Two advantages of pet nutrition cream syringe

 Pet nutrition cream is a quick-replenishing nutritional supplement, which is mainly used for various nutritional supplements of pets. The pet nutrition cream syringe is a packaging form of this supplement, which is different from ordinary pharmaceutical packaging, and has the function of drug storage and administration at the same time. So, what are the advantages of this special packaging?

30ml oral dose syringe for dog

1. Easy to use: The pet nutrition cream syringe is composed of a tube sleeve, a push rod, a piston, a protective cap and a positioning ring. When the protective cap is closed, it is a drug storage container. turned into a drug delivery tool. This package is very convenient to use, remove the protective cap, hold the push rod and handle part with your hand, and gently push the push rod to complete the drug delivery.

2. Quantitative feeding: As a supplement, pet nutritional cream also has certain requirements for feeding dose. Excessive administration can easily lead to excessive nutrition for pets, resulting in problems such as excessive obesity, which is not conducive to the health of pets. The feeding dose is insufficient, and the nutritional supplement effect cannot be achieved. The pet nutrition cream infuser has the function of quantitative feeding. There is a standard scale printed on the push rod. Slide the positioning ring to the corresponding scale, push the push rod, and stop when it reaches the positioning ring, so that the effect of precise dose control can be achieved. .

The pet nutrition cream syringe has two advantages of convenient use and quantitative feeding. This packaging is also widely used in the packaging of cow mastitis drugs, horse oral paste, cockroach medicine and other drugs.

15ml feeding syringe for dog

How to prevent moisture in child resistant packaging

 With the concern of children's drug poisoning incidents, many drugs have chosen child-safe packaging with protective functions, such as some tablets, capsules or liquid preparations. For solid preparations, moisture resistance is an essential function of packaging. So, how does this packaging prevent moisture?

28 410 child resistant cap

desiccant cap with crc

child resistant cap

Child-resistant packaging is packaging that is difficult for children under 52 months to open (or access to the contents) within a reasonable amount of time, but which is properly used by adults under 70 years of age (including 70 years of age). This kind of package increases the difficulty of opening through the special design of the lid, in order to prevent children from opening the package at will and accidentally eating the medicine. This kind of packaging is essentially a medicinal plastic bottle, and the internal moisture resistance is mainly achieved in two ways:

One is to pack the desiccant in a non-woven bag, then place it inside the bottle, and store it directly with the medicine. With the continuous update and iteration of packaging, a cover with moisture-proof function gradually appeared. It utilizes the space at the top of the lid and stores the desiccant in the small medicine compartment on the top of the lid, which not only realizes the moisture-proof function, but also prevents the direct contact between the medicine and the desiccant.

At present, this kind of packaging with both moisture-proof and child-proof functions has been applied to more and more medicines, and has played a very important role in protecting children's safety and preventing them from eating medicines by mistake.

What is a Pet Syringe Applicator

 There are many kinds of veterinary drugs, including liquid preparations, solid preparations, pastes, etc., and the types of packaging are also very diverse, such as plastic bottles/barrels, aluminum foil bags, droppers, etc. The pet nutrition cream syringe applicator is a great type of packaging. 

pet syringe

Ordinary plastic bottle packaging is generally only used to store medicines. The pet syringe applicator can store medicines and can also be used as a drug delivery tool. It consists of a tube sleeve, a push rod, a piston, a protective cap and a positioning ring. It is a drug storage container in a sealed state, and when we open the protective cap and push the push rod, it turns into a drug delivery Tool of.

30ml dial a dose syringe

The magic of this packaging is that it allows precise control of the dose administered. There is a standard scale printed on the push rod, slide the positioning ring to the corresponding scale, and then push the push rod to achieve precise drug delivery. Especially for pets, the control of nutritional cream dosage is very important for their health.

In general, the pet syringe applicator, based on the drug storage function, satisfies the market's precise control of drug dosage, and is a functionally outstanding package. It is also used in the packaging of cow mastitis medicine, cow endometritis medicine, horse oral paste, calf oral paste and other medicines.

Application of plastic veterinary syringes-Cat Lysine Paste

 Veterinary drug packaging should have more functionality, and plastic veterinary syringes are such a multifunctional package. The lysine paste commonly used by cat breeders is the packaging of choice.

Feline Lysine Paste is a feline nutritional supplement developed and formulated for cats infected with or with feline herpesvirus, the causative agent of feline rhinotracheitis (feline flu). Feline herpes virus relies on arginine, an essential amino acid without which the virus cannot replicate. L-Lysine is also an amino acid. If it is given to animals as a supplement, it can compete with arginine, resist the growth-promoting effect of arginine on the virus, and inhibit the replication of feline herpes virus.

30ml dial a dose syringe

The plastic syringe is composed of a tube sleeve, a push rod, a piston, a protective cap, and a positioning ring. When the protective cap is tightly closed, it is a veterinary drug package, but when the protective cap is removed and the push rod is pushed, it transforms into a become a drug delivery tool. There is a standard scale on the push rod, turn the positioning ring to the appropriate scale, push the push rod to achieve drug delivery, and the push rod will stop pushing when it reaches the positioning ring, so that the dosage of the drug is well controlled, which is conducive to better efficacy of the drug and the healthy growth of pets.

In addition to being used as a packaging for cat lysine paste, the plastic paste syringe has a very wide range of applications in dairy cow mastitis medicine, horse medicine, cockroach medicine, etc. It is a versatile packaging form.

Application steps of pet syringe

 Pet nutritional cream is a quick-replenishing nutritional supplement, especially for some pets who are malnourished, postpartum, and after high-intensity training. As a kind of pet medicine, it uses a pet syringe that has both drug storage and drug delivery functions on the package. What is the structure of this package and how should it be used?

pet syringe

The pet syringe is composed of five parts: a sleeve, a push rod, a piston, a protective cap, and a positioning ring. The steps to use this package are as follows:

1. Calculate the dose: The feeding of pet nutrition cream should also follow the appropriate dose. Insufficient or excessive feeding is not conducive to the health of pets. A standard scale is printed on the push rod, the actual dose is calculated according to the pet's weight, and the positioning ring is slid to the corresponding scale.

2. Push the push rod: Open the protective cap, gently push the push rod, the medicine will be squeezed out under the pressure of the push rod, and then let the pet lick it directly.

3. Drug packaging: Pet nutritional cream is not a single-dose drug. After feeding, the protective cap should be covered and the seal should be confirmed to avoid contamination of the drug.

The above are the specific steps of using the pet nutrition ointment syringe. When administering, the prescribed dosage must be followed to avoid overdosing and causing health problems such as excessive pet nutrition.

30ml dial a dose syringe

Focus on Bovine Mastitis Treatment

 Intramammary or Systemic Administration?

Treatment of mastitis should be based on bacteriological diagnosis and take national and international guidelines on prudent use of antimicrobials into account. In acute mastitis, where bacteriological diagnosis is not available, treatment should be initiated based on herd data and personal experience. Rapid bacteriological diagnosis would facilitate the proper selection of the antimicrobial. Treating subclinical mastitis with antimicrobials during lactation is seldom economical, because of high treatment costs and generally poor efficacy. All mastitis treatment should be evidence-based, i.e., the efficacy of each product and treatment length should be demonstrated by scientific studies. Use of on-farm written protocols for mastitis treatment promotes a judicious use of antimicrobials and reduces the use of antimicrobials.

An important question regarding the treatment of mastitis is whether the antimicrobial should accumulate in the milk or in the udder tissue [9]. The target site may depend on the causative agent: streptococci are known to remain in the milk compartment, but S. aureus penetrates udder tissue and causes deep infection (Table 1). The most common route of administration of antimicrobials in mastitis is the IMM route. The advantages of this route are high concentrations of the substance achieved in the milk and low consumption of the antimicrobial as the drug is directly infused into the diseased quarter. For example, concentration of penicillin G in milk after IMM administration is 100-1000 times as high as the concentration after systemic (parenteral) administration [15, 16, 59, 32]. A disadvantage of the IMM administration is uneven distribution throughout the udder [53, 7, 8] and the risk of infecting the quarter when infusing the product via the teat canal. Efficacy of IMM treatment varies according to the causative pathogen, with the best therapeutic response being shown for mastitis caused by streptococci, coagulase-negative staphylococci, and Corynebacterium spp.

5ml syringe for cow mastitis

Source from: https://irishvetjournal.biomedcentral.com/articles/10.1186/2046-0481-62-S4-S40 

Requirements for COP vials of cell-based drugs

 In recent years, the field of cell therapy has entered a period of rapid development. It has shown increasing application value in cancer, blood disease, cardiovascular disease, diabetes, Alzheimer's disease, familial hypercholesterolemia and other fields, and has become a research topic at home and abroad. hot spot. As a high value-added drug, what are the requirements for COP bottle packaging?

5ml COP vial

100ml COP injection vial

The packaging, along with the market circulation, transportation and storage period of the drug, plays a very important role in the stability and safety of the drug. Cell-based drugs refer to a class of compounds that kill cells by disturbing the basic metabolic process of cells. A notable feature of this type of drug is that it contains protein components, and the protein is easily adsorbed on the surface of the package, causing waste of the drug and affecting the dosage of the drug. Therefore, the packaging of cell-based drugs must have low protein adsorption.

Cell-based drugs generally need to be stored in a liquid nitrogen environment, and an ultra-low temperature environment can ensure the activity of the drug. Therefore, COP bottles must have good low temperature resistance in order to meet the storage requirements of such drugs.

To sum up, low protein adsorption and low temperature resistance are the two basic requirements of cell-based drugs for COP bottles, and are also two key properties to ensure drug stability during storage. In addition, this kind of packaging also has the characteristics of very good chemical stability, and it is not easy to change color after irradiation sterilization. It is a commonly used packaging for high pH drugs and antitumor drugs.

FDA Approves Simplera Otic Solution to Treat Ear Infections in Dogs

 September 28, 2022

Today the U.S. Food and Drug Administration approved Simplera Otic Solution, the first generic drug product that has a single dose treatment with a 30-day duration of effect for otitis externa (outer ear infection) in dogs associated with susceptible strains of yeast (Malassezia pachydermatis) and bacteria (Staphylococcus pseudintermedius).

Simplera Otic Solution contains the same active ingredients (florfenicol, terbinafine, mometasone furoate) in the same concentration and dosage form as the approved brand name drug product, Claro, which was first approved on September 20, 2015.

Simplera is a prescription product, meaning a veterinarian’s expertise is required to diagnose otitis externa and to determine whether Simplera is an appropriate treatment.

Dogs that are administered Simplera should be restrained to minimize post-application head shaking. People who are administering Simplera or restraining dogs should wear eye protection. Reducing the potential for splatter of product will help prevent accidental eye exposure in people and dogs and help to prevent eye injuries. Precautions should also be taken to prevent medication getting in the eyes of the dog being treated. If accidental exposure to the eyes of people or dogs occurs, seek medical care.

Simplera is supplied in a single-use dropperette in a blister. Each dropperette contains one 1 mL dose. Simplera is available in cartons of 10 dropperettes.

Simplera is sponsored by Vetoquinol USA, Inc., based in Fort Worth, Texas.

single dose appicator

30ml dial a dose syringe

plastic injection vial

Source from FDA

Printing method of syringe plunger scale

 In the process of veterinary drug use, precise control of dosage is equally important. The plastic syringe is a special package with a dosing device, with a standard scale printed on the push rod, used together with a positioning ring. The shape of the push rod is uneven, what printing method is used for it?

60ml syringe with dosing plunger

At present, there are various printing methods on the market, including offset printing, screen printing, pad printing, etc. The scale on the plunger of the syringe adopts the pad printing method. Pad printing is one of the special printing methods, which can print text, graphics and images on the surface of irregular shaped objects, and is now becoming an important special printing. For example, the text and patterns on the surface of mobile phones are printed in this way, and the surface printing of many electronic products such as computer keyboards, instruments, and meters are all done by pad printing.

This printing method has mature technology, exquisite printing effect, ink saving, odorless and non-polluting, which ensures the firmness and beauty of the scale of the syringe plunger push rod.

Extractable matter testing of caps for effervescent tubes

 As an important part of the packaging, the cap of the effervescent tube is of great significance to the overall sealing and moisture resistance of the packaging. In addition, as the material in direct contact with the drug, the dissolution test must be carried out to ensure that the material does not contain ingredients that affect the safety and stability of the drug.

144mm*29mm effervescent tube packaging

caps for effervescent tube

In China, the standard implemented for effervescent tube caps is YBB00172004-2015 "Quality Standard for Oral Solid Medicinal Low Density Polyethylene Moisture-Proof Combination Caps". The dissolution test in the standard mainly includes three items: easy oxides, nonvolatiles and heavy metals Detection:

Accurately measure 20ml of water test solution for easy oxide, accurately add 20ml of potassium permanganate titration solution (0.002mol/L) and 1ml of dilute sulfuric acid, boil for 3 minutes, cool rapidly, add 0.1g of potassium iodide, and place in a dark place for 5 minutes. Titrate with sodium thiosulfate titration solution (0.01mol/L), when the titration is near the end point, add 5 drops of starch indicator solution, continue to titrate until it is colorless, and take another water blank solution and operate in the same way, both of which consume sodium thiosulfate titration solution. (0.01mo/L) The difference should not exceed 1.5ml.

Non-volatile matter Precisely measure 50ml of water, 65% ethanol, n-hexane test solution and blank solution, respectively, and place them in an evaporating dish with constant weight, evaporate to dryness in a water bath, and dry at 105 °C for 2 hours. The difference between the non-volatile residue of the test solution and the residue of the blank solution should not exceed 12.0 mg: the difference between the non-volatile residue of 65% ethanol and the residue of the blank solution should not exceed 50.0 mg: the difference between the non-volatile residue of n-hexane and the residue of the blank solution should not exceed 50.0 mg. 200.0 mg·

Heavy metals: Precisely measure 20ml of water as test solution, add 2ml of acetate buffer (pH3.5), and check according to the law (the first method of Chinese Pharmacopoeia 2015 edition general rule 0821), and the heavy metal content shall not exceed one millionth.

The dissolution test of effervescent tube caps is an important test item to ensure the quality of packaging. Xinfuda has been engaged in drug packaging for 20 years, and its products have passed ISO15378 certification, US DMF filing and other certifications. If you are choosing packaging for drugs, Welcome to contact us.

Printing method of syringe plunger scale

 In the process of veterinary drug use, precise control of dosage is equally important. The plastic syringe is a special package with a dosing device, with a standard scale printed on the push rod, used together with a positioning ring. The shape of the push rod is uneven, what printing method is used for it?

60ml syringe with dosing plunger

At present, there are various printing methods on the market, including offset printing, screen printing, pad printing, etc. The scale on the plunger of the syringe adopts the pad printing method. Pad printing is one of the special printing methods, which can print text, graphics and images on the surface of irregular shaped objects, and is now becoming an important special printing. For example, the text and patterns on the surface of mobile phones are printed in this way, and the surface printing of many electronic products such as computer keyboards, instruments, and meters are all done by pad printing.

This printing method has mature technology, exquisite printing effect, ink saving, odorless and non-polluting, which ensures the firmness and beauty of the scale of the syringe plunger push rod.