Common veterinary medicines contained in oral liquid bottles

 Oral liquid bottle is a packaging container made of polypropylene, polyethylene, polyester and other raw materials. It has good sealing and barrier properties. It is very suitable for holding veterinary oral liquid drugs. Common drugs Including the following types:

100ml transparent PP vial

plastic vaccine vial

Shuanghuanglian Oral Liquid: It has the effects of pungent and cool to relieve symptoms, clear away heat and detoxify. It can effectively relieve clinical symptoms caused by colds caused by exogenous wind-heat. It can accelerate the body's recovery and quickly resume feeding.

Yangshuhua Oral Liquid: Returns to the gastrointestinal meridian, clears away heat and detoxifies, astringes the intestines and relieves diarrhea, resolves dampness and relieves dysentery, strengthens the spleen and nourishes the stomach. Clinical use of poplar flowers or its preparations has significant effects on bacillary dysentery and intestinal diseases.

Pulsatilla Oral Liquid: It has significant curative effect on diarrhea caused by unknown reasons, diarrhea caused by feeding stress, physiological diarrhea and excessive feeding. It has significant antagonistic and scavenging effects on bacterial endotoxins.

Sini Decoction Oral Liquid: It mainly treats cold limbs, weak and weak pulse, and Yang deficiency. Symptoms of yang deficiency include depression, aversion to chills and trembling, shallow breathing, greatly reduced or inexhaustible appetite, weakened gastrointestinal peristaltic sounds, lowered body temperature, coldness in the ears, nose, lips, extremities or the whole body, white color in the mouth, tongue The body fluids are moist and the pulse is thin and weak.

The above are common drugs contained in veterinary traditional Chinese medicine oral liquid bottles, in addition to Huoxiang Zhengqi oral liquid, Yimu Shenghua mixture, etc. The packaging capacity of this type of medicine is generally relatively large, which is also to adapt to the large-scale breeding needs of farms.

Choose this way for high-quality effervescent tablet packaging

 A high-quality packaging is of great significance to the safety and stability of medicines during storage. Vitamin effervescent tablets are common nutritional supplements in our lives. Its dosage form is thick and large. So how should we choose high-quality effervescent tablet packaging? ? There are 4 points to note:

effervescent tablet packaging

caps for effervescent tube

1. Packaging materials: Packaging materials are the first thing we need to consider, as they are related to the overall quality of effervescent tablet packaging. Generally, the tube is made of polypropylene and the lid is made of low-density polyethylene. The combination of the harder polypropylene and the soft low-density polyethylene can achieve better sealing and provide more stable protection for the effervescent tablets. When choosing, we must consider whether the material manufacturer and the pharmaceutical packaging material company have a good material management system to ensure that packaging materials are well stored.

2. Special design: Different from ordinary plastic bottles, effervescent tubes are packaged in straight barrels. The diameter of the bottle is generally slightly larger than the diameter of the effervescent tablets. There is a desiccant bin on the top of the cap, which can store desiccant and maintain the inside. environmental stability. Due to the large dosage form, in order to prevent damage during transportation, there will be a soft coil spring on the cap, which can compress the tablet and protect the integrity of the tablet. Of course, there are also caps without springs. . Here we need to consider the special design of the cover based on the actual situation, including the type and amount of desiccant.

144mm*29mm effervescent tube packaging

3. Specification selection: There are many specifications for effervescent tablet packaging, the common ones are 84mm/96mm/99mm/133mm/144mm, etc. The size here is calculated based on the height of the tube. When selecting specifications, we need to choose the packaging of corresponding specifications according to the diameter and thickness of the film. If there are special needs, we can also make exclusive customizations.

4. Manufacturer strength: The above is considered from the perspective of products. On the other hand, we must also start from the strength of pharmaceutical packaging material manufacturers and comprehensively consider factors such as production scale, equipment, quality management, and services. These are related to Whether the product can be delivered on schedule, product quality control, etc.

How to choose the packaging of high-quality effervescent tablets? It can be easily done by examining factors such as packaging materials, special design, specification selection, and manufacturer’s strength. Have you learned it?

Multi-dose Syringe Drug Delivery

 Horse oral paste in the form of a syringe is a commonly used package for horse medicine at home and abroad. It is mainly used in some nutritional ointments, anthelmintics and other medicines. Horses are larger in size, and medicines in this type of packaging are more convenient for administration. So, how to administer medication with a multi-dose syringe?

multi dose syringe

30ml dial a dose syringe

The syringe consists of a tube sleeve, a push rod, a piston, a positioning ring, and a protective cap. It has the characteristics of convenient administration, no residue, and reduced pollution.

The dosage of equine oral paste drugs is generally determined based on body weight. First, before starting administration, the weight of the animal should be as accurately known as possible, the actual dosage should be calculated, and the positioning ring should be set to the scale corresponding to the dosage. , to ensure the accuracy of medication. Remove the protective cap of the syringe, insert the tip end into the horse's mouth in the interdental area, push the push rod, and apply the paste on the base of the tongue. After administration, immediately raise the horse's head for a few seconds to ensure that it has swallowed the medicine. 

It should be noted that the same syringe can be applied to two different animals only when the two horses are in the same space and in direct contact, otherwise cross-infection may easily occur. Oral pastes are generally intended for horses over 4 weeks of age and are not suitable for horses that are too young.

The correct method of drug administration is the key to ensuring the therapeutic effect. The various advantages of multi-dose syringe make the dosage of large animals such as horses and cattle more precise and the process more convenient. It is a new type of packaging recognized by the market.

Application of effervescent tube - electrolyte effervescent tablets

 Electrolyte effervescent tablets are a convenient, quick solution for replenishing fluids and electrolytes, especially suitable for people with busy lifestyles and those who need a quick recovery. The effervescent tube plays a vital role in electrolyte effervescent tablets. Its design and function allow users to conveniently replenish the required water and electrolytes at any time and anywhere.

144mm*29mm effervescent tube packaging

caps for effervescent tube

First of all, the portability of effervescent tubes is one of its very big advantages. Thanks to its compact, lightweight design, users can easily slip it into their pocket or bag and take it with them at any time. This allows users to conveniently replenish water and electrolytes during outdoor activities, sports competitions or travel, ensuring that the body maintains adequate levels and electrolyte balance.

Secondly, the effervescent tube has a built-in desiccant, and the material is made of raw materials with very good barrier properties and has good moisture-proof performance. This means that even in humid environments, the effervescent electrolyte tablets maintain their quality and effectiveness, ensuring users get optimal rehydration when they need it.

In addition, the effervescent tube adopts a coil spring design to compress the tablets and prevent the medicine from being damaged during transportation. This design ensures that every effervescent tablet received by users is intact, thereby ensuring product quality and reliability.

Therefore, the effervescent tube plays a key role in electrolyte effervescent tablets. Its portability, moisture-proof performance and drug protection function allow users to obtain the required water and electrolyte supplements anytime and anywhere, providing convenience and guarantee for health and vitality.

How to ensure the sealing of veterinary vaccine bottles

The prevention and control of animal diseases is of great significance to the breeding industry and food safety. At present, the main way to prevent and control diseases is still to inject vaccines in advance. The sealing of vaccine bottles is crucial to ensuring the safety and effectiveness of the vaccine. The key factors affecting the sealing have a lot to do with the bottle cap and its butyl rubber stopper.

100ml transparent PP vial

A vaccine bottle is a container used to store vaccines. Its sealing performance is directly related to the bottle cap. The connection between the bottle thread and the bottle cap is the most likely location for leakage, and it is also the focus of the bottle cap sealing performance testing. Therefore, the bottle cap The sealing performance can basically reflect the sealing performance of the vaccine bottle.

plastic vaccine vial

The sealing performance is generally tested by the following method: take 20 samples, put an appropriate amount of glass beads into the bottles, tighten the caps, and seal them with a capping device. The bottle mouth and caps should match appropriately. Place it in a container with an air extraction device, immerse it in water, and vacuum it until the vacuum degree is 27kpa. Maintain it for two minutes. There should be no water intrusion or bubbling in the bottle.

On the other hand, the sealing performance of vaccine bottles is closely related to the quality of butyl rubber stoppers. Butyl rubber stoppers have very good performance in terms of cleanliness, chemical stability, air tightness, etc., and are widely used in the pharmaceutical industry. Due to direct contact with drugs, the country has issued many relevant standards to control the product quality of butyl rubber stoppers.

The regulations regarding the tightness between the rubber stopper and the device body are as follows: Take 10 samples and preprocess them according to the method specified in the pharmaceutical packaging material standard. Put the pretreated experimental sample into a container with an air extraction device containing 10% methylene blue solution, evacuate to a vacuum degree of 25kPa, maintain it for 30 minutes, return the vacuum device to normal pressure, spin for another 20 minutes, take it out, and use water Rinse the outer wall of the bottle and observe that the methylene blue solution must not penetrate into the bottle.

Bottle caps and rubber stoppers are two important factors that affect the sealing of vaccine bottles. When selecting vaccine bottles, pharmaceutical companies must fully consider the importance of packaging to medicines and ensure the quality of vaccine bottles.

Child resistant caps for oral dosage forms

 In the home medicine cabinet, safe storage of medications is crucial to prevent children from ingesting them. Because of their curiosity and desire to explore, children often try to open a variety of containers, including pharmaceutical packaging. In order to reduce this risk, many oral preparations adopt an inner and outer double-layer structure design, which increases the difficulty of opening, thereby effectively protecting children from accidental ingestion of drugs.

 

28mm child resistant  cap for liquid medicine

Solid dosage forms, such as tablets and capsules, often attract the attention of children because of their variety of shapes and colors. Children may mistake these medicines for toys or candy and try to open and ingest them. In this case, the role of child proof caps for oral dosage forms is particularly important. It makes it more difficult for children to open medicine packaging, thereby reducing the likelihood of accidental ingestion. On the other hand, liquid preparations such as oral solutions and syrups usually taste sweeter and are more likely to be mistaken for drinks by children. If the packaging of this type of medicine does not have child-proof functions, it will greatly increase the risk of children accidentally ingesting it.

Child-resistant closures are suitable not only for solid dosage forms but also for liquid dosage forms, demonstrating their wide range of applications. At the same time, it is also compatible with packaging made of two different materials, glass bottles and plastic bottles, providing more choices for pharmaceutical manufacturers and consumers.

Overall, child resistant caps for oral dosage forms are a simple and effective solution that reduce the risk of children ingesting medications by making it more difficult to open pharmaceutical bottle caps. When choosing pharmaceutical packaging, we should pay attention to whether it has this safety function, so as to provide a safer growing environment for our children.

High-density polyethylene bottles with moisture-proof function

 During the production, packaging and transportation of pharmaceuticals, maintaining drug quality and stability is crucial. Solid pharmaceutical desiccant, as an important component of HDPE moisture-proof bottles, plays a key role. It is not only a simple additive, but also an important guarantee for maintaining the stability of medicines during storage and preventing moisture, mildew and other adverse situations from occurring.

50ml pharma desiccant bottle

1. Key guarantees for internal moisture-proofing:

When medicines become damp, their chemical composition will often change, affecting their efficacy or even making them ineffective. Therefore, internal moisture-proofing is the key to ensuring drug quality. Solid pharmaceutical desiccant effectively reduces the humidity in pharmaceutical containers by absorbing moisture in the air and prevents pharmaceuticals from getting damp. This internal moisture-proof function enables the medicine to maintain its original quality and stability during storage and use, ensuring the effectiveness of the medicine.

2. Maintain drug stability:

Many drugs are very sensitive to humidity and moisture. Excessive humidity may cause degradation, deterioration or even failure of the drug. Solid pharmaceutical desiccant can effectively control the humidity in pharmaceutical moisture-proof bottles and provide a dry environment for drugs, thereby extending the stability and shelf life of drugs. This is particularly important for pharmaceuticals that require long-term storage, especially in hot and humid climates, where solid pharmaceutical desiccants are indispensable.

3. Prevent mildew and other undesirable conditions:

In addition to the degradation and failure of drugs due to moisture, humidity may also provide a suitable environment for the growth of mold and bacteria, leading to mold and other undesirable conditions in drugs. The function of solid medicinal desiccant is to reduce the humidity in medicinal moisture-proof bottles, effectively prevent the growth of mold and bacteria, thereby ensuring the purity and safety of medicines.

desiccant bottle with silica gel

As an important component of HDPE moisture-proof bottles, solid pharmaceutical desiccant plays an important role in the storage and use of pharmaceuticals.

AAV ophthalmic gene drug packaging-COP

 In 2017, the world's first ophthalmic gene therapy, Luxturna, was approved for marketing in the United States, setting off a craze for ophthalmic gene therapy, and major companies have begun to make plans. According to incomplete statistics, there are nearly 30 pharmaceutical companies in China deploying AAV ophthalmic gene therapy, and the intensity is evident. So, as a special drug, what are its packaging requirements?

RTU(ready to use) 2ml COP vial

Polymer Vial for cell and gene therapies

1. Packaging materials: Packaging materials for AAV gene therapy drugs should have a high degree of biocompatibility and chemical stability. For example, cyclic olefin polymer COP has good drug solubility resistance and protective properties, and can ensure long-term stability even for drugs with a pH value greater than 10.

2. Temperature resistance: AAV gene therapy drugs need to withstand certain temperature conditions during the packaging process, including preparation, sterilization and storage. Therefore, packaging materials must have high temperature resistance and be able to maintain stability at appropriate temperatures and not be affected by thermal decomposition or chemical changes. COP vials can withstand environments ranging from -196°C to 121°C and are excellent in temperature resistance.

3. Oxygen and humidity barrier properties: AAV gene therapy drugs are highly sensitive to oxygen and humidity, so packaging materials need to have good barrier properties to avoid the penetration of oxygen and humidity. COP raw materials have very high barrier properties and are ideal materials for high-end pharmaceutical packaging.

4. Sealing: Packaging containers need to have good sealing performance to effectively prevent drug leakage or the intrusion of external contamination. CZ vials with rubber stopper aluminum caps can achieve good sealing of packaging and create a stable storage environment for drugs.

In addition to the above requirements, the packaging of AAV ophthalmic gene drugs also needs to comply with the regulations and requirements of relevant regulatory agencies (such as drug regulatory agencies). These regulations include labeling and package insert requirements, batch tracking, and quality control to ensure the safety and effectiveness of gene therapy drugs. The Chinese CDE registration number of Xinfuda COP bottles has been activated and has been registered through the US DMF, which can help your drugs go on the market faster.