Humanized design of eye drop bottle

 Eye drop bottle is a special pharmaceutical packaging for eye drops. With the continuous changes in market demand, on the basis of satisfying functional design, humanized design has gradually become an important way for eye drop bottle manufacturers to improve their product competitiveness.

eye dropper bottle

Humanized design is a design that pays attention to the needs of human nature. From the perspective of consumers, humanized design starts from the perspective of ergonomics to make products conform to people's daily use habits. Eye drops directly contact the eyes, which is a high-risk route of administration. The humanized design of the eye drops bottle can increase the comfort and convenience of the route of administration.

The humanized design of the eye drop bottle is first reflected in the selection of materials. The eye drops generally need to be squeezed gently by hand when administering, so the material of the bottle should not be too hard, which is not conducive to the export of the liquid. Among many plastic materials, low-density polyethylene with good flexibility has become the best choice for eye drop bottle materials.

The humanized design of the eye drop bottle is also reflected in the volume of its packaging. Generally, the eye drop needs to be used up within four weeks after it is opened and cannot be used after it expires. Therefore, the packaging capacity of the eye drop bottle is mostly 5ml or 10ml, and the specific capacity will be calculated according to the method of use of the liquid medicine to avoid waste due to excessive amount of liquid medicine due to expiration.

The humanized eye drop bottle design not only improves the market competitiveness of the product, but also the key for enterprises to win in the fierce market competition. As humanized products are gradually being favored by the market, the production and design of humanized products has become every An important direction for an enterprise in product design.

Test requirements for easy oxides of eye drop bottles

 Pharmaceutical packaging can protect medicines from environmental influences and maintain the original properties of medicines, facilitating their storage, transportation and use. Eye drop bottles are commonly used packaging for ophthalmic drugs, and their quality directly affects the health and safety of patients. In its quality standards, there are many test items involved, and easy oxide is a very important one.

LDPE eye dropper bottle

Easily oxidized substances refer to substances that are prone to chemical reactions with oxygen in ordinary environments. The common ones are metals that are prone to rust. In the pharmaceutical packaging industry, they generally refer to substances that are prone to oxidation reactions with oxygen, such as organic matter, reducing agents, Sulfur, phosphorus, etc. The control of easy oxides is of great significance to ensure the quality of the drug within the validity period, prevent the chemical reaction between the precipitated reducing substances and the drug, and affect the efficacy and safety of the drug.

For the detection of easy oxides, there are specific requirements in YBB20072012 "Low Density Polyethylene Medical Eye Drop Bottles": a precise amount of 20mL of the test solution, precise addition of 20mL of potassium permanganate titrant (0.002mol/L) and Dilute sulfuric acid 1mL, boil for 3 minutes, quickly cool, add 0.1g potassium iodide, place in a dark place for 5 minutes, titrate with sodium thiosulfate titrant (0.01mol/L) to light brown, and then drop 5 drops of starch indicator solution Titrate to colorless, take another blank solution of water and operate in the same way. Do a blank test at the same time. The difference between the two consumption of sodium thiosulfate titrant should not exceed 1.5mL.

The eye drop bottle is used as a pharmaceutical package that directly contacts the eye. If the easy oxide exceeds the standard, it will cause the deterioration of the medicine and affect the patient's eye health. The quality and safety of pharmaceutical packaging materials and their compatibility with drugs have a very important impact on drug safety. In order to protect people's drug safety, manufacturers of pharmaceutical packaging materials should pay attention to their quality control.

Application of eye drop bottle in common ophthalmology medicine

 The prevalence of electronic products has made eye diseases more and more common in our lives. Common eye diseases include glaucoma, cataracts, mydriasis, dry eye, sty, bacterial conjunctivitis, etc. The common drugs used to treat eye diseases are mostly eye drops. Therefore, eye drop bottles are also widely used in common ophthalmology drugs.

eye dropper bottle

Data show that from 2013 to 2017, the size of my country's ophthalmology market increased from 46.7 billion yuan to 86.6 billion yuan, with an average annual compound growth rate of 16.7%. With the increase in the incidence of ophthalmology, the upgrading of ophthalmic treatment technology, and the improvement of patient diagnosis and treatment awareness, the scale of my country's ophthalmology market is expected to continue to grow at a growth rate of about 14% between 2018 and 2022.

There are tablets for the treatment of ophthalmic diseases, such as: latanoprost, diclofinamide, zhangyanming tablets, scopolamine, dehydrocholic acid tablets, voriting tablets, etc.; there are also cream drugs, such as dementia Eye ointment, tetracycline ointment, yellow mercury oxide ointment, etc., among which there are many kinds of eye drops, such as timolol, clonidine, chlortetracycline, rifampicin, chloramphenicol, sodium sulfacetamide, Shaoyanning, Xiaolaiwei, sodium hydroxymethylcellulose, phthalazin, phthalazin, etc., almost every kind of eye disease treatment medicine has eye drops. Therefore, in the ophthalmic medicine packaging, eye drops Bottles occupy a large market.

With the increase in ophthalmological diseases, the market demand for ophthalmic drugs such as eye drops is also increasing. On the whole, the application of eye drop bottles in common ophthalmic drugs packaging will become more common.

Eye drop bottle purchase to control these points

 Eye drops are common drugs for the treatment of eye diseases. As packaging materials for direct contact with drugs, the quality of eye drops bottles is the focus of attention of pharmaceutical companies. At present, there are many types of pharmaceutical packaging materials. How to choose high-quality and suitable eye drop bottles has become the key to many pharmaceutical companies to improve their product competitiveness.

5ml eye dropper bottle

The eye drop bottle is composed of a bottle cap, a bottle body and a bottle mouth. Due to the high reusability, the torque of the bottle cap will directly affect the tightness of the package. Pharmaceutical companies should fully consider this factor when choosing eye drop bottles. . According to the regulations of "Low Density Polyethylene Medical Eye Drop Bottle", when the bottle cap is twisted at 55-80Ncm, the bottle mouth and cap should match properly, and the teeth should not be slippery.

Secondly, consider the tightness of the eye drop bottle. The detection method is as follows: take a few of this product, first open the bottle, and then tighten the cap (use a force wrench to tighten the bottle and cap with a torque of 55-80Ncm, and place it in Add a baffle to the container with an air extraction device, immerse it with water, and vacuum to a vacuum of 20kPa and maintain it for 2 minutes. There should be no water or bubbling in the bottle.

Eye drops are in direct contact with the eyes, which is a high-risk route of administration. Under certain conditions, plastic packaging will migrate some of the substances contained in it to the contents, which may trigger a reaction to the contents. Therefore, the eye drops bottle Non-volatiles detection is very important. Detection method: Precisely measure 50.0ml each of the test solution and the blank solution and place them in an evaporating dish with constant weight. After evaporating to dryness in a water bath, dry to constant weight at 105°C. The difference between the two should not exceed 5.0mg.

In summary, the quality of eye drop bottles is related to the effectiveness and safety of drugs. Cap torque, tightness, and non-volatile detection are several factors that pharmaceutical companies should focus on when choosing packaging. A powerful means to control packaging quality to ensure drug safety and improve product competitiveness.

Eye drop bottle purchase to control these points

 Eye drops are common drugs for the treatment of eye diseases. As packaging materials for direct contact with drugs, the quality of eye drops bottles is the focus of attention of pharmaceutical companies. At present, there are many types of pharmaceutical packaging materials. How to choose high-quality and suitable eye drop bottles has become the key to many pharmaceutical companies to improve their product competitiveness.

5ml eye dropper bottle

The eye drop bottle is composed of a bottle cap, a bottle body and a bottle mouth. Due to the high reusability, the torque of the bottle cap will directly affect the tightness of the package. Pharmaceutical companies should fully consider this factor when choosing eye drop bottles. . According to the regulations of "Low Density Polyethylene Medical Eye Drop Bottle", when the bottle cap is twisted at 55-80Ncm, the bottle mouth and cap should match properly, and the teeth should not be slippery.

Secondly, consider the tightness of the eye drop bottle. The detection method is as follows: take a few of this product, first open the bottle, and then tighten the cap (use a force wrench to tighten the bottle and cap with a torque of 55-80Ncm, and place it in Add a baffle to the container with an air extraction device, immerse it with water, and vacuum to a vacuum of 20kPa and maintain it for 2 minutes. There should be no water or bubbling in the bottle.

Eye drops are in direct contact with the eyes, which is a high-risk route of administration. Under certain conditions, plastic packaging will migrate some of the substances contained in it to the contents, which may trigger a reaction to the contents. Therefore, the eye drops bottle Non-volatiles detection is very important. Detection method: Precisely measure 50.0ml each of the test solution and the blank solution and place them in an evaporating dish with constant weight. After evaporating to dryness in a water bath, dry to constant weight at 105°C. The difference between the two should not exceed 5.0mg.

In summary, the quality of eye drop bottles is related to the effectiveness and safety of drugs. Cap torque, tightness, and non-volatile detection are several factors that pharmaceutical companies should focus on when choosing packaging. A powerful means to control packaging quality to ensure drug safety and improve product competitiveness.

Basic requirements for pharmaceutical packaging

 Pharmaceutical packaging is a container used to store medicines, with different materials and shapes. The main function is to protect medicines in circulation and maintain the safety of medicines within the validity period. The quality of the packaging is related to the efficacy of the medicine and will have a direct impact on the patient's condition. So what should pharmaceutical companies pay attention to when it comes to pharmaceutical packaging?

eye dropper bottle

1. The choice of pharmaceutical packaging should be based on the in-depth knowledge of pharmaceutical companies on medicines. Only by combining the characteristics of medicines to choose the right packaging can better protect the quality of medicines and maintain good efficacy.

2. Make sure that the pharmaceutical packaging complies with the relevant regulations of the national and professional standards.

3. Under normal storage and transportation conditions, medical packaging must ensure that qualified drugs do not deteriorate within the validity period.

effervescent tablet tube

4. Medical packaging (including transportation packaging) must be sealed, sealed, sealed, or used with anti-theft caps, bottle cap sleeves, etc. The label must be affixed and adhered firmly, and must not be put into the bottle together with the drug; any damaged seal, label, packaging container, etc. shall not be shipped or sold.

5. The transport packaging of various drugs must meet the requirements of their physical and chemical properties. All medicines that are afraid of freezing and heat are shipped to different regions in different seasons, and corresponding measures to prevent cold or heat must be taken.

child proof bottle

6. The storage and transportation pictorial signs of drug transport packaging, and the packaging signs of dangerous goods, etc., must comply with national standards and relevant regulations.

Pharmaceutical packaging is nothing trivial. When pharmaceutical companies do a good job in drug research and development, only by choosing qualified and high-quality packaging can they better protect drugs and contribute to human health.

Eye drop bottle purchase to control these points

 Eye drops are common drugs for the treatment of eye diseases. As packaging materials for direct contact with drugs, the quality of eye drops bottles is the focus of attention of pharmaceutical companies. At present, there are many types of pharmaceutical packaging materials. How to choose high-quality and suitable eye drop bottles has become the key to many pharmaceutical companies to improve their product competitiveness.

5ml eye dropper bottle

The eye drop bottle is composed of a bottle cap, a bottle body and a bottle mouth. Due to the high reusability, the torque of the bottle cap will directly affect the tightness of the package. Pharmaceutical companies should fully consider this factor when choosing eye drop bottles. . According to the regulations of "Low Density Polyethylene Medical Eye Drop Bottle", when the bottle cap is twisted at 55-80Ncm, the bottle mouth and cap should match properly, and the teeth should not be slippery.

Secondly, consider the tightness of the eye drop bottle. The detection method is as follows: take a few of this product, first open the bottle, and then tighten the cap (use a force wrench to tighten the bottle and cap with a torque of 55-80Ncm, and place it in Add a baffle to the container with an air extraction device, immerse it with water, and vacuum to a vacuum of 20kPa and maintain it for 2 minutes. There should be no water or bubbling in the bottle.

Eye drops are in direct contact with the eyes, which is a high-risk route of administration. Under certain conditions, plastic packaging will migrate some of the substances contained in it to the contents, which may trigger a reaction to the contents. Therefore, the eye drops bottle Non-volatiles detection is very important. Detection method: Precisely measure 50.0ml each of the test solution and the blank solution and place them in an evaporating dish with constant weight. After evaporating to dryness in a water bath, dry to constant weight at 105°C. The difference between the two should not exceed 5.0mg.

In summary, the quality of eye drop bottles is related to the effectiveness and safety of drugs. Cap torque, tightness, and non-volatile detection are several factors that pharmaceutical companies should focus on when choosing packaging. A powerful means to control packaging quality to ensure drug safety and improve product competitiveness.

China's pharmaceutical packaging industry is advancing under supervision

 In recent years, with the vigorous development of the pharmaceutical industry, the pharmaceutical packaging industry in its downstream industries has also ushered in a period of rapid development. The development of the industry is inseparable from the norms of the opening standards. Looking at the development history of the pharmaceutical packaging industry, it is actually the history of perfection of the industry's regulatory policies.

eye dropper bottle

Compared with developed countries, my country's pharmaceutical packaging industry started late, but the speed of development is amazing. In 1978, the former State Administration of Pharmaceutical Administration was established, which opened a new phase of unified management and standardized development of my country's pharmaceutical field. So far, the supervision of my country's pharmaceutical packaging industry has gone through three stages, from enterprise production licenses, product registration approvals, to the review and approval of drug preparation registration applications.

effervescent tablet tube

"Administrative Measures for Drug Packaging (Trial)", "Production License for Pharmaceutical Packaging Materials and Containers", "Administrative Measures on Packaging Materials and Containers Directly Contacting Drugs", "Opinions of the State Council on Reforming the Review and Approval System of Drugs and Medical Devices", Opinions on Deepening the Reform of the Review and Approval System and Encouraging the Innovation of Drugs and Medical Devices, "Announcement of the General Administration on Adjusting the Review and Approval Items of APIs, Excipients and Packaging Materials"... After more than 40 years of deepening reforms, the National Pharmaceutical The Drug Evaluation Center of the Supervision Bureau has established a registration information platform for APIs, pharmaceutical excipients and pharmaceutical packaging materials. Relevant enterprises or units can submit the registration data of APIs, pharmaceutical excipients and pharmaceutical packaging materials through the registration platform, and after obtaining the registration numbers of APIs, pharmaceutical excipients and pharmaceutical packaging materials, they can be reviewed together with the registration application for pharmaceutical preparations.

In addition, comprehensive market trends such as volume procurement, drug consistency evaluation, and various policies for the healthy development of the industry have greatly promoted the high-quality development of the pharmaceutical packaging industry. As the country continues to increase investment in the medical industry, the pharmaceutical packaging industry's own regulatory policies continue to improve, and the pharmaceutical packaging industry will usher in long-term development.

Microbial Limit Test of Eye Drop Bottle

 The microbial limit inspection method is a method to inspect the degree of microbial contamination of non-specified sterilized preparations and their raw materials and auxiliary materials. The inspection items include the number of bacteria, molds, yeasts and control bacteria. At present, most pharmaceutical packaging has specific regulations on microbial limits, and eye drop bottles used as eye medications are no exception. So, how to detect the microbial limit of the eye drop bottle? How is it required in relevant industry standards?

eye dropper bottle

The eye drop bottle consists of a bottle body, an inner stopper and a bottle cap. The specification is generally 5ml-100ml, and the material is mostly low-density polyethylene.

According to the relevant standards of "YBB20072012 Low Density Polyethylene Medical Eye Drop Bottles", the microbial limit detection follows the following methods and standards: Take several test bottles, add 1/2 nominal volume of sodium chloride injection, and tighten the cap , Shake for 1 minute to get the test solution. The test solution shall be tested in accordance with the law after membrane filtration (Chinese Pharmacopoeia 2010 Edition Two Appendix XIJ). Bacteria must not exceed 100cfu per bottle, molds and yeasts must not be detected, Staphylococcus aureus must not be detected, and Pseudomonas aeruginosa must not be detected. Check out.

Whether the microbial limit meets the standard is related to the quality of the eye drop bottle. If the unqualified product is used in the medicine, it will not only pollute the medicine, but also seriously affect the health of the patient. The importance of pharmaceutical packaging cannot be ignored, and pharmaceutical packaging material manufacturers should strictly control the quality to protect the safety of drugs.