Analysis of Factors Affecting the Sealability of Vaccine Bottles

 Plastic vaccine bottles are a common type of veterinary packaging. With the promotion of the national compulsory immunization program, the quality of packaging has also received more attention. The tightness of the bottle is an important criterion for measuring the quality of packaging.

plastic injection vial

There are many types of animal vaccines, including inactivated vaccines, attenuated vaccines, subunit vaccines, metabolite vaccines, etc. Different vaccines have different requirements for the storage environment, but the same is that these vaccines need to be stored in the vaccine bottle, and can Whether to maintain a good immune effect during the validity period is directly related to the tightness of the bottle. If the bottle's tightness is not good, liquid leakage will occur, which will affect the quality of the vaccine. Therefore, tightness is an important test item for veterinary packaging.
Generally, the factors that affect the tightness of the vaccine bottle mainly include the accuracy of the bottle mouth size and the bottle cap. The inaccurate diameter of the bottle mouth will cause the bottle cap to be tightly sealed and prone to liquid leakage. Whether the quality of the bottle cap is satisfactory and whether the barrier performance meets the standard requirements will also affect the overall tightness of the bottle. Pharmaceutical packaging manufacturers need to strictly control all production processes in order to produce high-quality packaging.
Reasonable and effective immunization of animals is an effective means to prevent the occurrence of epidemics, and it is also the basis for promoting the healthy development of animal husbandry. The main factors affecting the tightness of the vaccine bottle are the size of the bottle mouth and the bottle cap. Only high-quality packaging can ensure a good immune effect.

Choose a tablet medicine bottle to master these four principles

 The tablet medicine bottle is mainly used for the packaging of solid medicines such as sustained-release tablets and dispersible tablets. There are various styles and shapes according to the material of the bottle and the different packaging requirements of the medicine. Appropriate packaging can ensure a good storage state of the drug and ensure the stability of the drug effect within the validity period. How to choose the right packaging for tablets?

Child proof bottle

At present, the tablet and medicine bottles on the market are mainly made of plastic materials such as polyethylene, polypropylene, polyester, etc. The following four aspects can be considered when choosing:

1. Production materials

The raw materials of pharmaceutical packaging must meet the requirements of non-toxic and odor-free. There are many types of raw materials available on the market, which requires evaluation of the comprehensive performance of the raw materials. Generally, high-density polyethylene and polypropylene raw materials are selected for tablets. You can choose PET raw materials if the transparency of the bottle is required.

effervescent tablet tube

2. Tightness and permeability

Tightness and water vapor permeability are two important technical indicators of pharmaceutical plastic bottles such as tablet medicine bottles, which play a vital role in the stability of the drug inside.

3. Stability and compatibility

For the selection of packaging for tablets, especially for new drugs, a loading test should be carried out first to examine the stability of the loading and the compatibility between the packaging and the drug. The mutual penetration, dissolution, adsorption, chemical reaction, and denaturation of drugs and packaging materials must be determined through scientific testing.

4. Product quality standards

From the manufacturer’s product quality standards, the pros and cons of product quality can be analyzed and judged, and the comprehensive strength of the manufacturer can also be reflected from the side.

The choice of tablet medicine bottle can be comprehensively considered from the above four aspects, and the above principles are also applicable to the choice of other pharmaceutical packaging.

plastic bottle injection supplier _Xinfuda

Plastic injection vial empaty vaccien bottle_Xinfuda

Application of COP vial in recombinant protein drugs

Recombinant protein drugs are products expressed by genetic engineering technology to make up for the lack of certain functional proteins in the human body. These drugs have high protein content and are mostly packaged in glass bottles. However, glass has protein adsorption properties. How to improve the accuracy of the dosage of these drugs has become a problem that pharmaceutical companies need to consider. The emergence of plastic COP vials makes this The problem is solved.

COP vial

With the advancement of drug production technology and the increase in drug demand, the types of recombinant protein drugs in China continue to be enriched. At present, China's recombinant protein drugs mainly include: recombinant insulin, recombinant interferon, recombinant blood coagulation factor, recombinant erythropoietin, recombinant granulocyte colony Stimulating factors, enzymes instead of recombinant protein drugs, recombinant growth hormones, etc. Among them, recombinant insulin occupies an important position in China's recombinant protein drug market. Subdivided products such as recombinant interferon and recombinant erythropoietin have great development potential, especially long-acting drugs.

COP vilal is a new type of drug packaging. This material has the characteristics of low protein adsorption, high transparency, high rigidity, and good water vapor airtightness, and it meets FDA standards. Although the cost of the COP bottle is relatively higher than that of the glass bottle, the glass bottle will absorb a part of the drug, which means that the pharmaceutical company must fill more doses to ensure the accuracy of the patient's dosage. Recombinant protein drugs are high value-added drugs, and the extra dose has far exceeded the investment of pharmaceutical companies in packaging. Therefore, no matter from the characteristics of the drug or the overall cost, the COP vial is the best choice for protein drugs.

In foreign countries, the application of COP vial in the packaging of anti-cancer drugs and anti-tumor drugs has been very mature. With the acceleration of the development of innovative drugs in my country, this kind of packaging will also be more commonly used in China.

What is an eye drop bottle

 With the development of technology, electronic products such as computers, mobile phones, and tablets have gradually become necessities of people's lives, and eye health problems caused by excessive eye use have become more prominent. Among all eye treatment drugs, eye drops are commonly used, and they are placed in special eye drops bottles.

5ml eye drop bottle

The eye drop bottle is a special pharmaceutical packaging container, mainly used for the packaging of eye drop drugs. This kind of packaging consists of a bottle cap, a nozzle, and a bottle body. The bottle body is made of low-density polyethylene raw materials through injection and blowing technology. The low-density polyethylene has good flexibility, extensibility, electrical insulation, transparency, and easy Processability and certain air permeability. It has good chemical stability, alkali resistance and general organic solvent resistance.

When administering the eye drop bottle, take the supine or sitting position, pull the lower eyelid with the thumb and index finger of the left hand, turn the eyeball upward, hold the bottle with the other hand, and squeeze it with the mouth of the bottle facing downwards Pinch 1 drop of the eye drops, then immediately pull the eyelids, and gently close the eyes, so that the eye drops spread to the entire conjunctival sac.

It should be noted during administration that the eye drop bottle should be kept at a safe distance of more than two centimeters from the eyelid. If the liquid is a suspension, it should be shaken well before use. Under normal circumstances, eye drops should be stored in a cool, dry, and ventilated place, avoid direct sunlight, the mouth of the bottle should be up, and the cap should be tightened to prevent the liquid from leaking.

Three inspection rules for veterinary syringes

The veterinary syringe is a special package for dairy cow mastitis drugs, pet nutrition cream, horse nutrition cream and other drugs. There are different standards for different veterinary packaging in the industry, but the inspection rules are the same, and they are divided into factory inspection and type. The three methods of inspection and supervision and inspection are applied to different scenarios.

paste syringe

Factory inspection means that each batch of veterinary syringes has been inspected by the manufacturer's quality inspection department and can be delivered only after the product qualification certificate is attached. The inspection items include the appearance quality, tightness, lubricity, ignition residue, and dissolution of the product. , Decolorization test, residual ethylene oxide, sterility, abnormal toxicity, etc.
Supervision and inspection are the activities of the national quality supervision agency to conduct sampling inspections of manufacturers in accordance with regulations.
Type inspection refers to the comprehensive assessment of product quality, that is, the inspection of all the technical requirements specified in the product standard. In general, new product filing, product re-production after major quality accidents, supervision and random inspection, and resumption of production after product shutdown are all subject to type inspection. It is required to carry out a type inspection at least once a year, and some special items such as ignition residues, leachables, and ethylene oxide residues shall be inspected at least once within six months.
Although the inspection requirements and time are different, these inspection rules are to better guarantee the product quality of veterinary syringes, ensure drug safety, and avoid packaging quality problems that affect animal health and treatment effects.

What is the eye drops container made of

 The eye drops container is composed of a cap, a dropper, and a bottle body, and is a common pharmaceutical packaging for ophthalmic drugs. The material of the packaging plays an important role in maintaining the efficacy of the medicine and protecting the safety during the transportation of the medicine. So, what material is the eye drop bottle made of?

eye drop bottles

Eye drops container is a kind of plastic bottle. Its raw material is mainly low-density polyethylene (LDPE). It is the lightest variety in polyethylene resin. It is milky white, tasteless, odorless, non-toxic, and has no surface. Glossy waxy particles. It has good flexibility, extensibility, electrical insulation, transparency, easy processing and certain air permeability. It has good chemical stability, alkali resistance and general organic solvent resistance. LDPE has been industrialized for more than 70 years. Although with the discovery and development of olefin polymerization catalysts, the variety and output of polyethylene have made great progress, LDPE still occupies an important position, and some pharmaceutical packaging, daily necessities packaging, etc. are used Here comes this raw material.

After adding organic solvent, LDPE is processed by injection blowing process. First, the injection machine injects the molten plastic into the injection mold to form a tube blank. The tube blank is formed on a hollow convex mold with micro holes on the peripheral wall; then it is moved to the blow mold while it is hot; then the mold is closed and passed through the pipe of the mandrel Enter the compressed air to inflate the parison and stick it to the cavity wall of the mold; finally, after holding the pressure, cooling and setting, the compressed air is released and the mold is opened to take out the plastic part.

The eye drops container made of LDPE material is soft, easy to squeeze, and can quickly return to its original shape after squeezing, without creases. Whether it is in terms of the characteristics of the material and the convenience of the patient It is a better raw material for production.

Multi-layer biofactory process and precautions

 The multi-layer biofactory is a well-designed cell culture system that makes full use of the maximum culture surface in a limited space, thereby saving space; it can be used for industrial-scale production such as vaccines, monoclonal antibodies or biopharmaceuticals, and is particularly suitable for Adherent cells can also be used in suspension culture. The specific operation process of the cell factory is as follows:

multi-layer biofactory

1. Unscrew the lid, and inject the culture medium into the multi-layer biofactory by tilting or pumping. The cell suspension slowly flows into each layer of the cell factory, and the lid is closed and it is still;

2. Slowly stand the multi-layer biofactory on its side, with the side with the liquid filling port facing away from you, and let it stand to make the cell suspension flow into each layer slowly and evenly;

3. Rotate 90 degrees laterally, keep the liquid inlet upward, and let it stand to make the cell suspension flow into each layer slowly and evenly;

4. Hold the side of the liquid inlet with both hands and slowly level it to avoid large shaking of the liquid;

5. Move to a suitable cell culture incubator for culture, make sure to move slowly and steadily, and don't let liquid flow into other layers;

6. After the cultivation, pour the culture medium into the collection container.

Precautions:

1. In order to ensure the uniform distribution of each layer of solution, try to keep it level when moving the multi-layer biofactory;

2. The platform shelf where the multi-layer biofactory is placed must be level to prevent the thickness of the cells on the same layer from being different;

3. When cleaning the cell factory, do not use rapid water flow, otherwise it will cause damage to the cell factory.

Material characteristics of animal serum bottle

Animal serum refers to the light yellow transparent liquid separated from the plasma after the fibrinogen and certain coagulation factors have been removed after blood coagulation or refers to the plasma from which the fibrinogen has been removed. Animal serum bottles that store serum are generally made of polyester (PET). What are the characteristics of this type of material?

PET media bottle

The storage temperature of serum is generally between -5°C and -20°C. The main function is to provide basic nutrients, provide hormones and various growth factors, provide binding proteins, provide contact promotion and growth factors to make cells adhere to the wall and prevent mechanical damage. Cells in culture play a certain protective role. The PET serum bottle has the following characteristics:

1. High transparency and good gloss;

2. Good mechanical properties, impact strength 3-5 times that of other films, and good folding resistance;

3. Resistant to oil, fat, dilute acid, dilute alkali, and most solvents;

4. Good heat aging resistance, the brittleness temperature is -70℃, and it still has a certain degree of toughness at -30℃; PET is not easy to burn, the flame is yellow, and the burning oil drips;

5. Non-toxic, tasteless, good hygiene and safety, and can be directly used for food packaging;

6. The permeability of gas and water vapor is low, and it has excellent gas, water, oil and peculiar smell performance.

The excellent characteristics of PET material fully meet the storage requirements of serum. This animal serum bottle can also be used for long-term storage of aqueous solutions, such as culture media, pancreatin, reagents, etc.

What are the types of caps for empty medicine bottles

The bottle cap is an important part of the bottle. Its function is mainly to isolate the external environment from the influence of the contents. On the other hand, it also plays a certain decorative role. Empty medicine bottle is a common packaging form of medicine packaging. Generally, the bottle cap has the following types:

desiccant cap

1. Ordinary caps: Generally, ordinary screw caps are selected for drugs that do not have special requirements for bottle caps. In order to ensure that the bottle has a good seal, this type of bottle cap will be sealed with aluminum foil gaskets, and its function is mainly to block The direct contact between the bottle mouth and the inside of the bottle cap prevents the bottle cap from being unable to completely block the external air.

2. Press and screw cap: This is a special bottle cap composed of an inner and outer double layer structure. When opening, it is necessary to screw down the cap while applying pressure. This opening method is suitable for children who are still in the developmental stage. It is said that it has a certain degree of difficulty, and it can avoid the accident of children ingesting drugs by mistake. Mainly used in some prescription drugs for lowering blood pressure, lowering blood sugar, and cardiovascular and cerebrovascular.

3. Moisture-proof cap: This is a new type of bottle cap that combines desiccant and bottle cap into one. Generally, the desiccant is placed inside the bottle in the form of a bag, while the moisture-proof cap takes advantage of the space on the top of the bottle cap. The desiccant is placed in the small medicine bin on the top of the bottle cap, which not only avoids direct contact between the medicine and the desiccant, but also prevents children from ingesting the desiccant by mistake. This kind of bottle cap is mainly used in tablet medicine bottles with higher dryness requirements and larger dosage forms, such as effervescent tablets and candy compression tablets.

The above are three types of caps for empty tablet medicine bottles. Different drug dosage forms have different requirements for caps. In order to distinguish them from other brands, some pharmaceutical companies have special requirements for the color of caps.

What is the eye drops container made of?

 The eye drops container is composed of a cap, a dropper, and a bottle body, and is a common pharmaceutical packaging for ophthalmic drugs. The material of the packaging plays an important role in maintaining the efficacy of the medicine and protecting the safety during the transportation of the medicine. So, what material is the eye drop bottle made of?

eye drop bottles

Eye drops container is a kind of plastic bottle. Its raw material is mainly low-density polyethylene (LDPE). It is the lightest variety in polyethylene resin. It is milky white, tasteless, odorless, non-toxic, and has no surface. Glossy waxy particles. It has good flexibility, extensibility, electrical insulation, transparency, easy processing and certain air permeability. It has good chemical stability, alkali resistance and general organic solvent resistance. LDPE has been industrialized for more than 70 years. Although with the discovery and development of olefin polymerization catalysts, the variety and output of polyethylene have made great progress, LDPE still occupies an important position, and some pharmaceutical packaging, daily necessities packaging, etc. are used Here comes this raw material.

After adding organic solvent, LDPE is processed by injection blowing process. First, the injection machine injects the molten plastic into the injection mold to form a tube blank. The tube blank is formed on a hollow convex mold with micro holes on the peripheral wall; then it is moved to the blow mold while it is hot; then the mold is closed and passed through the pipe of the mandrel Enter the compressed air to inflate the parison and stick it to the cavity wall of the mold; finally, after holding the pressure, cooling and setting, the compressed air is released and the mold is opened to take out the plastic part.

The eye drops container made of LDPE material is soft, easy to squeeze, and can quickly return to its original shape after squeezing, without creases. Whether it is in terms of the characteristics of the material and the convenience of the patient It is a better raw material for production.

What kind of eye drop bottle is easier to squeeze out

 Eye drops are one of the commonly used drug formulations for ophthalmological diseases, which have direct and quick treatment effects on many ocular diseases. The eye drop bottle is a special packaging for eye drops. The drug needs to be squeezed out of the bottle during administration. There are various materials used for plastic eye drop bottle packaging. Which material is easier to squeeze out the drug?

5ml eye dropper bottle

Common raw materials for plastic bottles include polyethylene (PE), polypropylene (PP), polyester (PET), high barrier (EVOH), etc., among which low-density polyethylene (LDPE) and polypropylene can be used as eye drop bottles. Both of the raw materials for production are non-toxic and tasteless, and can resist corrosion by various acids, alkalis and other solvents. The difference is that low-density polyethylene feels soft and easy to squeeze. Compared with LDPE, polypropylene is harder, less flexible, and fragile at low temperatures. It is generally used in powder bottles or small-capacity liquid bottles.

In terms of ease of use, LDPE material is more in line with the use requirements of eye drop bottles, and will be squeezed without creases, and will return to its original shape. The eye drops are usually administered by the patient themselves. If the bottle body is too hard, it will affect the patient’s experience and make it resistant to the brand of eye drops. To a large extent, no second purchase will be made. In addition, packaging will also have a certain impact on the reputation of the drug.

In general, LDPE eye drop bottles are more convenient than polypropylene in terms of drug delivery experience, and are favored by many eye drop manufacturers.

Appearance requirements of mastitis tube

The appearance of the package plays an important role in the circulation of goods. It not only protects the safety and stability of the contents, but also improves the competitiveness of the product. The same is true for mastitis tube used for the veterinary packaging of drugs such as dairy cow mastitis, pet nutrition cream, and dairy cow endometritis.

5ml cow mastitis syringe

Today, when the homogeneity of the veterinary drug market is obvious, the appearance of the product is easier to help the drug to stand out, and whether the appearance of the package is good and flawless will affect the purchase behavior of buyers. In China's T/CVDA 1-2019 "Prefilled Plastic Breast Injector for Veterinary Use" standard, the appearance of the mastitis tube is required as follows:
Needle tube: The head should be flat, free of burrs, bends, cracks, and gag defects.
Tube body: The inner wall is flat and smooth, without color difference.
Cap: Fully formed, uniform color, no cracks, no deformation.
Push rod: full forming, uniform color and no deformation.
Piston: full molding, no flash, no obvious shrinkage.
The needle tube is the outlet for the drug to be exported, and the drug can be better exported if it is flat and not gagged. The barrel is related to the overall aesthetics of the mastitis tube. A qualified cap can improve the appearance of the product and avoid leakage. Deformation of the push rod and shrinkage of the piston will cause difficulty in pushing out the liquid medicine, which is not conducive to the user's experience.
The above are the requirements of the Chinese standard for the appearance of veterinary syringes, whether it is needle tube, tube body, tube cap, push rod, piston, any part of the appearance or the convenience of product use will be affected if any part does not meet the standard.

Common problems of HDPE bottle blow molding

 HDPE bottles are commonly used packaging for capsules, oral liquids, tablets and other medicines. The quality of the bottle is of great significance to the efficacy of the medicine. In the process of blow molding, plastic bottles often encounter some quality problems. If these problems are controlled, the quality of the bottles will be more guaranteed.

HDPE pill bottle

1. Some parts of the HDPE bottle will appear whitish and excessively stretched. This is due to the fact that the central temperature is too low or the pre-blowing is formed too early. This can be solved by controlling the temperature and the timing of the pre-blowing. problem.

2. There are wrinkles in the bottom of the bottle. If the bottom temperature is too high, the pre-blowing is too late, the pre-blowing pressure is too low or the flow rate is too small.

3. The bottom of the bottle is thick and thin at the top. This phenomenon is mostly caused by uneven baking or insufficient temperature at the bottom of the bottle.

4. The eccentricity of the bottom of the plastic bottle is related to the temperature of the plastic preform, stretching, pre-blowing, high-pressure blowing, etc. Reduce the temperature of the plastic preform, accelerate the stretching speed of the plastic bottle, check the gap between the tie rod head and the bottom mold, extend the pre-blowing time, and reduce the pre-blowing pressure. Or postpone high-pressure blowing to check whether the preform is eccentric.

5. High-density polyethylene bottles are also particularly prone to deformation. If the wall thickness difference between the longitudinal wall thickness position and the radial wall thickness position is too large, it is easy to deform. The shrinkage formed by the position of the parting line of blow-molded container products is more serious than that of the adjacent position, which is that the cooling rate of the thicker area is much slower than that of the surrounding area. Different cooling rates cause different shrinkage and deformation. This defect is best dealt with by controlling the longitudinal wall thickness and the radial wall thickness at the same time.

The above are the common problems in the blow molding process of HDPE bottles. According to the specific problems that arise, the corresponding solutions can be selected to ensure the quality of the bottles and better protect the safety of medicines.

Precautions for aseptic operation during cell culture

 Aseptic operation is a key factor that determines the success or failure of cell culture. Even if a well-equipped laboratory is used, if the experimenter is careless and the operation is not standardized, it will also cause contamination. Therefore, all operations must be aseptic as possible, and every work must be orderly and completely reliable.

Cell Culture Chambers

1. Before the experiment: Make an experiment plan and operating procedures before starting the experiment. The calculation of the relevant data should be done in advance. According to the experimental requirements, prepare various required equipment and items, place them in the operation place (cultivation room, ultra-clean table) after inventory is correct, and then start disinfection. This can avoid increasing the chance of contamination due to incomplete items being taken back and forth after starting the experiment.

2. The working area for aseptic operation should be kept clean and spacious. Necessary items such as test tube racks, straw extractors or straw boxes can be temporarily placed, and other experimental supplies should be removed when they are used up to facilitate the flow of airflow. The experimental supplies were wiped with 70% ethanol before being brought into the sterile operating table. Cell culture experiments should be performed in the central aseptic area of the raised surface, and do not operate in the non-sterile area at the edges. To

3. Take care to use sterile experimental items to avoid contamination. Do not touch the tip of the straw or the mouth of the container, and do not operate the experiment directly above the opened container. After the container is opened, hold the bottle cap with your hands and hold the bottle body, and use it at an angle of about 45°. Try not to put the bottle cap on the table top. To

4. The staff should pay attention to their own safety and perform experiments only after wearing lab coats and gloves. For cell strains derived from humans or virus infections, you should be especially careful and choose an appropriate level of aseptic operating table (at least Class II). During the operation, avoid causing the production of aerosol, be careful with toxic drugs, such as DMSO and TPA, and avoid injury from sharp needles. To

5. Regularly check the following items

Erlenmeyer Culture Flask

(1) CO2 pressure of the CO2 cylinder; (2) CO2 concentration, temperature, and whether the water pan is contaminated (the water in the water pan is sterile water, which is replaced weekly); CO2 incubator is regularly disinfected; (3) aseptic operation Whether the airflow pressure in the station is normal, replace the ultraviolet lamp and HEPA filter membrane, pre-filter (300 hours/pre-filter, 3000 hours/HEPA) regularly.

What kind of material is the eye drop bottle

 Eye drops are one of the commonly used drug formulations for ophthalmological diseases, which have direct and quick treatment effects on many ocular diseases. The eye drop bottle is a special packaging for eye drops. The drug needs to be squeezed out of the bottle during administration. There are various materials used for plastic pharmaceutical packaging. Which material is easier to squeeze out the drug?

5ml eye drop bottle

Common raw materials for plastic bottles include polyethylene (PE), polypropylene (PP), polyester (PET), high barrier (EVOH), etc., among which low-density polyethylene (LDPE) and polypropylene can be used as eye drop bottles Both of the raw materials for production are non-toxic and tasteless, and can withstand the corrosion of various acids, alkalis and other solvents. The difference is that low-density polyethylene feels soft and easy to squeeze. Compared with LDPE, polypropylene is harder, less flexible, and fragile at low temperatures. It is generally used in powder bottles or small-capacity liquid bottles.

In terms of ease of use, LDPE material is more in line with the use requirements of eye drop bottles, and will be squeezed without creases, and will return to its original shape. The eye drops are usually administered by the patient themselves. If the bottle body is too hard, it will affect the patient’s experience and make it resistant to the brand of eye drops. To a large extent, no second purchase will be made. In addition, packaging will also have a certain impact on the reputation of the drug.

In general, LDPE eye drop bottles are more convenient than polypropylene in terms of drug delivery experience, and are favored by many eye drop manufacturers.

Application of syringe in ivermectin ointment

 Ivermectin is a new broad-spectrum, high-efficiency, low-toxic antibiotic antiparasitic drug, which has a good repellent effect on internal and external parasites, especially nematodes and arthropods. This medicine is divided into three forms: paste, powder and liquid. Among them, the ivermectin syringe packaging is mainly used for the packaging of paste preparations.

paste syringe

Ivermectin is widely used in gastrointestinal nematodes, lung nematodes and parasitic arthropods of cattle, sheep, horses and pigs, intestinal nematodes of dogs, ear mites, scabies, heartworms and microfilaria, and poultry stomachs Intestinal nematodes and ectoparasites. Among them, the cream Ivermectin is mainly used for deworming horses. Paste medicines are generally thicker. For large horses, convenient veterinary syringes have become the first choice for this type of medicine.
The ivermectin syringe is composed of a sleeve, a push rod, a piston, a protective cap, and a positioning ring. Make sure that there is no feed in the horse’s mouth before administering. Calculate the appropriate drug dose based on the horse’s weight, and slide the positioning ring to the mark At the scale, open the protective cap, insert the tip of the syringe into the gap between the horse's teeth, push the push rod to the scale of the positioning ring, and immediately raise the horse's head for a few seconds after the drug is administered to ensure that the horse can take the medicine. This method of administration is simple and convenient, and has been favored by many farmers.
The ivermectin syringe has both storage and administration functions. It is a new and convenient veterinary drug packaging. Ivermectin ointment is only one aspect of its many applications. It can also be used in pet nutrition ointment and dairy cow mastitis. Packaging of medicines, cockroach medicine and other medicines.

Common problems solutions in twin neck measuring bottle molding

 The twin neck measuring bottle is an innovative type of packaging, which is widely used in solutions that need to be diluted, such as pesticides, pH buffers, and fluorescent leak detectors. This kind of special-shaped bottle is processed by extrusion and blowing technology, and some failures may be encountered during the forming process, but as long as the specific reason is found, the corresponding solution can be selected to ensure the quality of the bottle.

Common problems in the molding process of twin neck measuring bottle include the following:
1. Reasons for the rough surface of the parison: ①The melt temperature is too low and the plasticization is not good; ②Extrusion and pressing speed are too fast; ③Improper die structure.
    Solution: ①Adjust the molding temperature (mainly the die); ②Appropriately reduce the speed; ③Increase the shaping section.
2. Reasons for product deformation: ①The melt temperature is high and the blow molding cycle is short; ②The cooling efficiency of the mold body is poor; ③The blow molding pressure is small.
    Solution: ①Reduce the melt temperature and extend the blow molding time; ②Increase the cooling water volume and cooling temperature, and check whether the cooling water channel is unblocked; ③Increase the blow molding pressure to not less than 0.196MPa (2kg/cm2).

twin neck bottle

3. Reasons for bubbles in the product: ①The raw material has high moisture content or volatile matter; ②The molding temperature is too high, and the part is overheated and decomposed.
    Solution: ①Pre-dry the material or change the formula; ②Reduce the molding temperature to prevent local overheating or partial storage of the material.
4. The obvious reasons for the suture line of the product: ①The temperature of the die is too low; ②The resin melt viscosity is large or the MFR is small; ③The structure of the die is not good.
    Solution: ① adjust the temperature of the die; ② increase the molding temperature or replace the material with a large MFR; ③ increase the choke device or lengthen the shaping section.
5. Reasons for dents in the cutting edge: ①Improper overflow angle of the cutting edge; ②The closing speed of the mold is too fast.
Solution: ① Repair the angle of the knife edge; ② Slow down the mold closing speed.
In the production process, all aspects such as raw materials, temperature, blow molding time, etc. must be strictly controlled, so as to produce high quality twin neck measuring bottle.