Application of effervescent tubes in acetaminophen medicines

 Effervescent tubes are a kind of pharmaceutical packaging with very good moisture-proof performance. They are mainly used for tablets, capsules and other drugs that are sensitive to water molecules. Among many types of drugs, acetaminophen is a common one.

86mm*18mm effervescent tablet tube

Acetaminophen is a metabolite of phenacetin in the body. It reduces the synthesis and release of prostaglandins PGE1, bradykinin and histamine by inhibiting prostaglandin synthase in the hypothalamic thermoregulatory center. Mainly used for colds, fever, joint pain, neuralgia, migraine, cancer pain and post-surgery analgesia. It can also be used for patients who are allergic to, intolerant or unsuitable for aspirin (chickenpox, hemophilia and other bleeding diseases, etc.).

HDPE pill bottle with CRC cap

25ml pharma desiccant bottle

The moisture-proof performance of the effervescent tube is mainly due to the excellent performance of the material. The tube body is made of high-density polyethylene, which has good barrier properties and can isolate the intrusion of external impurities and water molecules. In addition, in order to maintain the stability of the internal environment, there is a desiccant in the small medicine compartment on the top of the lid, which can absorb internal moisture and prevent the medicine from getting damp and deteriorating.

The above is the application of effervescent tubes in acetaminophen drugs. In addition, this kind of packaging is also used for the packaging of vitamin C effervescent tablets, calcium tablets, tablet candies and other drugs.

Three major factors that affect the size of child resistant cap

 Child Resistant Cap for oral preparations are an important part of pharmaceutical packaging, and they play a very important role in the sealing of the entire packaging. The size of the cap is related to whether it can achieve a good fit with the bottle mouth, which in turn affects the sealing of the packaging. During the production process, the factors that affect the size of the cover mainly include the following three aspects:

28mm bottle cap

child resistant cap

1. Holding pressure and time

As the holding time increases, the weight of the bottle cap gradually increases, resulting in an increase in volume. Similarly, as the holding pressure increases, the weight of the raw material increases in the same period of time, and the weight of the bottle cap increases, which will lead to an increase in volume (increase in size).

2. Cooling time

Regardless of visual analysis or experimental data, as the cooling time of the medicine bottle cap in the mold increases, the temperature of the bottle cap will obviously show a linear decrease. This phenomenon also exists when the lid is cooled after demoulding, but it will take longer to reduce the same temperature. That is to say, within the same period of time, the cooling effect in the mold is far better than the cooling after demoulding.

The cooling rate (°C/min) will affect the density of the cap. As the cooling rate increases, the density of the bottle cap gradually decreases.

That is, as the cooling time increases, the grammage remains unchanged and the density decreases, the volume becomes larger (the size becomes larger).

3. Raw material temperature

As the temperature of the raw material increases, if the cooling time remains unchanged, the temperature of the resulting bottle cap will be higher. After natural cooling after demoulding, the volume will become smaller (the size will become smaller) due to the principle of thermal expansion and contraction. The injection molding equipment parameters corresponding to the raw material temperature include screw temperature and mold temperature.

The above are the three major factors that affect the size of medicinal bottle caps. When producing caps, you should focus on these three aspects of data to ensure the accuracy of the finished product size.

FDA approves multiple generics of ADHD and BED treatment

 Action 

FDA has approved several first generics of Vyvanse (lisdexamfetamine dimesylate) capsules and chewable tablets for attention-deficit/hyperactivity disorder (ADHD) in patients six years and older and moderate to severe binge-eating disorder (BED) in adults. See Vyvanse’s prescribing information for details on dosing.  

Disease or Condition 

People with ADHD may have trouble paying attention, controlling impulsive behaviors (may act without thinking about what the result will be), or be overly active. ADHD is one of the most common neurodevelopmental disorders of childhood, affecting approximately 10% of children. It is usually first diagnosed in childhood and can last into adulthood. ADHD can be successfully managed with behavioral and pharmacological treatment, and some symptoms may improve as the child ages. 

Patients with BED have recurrent episodes of compulsive overeating during which they consume larger amounts of food than normal and experience the sense that they lack control. Patients with this condition eat when they aren’t hungry and often eat to the point of being uncomfortably full. Patients may feel ashamed and embarrassed by how much they are eating, which can result in social isolation. BED may lead to weight gain and to other health problems. 

Safety  

FDA-approved generic medicines work in the same way and provide the same clinical benefit and risks as their brand-name counterparts.  

The prescribing information for lisdexamfetamine dimesylate capsules and chewable tablets contains a boxed warning to inform health care providers and patients about the potential risk of abuse and dependence. Drugs that increase the levels of certain chemicals in the brain, such as amphetamines and methylphenidate-containing products (including lisdexamfetamine dimesylate), have a high potential for abuse, which can lead to addiction and overdose. Health care providers should assess the risk of abuse prior to prescribing and monitor for signs of abuse and dependence while on therapy. To address continuing concerns of misuse, addiction and overdose, FDA recently required updates to the labeling of prescription stimulants to standardize prescribing information and clearly inform patients, caregivers, and health care professionals of these risks.  

The prescribing information also includes warnings and precautions regarding serious cardiovascular reactions, blood pressure and heart rate increases, psychiatric adverse reactions, suppression of growth, peripheral vasculopathy (reduced circulation of blood flow to body parts), and serotonin syndrome (a potentially life-threatening overage of serotonin). Please see Vyvanse’s full prescribing information for additional details. 

The most common side effects in children, adolescents and/or adults with ADHD taking lisdexamfetamine dimesylate capsules and chewable tablets were anorexia, anxiety, decreased appetite, decreased weight, diarrhea, dizziness, dry mouth, irritability, insomnia, nausea, upper abdominal pain, and vomiting. The most common side effects in adults with BED were dry mouth, insomnia, decreased appetite, increased heart rate, constipation, feeling jittery, and anxiety.

Designation 

Many abbreviated new drug applications (ANDAs) for lisdexamfetamine dimesylate received priority review. Information on priority review of ANDAs is available in the Manual of Policies and Procedures 5240.3 Rev. 6, Prioritization of the Review of Original ANDAs, Amendments, and Supplements.  

HDPE pill bottle with CRC cap

25ml pharma desiccant bottle

Source from FDA: https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-multiple-generics-adhd-and-bed-treatment

Empty paste syringe for probiotics

 With the prevalence of the pet economy, people's attention to pet medicine packaging is also increasing. In addition to considering factors such as compatibility with drugs and sealing performance, the choice of packaging also deserves attention in terms of market acceptance.

pet syringe

30ml dial a dose syringe

Xnfuda's pet paste probiotic syringe is not only easy to use and has less residue, but also realizes the function of quantitative feeding through a special design, which is favored by many pet owners. Syringe is a special package with both drug storage and drug delivery functions. It consists of a sleeve, a push rod, a piston, a protective cap, and a positioning ring. This package has the following advantages:

Pets are naturally lively and active, and it is difficult to administer medicines. A convenient packaging can make the administration process easier. When using the syringe, open the protective cap first, put the tip into the pet's mouth, and push the push rod to realize direct feeding, which is very convenient to operate.

Precise feeding: The feeding of ointment probiotics should follow the prescribed dosage, excessive or insufficient is not conducive to the health of pets. There is a standard scale printed on the push rod of the syringe. When in use, turn the positioning ring to the required scale, and push the push rod to stop at the positioning ring, so that precise feeding of the nutritional cream can be achieved.

Residue reduction: Unlike common tablet medicines, pet ointment probiotics are in the form of a paste, relatively thick, and ordinary packaging is prone to residues, which will cause unnecessary waste. The syringe uses the hydraulic principle to export the probiotics in paste form through the driving force of the push rod, which can greatly reduce the residue and avoid waste.

As a member of the family, pets are also an emotional sustenance for the owner. Pet owners will consider many factors comprehensively when choosing food, supplies, and medicines. The easy-to-use and functional packaging of syringes has become the mainstream packaging form of pet probiotics, which will better assist pets in scientific feeding.

What is the function of the protective cap of the veterinary syringe

 Veterinary syringe is a multi-component special packaging, which is composed of sleeve, push rod, protective cap, positioning ring and other components. These seemingly inconspicuous components play important roles in the storage or delivery of drugs. So do you know the function of the protective cap?

30ml dial a dose syringe

pet syringe

The protective cap is located at the tip of the veterinary syringe. According to different packaging purposes, the size and size of the protective cap will vary, but the function is the same, mainly for sealing. In the state of tightly closing the protective cap, the contact between the external environment and the medicine contained in it can be isolated, and the stability of the medicine can be protected. What we need to pay attention to is that the sealing function of the protective cap needs to be realized together with the push rod, otherwise the complete sealing purpose cannot be achieved.

The above is the function of the plunger of the veterinary syringe. Although it is only a very small component of the package, its function cannot be ignored, and it plays a very important role in the safety and stability of the drug during storage. Xinfuda has been focusing on pharmaceutical packaging for 20 years, and its products have passed the DMF record. Welcome to discuss cooperation.

Oseltamivir dry suspension is very different from granules and capsules

 Oseltamivir is an antiviral neuraminidase inhibitor used for the treatment and prophylaxis of influenza infection with viruses A and B. The mechanism of oseltamivir antiviral activity is by inhibiting the activity of the viral neuraminidase enzyme present on the surface of the virus, which stops viral replication and infectivity. Oral suspensions of oseltamivir phosphate are dispensed orally capsules and suspension. However, the use of oral suspension for pediatric administration is preferable and is prepared as a powder for suspension. 

60ml PET oral liquid bottle

Oseltamivir medicine packaging

28mm crc cap

Different indications

Oseltamivir granules and capsules are indicated for the treatment of influenza in adults and children 1 year and older, and for the prevention of influenza in adults and adolescents 13 years and older.

The therapeutic indications of oseltamivir dry suspension are people over 2 weeks old, and the preventive indications are people 1 year old and above, which can supplement the indications for treatment and preventive medication in this stage of the population.

Different usage and dosage

The instructions for oseltamivir granules and capsules describe the therapeutic dose for adults and children 1 year and older, and the prophylactic dose for adults and adolescents 13 years and older.

The instructions for oseltamivir dry suspension give the treatment for people over 2 weeks old, and the prevention for people over 1 year old, filling in the usage and dosage for children’s influenza prevention.

Different ways to use

1. Oseltamivir dry suspension is equipped with a dosing device, which can accurately control the dosage of children, and is flexible and convenient for young children;

5ml oral dosing pipette

10ml oral dosing syringe

2. Oseltamivir granules can be taken directly with warm water, which is easy to operate and convenient for administration;

50ml HDPE bottle with desiccant cap

3. Oseltamivir capsules can mask the bitter taste of the drug and are friendly to adults with normal swallowing function, but the contents can also be disassembled and used when children’s dosage forms are not available.