Ethylene oxide sterilization process for veterinary syringes

 Veterinary syringes are commonly used as packaging for veterinary drugs, and their sterility is very important to the safety of drugs. The sterilization method is generally based on ethylene oxide sterilization, and the sterilization process is as follows:

30ml dial a dose syringe

1. The ethylene oxide sterilization procedure needs to include preheating, pre-wetting, vacuuming, injecting vaporized ethylene oxide to reach a predetermined concentration, maintaining the sterilization time, removing the ethylene oxide gas in the sterilization cabinet, and analyzing Remove ethylene oxide residues in sterilized items.
2. 100% pure ethylene oxide or mixed gas of ethylene oxide and carbon dioxide can be used for ethylene oxide sterilization. The use of Freon is prohibited.
3. The analysis can be continued in an ethylene oxide sterilizer, or it can be placed in a special fume hood, and natural ventilation should not be used. The repeatedly input air should be filtered with high efficiency, which can filter out more than 99.6% of particles ≥0.3um.
4. Ethylene oxide residues mainly refer to the ethylene oxide remaining in articles and packaging materials after ethylene oxide sterilization and its two by-products, ethanol ethane and ethylene glycol ethane; exposure to excessive ethylene oxide Alkane residues can cause animal burns and irritation. The amount of ethylene oxide residue is related to the material of the veterinary syringe, sterilization parameters, packaging materials and packaging size, loading capacity, analysis parameters, etc. When the polyvinyl chloride catheter is at 60℃, it is analyzed for 8h; when it is 50℃, it is analyzed for 12h. Some materials can shorten the resolution time, such as metal and glass can be used immediately, and some materials need to extend the resolution time, such as a built-in pacemaker.
The above is the veterinary syringe ethylene oxide sterilization process. Ethylene oxide is harmful to the human body. When sterilizing in this way, the relevant technical operating procedures must be strictly followed, and all links must be strictly controlled to ensure the safety of personnel and the environment.

5ml COP vials manufacturer China

 

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5ml COP vials

Size: 5ml

Material: Cyclo Olefin Polymer

Hight: 40mm


Diameter: 22mm

COP is a high performance thermoplastic that overcomes limitations of traditional packaging materials with its enhanced barrier,transparency,purity and strength properties.

COP vials as an ideal material for contrast media cartidge,prefilled syringes,medical vial and other pharmaceutical packaging applications. 

Medications that meet these characteristics can use COP vials

 Drug packaging is an important part of drugs. Choosing suitable packaging for drugs is a prerequisite to ensure drug stability and patient health. However, there are always some drugs with special properties, which require special packaging to ensure drug stability. COP bottles (cyclic olefin pharmaceutical polymer bottles) are such a special kind of packaging.

100cc COP injection vial

COP is an optical material developed and produced by Zeon Corporation in Japan. It is used for medical optical components and high-end pharmaceutical packaging materials. It has high transparency, low birefringence, low water absorption, high rigidity, high heat resistance, and water vapor. Good airtightness and other characteristics, in line with FDA standards. Generally speaking, there are mainly the following types of drugs used in COP bottles:

1. High value-added drugs, and are very afraid of damage (such as lymphocyte antigens, hormone drugs, anesthetics). COP has excellent mechanical properties, higher tensile strength and elastic modulus than PC, not easy to break, and easy to transport;

2. Drugs with PH value greater than 9. Drugs with high PH value will peel off when stored in glass bottles, and metal ions will be precipitated, which is not conducive to the storage of drugs. COP is a green plastic with very little impurity content, so there is no need to worry about the analysis of debris. And medical device requirements;

3. Drugs that are easily adsorbed on the glass surface (such as protein-based biopharmaceuticals, vaccines, etc.). Protein-based drugs will be adsorbed on the glass surface, which is not conducive to the precise control of drug dosage. COP has low protein adsorption characteristics, which can ensure the accuracy of drug dosage;

4. Other drugs that are easily oxidized.

In foreign countries, the application of COP bottles in pharmaceutical packaging has become very common, and it is also in the stage of gradual popularization in China. In order to ensure the stability of drug storage and better ensure the value of the drug, the above several drugs can be packaged in COP vials.

Introduction of two caps for effervescent tablet packaging

 Effervescent tablet packaging is a packaging containing vitamin effervescent tablets or chewable tablets and other dosage forms. It has good moisture resistance. According to the different packaging requirements of pharmaceutical companies, this packaging contains two types of bottle caps.

caps for effervescent tube

Spring cap: This bottle cap is characterized by a spiral spring on the cap, this spring is made of LDPE raw materials, can play a role in compressing the tablets, and avoid being broken due to various external forces during transportation. It also reduces unnecessary losses for pharmaceutical companies. The LDPE material has good flexibility. The use of this material as a coil spring will neither crush the fragmentation agent due to the too hard texture, nor cause the medicine to be poorly fixed due to the too soft texture and too small pressure. It can give full play to the spring design. The advantages. In addition, this kind of bottle cap also has a feature that it has a desiccant. Unlike ordinary medicine bottles, the effervescent tablet packaging puts the desiccant on the cap, saving space, and is a cap with moisture-proof function. .

effervescent tablet tube 84mm

Non-spring cap: This kind of bottle cap is different from the spring cap. There is no spring on the cap, but it also has a moisture-proof function. Generally, vitamin chewable tablets and small-dose candy tablets will choose this kind of cap, and some vitamin C effervescent tablet manufacturers will also use this kind of bottle cap.

The above are the two types of caps and their characteristics for effervescent tablet packaging. These two different types of caps meet the differentiated needs of pharmaceutical companies for packaging, and are also a manifestation of the continuous development and diversification of pharmaceutical packaging.

Five common applications of veterinary syringes

 At present, the form of drug packaging is constantly being developed, and the veterinary syringe is a new type of packaging that can store drugs and have the function of drug delivery.

The veterinary syringe is composed of a sleeve, a push rod, a piston, a protective cap, and a positioning ring. It has the advantages of convenient use, reduced pollution and residue, etc. The five common application scenarios are as follows:

15ml syringe for pets feeding

1. Pet nutrition cream: The pet industry is developing rapidly. As a nutritional supplement for pets with weak physique such as newborn pets, postpartum, and sterilization, pet nutrition cream has also ushered in rapid development. The packaging is convenient to use, and the design of the positioning ring can also control the feeding dose, so as to realize the scientific feeding of pets.
2. Anti-inflammatory drugs for dairy cows: mainly used for the packaging of drugs for dairy cow mastitis and endometritis, and can be administered with the help of catheters to reduce pollution.

5ml syringe for cow mastitis

3. Cockroach medicine: When used in the packaging of cockroach medicine, the thin-head design is adopted to allow the medicine to reach all corners of the cockroach infestation such as door cracks and wall cracks, and completely eliminate cockroaches.
4. Horse oral paste: It is mainly used in some nutritional creams, anthelmintics and other medicines. Horses are larger in size, and the medicines in this kind of packaging are more convenient for administration.
5. Lubricating grease: Compared with the lubricating oil in the form of drops, the grease packaged in a veterinary syringe can accurately control the dosage during use without causing excessive lubrication. It is an efficient packaging form.

60ml horse syringe

The above are five common application scenarios for prefilled syringes. As market demand continues to deepen, this packaging will continue to innovate and be applied to more scenarios.

Features of eye drops bottle

 With the development of technology and the transformation of people's working methods, eye diseases are more common, and the demand for ophthalmic drugs is also rising, which will drive the market growth of eye drop bottles. what are the characteristics of the eye drop bottles？

5ml eye dropper bottle

The eye drop bottle is the main packaging of ophthalmic drugs. It is composed of a cap, a nozzle and a bottle body. It is generally processed from low-density polyethylene raw materials. It has good flexibility, extensibility, easy processing, and corrosion resistance. Wait. It is a kind of packaging container with convenient use and good sealing performance.

Application of plastic syringe for horse

The syringe is a new type of packaging that is convenient to use and has a wide range of applications. It is more common in the application of horse nutrition ointment and medicine.

60ml horse syringe

The horse syringe is a new type of packaging that integrates the functions of drug storage and injection. It consists of a push rod, a protective cap, a piston, and a positioning ring. When in use, you only need to open the protective cap to directly administer the drug. The design of the positioning ring can also allow The dosage of the medicine is more precise, and it has the advantages of convenient use, reduced pollution, and avoidance of residues, which can meet the administration needs of horse oral paste drugs.
The application of the veterinary paste syringe in horse oral paste medicine is only one aspect of its application range. Thanks to the advantages of convenient use and less residue, it has also been used in the dairy farming industry, cockroach-killing drugs, pet nutrition ointment, etc. The universal application is favored by many veterinary drug companies.

The importance of effervescent tablet packaging in protecting the safety of medicines

 Vitamin C effervescent tablets contain disintegrants, which are easy to decompose when exposed to moisture. The packaging of effervescent tablets plays a vital role in protecting the safety of medicines.

1.The packaging of effervescent tablets has good airtightness to protect vitamin C effervescent tablets and keep them in a good storage environment. First of all, this packaging is generally processed from polyethylene or polypropylene raw materials, which is a barrel-shaped bottle. The diameter is slightly larger than the diameter of the tablet, which is convenient for filling and easy for patients to take out the medicine. The raw materials of the packaging have good barrier properties, which can isolate the intrusion of external impurities.

84mm effervescent tablet tube 

2. The packaging of effervescent tablets protects the safety of medicines. The medicines are unavoidably subjected to various external forces during transportation. There is a spiral spring on the packaging bottle cap. This spring is made of soft low-density polyethylene. Plays the role of compressing the tablet to prevent the drug from being damaged during transportation.

desiccant cap

3. Another important function of effervescent tablet packaging is moisture prevention. Unlike ordinary medicine bottles, which put the desiccant in the bottle in the form of a bag, this kind of packaging puts the desiccant in a small medicine bin on the bottle cap. This not only avoids the direct contact between the medicine and the desiccant, but also effectively prevents children from ingesting the desiccant by mistake.

Three advantages of pet nutrition ointment syringe

 Pets play an important role in our lives. When choosing supplies or medicines for pets, in addition to considering their own effects, packaging is also a very important aspect. As a new type of packaging, pet nutrition ointment syringe has many advantages and has won the favor of many pet owners.

15ml syringe for pet feeding

1. Easy to use: The pet nutrition ointment syringe is composed of a tube sleeve, a push rod, a piston, a protective cap, and a positioning ring. Open the protective cap during use and push the push rod to administer medicine. It is more convenient to use.
2. Scientific feeding: While pets accompany us, they also bring us a lot of joy. Pet owners also regard them as a member of the family and give them considerate care. If the dosage is not properly controlled when feeding the nutrient cream, it will easily cause pets to eat too much, resulting in overnutrition and affecting the health of pets. This special package is printed with a scale on the push rod. When using the positioning ring, turn the positioning ring to a suitable scale, which can make the feeding amount more accurate and realize the scientific feeding of the pet.

paste syringe

3. Reducing residues: There are currently two ways of packaging pet nutrition cream: hose and syringe. The hose packaging is prone to residues, leading to waste. The syringe uses the pressure of the push rod to greatly reduce the residual nutrient paste and avoid waste.
These advantages of pet nutrition ointment syringes are the points that pet owners value more. Choosing this kind of packaged nutrition ointment will also have a greater advantage in the market, which will help shape the corporate brand image.

How to confirm the quality of dial a dose syringe

 The dial a dose syringe is a kind of high-tech, practical, new type of injection packaging that is quietly emerging in recent years. This type of packaging originated from abroad and is mainly used in the packaging of drugs such as dairy cow mastitis and pet nutrition ointment.How to confirm the quality of dial a dose syringe?

30ml dial a dose syringe

1.Look at the appearance
Qualified plastic syringes must first look at their appearance, overall shape, comfortable color tone, consistent color, smooth and smooth surface, no deformation, burrs and obvious scratches, smooth inner wall of the sleeve, no corrugation, and flat and smooth head of the syringe, The push rod and the sleeve have a good fit.
2.Test the seal
Pharmaceutical packaging has high requirements for tightness, and dial a dose syringes are no exception, and their tightness should be tested when choosing a syringe. Detection method: inject half of the water into the syringe, insert the piston into the syringe, remove the protective cap, remove the residual air, and block it with the protective cap. Apply an axial pressure of 30N on the plunger rubber plug inside the syringe through the push rod. Keep it for thirty seconds, and there should be no leakage at the seal of the protective cap and the seal of the piston.
3.Sterilization
Since plastic syringes are in direct contact with drugs, their sterility must be ensured, so the production environment of the product is very important. Generally, the syringe should be produced in a clean workshop that meets the national standards, and has been sterilized by ethylene oxide. The ethylene oxide sterilization indicator card changes from red to blue to indicate complete sterilization.
The choice of plastic veterinary syringes directly affects the later use, the safety and efficacy of drug injection. I hope that the above methods can be helpful to you who need to purchase dial a dose syringes.