How to choose desiccant in plastic tube vials

The plastic tube vials produced by test paper barrel manufacturers are mostly used in the packaging of blood glucose test paper, urine test paper packaging, and other test strips packaging. Common test papers have high requirements for moisture-proof packaging and sealing oil. Therefore, placing the desiccant in the bottle cap can effectively prevent the test strip from getting wet, extend its shelf life, and also avoid direct contact between the test strip and the desiccant.

test strip packaging

Test paper tubes manufacturers generally choose silica gel desiccant and molecular sieve when choosing desiccant. Silica gel desiccant is a kind of highly active adsorbent material, usually made by reacting sodium silicate with sulfuric acid, and after a series of post-treatment processes such as aging and acid bubbles. Silica gel is an amorphous material, and its chemical formula is mSiO2. nH2O.

Molecular sieve desiccant is a synthetic desiccant product with strong adsorption to water molecules. The pore size of the molecular sieve can be controlled by different processing techniques. In addition to adsorbing water vapor, it can also adsorb other gases. Under the high temperature above 230 ℃, it can still hold water molecules well.

The proportion of desiccant in the bottle cap of the test strip tube manufacturers is mostly (4: 6), but it can also be reasonably adjusted according to some special conditions of the test paper to achieve a better moisture proof effect.

Supervision of pharmaceutical packaging

Packaging is a non-medicinal part of medicines. Direct contact with medicines will have an important impact on the quality and safety of medicines. Therefore, the supervision of pharmaceutical packaging must be synchronized with pharmaceutical quality management.

vitamin c tablets tubes with desiccant caps

Industry insiders pointed out that the production requirements of medical packaging are very strict. Taking plastic bottles as an example, China consumes more than 10 billion medical plastic bottles every year, but because of the strict requirements for medical plastic bottles, including light weight and high strength , It is not easy to break, good sealing performance, moisture-proof, and hygienic. It can be used directly for pharmaceutical packaging without washing and drying after one-time molding. At present, all domestic production equipment for pharmaceutical packaging bottles need to rely on imports.

child proof bottle

The direct contact between the medicinal bottle and the drug, and the long-term contact due to material stability and other reasons may cause problems such as reaction, seriously affecting the quality of the drug, and even causing pathogenic and fatal factors. Therefore, the relevant domestic authorities are also supervising this Keep increasing.

Earlier, the Food and Drug Administration has issued Notice No. 132, requiring that for injections sensitive to biological products, partial acids and bases and sensitive to ph, the 121 ℃ granule method water resistance should be selected as Class 1 and the inner surface water resistance should be Class HC1 Medical glass or other suitable packaging materials. There are more clear regulations on pharmaceutical packaging materials, which are considered by the industry as a signal for the relevant state departments to tighten industry standards.

Relevant experts believe that the domestic pharmaceutical field and related industries are in a critical period of transformation and upgrading. Continuously raising industry standards and continuously achieving international integration are development goals and basic requirements for further market expansion.

Domestic pharmaceutical packaging manufacturers can only guarantee the safety performance of products before the industry by continuously improving production standards and developing packaging requirements suitable for more varieties and dosage forms.

What are nutraceuticals packaging

The definition of Nutraceuticals on a global stage is highly divergent. It could refer to products that range from isolated nutrients, dietary supplements, herbal medicines, functional foods, medical/ specific diets and beverages. In India, nutraceuticals and herbal medicinal products fall under the purview of different regulatory bodies, FSSAI, AYUSH or CDSCO, depending on the health claims made and ingredients used.

empty vitamin tablet tubes

The Indian nutraceuticals industry is in a growth phase, with several key drivers such as consumer awareness, emphasis on prevention over cure and clinical receptiveness, being some of them.

India also fosters a thriving market for herbal extracts. Much of the traditional medicine practised worldwide can trace its roots to India, and the country is a hot bed for cultivation of herbal plants. The herbal extracts industry is estimated at $1.3 billion, with exports accounting for a sizeable 47 per cent of sales.

India also has the unique advantage of long-standing heritage and knowledge, when it comes to traditional medicines. Equipped with local sourcing and supply of raw materials, herbal extract manufacturers have emerged as highly price competitive in the global markets and have established a strong presence as a preferred supplier in many export markets.

Xinfuda as a manufacturer for effervescent tubes, we have 20 years history.

What are nutraceuticals

The definition of Nutraceuticals on a global stage is highly divergent. It could refer to products that range from isolated nutrients, dietary supplements, herbal medicines, functional foods, medical/ specific diets and beverages. In India, nutraceuticals and herbal medicinal products fall under the purview of different regulatory bodies, FSSAI, AYUSH or CDSCO, depending on the health claims made and ingredients used.

empty vitamin tablet tubes

The Indian nutraceuticals industry is in a growth phase, with several key drivers such as consumer awareness, emphasis on prevention over cure and clinical receptiveness, being some of them.

India also fosters a thriving market for herbal extracts. Much of the traditional medicine practised worldwide can trace its roots to India, and the country is a hot bed for cultivation of herbal plants. The herbal extracts industry is estimated at $1.3 billion, with exports accounting for a sizeable 47 per cent of sales.

India also has the unique advantage of long-standing heritage and knowledge, when it comes to traditional medicines. Equipped with local sourcing and supply of raw materials, herbal extract manufacturers have emerged as highly price competitive in the global markets and have established a strong presence as a preferred supplier in many export markets.

Xinfuda as a manufacturer for effervescent tubes, we have 

Notes on preparation and packaging of effervescent tablets

Effervescent tablet tube generally mainly applies in the effervescent piece's packing to rise to moistureproof with the function that prevent damage, effervescent piece early when packing pays most attention to the dry sex of sealing of packing. Another design of the effervescent bottle is the spiral spring on the platform, which prevents the effervescent from being damaged in transit.

plastic tube for effervescent tablets

Notes for preparation and packaging of effervescent tablets:

1. During granulation, acid and alkali should not be prepared together with the main drug, because the general acid or alkali will affect the stability of the drug, which may lead to unqualified degradation products.
2. Disintegration degree is not more than 5 minutes according to the pharmacopoeia, which is relatively easy to achieve. Our internal control standard is 90 seconds. Granulation is made with a low viscosity binder and a high concentration of ethanol (such as anhydrous ethanol), so that it dries quickly, the particles are loose and disintegrate easily. But pay attention to the crispness, the pharmacopoeia does not exceed 1%. (however, special applications for effervescent tablets seem to be allowed, with appropriate relaxation.) Finally, acid and base are added as excipients.
3. pay attention to the prepared particles do not store too long, and control the humidity.
4. pressing also need to control the humidity, in order to prevent water absorption.
5. As for the packaging, you can choose the double aluminum packaging that is impervious to water and oxygen, or the packaging of high-density polyethylene bottle or PP plastic bottle to ensure its stability.

What are nutraceuticals

The definition of Nutraceuticals on a global stage is highly divergent. It could refer to products that range from isolated nutrients, dietary supplements, herbal medicines, functional foods, medical/ specific diets and beverages. In India, nutraceuticals and herbal medicinal products fall under the purview of different regulatory bodies, FSSAI, AYUSH or CDSCO, depending on the health claims made and ingredients used.

empty vitamin tablet tubes

The Indian nutraceuticals industry is in a growth phase, with several key drivers such as consumer awareness, emphasis on prevention over cure and clinical receptiveness, being some of them.

India also fosters a thriving market for herbal extracts. Much of the traditional medicine practised worldwide can trace its roots to India, and the country is a hot bed for cultivation of herbal plants. The herbal extracts industry is estimated at $1.3 billion, with exports accounting for a sizeable 47 per cent of sales.

India also has the unique advantage of long-standing heritage and knowledge, when it comes to traditional medicines. Equipped with local sourcing and supply of raw materials, herbal extract manufacturers have emerged as highly price competitive in the global markets and have established a strong presence as a preferred supplier in many export markets.

Xinfuda is developing with Zoetis help

Shijiazhuang Xinfuda Medical Packaging Co., Ltd. has been a qualified supplier of Zoetis, the first brand of international animal protection since 2013. During the cooperation with Zoetis, we were convinced by Zoetis's strict quality management system. We are fortunate ourselves that we have the opportunity to cooperate with the first brand of international animal protection companies. In the process of our cooperation with Zoetis, we have continuously obtained Zoetis's recognition and improved our (hereinafter referred to as Xinfuda) quality system.

factory

Zoetis deserves to be the No. 1 brand of international animal protection. The reason for this is that Shuo Teng not only gives us time to grow and learn, but also helps us improve our quality management level, and even sends someone to our company to guide and Training.

plastic veterinary syringe

In the course of this cooperation, we have mainly made improvements and qualitative leaps from the following four aspects:

1. Perfect operation process

In the same way as the product packaging method of Zoetis Cooperative, in order to ensure that the products of other customers meet the requirements of customers, we have gone through repeated tests and verifications, and finally determined the requirements of the pumping time, pumping pressure, inspection method and placement time, and finally An operation SOP has been formed, and all operators have been trained to ensure that product quality fully meets customer requirements.

vaccine bottle for veterinary medicine

2. Strict QA supervision and inspection system

The full name of QA is Quality Assurance, which means quality assurance. At the beginning, everyone didn't know what QA was, they only knew that they would measure the size, but in fact, our QA personnel not only need to measure the product size, monitor the stability of product quality, but also supervise and inspect the production process of the clean workshop. , Including whether the personnel's clean clothes meet the requirements, whether the personnel's operations meet the requirements, whether the hand disinfection is carried out regularly, whether the machine is cleaned on time, and whether the mechanics carry out equipment maintenance on time... Now everyone understands that QA is to pass each Various rules and regulations and supervision and inspection ensure product quality, so as to control in advance rather than afterwards.

workshop GMP

3. Fine site management

The on-site management has been upgraded from 5S to 6S management. The on-site items must be set and sorted in place, whether in the warehouse or the workshop, from the sampled sample to the record, standard card, as small as a small label must also be positioned , So that the operator has all the evidence to follow, put an end to confusion, and improve the level of visual management.

4. Complete CAPA cycle

CAPA is a corrective and preventive measure. The purpose of CAPA is to reduce risks and maintain the "continuous stability and improvement" of the verification status of plants, facilities, equipment, inspection instruments, production operating procedures, and inspection methods. At the time, the level of understanding of CAPA was not high, and it was not possible to deeply understand its true meaning and purpose. Through in-depth communication with Shuo Teng again and again, our current CAPA can be well implemented, effective measures are formulated, and supervision and inspection are in place , Time and time again reduce customer complaints and returns, avoiding quality accidents.

There is no best quality, only better. In the pursuit of quality, we will adhere to the principle of quality first, continuous improvement, and improve the quality management level of Xinfuda. 

Tirpinimo bandymas of plastic veterinary syringe

Tirpinimo bandymas of plastic veterinary syringe:

Preparation of test solution: Take the internal surface area of this product (needle tube) 600cm2 (split into pieces of 5cm long and 0.3cm wide), set

Add appropriate amount of water to the conical flask, shake and wash the small pieces, discard the water, and repeat the operation twice. After drying at 30 ～ 40 ℃, use water (70 ℃ ± 2 ℃)

After soaking in 200ml for 24 hours, take it out and let it cool to room temperature, use the same batch of test solvent to make up the original volume as the test solution, and use the same batch of water as a blank

Liquid, perform the following tests:

6.6.1 pH change

Take 20ml each of the test solution and the water blank solution, add 1.0ml of potassium chloride solution (1 → 1000) respectively, and determine according to the law ("Chinese People's

"He Guoguo Pharmacopoeia" 2015 edition two general rules 0631) measured, the difference between the two pH value should not exceed 1.0.

dial a dose syringe

6.6.2 Heavy metals

Accurately take 20ml of water for the test solution, add 2ml of acetate buffer (pH 3.5), and determine according to the law ("Veterinary Pharmacopoeia of the People's Republic of China")

The 2015 edition of the General Principles of the Second Department (0821, Act 1), containing heavy metals shall not exceed one part per million.

6.6.3 Easy oxide

Accurately take 20ml of water for the test solution, add 20ml of potassium permanganate titration solution (0.002mol / L) and 1ml of dilute sulfuric acid, and boil for 3 minutes.

Quickly cool to room temperature. Add 0.1g potassium iodide, place in the dark for 5 minutes, titrate with sodium thiosulfate titration solution (0.01mol / L), titrate

To the near end, add 5 drops of starch indicator solution and continue titration until colorless. Take another water blank solution and operate in the same way, both consume sodium thiosulfate drops

The difference of fixed solution (0.01mol / L) should not exceed 1.5ml.

6.6.4 Non-volatile matter

Accurately take 50ml each of the test solution and the blank solution, put them in an evaporating dish with constant weight, evaporate to dryness in a water bath, and dry to constant weight at 105 ℃.

The difference between the two should not exceed 12.0mg.