Product advantages of calmer syringe

 With the emergence of various new materials and processing techniques, veterinary drug packaging is constantly innovating. Some new packaging that is convenient to use and more functional has gradually entered the market and has become a trend. Calmer syringes are such a packaging.

horse equine paste syringe

The calmer syringe is composed of a sleeve, a push rod, a piston, a protective cap, and a positioning ring. It is an upgraded product of the syringe. It is a new type of packaging that injects drugs into the sleeve in advance and has injection functions. Its main applications It is used in the packaging of dairy cow mastitis drugs, dairy cow endometritis drugs, pet nutrition cream, cockroach medicine, horse oral paste and other products. The calmer syringe has the following advantages:
1. Easy to use: when the packaging is used, open the protective cap or use a dedicated catheter to achieve drug delivery, which is convenient to use;
2. Avoid contamination: This kind of packaging has already filled the medicine in advance, which reduces the process of drawing the liquid from the syringe, and also avoids cross-infection in this process;
3. Precise medication: Precise medication dosage is very important to the health of animals. This kind of packaging can print specific scales on the push rod and use it with the positioning ring to make the medication dosage more accurate. Such as pet nutrition cream, dairy cow endometritis and other drugs.
Good packaging not only meets the requirements of national standards in terms of quality, but also pays attention to the convenience of consumers in the process of use. The above are the advantages of calmer syringe. These advantages also make its application scope continue to expand and become a trend.

Abnormal toxicity detection of veterinary syringe

 The veterinary syringe is composed of a tube sleeve, a push rod, a piston, a protective cap, and a positioning ring. It is a new type of packaging that has both drug storage and injection functions. In the quality standard of the syringe, abnormal toxicity detection is a special and very necessary indicator.

paste syringe

The veterinary syringe is mainly used for the packaging of drugs such as dairy cow mastitis, dairy cow endometritis, pet nutrition ointment, etc. It has the characteristics of convenient use, reduced pollution and less residue. Abnormal toxicity is different from the toxicity characteristics of the drug itself. It refers to the toxicity caused by the introduction during the production process or other reasons. This test aims to prove whether the veterinary syringe is contaminated with exogenous toxic substances and whether there is unexpected unsafe factor.

intramammary syringe

In China’s T/CVDA 1-2019 "Pre-filled Plastic Breast Injector for Veterinary Use" standard, the detection requirements for abnormal toxicity are as follows: Take a few of this product, rinse the syringe with water, cut it, and take 500cm2 (within Surface area meter), add 50ml of sodium chloride injection, put it in the autoclave 110 for 30 minutes, take it out, cool it for use, use the same batch of sodium chloride injection as a blank, intravenously, and inspect according to law ("The People's Republic of China Veterinary Pharmacopoeia 2015 Edition Two General Rules 1111), should meet the requirements.
The detection of abnormal toxicity is a mandatory item for veterinary syringes, and it is also the key to ensuring the safety of medicines and the effect of animal treatment. As people's awareness of food safety continues to increase, the country's requirements for veterinary drug packaging will also become higher and higher.

Introduction to the production process of eye drops bottle

 Plastic bottles play an important role in people's production and life. No matter what the bottle is, it must be formed and processed, and our common eye drop bottles are no exception. The eye drop bottle is composed of a bottle body, a bottle cap and a dripper. What kind of production technology is used to process the bottle with this structure?

eye drop bottles

Eye drop bottles are generally made of soft low-density polyethylene raw materials through injection-blowing technology. The capacity ranges from 5ml-15ml. First, the injection machine injects the molten plastic into the injection mold to form a tube blank. The microporous hollow punch is formed; then it is moved to the blow mold while it is hot; then the mold is closed and compressed air is introduced from the pipe of the mandrel to inflate the parison and stick to the cavity wall of the mold; After holding pressure, cooling and shaping, the compressed air is released and the mold is opened to take out the plastic part. This process has the following characteristics:

1. The product has exquisite appearance, accurate size, uniform wall thickness and no flash, and the production of parts does not require secondary processing;

2. Plastic products are made by one-time blow molding of injection moulds, with no waste at the mouth and bottom of the bottle, and the mouth is flat and has good sealing performance;

3. The injection parison has a bottom, so there is no split seam at the bottom of the plastic part, which has high strength and high productivity. It is mostly used for mass production of small plastic parts.

The eye drop bottle produced by the injection-blowing process has good sealing properties and a more high-end appearance. This process is also used in the processing of small refined containers and wide-mouth containers such as cosmetics, daily necessities, food and pharmaceutical packaging bottles.

The structure and function of the effervescent tube cap

 The advantages and disadvantages of the pharmaceutical packaging and the functional design are very important for the storage of medicines. The effervescent tube is a special type of medicine packaging. Its bottle cap is composed of a desiccant, a coil spring and an anti-theft ring. Each design is large. useful.

sprial cap

Desiccant: In order to prevent the medicine from absorbing moisture and deteriorating, a desiccant is placed inside the medicine packaging. Commonly used desiccants include quicklime, magnesium chloride, calcium chloride, phosphorus pentoxide, molecular sieves, etc. Unlike other packaging, the desiccant of the effervescent tube is placed in the small medicine bin on the top of the bottle cap. This design reduces the contact between the desiccant and the medicine, and also reduces the risk of children ingesting the desiccant by mistake.

Coil spring: The effervescent tablet has a large dosage form and is easily damaged by various external forces during transportation. The spiral spring on the bottle cap is soft and can compress the tablets to prevent the effervescent tablet from breaking during transportation and handling, and it protects the integrity of the medicine.

Anti-theft ring: The design of the anti-theft ring on the cap of the effervescent tube is derived from the beverage bottle. When the cap is unscrewed, the anti-theft ring will fall off and stay on the bottle. We can judge whether the medicine has been opened according to the state of the anti-theft ring.

The special design of the effervescent tube cap is the result of the ever-changing market demand, and it is also the embodiment of the packaging manufacturer's continuous innovation and innovation in the production process. With the increase of various kinds of medicines, there will be more and more new medicines, and the design of medicine packaging will also show a diversified development trend.

What is required on a supplement label?

 Introduction

The Food and Drug Administration (FDA) receives many questions about the labeling of dietary supplements. These questions are a consequence of the activity in this area over the past several years. Some of the important events relating to the labeling of dietary supplements include:

The Nutrition Labeling and Education Act of 1990 amended the Federal Food, Drug, and Cosmetic Act (the act) in a number of important ways. Notably, by requiring that most foods, including dietary supplements, bear nutrition labeling.

The Dietary Supplement Health and Education Act of 1994 (the DSHEA) amended the act, in part, by defining "dietary supplements," adding specific labeling requirements for dietary supplements, and providing for optional labeling statements.

On September 23, 1997 (62 FR 49826), we implemented the DSHEA by publishing several key regulations on the statement of identity, nutrition labeling, ingredient labeling, and nutrient content and health claims for dietary supplements. On June 5, 1998 (63 FR 30615), we amended the regulations pertaining to the nutrition labeling of extracts used in dietary supplements.

On January 15, 1997 (62 FR 2218), we published regulations that require a label warning statement on dietary supplements with added iron. These regulations also required the unit-dose packaging of supplements containing 30 milligrams or more, but this requirement has been eliminated as a result of a court challenge in January, 2003.

On July 11, 2003 (68 FR 41434), we published a final regulation that amended the labeling requirements for dietary supplements, as well as for conventional foods, that would make the declaration of trans fat mandatory in nutrition labeling. This regulation requires that, when present at 0.5 g or more, trans fat be listed in the Supplement Facts panel of dietary supplements on a separate line under the listing of saturated fat by January 1, 2006.

We have prepared this guide to help assure that the dietary supplements sold in the United Stated (U.S.) are properly labeled. This guide applies to dietary supplements produced domestically as well as those produced in foreign countries. Under our regulations, label approval is not required to import or distribute a dietary supplement.

We have included the most frequently raised questions about the labeling of dietary supplements using a "question and answer" format. If you have a question not addressed in this guide, please contact an FDA District Office (see Appendix A of this guide) or the:

Division of Dietary Supplement Programs (HFS-810)

Office of Nutritional Products, Labeling, and Dietary Supplements

Center for Food Safety and Applied Nutrition

Food and Drug Administration

5001 Campus Drive

College Park, MD 20740-3835

240-402-2375

Please be advised that you must comply with any requirements for dietary supplements that may publish after this booklet is issued. New regulations are published in the Federal Register prior to their effective date and are compiled annually in Title 21, Part 101 of the Code of Federal Regulations (21 CFR 101). Summaries of our new regulations (proposed regulations and final regulations) are posted on our Internet Website (http://www.fda.gov).

FDA's guidance documents, including this guidance, do not establish legally enforceable responsibilities. Instead, guidances describe the agency's current thinking on a topic and should be viewed only as recommendations, unless specific regulatory or statutory requirements are cited. The use of the word "should" in agency guidances means that something is suggested or recommended, but not required.

HDPE pills bottle

effervescent tablet packaging

Resources come from FDA Web

Pay attention to these points in veterinary drug packaging design

 Veterinary drug packaging is an important part of drugs. It plays a key role in drug information transmission and safety protection. Especially in the design of veterinary drug packaging, if the design is not paid attention to, it will not only be harmful to the promotion of its own brand, once the label, Errors in the logo will cause unignorable consequences to the market. Therefore, the following points should be paid attention to in the design of veterinary drug packaging:

twin neck bottle

1. Simplify the complexity
The design of veterinary drug packaging should be intuitive, especially in this fast-paced era, most people will not spend too much time on packaging browsing, so the packaging design should be simplified, and the product design The description is clear and clear, so that the buyer can understand the purpose of the medicine at a glance.

cow mastitis syringe

2. Reflect the efficacy and characteristics of drugs
In order to facilitate identification, veterinary drug packaging will show the drug's efficacy and effects to the purchaser, and some drugs are already reflected in the name. In addition, the characteristics of the product must have a distinct visual performance that matches it to attract the attention of buyers. For example, for different animals such as sheep and pigs, it can be emphasized on the packaging. This is also a way of communicating with buyers. Effective way.

plastic injection vial

3. Eye-catching brand identity
The brand identity of veterinary drug packaging is an effective measure for pharmaceutical companies to promote themselves. Generally, the appearance of packaging should include information such as drug name, characteristics, production batch number, and expiration date. How to highlight brand elements in a limited space is a key issue that pharmaceutical companies need to consider. For example, it can be achieved by enlarging the brand name, creating strong color contrast, and personalized font design.
With the emergence of various new packaging materials and packaging forms, veterinary drug packaging will usher in better development in design, technology, equipment, quality and other issues to adapt to the continuous changes in the market.

How to achieve aseptic requirements for high-density polyethylene bottles?

Medicine bottles are an important part of the circulation of medicines. The common pharmaceutical packaging is mainly plastic bottles and PTP aluminum foil, especially high-density polyethylene bottles, which can be used for the packaging of solid and liquid medicines. As a special commodity, medicine has high requirements for packaging, and sterility is the most basic condition. So, how can high-density polyethylene bottles meet the requirements for sterility?

Aseptic packaging is a method of sterilizing packaging in a sterile environment using instant ultra-high temperature sterilization technology. The sterile high-density polyethylene bottle can better maintain the ingredients of the medicine, extend the shelf life, inhibit bacterial contamination, and ensure the safety of medication. If the package contains bacteria, it will greatly shorten the shelf life of the medicine, seriously affect the efficacy of the medicine, and even cause a safety accident of the medicine. Therefore, the sterility of the drug package is the focus of the pharmaceutical companies.

child proof bottle

The sterility of high-density polyethylene bottles must first be derived from the sterility of the production environment. According to GMP requirements, the production of pharmaceutical packaging materials must be completed in a clean workshop. The clean workshop has Pressure difference, illuminance, noise, etc. have strict standards. From the production process to sorting to packaging, they must be strictly controlled to ensure that the entire production process is carried out in a sterile space.

Secondly, high-density polyethylene bottles will undergo secondary sterilization after the production is completed. The main sterilization methods used are ethylene oxide sterilization or cobalt 60 sterilization to ensure that they meet the requirements of the industry standard for microbial limits ( Inspect according to law (Chinese Pharmacopoeia 2015 Edition General Rules 1105, 1106), the number of bacteria must not exceed 1000cfu per bottle, the number of molds and yeasts must not exceed 100cfu per bottle, and each bottle of Escherichia coli must not be detected).

It is not a separate action for high-density polyethylene bottles to achieve aseptic requirements. It needs to be strictly controlled from the production environment, packaging, sterilization and other links in order to achieve true sterility. With the substantial increase in the production standards of the pharmaceutical industry, the industry's requirements for aseptic packaging will become higher and higher.

 

Material is very important when choosing eye drop bottles

 As an important part of drug circulation, pharmaceutical packaging plays an important role in protecting drug safety. For eye drops with high-risk routes of administration, the importance of packaging is particularly important. How to choose a high-quality eye drop bottle, first of all, we must start with the material.

eye drop bottle

With the popularization of electronic products, the resulting market share of ophthalmic drugs has continued to increase, and with the improvement of people's health awareness, attention to drug packaging has also increased. The material of pharmaceutical packaging is the primary consideration when choosing eye drop bottles. The eye drop bottle is used to squeeze the bottle body to achieve eye administration. If the material is too hard, it will not be able to squeeze out, or the amount of medicine will exceed the standard due to excessive force, resulting in waste.

Secondly, as a medicine packaging material, the raw materials of the eye drop bottle must be non-toxic, tasteless, and resistant to most acids and alkalis to ensure that the medicine and the container will not react. Of course, this needs to be proved through actual tests.

In summary, the material of the eye drop bottle is related to whether the eye drops are used smoothly and conveniently, and also related to the safety of drug storage. At present, the eye drop bottles on the market mostly use low-density polyethylene (LDPE) raw materials. Compared with high-density polyethylene, this raw material has good flexibility, resistance to corrosion by most acid and alkali solvents, and will not be squeezed. It produces creases and is a good packaging material.

Requirements for packaging of veterinary drugs for different drugs

 Veterinary drugs refer to substances used to prevent, treat and diagnose animal diseases or to purposely regulate animal physiological functions, including vaccines, diagnostic products, antibiotics, biochemical drugs, Chinese medicinal materials, disinfectants, etc., according to the different drug formulations, the packaging of veterinary drugs The requirements are also different.

veterinary syringe

Although there are many types of veterinary drugs, they are mainly divided into two categories: liquid drugs and powder drugs according to their dosage forms. Liquid medicines generally choose plastic packaging bottles, and the raw materials mainly include polyethylene, polypropylene, polyester, high barrier, etc. Oral liquid and injection medicines will require the bottle to be transparent and shading. In order to ensure that the medicine is not decomposed and deteriorated under the influence of light, a brown polyester bottle is chosen. Liquid medicines have high requirements on the tightness of the bottle, so in the choice of bottle caps, choose more aluminum caps with rubber plugs to achieve a good sealing effect.

twin neck bottle

The powder dosage form accounts for a relatively small proportion of veterinary drugs. This type of drug requires moisture-proof packaging for veterinary drugs. Plastic packaging bottles are usually the main ones, sealed with aluminum foil gaskets, and a desiccant is placed in the bottle to ensure the dryness of the internal environment. , Prevent the medicine from being damp and deteriorate
In addition, some highly corrosive drugs (such as disinfectants) require high barrier properties for veterinary drug packaging, and packaging of high barrier materials will be selected to ensure that the drug is in a good state of preservation.
The above are the requirements for the packaging of veterinary drugs for several different veterinary drug types. Choosing the appropriate veterinary drug packaging according to the characteristics of the drug is the basic condition to ensure the safety and effectiveness of the drug.

How to choose a manufacturer of medicinal HDPE pills bottles?

 Pharmaceuticals are necessities of people's lives. Plastic bottles for packaging capsules, powders and liquid preparations are usually called medical plastic bottles. High-density polyethylene bottles are the most widely used category. Pharmaceutical packaging material manufacturers on the market There are so many, how do pharmaceutical companies choose the right supplier?

HDPE pills bottle

The quality of medicinal HDPE(high-density polyethylene) pills bottles is related to whether the drug can maintain good efficacy during the validity period. Choosing an excellent pharmaceutical packaging material supplier is a prerequisite for ensuring the quality of packaging. Generally speaking, manufacturers of pharmaceutical packaging need to have the following conditions and capabilities:

1. Certificate of medicine packaging material:

The certificate of pharmaceutical packaging materials is a basic requirement for a supplier of pharmaceutical packaging materials, and the number of certificates often determines the strength of the company. The certificate of pharmaceutical packaging materials refers to the "Registration Certificate for Pharmaceutical Packaging Materials." The Measures for the Administration of Pharmaceutical Packaging Materials and Containers (Interim) (Bureau Order No. 21) stipulate that "medical packaging materials must be registered by the drug regulatory authority and obtained the "Registration of Pharmaceutical Packaging Materials" It can be produced only after the certificate, and unregistered pharmaceutical packaging materials shall not be produced, sold, operated or used.

2. Clean workshop:

Medicine is a kind of special commodity, which has high hygiene requirements. As a supplier of pharmaceutical packaging, it is necessary to have a clean workshop. Only in this way can the medicinal high-density polyethylene bottles meet the hygienic standards and meet the requirements of medicinal packaging.

3. Production scale:

In addition to the certificate of pharmaceutical packaging materials and the clean workshop, the supply strength and scale of the pharmaceutical packaging material manufacturers cannot be ignored, which will determine whether the later packaging production line can operate normally and deliver on time.

Pharmaceutical companies can consider the above aspects when choosing a manufacturer of high-density polyethylene bottles for pharmaceuticals. In addition, they should also pay attention to factors such as the quality of the product itself. 

FDA and pets food packaging requirement

 At FDA,the safety of food for animal, including our pets,is just as important as the safety of food for people. In fact,Congress directed FDA to protect"articles used for food or drink for man or other animals." Under this lae, we are determined to make sure the food and treats we give our dogs and cats, of course, but also companion animals like horse, hamsters, birds, and fish, is safe for the animal to eat.

According to law, companies producing canned pet food must follow a specific set of regulations to eliminate harmful becteria inside the can. These are the same regulations that manufacturers of canned foods for people must follow. Pets food and treats must also be truthfully labeled, and federal regulations require labels on pet foods and treats to have four specific pieces of information.

Number one: The label must contain a list of the ingredients.
INGREDIENTS: Wheat Flour Wheat Bran, Meat and Bone Meai Milk, Wheat Germ, Beef Fat (Preserved withtocopherols), Dicalcium Phosphate, Caramel Color, Salt, Natural Flavor, Artificial Beef Flavor,
Vitamins and Minerals(Choline Chloride, Zinc Sulfate, Vitamin E Supplement L-ascorbyl-2-polyphosphate Biotin, Ferrous Sulfate, D-calcium, Niacin Supplement, Riboflavin Supplement, Vitamin B12 Supplement, Ferrous Sulfate, D-calcium Pantothenate, Vitamin A Supplement, Pyridoxine Hydrochloride, Menadione Sodium Bisulfite Complex, Manganous Oxide, Copper Sulfate, Ethylenediamine
Dihydriodide ( Source of lodine Vitamin D3 Supplement, Folic Acid, Sodium Selenite), Calcium Carbonate, Brewers Dried Yeast, Malted Barley Flour, Sodium Metabisulfite( Used as a Preservative), AD04.01D9
Number two: The label must properly identify the product.

Number three: A pet food label must including a net quantity statement. This tells you how mucg product is in the container.

Number four: The label must include the manufacturer's or distributor's name and address.

Both the atstes and FDA can inspect pets food manufacturing facilities to make sure the appropriate regulations for manufacturering and labeling products and being followed.

15ml pets syringe

Resources come from FDA news