Effervescent tube is a kind of drug storage container with very good moisture-proof performance. The performance of the desiccant directly affects the moisture-proof function of the packaging, so what are the requirements for the short-term moisture absorption rate of the desiccant?
144mm*29mm effervescent tube packaging
The desiccant of the effervescent tube is mostly silica gel, molecular sieve or a mixture of the two in equal proportions. According to the requirements of China YBB00172004-2015 "Quality Standard for Oral Solid Medicinal Low Density Polyethylene Moisture-Proof Combination Caps", the short-term moisture absorption rate of the desiccant is required. as follows:
In an environment where the relative humidity is less than 60%, take 5 finished bottle caps from the same packaging bag, accurately weigh W0, and put the caps into a constant temperature with a temperature of 25°C±2°C and a relative humidity of 60%±5%. In the constant humidity box, take it out after 1 hour, weigh W1, carefully remove the cardboard, and take out the desiccant that has absorbed moisture: wipe the cardboard and bottle cap clean, and weigh W2 together. Calculated according to the following formula, the short-term moisture absorption rate of silica gel, macromolecular sieve, silica gel: macromolecular sieve (4:6) mixed desiccant shall not exceed 3%, 4.5%, and 3.5%, respectively.
The short-term moisture absorption rate of the desiccant is an important indicator to measure the moisture-proof effect of the packaging in a short time. It is related to whether the moisture-proof function of the packaging can be well exerted, and plays an important role in the stability of the drug during the storage period.
没有评论:
发表评论