and the bottle cap into one. There is a small medicine storehouse on the top of the bottle cap to store silica gel and molecular sieve, which can absorb the moisture in the effervescent tube and keep the medicine dry. This design saves space and avoids the risk of children accidentally ingesting the desiccant, and is suitable for test strips and tablet packaging with larger dosage forms.

The special moisture-proof cover design of the effervescent tube is an inevitable trend for pharmaceutical packaging companies to adapt to the changing market needs. We will wait and see what innovative designs for pharmaceutical packaging in the future.

Why are effervescent tablets contaminated and deteriorated

 Effervescent tablets are a new type of preparation that originated from abroad and has also been widely used in China in recent years. Due to the complex production process, high difficulty and high production cost, this formulation has very strict requirements on packaging. The effervescent tube must not only meet the basic moisture-proof and sealing requirements, but also consider the impact of various impact forces on the tablet during transportation.

effervescent tablet tube

The effervescent tube is a necessary part of the effervescent tablet to enter the market. If the effervescent tablet is contaminated and deteriorated, it is generally related to these factors of the effervescent tube. First of all, it depends on whether the effervescent tube is completely sealed. If the seal is not complete, external water vapor will invade the inside of the package, and the effervescent tablet has the characteristics of moisture absorption, which can easily cause deterioration of the preparation by moisture.

Secondly, the anti-drop performance of the packaging should be considered. This performance is mainly to prevent damage to the packaging and damage to the contents due to various external forces during the packaging, transportation, handling, and shelf circulation. The heavier the item, the higher the distance it falls, the higher the impact energy generated, and the higher the strength requirements of the packaging. The anti-drop performance of the effervescent tube can be tested as follows: the desiccant cap and bottle body are dropped at a height of 1 meter, the bottle cap is not broken, and the desiccant must not leak. Since the desiccant of the effervescent tube is generally placed in the cap, if the desiccant leaks, the silica gel and the molecular sieve will directly contact the drug, which will cause pollution to the effervescent tube.

Pharmaceutical packaging is a very rigorous industry, and any one of the packaging testing failures will have a certain impact on the drugs, and even affect the health of patients. When selecting effervescent tube suppliers, manufacturers of effervescent tablets should strictly examine their product quality and production qualifications to ensure drug safety.

Spring on the lid of the effervescent tube

 Effervescent tablets originate from abroad and are popular among young people for their diverse tastes and unique taste. Effervescent tablets contain disintegrating agents, which will produce a lot of carbon dioxide when placed in water. The effervescent tube containing the effervescent tablet is also special, mostly tubular. Many people may have noticed that there is a spiral spring on the lid of the package. So what is the magical effect of this cap spring?

spiral cap

The prescription of an effervescent tablet consists of the main drug, diluent, binder, disintegrant, lubricant and other auxiliary materials. The diluent, binder, lubricant and other auxiliary materials used are the same as ordinary tablets. The appropriate variety should be selected according to the preparation process. Due to the particularity of tablets, effervescent tablets packagingrequirements, and moisture resistance is the most basic requirement. In addition, the effervescent tube is specially designed on the lid. The spiral spring made of LDPE material can compress the tablets in the bottle to prevent them from being broken due to the impact of bumps during transportation, which reduces unnecessary loss. The LDPE material has good flexibility. The use of this material as a coil spring will neither crush the fragmentation agent due to the too hard texture, nor cause the medicine to be poorly fixed due to the too soft texture and too small pressure. The spring design can be maximized the advantages.

With the popularity of effervescent tablets at home and abroad, higher requirements have been placed on pharmaceutical packaging. Nothing is immutable, not only the coil spring, but the small medicine warehouse and anti-theft ring on the bottle cap are the products of industry innovation. With technological innovation and the continuous advent of various new materials, it is believed that the effervescent tube will have a greater improvement in function, and the safety and practicality of the product will be better reflected.

What are the sealing methods for HDPE bottles?

The common sealing method of HDPE bottles, the demand for new drugs will inevitably lead to the further development of pharmaceutical packaging materials, and the use of ever-increasing technological development capabilities to select more reasonable packaging materials, and will continue to improve and improve the oral solid and liquid pharmaceutical packaging forms.

child proof bottle with caps

HDPE bottles for pharmaceutical sealing method: firstly, the neck thread and the cap thread are matched; secondly, the flat pressure type sealing is adopted, and the cap surface is in contact with the sealing gasket in the bottle cap to achieve sealing with the capping; the side is again Wall sealing, during the tightening of the cap, the cap with inverted vertebral body or ellipsoidal body plug is pressed into the interior of the bottle mouth, and the sealing is achieved by the interference fit between the inner plug and the bottle mouth. How to choose the sealing method depends on the characteristics of the drug itself. In general, oral solid preparation medicinal HDPE bottles are threaded with aluminum foil gaskets, in addition to a good sealing effect, taking into account the role of anti-counterfeiting and anti-opening. Oral liquid preparations medicinal HDPE bottles are sealed with a side wall and a buckle is designed on the inner wall of the bottle cap. The seal can be sealed by directly sealing the cap.

GMP process design for pharmaceutical bottles

In addition to selecting reliable injection molding equipment and precision molds, pharmaceutical bottle manufacturers must systematically design the corresponding GMP specifications and process flow. The main contents include:

Main indicators: 100,000 cleanliness

hdpe bottles for pharmaceutical

Three-level filtering (fine, medium, high, top send back mode)

Air exchange times ≥ 20 times / hr

Temperature T=26-28 degrees

2, chilled water system

Temperature T=5~15 degrees, pressure p≥0.2mpa, flow rate q≥rated value

3. Cooling water system

Temperature T≤28°, pressure p≥0.2mpa, flow rate q≥rated spray, circulation system

4, compressed air system

Pressure p≥1.0mpa, flow rate q≥calibration value, configuration regulator tank, freeze dryer, secondary filtration, automatic drain valve, compressed air temperature 65 degrees <20 degrees

5, mold thermostat

Water medium mold temperature machine: working temperature tmax ≥ 120 degrees, p ≥ 0.4mpa, microprocessor or pid control

Oil medium mold temperature machine: working temperature tmax is equal to 30-300 degrees, p≥0.2mpa, pid or one-position control instrument

(Recommendation: The use of water medium mold temperature machine for the production of medicinal plastic bottles to ensure the quality of the medicine bottles and prevent leakage of oil medium)

6, mixing, feeding, crushing device

The mixing time is controllable, and the best mixing effect can not be achieved if the length is too long or too short. The feeding method is recommended to use top layer feeding or automatic vacuum feeding method, but the coloring of the concentrated masterbatch should be used to prevent the dust pollution in the workshop from exceeding the standard. The pulverizer should use a low-noise, high-efficiency rotary cutter (mainly crushing the bottle cap injection flow channel rack and a small amount of waste bottles), and the amount of returning material should be reasonable and appropriate (less than 15% wt) to prevent repeated cycle degradation. Performance, raw materials of different grades must be processed separately and cannot be mixed at will.