The Evolving World of Oral Liquid Packaging

 Oral liquid medications, supplements, and health drinks are an integral part of daily wellness and medical treatments. Whether it's a prescription drug or a convenient vitamin solution, how these liquids are packaged plays a significant role in ensuring safety, efficacy, and ease of use. Over the years, oral liquid packaging has evolved with both functional and aesthetic considerations in mind. In this blog, we'll dive into the importance of packaging for oral liquids and explore some of the latest trends and innovations in the field.

oral liquid packaging

The Importance of Oral Liquid Packaging

When it comes to liquid formulations, packaging isn't just about convenience or appearance—it's a critical component in maintaining the integrity and safety of the product. Here are some key factors that make packaging crucial for oral liquids:

Preserving the Product's Integrity: Oral liquids are prone to contamination, degradation, and evaporation. Proper packaging materials can help protect the product from external factors like light, air, and moisture, ensuring that the liquid remains potent until it reaches the consumer.

Safety and Child Resistance: Child-resistant caps and tamper-evident seals are essential for preventing accidental consumption, especially for liquid medications. The packaging must not only be functional but also designed to deter children from accessing the product.

PP28mm child resistant cap

Ease of Use: The packaging should be user-friendly, especially for elderly or disabled individuals. Measuring cups, syringes, and other dosage control systems can make administration easier, preventing over- or under-dosing.

Child-Resistant and Tamper-Evident Features:

Child-resistant closures have been around for a while, but they’ve become more sophisticated with advancements in design. New mechanisms, such as push-and-turn caps and tamper-proof seals, are being used to enhance safety without compromising ease of use for adults.

Common veterinary medicines contained in oral liquid bottles

 Oral liquid bottle is a packaging container made of polypropylene, polyethylene, polyester and other raw materials. It has good sealing and barrier properties. It is very suitable for holding veterinary oral liquid drugs. Common drugs Including the following types:

100ml transparent PP vial

plastic vaccine vial

Shuanghuanglian Oral Liquid: It has the effects of pungent and cool to relieve symptoms, clear away heat and detoxify. It can effectively relieve clinical symptoms caused by colds caused by exogenous wind-heat. It can accelerate the body's recovery and quickly resume feeding.

Yangshuhua Oral Liquid: Returns to the gastrointestinal meridian, clears away heat and detoxifies, astringes the intestines and relieves diarrhea, resolves dampness and relieves dysentery, strengthens the spleen and nourishes the stomach. Clinical use of poplar flowers or its preparations has significant effects on bacillary dysentery and intestinal diseases.

Pulsatilla Oral Liquid: It has significant curative effect on diarrhea caused by unknown reasons, diarrhea caused by feeding stress, physiological diarrhea and excessive feeding. It has significant antagonistic and scavenging effects on bacterial endotoxins.

Sini Decoction Oral Liquid: It mainly treats cold limbs, weak and weak pulse, and Yang deficiency. Symptoms of yang deficiency include depression, aversion to chills and trembling, shallow breathing, greatly reduced or inexhaustible appetite, weakened gastrointestinal peristaltic sounds, lowered body temperature, coldness in the ears, nose, lips, extremities or the whole body, white color in the mouth, tongue The body fluids are moist and the pulse is thin and weak.

The above are common drugs contained in veterinary traditional Chinese medicine oral liquid bottles, in addition to Huoxiang Zhengqi oral liquid, Yimu Shenghua mixture, etc. The packaging capacity of this type of medicine is generally relatively large, which is also to adapt to the large-scale breeding needs of farms.

Requirements for veterinary drug packaging for different drugs

 Veterinary drugs refer to substances used to prevent, treat, diagnose animal diseases or purposefully regulate animal physiological functions, including vaccines, diagnostic products, antibiotics, biochemical drugs, traditional Chinese medicines, disinfectants, etc. Depending on the dosage form of the drug, the packaging of veterinary drugs The requirements also vary.

100ml PP vaccine vial

Although there are many types of veterinary drugs, they are mainly divided into two categories according to dosage forms: liquid drugs and powder drugs. Liquid medicines generally choose plastic packaging bottles. The main raw materials include polyethylene, polypropylene, polyester, high barrier, etc. Oral liquids and injections require bottles that are transparent and light-shielding. In order to ensure that the drugs are not affected by light and decompose and deteriorate, brown polyester bottles are chosen. Liquid medicines have high sealing requirements for bottles, so when choosing bottle caps, rubber stoppers and aluminum caps are often used to achieve a good sealing effect.

250ml PE plastic vaccine bottle

Powder dosage forms account for a relatively small proportion of veterinary drugs. The main requirement for veterinary drug packaging for this type of drugs is moisture resistance. They are usually packaged in plastic bottles. They are sealed with aluminum foil gaskets and a desiccant is placed inside the bottle to ensure the dryness of the internal environment. , to prevent the medicine from getting damp and deteriorating.

medicine bottle

In addition, some highly corrosive drugs (such as disinfectants) have higher barrier requirements for veterinary drug packaging, and packaging with high barrier materials will be selected to ensure that the drugs are in a good state of preservation.

The above are the requirements for veterinary drug packaging for several different veterinary drug dosage forms. Choosing appropriate veterinary drug packaging according to the characteristics of the drug is the basic condition to ensure the safety and effectiveness of the drug.

Oseltamivir dry suspension is very different from granules and capsules

 Oseltamivir is an antiviral neuraminidase inhibitor used for the treatment and prophylaxis of influenza infection with viruses A and B. The mechanism of oseltamivir antiviral activity is by inhibiting the activity of the viral neuraminidase enzyme present on the surface of the virus, which stops viral replication and infectivity. Oral suspensions of oseltamivir phosphate are dispensed orally capsules and suspension. However, the use of oral suspension for pediatric administration is preferable and is prepared as a powder for suspension. 

60ml PET oral liquid bottle

Oseltamivir medicine packaging

28mm crc cap

Different indications

Oseltamivir granules and capsules are indicated for the treatment of influenza in adults and children 1 year and older, and for the prevention of influenza in adults and adolescents 13 years and older.

The therapeutic indications of oseltamivir dry suspension are people over 2 weeks old, and the preventive indications are people 1 year old and above, which can supplement the indications for treatment and preventive medication in this stage of the population.

Different usage and dosage

The instructions for oseltamivir granules and capsules describe the therapeutic dose for adults and children 1 year and older, and the prophylactic dose for adults and adolescents 13 years and older.

The instructions for oseltamivir dry suspension give the treatment for people over 2 weeks old, and the prevention for people over 1 year old, filling in the usage and dosage for children’s influenza prevention.

Different ways to use

1. Oseltamivir dry suspension is equipped with a dosing device, which can accurately control the dosage of children, and is flexible and convenient for young children;

5ml oral dosing pipette

10ml oral dosing syringe

2. Oseltamivir granules can be taken directly with warm water, which is easy to operate and convenient for administration;

50ml HDPE bottle with desiccant cap

3. Oseltamivir capsules can mask the bitter taste of the drug and are friendly to adults with normal swallowing function, but the contents can also be disassembled and used when children’s dosage forms are not available.

Oral Liquid Bottle Quality Standard

 Oral liquid bottles are mainly used to contain various oral liquid or syrup drugs, and the packaging directly contacts the drugs.

60ml amber PET bottle

100ml PET oral liquid syrup bottle

Oral liquid bottles are generally processed from polyester raw materials with additives. From the perspective of material properties, polyester has high transparency, good barrier properties, and is light in texture, not fragile, easy to process and shape, and has a high degree of automation. It is a good packaging material. In addition to being used in pharmaceutical packaging, it has a wide range of applications in food, beverages, and health products.

At present, the oral liquid bottles of polyester raw materials implement the YBB00102002-2015 "Oral Liquid Medicinal Polyester Bottles" quality standard, and the test items involved include appearance, material identification, tightness, oscillation test, water vapor transmission, and burning Residue, leachable test, microbial limit, abnormal toxicity and many other aspects. Each test is of extraordinary significance. For example, the appearance is to ensure the aesthetics of the package and give consumers a good impression; the tightness test is to ensure that the package does not leak, and that the chemical solution is not polluted by the external environment; The test is to test the compatibility of the drug with the packaging and ensure that the two do not react.

Medicinal polyester bottle

First of all, the medicinal polyester bottle is light in weight, easy to form and firm in the bottle. The strength and elasticity are obviously higher than other plastic materials, and can withstand considerable impact without damage. It is most suitable as a medicine bottle with thin wall, light weight and high strength.

PET bottles with measuring cup

Secondly, the medicinal polyester bottle has good gas barrier properties. Among the commonly used plastic materials, polyester bottles have the best performance in blocking water vapor and oxygen, and can fully meet the special storage requirements of pharmaceutical packaging. PET has excellent chemical resistance and can be used for packaging all items except strong bases and some organic solvents.

PET bottles

Thirdly, the recycling rate of PET resin is higher than that of other plastics. When it is burned as a waste, it is flammable due to its low calorific value and does not generate harmful gases.

The most important thing is that food packaging made of PET meets food hygiene requirements, because PET resin is not only a harmless resin, but also a pure resin without any additives, which is quite strict through the United States, Europe and Japan.