Ethylene oxide sterilization process for veterinary syringes

 Veterinary syringes are commonly used as packaging for veterinary drugs, and their sterility is very important to the safety of drugs. The sterilization method is generally based on ethylene oxide sterilization, and the sterilization process is as follows:

30ml dial a dose syringe

1. The ethylene oxide sterilization procedure needs to include preheating, pre-wetting, vacuuming, injecting vaporized ethylene oxide to reach a predetermined concentration, maintaining the sterilization time, removing the ethylene oxide gas in the sterilization cabinet, and analyzing Remove ethylene oxide residues in sterilized items.
2. 100% pure ethylene oxide or mixed gas of ethylene oxide and carbon dioxide can be used for ethylene oxide sterilization. The use of Freon is prohibited.
3. The analysis can be continued in an ethylene oxide sterilizer, or it can be placed in a special fume hood, and natural ventilation should not be used. The repeatedly input air should be filtered with high efficiency, which can filter out more than 99.6% of particles ≥0.3um.
4. Ethylene oxide residues mainly refer to the ethylene oxide remaining in articles and packaging materials after ethylene oxide sterilization and its two by-products, ethanol ethane and ethylene glycol ethane; exposure to excessive ethylene oxide Alkane residues can cause animal burns and irritation. The amount of ethylene oxide residue is related to the material of the veterinary syringe, sterilization parameters, packaging materials and packaging size, loading capacity, analysis parameters, etc. When the polyvinyl chloride catheter is at 60℃, it is analyzed for 8h; when it is 50℃, it is analyzed for 12h. Some materials can shorten the resolution time, such as metal and glass can be used immediately, and some materials need to extend the resolution time, such as a built-in pacemaker.
The above is the veterinary syringe ethylene oxide sterilization process. Ethylene oxide is harmful to the human body. When sterilizing in this way, the relevant technical operating procedures must be strictly followed, and all links must be strictly controlled to ensure the safety of personnel and the environment.

equine oral paste administration way in syringe

Horse oral paste in syringe is a common veterinary packaging for horse medicine at home and abroad. It is mainly used in some nutritional creams, anthelmintics and other medicines. The horse is larger in size, and the medicines in this type of packaging are more convenient for administration. So how to administer horse oral paste in syringe?

veterinary syringe

The paste syringe is composed of a tube sleeve, a push rod, a piston, a positioning ring, and a protective cap. It has the characteristics of convenient administration, no residue, and reduced pollution. Oral paste medicines for horses are generally based on body weight to determine the dosage. First, before starting the administration, the weight of the animal should be grasped as accurately as possible, the actual dosage should be calculated, and the positioning ring should be set on the scale of the corresponding dosage. , To ensure the accuracy of medication. Remove the protective cap of the perfusion device, insert the tip of the needle into the mouth of the horse in the interdental area, push the push rod, and apply the paste to the base of the tongue. After the administration, immediately raise the horse’s head for a few seconds to ensure that it has swallowed the medicine. under.

It should be noted that the same veterinary syringe can be applied to two different animals only when the two horses are in the same space and in direct contact, otherwise cross-infection is likely to occur. Oral pastes are generally aimed at horses over 4 weeks old and are not suitable for horses that are too young.

The correct way of administration is the key to ensuring the therapeutic effect. The advantages of the veterinary syringe packaging make the dosage of large animals such as horses and cattle more accurate and the process more convenient. It is a new type of packaging recognized by the market.

veterinary syringe in horse oral paste

 The popularity of plastic materials makes veterinary medicine packaging styles continue to be developed, showing the characteristics of rich types and different performances. The veterinary infusion device is a new type of packaging that is convenient to use and has a wide range of applications. It is more common in the application of horse nutrition ointment and medicine.

paste syringe

The horse industry is divided into traditional horse industry and modern horse industry. The main feature of the traditional horse industry is that horses are mainly used for service, including agriculture, transportation, military and product production; the modern horse industry is mainly used for non-service, including horse racing, equestrianism, sports and entertainment. The horse industry in developed countries in the world has been in the stage of modern horse industry, showing the characteristics of sports entertainment, economy, sociality and internationalization. During the feeding process of horses, gastrointestinal diseases or excessive physical exertion lead to nutritional imbalance. The medicines used to treat these diseases are mostly oral pastes, such as horse nutrition ointment and deworming. Medicines, etc., due to the large size of horses, in order to facilitate the administration, these medicines are generally packaged in the form of a perfusion device.

The perfusion device is a new type of packaging that integrates the functions of drug storage and injection. It is composed of a push rod, a protective cap, a piston, a protective cap, and a positioning ring. When in use, you only need to open the protective cap to directly administer the drug. The positioning ring is designed It can also make the dosage of the medicine more accurate, and has the advantages of convenient use, reduced pollution, and avoidance of residues, which can meet the administration needs of horse oral paste drugs. There ar 10ml, 15ml, 20ml, 30ml  and 60ml sizes.

The application of the perfusion device in horse oral paste medicine is only one aspect of its application range. Thanks to the advantages of convenient use and less residue, it has also been used in the dairy farming industry, cockroach-killing drugs, pet nutrition ointments, etc. The universal application is favored by many veterinary drug companies.

How to treat dairy cow endometritis through syringe

 Postpartum endometritis is a common disease in the dairy farming industry. It is usually caused by postpartum endometrium or deeper infections. It is one of the common causes of infertility in dairy cows. It seriously affects the economic benefits of farms and treats the uterus. Meningitis can be administered locally through a veterinary syringe in conjunction with systemic treatment.

intramammary syringe

The conventional treatment time for cow endometritis is generally during the cow's estrus period, when the cow's cervix is opened to facilitate the administration of drugs. For mild endometritis, uterine irrigation is generally not necessary, and anti-inflammatory drugs can be injected directly into the uterus using the syringe. Take 2 million units of penicillin and 1 million units of streptomycin, dissolve them with 20 ml of distilled water, and inject them into the uterus according to the method of rectal insemination. This method is used once a day for 2-3 days as a course of treatment.

Severe endometritis is caused by deep-seated inflammation and can be treated comprehensively by a combination of irrigation and perfusion local treatment. It should be noted that every time the irrigation fluid perfused into the uterus should be exported as much as possible, so as not to flush the dirt or irrigation fluid in the uterus into the fallopian tube and cause the fallopian tube to be blocked. Generally, 1500-3000 ml can be used for postpartum uterine verification in cattle. If the reflux fluid is turbid, additional flushing fluid should be added until the reflux fluid is clean.

The key to the treatment of cow endometritis is to eliminate inflammation and promote the discharge of pathological secretions in the uterine cavity. Perfusion therapy is one of the more effective treatment methods. Symptomatic treatment for different symptoms can minimize the loss.

Cow endometritis treatment

 Dairy cow endometritis is a common reproductive disorder in the dairy farming industry. It not only affects the reproductive ability of dairy cows, but also causes a decrease in milk production. It can even induce diseases such as dairy cow mastitis, and bring huge economic losses to farmers. A good therapeutic effect can be achieved by using a veterinary syringe and a catheter to treat the uterus such as pharmaceutical preparations.

syringe for cow mastitis

According to statistics, about 50% of the cows eliminated each year are caused by endometritis. Inadequate disinfection during delivery or dystocia, careless cleaning and disinfection of the cow's vulva, unclean cow houses, poor sanitation, and the intrusion of certain infectious disease pathogens into the reproductive system of cows can all cause cow endometritis. The key to treatment is to control infection, eliminate inflammation and promote the excretion of pathological secretions in the uterine cavity, and perform symptomatic treatment according to the severity of the disease.

The perfusion device is a new type of drug delivery device that integrates the functions of drug storage and injection. It is composed of a tube sleeve, a push rod, a piston, a protective cap or a positioning ring. When in use, the protective cap is opened, the drug delivery end is connected to the catheter, and the drug is inserted into the cow's uterus for drug delivery. This treatment method is simple to operate, less irritating to the cow, reduces drug pollution, and is safer and more effective.

The functionality and convenience of the packaging are the key to helping the product win the market. The perfusion device is not only used in the treatment of cow endometritis, but also in the treatment of cow mastitis, pet syringe nutrition cream, and cockroach-killing gel syringe. Wide range of applications.

What are the quality requirements of pet nutrition syringe

 Pet nutrition cream is a fast-replenishing type of nutrition, mainly used for the recovery of physical fitness of dogs and cats after surgery and illness, and can also regulate appetite and supplement daily nutrition. As people pay more and more attention to pets, the requirements for pet nutrition ointment syringe are getting higher and higher.

15ml oral paste syringe

At present, there are many kinds of pet nutrition cream products on the market, but their health care effects are basically the same. High-quality and functional packaging has become the key for pharmaceutical companies to improve their product competitiveness. As a kind of exclusive veterinary packaging, pet nutrition cream syringe should meet the following quality requirements:

1. Sterility: The pet nutrition ointment syringe is in direct contact with the medicine, and its sterility must be guaranteed. The packaging should be produced in a clean workshop that meets national or industry standards. If pharmaceutical companies have higher requirements for sterility, they can be sterilized by ethylene oxide or irradiation.

2. Airtightness: The airtightness of the pet nutrition ointment syringe is very important. If the seal is not tight, it will easily lead to the pollution and deterioration of the medicine, which will affect the health of the pet and damage the brand image. According to the standard requirements, inject half of the water into the syringe, insert the piston into the syringe, remove the protective cap, remove the residual air, and then block it with the protective cap, and apply an axial pressure of 30N on the push rod rubber plug inside the syringe through the push rod , Keep for thirty seconds, there should be no leakage at the seal of the protective cap and the seal of the piston.

Sterility and airtightness are two of the more important quality standards for pet nutrition ointment dispensers. In addition, attention should be paid to factors such as the appearance of the packaging and the compatibility of the piston and the push rod.

Cow endometritis treatment

 Dairy cow endometritis is a common reproductive disorder in the dairy farming industry. It not only affects the reproductive ability of dairy cows, but also causes a decrease in milk production. It can even induce diseases such as dairy cow mastitis, and bring huge economic losses to farmers. A good therapeutic effect can be achieved by using a veterinary syringe and a catheter to treat the uterus such as pharmaceutical preparations.

syringe for cow mastitis

According to statistics, about 50% of the cows eliminated each year are caused by endometritis. Inadequate disinfection during delivery or dystocia, careless cleaning and disinfection of the cow's vulva, unclean cow houses, poor sanitation, and the intrusion of certain infectious disease pathogens into the reproductive system of cows can all cause cow endometritis. The key to treatment is to control infection, eliminate inflammation and promote the excretion of pathological secretions in the uterine cavity, and perform symptomatic treatment according to the severity of the disease.

The perfusion device is a new type of drug delivery device that integrates the functions of drug storage and injection. It is composed of a tube sleeve, a push rod, a piston, a protective cap or a positioning ring. When in use, the protective cap is opened, the drug delivery end is connected to the catheter, and the drug is inserted into the cow's uterus for drug delivery. This treatment method is simple to operate, less irritating to the cow, reduces drug pollution, and is safer and more effective.

The functionality and convenience of the packaging are the key to helping the product win the market. The perfusion device is not only used in the treatment of cow endometritis, but also in the treatment of cow mastitis, pet syringe nutrition cream, and cockroach-killing gel syringe. Wide range of applications.

Veterinary medicine packaging helps livestock

 Animal diseases have always been the main factor restricting the healthy development of animal husbandry. Veterinary drugs play a key role in the prevention and control of animal diseases and safeguarding the healthy development of animal husbandry. The safety and effectiveness of veterinary drugs must be ensured to maximize their use in animal immunity. The efficacy of the drug requires high-quality packaging for veterinary drugs.

veterinary syringe

In recent years, with the continuous improvement of a series of regulatory policies such as the "Chinese Veterinary Pharmacopoeia" and "Veterinary Drug Production Quality Management Regulations", veterinary drugs have made phased progress in terms of production raw materials and production process control, and product quality. As the standards become more comprehensive and standardized, the veterinary drug packaging industry related to them is also gradually developing in a standardized direction. The quality of veterinary drug packaging is related to whether the drug can be stored well and the stability of the drug effect during the validity period. If pharmaceutical companies ignore this point when choosing veterinary drug packaging, it will easily cause the drug to become damp and deteriorate. The influx of deteriorated drugs into the market will not only give farmers Bringing losses will also cause a certain negative impact on veterinary drug manufacturers. Therefore, quality is essential when choosing pharmaceutical packaging.

vaccine bottle

The quality of veterinary drug packaging must first examine the qualification rate of the product in terms of product sealability, drop resistance, volatile matter, dissolution test, and microbial limit. Product qualification and compliance with standards are the most basic requirements. Secondly, it is necessary to conduct a compatibility test on the packaging according to the characteristics of the medicine to ensure that the medicine and the packaging will not react. Finally, it is necessary to comprehensively consider the production scale and various qualifications of the pharmaceutical packaging material supplier to ensure the timely delivery of orders and subsequent services.

plastic liquid bottle

To sum up, veterinary drugs and veterinary drug packaging are a closely connected industry chain, and the two complement each other to jointly help the prevention and control of animal diseases and the healthy development of animal husbandry.

Xinfuda is developing with Zoetis help

Shijiazhuang Xinfuda Medical Packaging Co., Ltd. has been a qualified supplier of Zoetis, the first brand of international animal protection since 2013. During the cooperation with Zoetis, we were convinced by Zoetis's strict quality management system. We are fortunate ourselves that we have the opportunity to cooperate with the first brand of international animal protection companies. In the process of our cooperation with Zoetis, we have continuously obtained Zoetis's recognition and improved our (hereinafter referred to as Xinfuda) quality system.

factory

Zoetis deserves to be the No. 1 brand of international animal protection. The reason for this is that Shuo Teng not only gives us time to grow and learn, but also helps us improve our quality management level, and even sends someone to our company to guide and Training.

plastic veterinary syringe

In the course of this cooperation, we have mainly made improvements and qualitative leaps from the following four aspects:

1. Perfect operation process

In the same way as the product packaging method of Zoetis Cooperative, in order to ensure that the products of other customers meet the requirements of customers, we have gone through repeated tests and verifications, and finally determined the requirements of the pumping time, pumping pressure, inspection method and placement time, and finally An operation SOP has been formed, and all operators have been trained to ensure that product quality fully meets customer requirements.

vaccine bottle for veterinary medicine

2. Strict QA supervision and inspection system

The full name of QA is Quality Assurance, which means quality assurance. At the beginning, everyone didn't know what QA was, they only knew that they would measure the size, but in fact, our QA personnel not only need to measure the product size, monitor the stability of product quality, but also supervise and inspect the production process of the clean workshop. , Including whether the personnel's clean clothes meet the requirements, whether the personnel's operations meet the requirements, whether the hand disinfection is carried out regularly, whether the machine is cleaned on time, and whether the mechanics carry out equipment maintenance on time... Now everyone understands that QA is to pass each Various rules and regulations and supervision and inspection ensure product quality, so as to control in advance rather than afterwards.

workshop GMP

3. Fine site management

The on-site management has been upgraded from 5S to 6S management. The on-site items must be set and sorted in place, whether in the warehouse or the workshop, from the sampled sample to the record, standard card, as small as a small label must also be positioned , So that the operator has all the evidence to follow, put an end to confusion, and improve the level of visual management.

4. Complete CAPA cycle

CAPA is a corrective and preventive measure. The purpose of CAPA is to reduce risks and maintain the "continuous stability and improvement" of the verification status of plants, facilities, equipment, inspection instruments, production operating procedures, and inspection methods. At the time, the level of understanding of CAPA was not high, and it was not possible to deeply understand its true meaning and purpose. Through in-depth communication with Shuo Teng again and again, our current CAPA can be well implemented, effective measures are formulated, and supervision and inspection are in place , Time and time again reduce customer complaints and returns, avoiding quality accidents.

There is no best quality, only better. In the pursuit of quality, we will adhere to the principle of quality first, continuous improvement, and improve the quality management level of Xinfuda. 

Test conditions of plastic veterinary syringe

Test conditions of plastic veterinary syringe

1.1.1 Test environment

Temperature 0 ~ 30 ℃, relative humidity 30 ~ 75%.

1.1.2 Blank extraction

Sampling at the beginning of each batch of production, sampling according to the number of cavities in the mold to ensure that each cavity is taken.

plastic veterinary syringe

1.2 Appearance quality

Take an appropriate amount of this product. In a place where the natural light is bright, the observer's eyes are about 300mm away from the segment.

Requirements.

1.3 Adhesion

Take an appropriate amount of this product, add half of the water (or colored solution) to the needle tube, match the push rod to expel the air, make sure there is no air in it, wear good care

Cap, through the push rod, apply pressure 30N above the push rod piston for 30 seconds, there should be no leakage at the seal of the protective cap and the seal of the piston.

gel filling way of veterinary syringe

The plastic veterinary syringe is usually composed of a sleeve, a push rod, a piston, a positioning ring and a protective cap. This product can be used as a drug packaging and a syringe, which not only saves the cost of pharmaceutical manufacturers, but also improves the efficiency of use.

intramammary syringe

Pre-filling is mainly divided into two types of cone head type and spiral head type: cone head type consists of tube sleeve, cone head cap, piston and push rod; spiral head type consists of glass needle tube, screw head cap, screw head, piston and Putter composition.

Plastic syringe filling process:

A semi-automatic filling machine is used to fill a fixed amount of medicine in a needle tube (with a cap), and the piston is pressed or screwed in to seal the medicine liquid, and then a push rod is added for packaging.

Another way is tube with cap and then filling from the bottom of the tube.

How to solve the sealing of veterinary syringe

Veterinary syringe should be able to have a good seal during the validity period of the drug, prevent the invasion of microorganisms and cause deterioration of the drug, thereby posing danger to users. The best solution to verify the pre-sealing of pet medicine packaging is to test the integrity of the seal bottle by bottle.

dial a dose syringe

The internationally accepted quality assurance process based on the design of the container sealing system, the production of sealing components, the completion of the sealing, and the verification of the integrity of the sealing, thereby ensuring the tightness of the finished product. Then the main factors affecting the sealability of the syringe of pet medicine packaging are the following:

First, the design of the sealing system is defective, resulting in a leak that cannot meet the requirements;

Second, there is a quality deviation in the container or sealed component;

Third, there are problems with the sealing process;

Fourth, the seal integrity verification scheme is unreasonable;

The solution is as follows:

Aiming at the problem of the design defect of the plastic syringe and sealing system for pet medicine packaging, a rigorous design scheme should be formulated in advance, and as far as possible, the use of sealing members in accordance with international standards can effectively avoid the risk of leakage.

For the problem of containers and sealed components, suppliers of rubber stoppers and pet medicine packaging pre-filling should be regularly audited to ensure their quality is stable and reliable.

For problems in the sealing process, a sampling test plan should be formulated to standardize the sealing process.

As the seal integrity verification scheme is unreasonable, the integrity of the seal system should be verified.

Plastic veterinary syringe features

Plastic Veterinary Syringes Features:
• Convenient, dial a dose (multiple measured dose) or single dose options
• Controlled dispensing and precision placement of cremes, pastes, fluids, and gels
• Wide and narrow nozzles
• Snap-locking, double-seal tip caps

dial a dose syringe
• Self venting, zero draft barrels
• Available in FDA comforming HDPE (white, clear, or custom colors available)
• Custom calibrations, decorating, and labeling available
• Integrally molded, one-piece plungers or two part design with snap on seal for improved compatibility and easier dispensing
• Available in 5, 8, 12, 20, 30, and 60cc multiple dose styles or single use styles

plastic veterinary syringe