Quality standard for aluminum caps of veterinary vaccine bottles

 The quality of the vaccine bottle is related to whether the veterinary vaccine can be effectively stored, and will also affect the effect of animal immunity in the later stage, which is of great significance to the sustainable and healthy development of animal husbandry. Factors that affect the quality of vaccine bottles include bottle sealing, drop resistance, sterility, etc. In addition, the quality of bottle caps is also one of the important factors affecting their quality.

100ml PP vaccine vial

250ml PE plastic vaccine bottle

Vaccine bottle caps generally use rubber stoppers and aluminum caps. In YBB00082005-2015 "Aluminum Caps for Injection Bottles", the quality standards for aluminum caps are specified in detail:

[Appearance] Take an appropriate amount of this product, place it in a place with bright natural light, and observe visually, it should be clean without residual lubricant, burr, or damage.

[Mechanical properties of aluminum parts] The tensile strength of the material should be 130-180N/mm, and the elongation should not be less than 2%.

[Convexity] Take an appropriate amount of this product, measure with a vernier caliper, accurate to 0.1mm, and the convexity should not exceed 3%.

[Opening force] B (two-bridge), C (three-bridge) type aluminum cover opening force: 25N<B type tear sheet<60N, 46N<C type tear sheet<76N; D (tear-off type) aluminum cover Tear force: 30N<bridge breaking force<50N; 5N<full opening force<25N.

[Thickness] The thickness should be determined within a given range through negotiation between the supplier and the buyer, and the thickness and tolerance should not exceed ±0.022mm.

[Sterilization resistance] Take an appropriate amount of this product, rinse it with water, and bake it in an oven at 180°C for 1 hour, there should be no obvious change on the surface, and there should be no bulge and detachment on the surface layer.

[Compatibility] Take an appropriate amount of this product after baking in an oven at 180°C for 1 hour, cover it on a suitable bottle with a nominal capacity of water (with a rubber stopper), and seal it with a capping device. Fracture and abnormal deformation.

[Coating firmness] Take an appropriate amount of this product (suitable for coated aluminum covers on the outer surface), bake in an oven at 180°C for 1 hour, and then wipe the surface with absorbent cotton soaked in 80% (V/V) ethanol solution for 30 Seconds, and then wipe the surface with absorbent cotton soaked in 70% (V/V) isopropanol solution for 30 seconds, the coating should be free of any abrasion.

Animal diseases have always been a major factor restricting the development of my country's animal husbandry. To do a good job in the prevention and control of animal diseases, reduce the incidence of infectious diseases, and promote the healthy development of my country's animal husbandry requires the joint efforts of every vaccine manufacturer and vaccine bottle supplier.

Different functions of medicinal bottle caps

 Pharmaceutical bottle caps are an important part of plastic bottles and play a vital role in the overall airtightness of packaging. With the continuous change of market demand, the functionality of the cap also presents a diversified development trend.

 

28mm child resistant  cap for liquid medicine

Desiccant cap: a bottle cap with moisture-proof function. It uses the space on the top of the cap to design a small medicine compartment to store desiccant to achieve moisture-proof effect. This design reduces the direct contact between the drug and the desiccant, and is suitable for tablet packaging of larger dosage forms, such as effervescent tablets, and can also be used for test strip packaging. There is also a cover that adds a coil spring on this basis to compress the tablet.

effervescent tube cap

Child Resistant Cap: a safety cap with a childproof function. It adopts an inner and outer double-layer structure design, and the interior is connected by a card slot. If the lid is opened, the outer layer cap needs to be pressed down, and the inner layer cap is driven to rotate at the same time. Such an opening method involves applying force in two directions, which can improve the safety of the bottle and prevent children from opening the package at will and accidentally eating the medicine. For solid packaging and liquid preparation packaging, the lids are slightly different in design, but there is no difference in function.

Moisture-proof cap with CRC: On the basis of press-spin, the moisture-proof function is added. The small drug compartment on the top of the medicinal bottle cap is used to store the desiccant to avoid direct contact between the drug and the desiccant. It is suitable for tablets, capsules and other drugs that require moisture-proof storage.

desiccant cap

The above are the different functions and applications of medicinal bottle caps. As a provider of overall functional packaging solutions, Xinfuda supplies various types of pharmaceutical bottle caps. For special needs, we can also provide exclusive customized services to meet your diverse needs.

Application of medicinal bottle cap in cough syrup medicine

 As an important part of medicinal plastic bottles, the medicinal bottle cap plays an important role in ensuring the stability of the drug. As people's attention to children's safety increases, plastic cap is not only used in solid drug packaging, but also in oral liquid drugs such as cough syrup.

 

28mm child resistant  cap for liquid medicine

Cough syrup is mainly used for relieving cough and reducing phlegm. It is suitable for colds, coughs, phlegm, bronchial asthma and other diseases. It is a prescription drug. In the selection of cough syrup, it is easy for children to accept cough syrup because of its sweet taste. It is precisely for this reason that children mistake medicines for beverages, and incidents of accidental ingestion of medicines emerge in endlessly, endangering children's safety.

desiccant cap

Medicinal l bottle cap is a cap with a special structure, which is composed of an inner and outer double-layer structure. The packaging cannot be opened only by rotating the outer cap. It must be rotated while pressing down the outer cap to open. Such an opening method is difficult for children, so that children can be prevented from opening the package arbitrarily, and accidents of eating medicines by mistake can be avoided.

child resistant cap

In fact, the United States, Australia and other countries have already enacted legislation to force the use of this kind of packaging for toxic drugs, which is also to better protect the safety of children. In China, many pharmaceutical companies have already adopted this kind of packaging. In short, this form of cover will be a big trend in the future.

Pay attention to these points when using veterinary vaccine bottles

 Veterinary vaccine bottles play a very important role in the transportation and storage of animal vaccines. They are mostly made of high-density polyethylene or polypropylene raw materials through different processes. So, what problems should be paid attention to during the use of this kind of packaging?

100ml PP vaccine vial

250ml PE plastic vaccine bottle

1. First of all, veterinary vaccine bottles before they are put into use should be stored in a cool, ventilated, and dry place, with no harmful or corrosive items around them.

2. Before the vaccine is immunized, first observe whether the veterinary vaccine bottle is completely sealed. If there is leakage, vaccine demulsification and delamination, it means that the vaccine has deteriorated or is contaminated, and it is forbidden to use it.

3. Before using the vaccine, check the instruction manual inside the box (box), and check the bottles one by one. The bottles are intact and tightly sealed. The name, batch number, production date, expiration date, specifications, etc. should be clearly marked on the bottle label.

4. The inactivated seedlings should be shaken well before use, and shake again before sucking the seedlings each time. the

5. Strictly follow the recommended dosage in the instruction manual. The vaccination dosage should be accurate, do not overdose, and do not reduce the dosage without authorization.

6. Registration should be done when using the vaccine, including the name of the vaccine, batch number, place of injection, date and number of livestock (poultry), etc.

After the vaccine immunization is completed, the discarded veterinary vaccine bottles should not be thrown away. They should be collected for pollution-free treatment to avoid secondary pollution of the farm.

The innovative design of oral liquid bottle cap

 The cap is an important part of the medicinal plastic bottle, which mainly plays the role of sealing. With the continuous changes in market demand, the functionality of the cap is also more diversified. For example, the oral liquid bottle cap adopts an innovative design on the basis of airtightness, so that it has the function of preventing children from opening, reducing the risk of children ingesting medicines by mistake.

 

28mm child resistant  cap for liquid medicine

Oral liquid is a sterile or semi-sterile oral liquid, which is based on traditional Chinese medicine decoction, extracts the active ingredients in the drug, adds flavoring agents, bacteriostatic agents and other additives, and is processed by filling and sealing injection ampoules. Liquid preparations. The pharmaceutical packaging is generally dominated by plastic bottles or glass bottles, and the lids are mostly ordinary plastic bottle caps. In order to improve the sealing performance, aluminum foil gaskets are used to seal.

Oral liquid tastes better and is easily accepted by patients, especially children. However, children are in the growth and development period and are full of curiosity about many things. It is easy to mistake the oral liquid for a drink, resulting in accidental ingestion. The press-and-screw oral liquid bottle cap adopts an inner and outer double-layer structure. It cannot be opened only by rotating the cap. It must be rotated while pressing down to open. Such an opening method involves the simultaneous application of force in two different directions, which is difficult for children, which can prevent them from easily opening the package in a short period of time and avoid accidental ingestion of medicines.

Rotational medicine caps are not only used in the packaging of liquid preparations, but are also widely used in solid pharmaceutical plastic bottles such as tablets and capsules. The functionality of the lid is well used.

How to Protect Child Resistant Bottles from Moisture

 As people pay more and more attention to the incidents of children accidentally ingesting medicines, child-proof medicine bottles are applied to more and more medicines to better protect children's safety. Among all pharmaceutical dosage forms, solid drugs have relatively high requirements for moisture-proof performance, so how can this kind of packaging be moisture-proof?

50ml pharma desiccant bottle

The child-resistant bottle adopts a special double-layer structure design, which is opened by pressing down and rotating. The moisture-proof function of the packaging is to prevent the intrusion of external water vapor on the one hand, and to maintain the stability of the internal environment of the bottle on the other hand. The bottle body of this kind of packaging is generally made of polyethylene or polypropylene material. These materials themselves have very good barrier properties. As packaging materials, they can block the invasion of external water vapor and impurities.

desiccant cap

effervescent tube cap

Of course, in addition to preventing the entry of external water vapor, the drug itself will also contain some water molecules during the production process, so it is also necessary to maintain the stability of the internal environment. A desiccant bag will be placed inside the package to absorb moisture. There are also some manufacturers who have made special designs, using the small medicine compartment on the top of the cover to store the desiccant. This kind of cover integrates the functions of moisture-proof and child-proof, and the overall appearance is more beautiful.

The moisture-proof function of the child-proof bottle is very important for solid medicines. It is related to whether your medicines can be well stored within the validity period without deterioration or failure.

Characteristics of inactivated vaccines and selection of vaccine bottles

 Animal vaccines are the basis for ensuring the healthy development of animal husbandry and play an important role in preventing the occurrence of various animal diseases. Inactivated vaccine is a common type of animal vaccine, so what are its characteristics, and how should its veterinary vaccine bottle be selected?

100ml PP vaccine vial

250ml PE plastic vaccine bottle

Inactivated vaccines, also known as dead vaccines, are vaccines made by treating microorganisms with physical or chemical methods to lose infectivity or toxicity while maintaining good immunogenicity. The advantage of this type of vaccine is that it is safe, does not return to the ancestors, does not return to strength, is convenient for storage and transportation, is not sensitive to the interference of maternal antibodies, and is easy to make combined vaccines and multivalent vaccines.

Inactivated vaccines are generally required to be stored at 2-8°C and can be stored in a refrigerator. Since this type of vaccine does not require high temperature and high pressure sterilization, polyethylene or polypropylene veterinary vaccine bottles are often used in packaging. Both materials have good corrosion resistance and can withstand the corrosion of most acid and alkali solvents. In addition, in order to facilitate the transportation of vaccines, their packaging containers must also be light in weight and not fragile, so as to avoid damage to the packaging due to external forces during transportation and affect the safety of vaccines.

Veterinary vaccine bottles play an important role in the transportation and storage of vaccines. Xinfuda has been engaged in pharmaceutical packaging for more than 20 years and specializes in the production of various pharmaceutical plastic bottles. Welcome to discuss cooperation.

What is COP

 COP is a plastic raw material named cyclo olefin polymer, developed and produced by Zeon Corporation of Japan, used for medical optical components and high-end pharmaceutical packaging materials, its raw material characteristics: high transparency, low birefringence, low water absorption, high rigidity, high heat resistance, water Good steam tightness, in line with FDA standards.

RTU(ready to use) 2ml COP vial

5ml COP vial

100ml COP injection vial

(1) The density is small, about 10% lower than PMMA (polymethyl methacrylate) and PC (polycarbonate), which is conducive to the lightweight of products;

(2) The saturated water absorption rate is small, and the water absorption rate of COC is much lower than that of PMMA, and there will be no effect of physical property degradation caused by water absorption, and almost no water absorption;

(3) Because it contains monomers with small polarity and anisotropy, it is an amorphous transparent material with small birefringence;

(4) It is a high heat-resistant transparent resin with a glass transition temperature of 140~170°C, and the glass transition temperature is an index of heat resistance of amorphous polymers;

(5) Easy injection molding;

(6) Excellent mechanical properties, higher tensile strength and elastic modulus than PC;

(7) Excellent replicability, so the product quality is high;

(8) Low dielectric constant, especially good high-frequency performance, is the material with the best dielectric properties in thermoplastics;

(9) Good scratch resistance, COC pencil hardness is similar to PMMA, scratch resistance is an important performance index of optical materials;

(10) The side chain of COC molecules has polar groups, which has good adhesion to inorganic and organic materials and is easy to seal;

(11) COP green plastic, with very little impurity content, so there is no need to worry about analyzing impurities, which is suitable for the requirements of semiconductors and medical devices;

(12) COP has excellent chemical resistance, acid resistance and alkali resistance;

(13) COP is almost impermeable to water vapor, which meets the requirements of applications that also require moisture protection.

Precautions for using pet ear drops bottle

 Pet ear drops are a standing drug for every pet family. It is mainly used to inhibit bacteria and remove mites, remove oil and deodorize, and protect the ear health of dogs and cats. Pet ear drops bottle is a special packaging for this kind of medicine. Pets are naturally active, so what should we pay attention to when administering medicine?

ear drop bottle

The pet's ear canal is "L"-shaped, and most of them are covered with rich ear hair, which is easy to accumulate grease and dust. The ear canal secretions adhere to the corner of the external auditory canal, which will breed bacteria, insects and mites, and need to be cleaned in time. Before using the pet ear drops bottle to give medicine to pets, we must first prepare cotton swabs or cotton balls, and then stabilize the dog's body, especially the head, don't let it move around, and erect the pet's ears. Drop the ear fluid into the ear canal, or dip a cotton swab into the ear fluid, and then slowly soak the ear canal.

Single Dose Applicators

After the ear liquid is dripped, stabilize the pet's ears, and at the same time massage its ears for about 1 minute, so that the ear liquid can fully integrate into the ear canal and moisturize the earwax. Then stabilize the riding pet's head, take a clean cotton swab, and help the dog clean up the dirt in the ear canal. It should be noted that after the massage, try not to let the pet dog shake its head or ears freely, which will shake the earwax in the ear canal everywhere.

In addition, we should also pay attention to the lid of the pet ear drop bottle should be tightly closed after the administration, and the remaining medicine should be stored in a ventilated and dry place.

The importance of desiccant in effervescent tubes

 Effervescent tablet is a kind of health care medicine containing disintegrant. Due to its special material, if the moisture-proof and moisture-absorbing function in the tube is not perfect, the effervescent tablet will be easily affected by moisture and deteriorate. Xinfuda is the production of effervescent tube The manufacturer will share with you the important role played by the desiccant in the effervescent tube:

silica gel desiccant in the caps

84mm effervescent tablet tube with sprial cap

There is a separate small medicine compartment on the cap of the effervescent tube, in which is a desiccant mainly composed of an equal proportion mixture of silica gel and molecular sieve. Among them, silica gel is a highly active adsorption material, and its interior is composed of many extremely small pores, which can absorb water and absorb it, and achieve the purpose of absorbing a large amount of water vapor. Molecular sieve is a synthetic desiccant. Molecular sieve can maintain moisture absorption function in high temperature environment and absorb a large amount of water vapor in the environment in low humidity environment.

The effervescent tube manufacturer has discovered the characteristics of these two materials, and after a certain proportion of adjustments, it can quickly absorb moisture while absorbing a large amount of water vapor, so as to ensure that the tablets in the effervescent tube will not deteriorate due to moisture.

The principle of nasal spray medicine

 With the continuous diversification of drug types, drug delivery methods are also constantly innovating to meet the different needs of the market. Among them, nasal spray administration is a new type of drug delivery method. Do you know the principle of nasal spray medicine? What are the characteristics of the Intranasal Atomization Device?

Disposable Intranasal Atomization Device

Let's take the new crown vaccine as an example. The nasal spray vaccine is vaccinated in the form of nasal spray. It converts the drug into mist particles through the nasal spray device and acts on the whole body through the nasal mucosa. In this way, the first-pass effect during oral administration is omitted, and the onset of action is faster. It effectively simulates the path of the new coronavirus entering and infecting the body, forms the first immune barrier in the respiratory tract to prevent the invasion of the new coronavirus, and enhances the immunity of the nasal mucosa, thereby exerting a broad-spectrum protective effect, and is expected to resist the new coronavirus beyond the first line of defense of the body.

Medical device registration certificate

The vaccination of nasal spray vaccine needs to be realized with the help of a special device - a one-time use Intranasal Atomization Device, which can atomize liquid medicine into particles of different particle sizes, and achieve the purpose of administration through the absorption of nasal mucosa. This device has the characteristics of fast drug absorption, painless, precise drug delivery, and safety.

On the whole, Intranasal Atomization Device is a safe and new way of administration, especially for the elderly and children, it can avoid the pain of injection administration and has strong compliance. As a special tool for nasal spray drug delivery, the Intranasal Atomization Device will help popularize this drug delivery method.

What is the function of the positioning ring of the plastic syringe

 Among all kinds of veterinary packaging, plastic syringes are very common, such as cow uterine infusion drugs, pet nutrition cream, and horse or calf oral paste. Careful, have you noticed that there is a circular positioning ring on its push rod, do you know its function?

5ml syringe for cow mastitis

30ml dial a dose syringe

pet syringe

The corresponding doses should also be followed for animal medicines. Excessive doses can easily cause overreactions, and insufficient doses can make it difficult to exert the efficacy and fail to achieve the corresponding therapeutic effect. The positioning ring of the veterinary syringe is mainly used to control the dosage of the drug.

There is a standard scale printed on the push rod. Before giving medicine to animals, we first calculate the corresponding dose, slide the positioning ring to the corresponding scale, and then push the push rod. When the push rod reaches the positioning ring, stop pushing, thus achieving Precise control of drug dosage.

The above is the main function of the positioning ring of the plastic veterinary syringe, do you understand it? Xinfuda has been engaged in pharmaceutical packaging for 20 years and supplies all kinds of veterinary packaging. Welcome to discuss cooperation.

Ideal packaging for biologics-Ready-to-use RTU (RTU) COP vials

 With the rapid development of biopharmaceuticals, it is possible to cure more and more diseases. However, biological drugs are more complex than traditional small molecule drugs, especially products such as monoclonal antibodies, cell and gene therapy. In addition to dealing with various risks in the drug development process, a high-quality, efficient Packaging is particularly important for the safe storage of drugs and the overall control of development costs.

2ml,5ml ,100ml COP vial

RTU means that the COP vials produced in a specific environment (ISO Class 8+ISO Class 5) are placed in trays or nests for sealing and packaging in bags to control the microbial load and insoluble particles of the COP vials, and then irradiated After sterilization, it can reach 10-6 sterility assurance level. In this way, after the company receives the package, it does not need to perform complex procedures such as cleaning and sterilization, and can directly fill it, saving investment in cleaning and sterilization equipment and reducing the total cost.

COP packaging

In recent years, cell-based drugs have become the research and development direction of many pharmaceutical companies. Such drugs generally need to be stored in a liquid nitrogen environment, which puts forward higher requirements for the low-temperature resistance of the packaging. COP vials are stable in the environment of -196°C-+121°C, meeting the low-temperature storage requirements of cell-based drugs.

COP vials are widely used in biopharmaceuticals. Most of these drugs contain protein components. If a glass bottle is used, a certain amount of drug will be absorbed and the usage rate of the drug will be reduced. The COP west bottle uses cycloolefin polymer as raw material. The low surface energy and hydrophobicity of the material endow the packaging with low protein adsorption characteristics, which solves this problem well.