Introduction of EO Sterilization for Pet Injection Bottles

 Pet injection bottle is a kind of pharmaceutical packaging. In order to prevent the microbes on the packaging from contaminating the vaccine, this packaging needs to be sterilized and can only be used after reaching the microbial limit. Ethylene oxide sterilization is a common sterilization method for this type of packaging.

250ml PE plastic vaccine bottle

Ethylene oxide is also called ethylene oxide. It is a colorless liquid at low temperature with aromatic ether smell. Its boiling point is 10.8 °C, its odor threshold is 760 mg/m~1064 mg/m, and its density is 1.52; it is flammable and explosive, and its maximum The low combustion concentration is 3%. Ethylene oxide does not damage sterilized items and has strong penetrating power, so most items that are not suitable for sterilization by general methods can be sterilized and sterilized with ethylene oxide. For example, electronic instruments, optical instruments, medical instruments, books, documents, fur, cotton, chemical fibers, plastic products, wood products, ceramics and metal products, endoscopes, dialyzers and disposable medical supplies, etc. One of the low temperature sterilization methods.

It is generally believed to be due to its non-specific alkylation with microbial proteins, DNA and RNA. EO can undergo alkylation with free carboxyl, sulfhydryl and hydroxyl groups on proteins, and replace unstable hydrogen atoms to form compounds with hydroxyethyl radicals. Reactive groups required in basic metabolism hinder the normal chemical reactions and metabolism of bacterial proteins, resulting in the death of microorganisms on pet injection vials.

The above is an introduction to the commonly used sterilization methods for pet injection bottles. Ethylene oxide sterilization is a mature sterilization method. Although it has a strong sterilization effect, there are many factors affecting its sterilization, such as concentration and temperature. sterilization effect.

How the effervescent tube control moisture-proof function

 As the main packaging form of vitamin C effervescent tablets, the moisture-proof function of effervescent tubes is a point that pharmaceutical companies pay great attention to when choosing packaging. So, how can this kind of packaging control its moisture-proof function?

144mm effervescent tube packaging

The moisture-proof function of packaging is mainly controlled in two aspects, one is to block the invasion of external water molecules, and the other is to maintain the stability of the internal environment of the packaging. Judging from the material of the body of the effervescent tube, polypropylene is the main raw material. This raw material itself has good barrier properties, which can block the invasion of external water molecules and exert the moisture-proof function of the outside of the packaging.

The packaging or tablet itself will carry a certain amount of water molecules during the manufacturing process, so the internal moisture protection is also important. From the internal structure of the package, the lid of the effervescent tube is composed of a bottle cap skeleton, cardboard, coil spring, anti-theft ring and desiccant. The desiccant is stored in a small medicine warehouse, which is composed of an equal proportion mixture of silica gel and molecular sieve. It can absorb the internal water molecules and maintain the stability of the internal environment, thereby ensuring the stability of vitamin C effervescent tablets within the validity period.

Therefore, the moisture-proof function of the effervescent tube is mainly performed in two aspects: external moisture-proof and internal moisture-proof. The raw material assumes the function of external moisture-proof, and the internal desiccant plays the important role of internal moisture-proof. The moisture-proof function of the packaging can be well played.

Application of 60ml Syringe

 Syringe is a type of packaging with outstanding functionality. Common specifications include 5ml, 8ml, 10ml, 13ml, 15ml, 20ml, 30ml, 60ml, etc. Different specifications will have different uses. In what areas is it applied?

60ml equine syringe

Nutritional ointment: Important application of the 60ml syringe is pet nutrition ointment, which is a quick-replenishing nutritional supplement that can quickly replenish the nutrients required by pets in a short period of time. This packaging form is mainly used because of its positioning ring design, which can well control the dosage of the medicine, and also has the characteristics of convenient use and less residue.

The 60ml syringe is one of the larger sizes in this package. The medicines it contains are generally administered multiple times, and the positioning ring plus the standard scale on the push rod can precisely control the dosage during administration to achieve The effect of scientific drug delivery.

Molnupiravir for moisture-proof packaging of drugs two requirements

 Molnupiravir is an antiviral drug that inhibits the replication of certain RNA viruses. For the treatment of COVID-19 in people infected with SARS-CoV-2. It belongs to a small molecule drug and is in the form of capsules. What are the requirements of this drug for moisture-proof packaging of drugs?

50ml desiccant bottle

40ml desiccant bottle

medicine cap

Capsules refer to capsules made of special film-forming materials (such as gelatin, cellulose, polysaccharides, etc.), into which the contents (such as powdered and liquid medicines, etc.) or doses are loaded for easy swallowing. Medicines in capsules are generally powders or granules that are irritating to the esophagus and gastric mucosa, or have bad taste, are easily volatile, are easily decomposed by saliva in the oral cavity, and are easily inhaled into the trachea. These medicines are packed into capsules, which not only protect the medicinal properties of the medicines from being destroyed, but also protect the digestive organs and respiratory tract. Removing the capsule shell may result in drug loss, drug waste, and reduced efficacy. In addition, some drugs need to be dissolved and absorbed in the intestine, and the capsule protects the drug from being destroyed by stomach acid.

Molnupiravir's requirements for moisture-proof packaging of pharmaceuticals are mainly moisture-proof and airtight. These drugs are very sensitive to water molecules, and are prone to adhesion and deliquescence after being exposed to moisture, and their efficacy is greatly reduced, and sometimes there are toxic and side effects. In order to maintain the stability of the internal environment of the packaging, a desiccant will be included in the moisture-proof packaging of medicines to absorb moisture. There are also strict requirements for indicators such as the water absorption rate of the desiccant. In terms of sealing, it is mainly the ability of the bottle mouth and the bottle cap to cooperate, and to ensure the accuracy of the size, in order to better ensure the good sealing of the package.

The above are the two requirements of Molnupiravir for moisture-proof packaging of drugs, which are also two very important aspects to maintain drug stability and safety. Pharmaceutical companies should pay attention when choosing packaging.

DMF List

Application of Veterinary Syringes-Praziquantel for Horses

 Veterinary syringes are a widely used drug packaging container, such as praziquantel, a deworming drug for horses.

Most horses are affected by parasites, which can cause serious physical problems if infected. When the parasites are present in low amounts they may cause only minor problems, if moderate or more severe, they can seriously affect the health of the horse, which can lead to the appearance and persistence of colic, malnutrition, gastrointestinal Disease, or even damage to internal organs. Praziquantel is a cream or gel anthelmintic that works by disrupting the tapeworm's outer layer, leaving the worm unable to maintain fluid and electrolyte balance.

10ml dosing syringe

Praziquantel for horses uses veterinary syringes as packaging, which is mainly due to the convenience and controllability of administration. When giving medicine, open the protective cap of the package, put the tip into the horse's mouth, and push the push rod. Deworming medicine needs to determine the dosage according to the weight of the horse. This packaging has a positioning ring design and a standard scale is printed on the push rod, which can well control the dosage of the medicine and avoid overdose or underdose.

In a word, the paste syringe is a very convenient package to use, and it also has a quantitative function. This kind of packaging is used for cow endometritis medicine, pet nutrition cream, etc., which is the main reason for its widespread application.

Application of Pet Syringes-Nutritional Cream for Dog and Cat Dermatology

 With the continuous changes in market demand, pharmaceutical companies have higher and higher functional requirements for packaging, and pet syringes are a kind of packaging with outstanding functionality. On the basis of being used as a drug packaging, it also has the function of drug delivery. This packaging form is chosen for the dog and cat skin disease nutritional cream.

15ml feeding syringe for dog

Dog and cat skin disease nutritional cream is one of many nutritional creams. It is mainly used to help pets repair their skin. If dogs and cats have dull hair, hair loss, dry skin, itching, etc., this nutritional cream can be used to improve . The pet syringe is composed of a tube sleeve, a push rod, a piston, a protective cap, and a positioning ring. When giving medicine to a pet, through the pressure of the push rod, the drug can be exported through the tip for the pet to eat.

Pet nutritional cream also has strict requirements on the dosage, and excessive or insufficient consumption is not conducive to the health of pets. This package comes with a locating ring and a standard scale printed on the push rod. Calculate the specific dosage before use, slide the positioning ring to the corresponding scale, and push the push rod. When the push rod reaches the position of the positioning ring, it will stop pushing, so as to control the pet's edible dose.

In conclusion, pet syringes are a very efficient and convenient packaging form, and their unique drug delivery design can also reduce drug residues and improve usage rates. This kind of packaging can also be used for the packaging of cow mastitis medicine, cockroach medicine and other medicines.

Application of test paper container-blood sugar test strip

 The test paper container is a very good moisture-proof packaging container, which is mainly used for in vitro diagnostic test strips that need moisture-proof preservation. Among many test strips, blood glucose test strips are the most widely used.

Blood glucose test strips are a kind of consumables used in conjunction with blood glucose detectors, coated with biological enzymes, and can detect the amount of glucose in peripheral blood through their color changes. The blood glucose test strip area consists of two thin sheets containing sensitive chemical components. Drop the blood on the test area (the center of the yellow part), put the test strip flat for one minute and then rinse the blood. Compared with the standard colorimetric plate, the chemical reaction that occurs will produce different degrees of color changes according to the glucose content in the blood. Glucose oxidase, peroxidase, on the test strip reacts with glucose in the blood. A color indication of the reaction along with the non-reactive components will be presented in the test area.

48mm glocuse test strip container

The enzyme reagents in blood glucose test strips are particularly sensitive to water molecules. Therefore, the test strips must be stored in a dry and stable environment to avoid deterioration. There is a small medicine compartment on the lid of the test strip barrel, which contains molecular sieve and silica gel desiccant, which can absorb the moisture inside the package, maintain the stability of the internal environment, and ensure that the test strips are stored well.

Although the test paper container has good moisture resistance, the frequency of blood sugar testing is relatively high, so the package will be opened frequently, and the lid should be closed immediately after removing the test paper to prevent the intrusion of external water vapor.