Effervescent Tubes with Desiccant and Stopper

 Usually effervescent tablets has two years expiration date, However it is used for 12-18 month in practical application. Two main desiccant are silica and molecular, and silica is the only one met demands of FDA. Desiccant and stopper caps make the vitamin and chew healthy and dry.

 

 

 84mm Effervescent tubes with desiccant and stopper

 

Silica of desiccant and stopper is a highly active adsorption material, It is hard, non-toxic, tasteless, non-corrosive, also strong chemical stability and thermal stability.

Silica has strong hydrophilia, at the same time has many holes with out eyes seeing on the surface of the silica gel desiccant cap, make its surface area has greatly increased, these characteristics of silica gel desiccant decided to become a good hygroscopicity of desiccant.

What should we pay more attention on choosing plastic pharma bottle

 Child resistant cap bottle mainly keep safe and prevent healthy people eatting by mistake, especially for children and psychopath. However desiccant bottle can offer dry condition for tablets. Today we talk something about plastic pharma bottle.

plastic pharma bottle with child resistant cap

Recently general plastic pharmaceutical packaging adopts the way of aluminum foil gasket seal to keep sealing. However after opening the gasket, sealing effect can not be get guarantee. The cap of tablets and capsules need to be opened frequently and the sealing is bad, which will cause drug absorption or oxidative deterioration. So there is a big hidden danger replying on gasket sealing. Second, when the cap is opened frequently, humidity will come into plastic bottle, and then speed up drug metamorphic. Especially for effervescent tablets, test strip and so on, it will be out of shape or go bad after moisture absorption. Excellent sealing bottle is important for tablets and capsules.

pharma desiccant bottle with CRC

So point of special child resistant cap bottle is having moisture proof, child resistant and desiccant cap can gurantee the drugs in the bottle can remain relatively sealed after opening, when using drugs. In order to prevent children opening and eating by mistake dangeriously. Recently the plastic pharma  bottle has applied for national patent.

The invention relates to the special structure of the bottle cap of the packaging bottle to achieve the purpose of the invention. The patent bottle cap is bilayer structure and equipped with child resistant cap, excellent sealing due to drug storehouse on the cap top, which can store desiccant and oxygen absorbent.

Take Care of Children, Starting with HDPE Child Resistant Cap Bottle

 HDPE bottle with push and down cap is a safe packaging  for children. It can be opened by double cover. In 2016, Center for drug evaluation and complete drug registration review and presented to the General Administration for approval for a total of 10060 pieces, 729 pieces of drug registration and complete review for reporting defects of applicants waiting for reply. There are so many kinds of drugs, but in terms of packaging, We only need material, compatibility and so on, External security and anti miseat in China now has no strong norms, promotion of high density polyethylene pressure screw cap bottle is also limited to the legal outside.

 

 

HDPE bottle with child resistant cap

In the United States, many tablets and capsules have been forced to use child resistant cap packaging. This package can not be said to prevent from the root of the eating event, but after 3 years of accumulated data comparison can be seen, the use of safe packaging after eating incident frequency dropped more than 36 percentage points before use.

 

 

75ml HDPE bottle with child proof cap  z007

 

Chinese pharmaceutical packaging appeals to tablet and capsule packaging using push and down cap packaging. In particular, mental, cardiovascular and cerebrovascular products try to use high-density polyethylene bottle, to protect life, from a bit start.

What Should We Pay More Attention On Choosing Child Proof Cap

 Child proof cap bottle mainly keep safe and prevent healthy people eatting by mistake, especially for children and psychopath. Today we talk something about child resistant cap.

 

 

pharma bottle with child proof cap

Recently general plastic bottle adopts the way of aluminum foil gasket seal to keep sealing. However after opening the gasket, sealing effect can not be get guarantee. The cap of tablets and capsules need to be opened frequently and the sealing is bad, which will cause drug absorption or oxidative deterioration. So there is a big hidden danger replying on gasket sealing. Second, when the cap is opened frequently, humidity will come into plastic bottle, and then speed up drug metamorphic. Especially for effervescent tablets, test strip and so on, it will be out of shape or go bad after moisture absorption. Excellent sealing bottle is important for tablets and capsules.

 

 

60ml plastic bottle with CRC

 

The invention relates to the special structure of the bottle cap of the pharmaceutical packaging bottle to achieve the purpose of the invention. The patent bottle cap is bilayer structure and equipped with child resistant cap, excellent sealing due to drug storehouse on the cap top, which can store desiccant and oxygen absorbent.

With the attention of drug safe, the using of patent child proof cap bottle.

What is Child Resistant Cap Bottle

 Child resistant cap bottle is aslo called CRC bottle, it is a necessary packaging for drug. It is safe for family who has children, especially for baby who can not distingwish anything. Children may eat tablets by mistake if open the pharma bottle.

pharma bottle with child resistant cap 

Pharmaceutical packagingchild resistant cap is contain with bottle and cap. The special design is the double cover, inner cap and thread of bottleneck connected, cover and inside links,it need external force to press the cover and turn to open. Which need people push down and turn can open the bottle. It adopts advanced injection blow molding which makes even bottleneck and uniform wall thickness. 

100ml child proof cap bottle

Excellent sealing and high security show the good quality. Child resistant cap is mainly used in medical and health care to prevent children eating pills or food by mistake.

Quality control point of vaccine vials

 Plastic bottles are widely used in many industries. Among them, our veterinary medicine industry also has a lot of applications. There are many types of injection vials, and the quality of products is also uneven. Manufacturers of vaccine vials need to control quality in many ways when producing bottles.

small injection vial

1. Capacity: Due to the particularity of drug packaging and medication, the shape is mostly round from a few milliliters to about 1,000 milliliters.

2. In order to ensure that the medicine is not affected by moisture and does not deteriorate during the validity period, the medical plastic bottle should have good sealing and barrier properties, and can prevent the effects of light, heat, water vapor, and oxygen on the medicine.

3. The inner wall of the oral liquid bottle is in direct contact with the drug. The bottle-making material must meet the requirements of the drug packaging to ensure the safety of the drug.

4. Oral liquid bottles belong to a class of packaging materials. It can be used for pharmaceutical packaging without cleaning and sterilization. Therefore, there are higher requirements for microbial limits, and the production environment and production process should meet the requirements of relevant regulations. 

5. The shape, size and structure of the oral liquid bottle should meet the requirements of various types of filling machines for pharmaceutical companies and the requirements of high-speed automatic filling machines.

Horse paste syringe appearance

 Our factory is a professional horse paste dispensing syringe manufacturer,we have our dial a dose syringe standard,and I will introduce the technical requirements from two aspects,one is sensory requirements,the other one is physical and chemical indicators.

veterinary syringe

I will introduce the appearance requirement of paste syringe.

1.Appearance,in natural light bright place,the syringe should have uniform colors,the surface should bright and clean,smooth,don't have obvious chromatic aberration.

2.The barrel of syringe is not crooked,the syringe don't have rags,deformation,cracks,sand hole,oil contamination,bubble;

3.The inside wall of barrel should be smoothness,don't have crinkle.

4.The syringe tip should be smooth

5.The syringe don't have defective printing which can influence of using

Introduction of two caps for effervescent tablet packaging

 Effervescent tablet packaging is a packaging containing vitamin effervescent tablets or chewable tablets and other dosage forms. It has good moisture resistance. According to the different packaging requirements of pharmaceutical companies, this packaging contains two types of bottle caps.

caps for effervescent tube

Spring cap: This bottle cap is characterized by a spiral spring on the cap, this spring is made of LDPE raw materials, can play a role in compressing the tablets, and avoid being broken due to various external forces during transportation. It also reduces unnecessary losses for pharmaceutical companies. The LDPE material has good flexibility. The use of this material as a coil spring will neither crush the fragmentation agent due to the too hard texture, nor cause the medicine to be poorly fixed due to the too soft texture and too small pressure. It can give full play to the spring design. The advantages. In addition, this kind of bottle cap also has a feature that it has a desiccant. Unlike ordinary medicine bottles, the effervescent tablet packaging puts the desiccant on the cap, saving space, and is a cap with moisture-proof function. .

effervescent tablet tube 84mm

Non-spring cap: This kind of bottle cap is different from the spring cap. There is no spring on the cap, but it also has a moisture-proof function. Generally, vitamin chewable tablets and small-dose candy tablets will choose this kind of cap, and some vitamin C effervescent tablet manufacturers will also use this kind of bottle cap.

The above are the two types of caps and their characteristics for effervescent tablet packaging. These two different types of caps meet the differentiated needs of pharmaceutical companies for packaging, and are also a manifestation of the continuous development and diversification of pharmaceutical packaging.

Pay attention to these four points when sterile dosing syringe

 Dosing syringe is used for sterilization, generally using ethylene oxide sterilization, but if you do not pay attention to these points, it is easy to have hidden dangers or affect the sterilization effect.

30ml dial a dose syringe

1. The ethylene oxide sterilizer must be placed in a well-ventilated place. Do not place it near the fire source. In order to facilitate maintenance and regular maintenance, 51cm of space should be reserved on each side (including the top) of the ethylene oxide sterilizer. Special exhaust ducts should be installed and completely isolated from other exhaust ducts in the sterilization site.
2. Items that need to be sterilized must be thoroughly cleaned. Note that they cannot be cleaned with saline. There should be no water droplets or too much water on the sterilized items to avoid dilution and hydrolysis of ethylene oxide. If the packaging material is changed, it should be verified to ensure the reliability of the sterilization of the sterilized items.
3. There should be gaps on the top, bottom, left and right of the loaded items in the sterilization cabinet (the sterilized items cannot touch the cabinet wall), and the items should be placed in a metal mesh basket or on a metal net rack; the amount of items loaded should not exceed the total volume of the cabinet 80% of it.
4. Sterilization treatment: It should be carried out in accordance with the operating instructions of the manufacturer of the ethylene oxide sterilizer; select the appropriate sterilization parameters according to the type, packaging, loading volume and method of the plastic dosing syringe.
Different from sterilization methods such as high temperature and high pressure, there will be a certain amount of residue after ethylene oxide sterilization. The sterilized veteriary syringe needs to be placed for a period of time to release the residue and ensure the safety of dosing syringe and medicine.

Packaging syringe for mastitis

Syringe for the packaging of products for the treatment of Mastitis. This type of packaging is commonly known as mastitis syringes in the veterinary environment, they are used by practically all veterinary pharmaceutical laboratories for the packaging of their products for the treatment, control and eradication of subclinical, clinical or chronic mastitis that occurs in dairy cattle, primarily, this condition is responsible for significant losses for dairy farms, especially those located in intensive production regions. Likewise, it is one of the main causes in making early dairy cow slaughter decisions, derived from the various and recurrent problems in the health of the mammary gland, about 27% of dairy cow slaughter is due to disorders associated with mastitis and loss of milk production.

5ml intramammary syringe

10ml udder injector

Therefore, the importance of having a suitable container for the application of pharmaceutical products for mastitis, which guarantees the useful life of the product in its transport, storage, shelf stays and especially in its due and correct application, all Syringe must meet at least the characteristics of tightness, seal, dimensions and measures available to its final use, whether it is the application of drugs for the control of mastitis or the application of dryers.
Other names by which it is known: Mastitis syringe, Intramammary syringe, Syringe with intramammary cannula, Syringe mastitis, Syringe with cannula for mastitis

Why eye drops bottle can only be used for four weeks after opening

 Eye drops occupies an important position in ophthalmic drugs and are a very common type of drug. Any medicine has a validity period. The validity period of eye drops is generally 1-3 years. If the eye drops bottle is opened, the validity period of the medicine is only four weeks.

eye dropper bottle

The 1-3 year validity period marked on the eye drop bottle packaging refers to the time when the package is unopened. The "People's Republic of China Pharmacopoeia" stipulates that "ophthalmic preparations can be used for up to 4 weeks after being used", even if the drug is still within the validity period. Inside, the eye drops can only be used for up to 4 weeks after opening.

This is because once the eye drops are opened, they are easy to come into contact with microorganisms and tears during storage and use, leading to drug contamination. Under normal circumstances, each eye drop will be available after opening in the manual [Precautions] Maximum time used. Some drugs can be used for less than 4 weeks after opening, and the specific instructions shall prevail. Patients are advised to indicate the opening time on the package after opening the eye drops to avoid expiration and deterioration.

Of course, there are some special cases. If it is a small package of eye drops without preservatives, it will not have any resistance to bacteria and viruses floating in the air after opening. Each small bottle is only used for one time. Open the eye drops bottle After that, it can only be used once, and it needs to be discarded after the medication is finished

Horse paste syringe appearance

 Our factory is a professional horse paste dispensing syringe manufacturer,we have our dial a dose syringe standard,and I will introduce the technical requirements from two aspects,one is sensory requirements,the other one is physical and chemical indicators.

veterinary syringe

I will introduce the appearance requirement of paste syringe.

1.Appearance,in natural light bright place,the syringe should have uniform colors,the surface should bright and clean,smooth,don't have obvious chromatic aberration.

2.The barrel of syringe is not crooked,the syringe don't have rags,deformation,cracks,sand hole,oil contamination,bubble;

3.The inside wall of barrel should be smoothness,don't have crinkle.

4.The syringe tip should be smooth

5.The syringe don't have defective printing which can influence of using                        

The importance of effervescent tablet packaging in protecting the safety of medicines

Vitamin C effervescent tablets contain disintegrants, which are easy to decompose when exposed to moisture. The packaging of effervescent tablets plays a vital role in protecting the safety of medicines.

1.The packaging of effervescent tablets has good airtightness to protect vitamin C effervescent tablets and keep them in a good storage environment. First of all, this packaging is generally processed from polyethylene or polypropylene raw materials, which is a barrel-shaped bottle. The diameter is slightly larger than the diameter of the tablet, which is convenient for filling and easy for patients to take out the medicine. The raw materials of the packaging have good barrier properties, which can isolate the intrusion of external impurities.

84mm effervescent tablet tube 

2. The packaging of effervescent tablets protects the safety of medicines. The medicines are unavoidably subjected to various external forces during transportation. There is a spiral spring on the packaging bottle cap. This spring is made of soft low-density polyethylene. Plays the role of compressing the tablet to prevent the drug from being damaged during transportation.

desiccant cap

3. Another important function of effervescent tablet packaging is moisture prevention. Unlike ordinary medicine bottles, which put the desiccant in the bottle in the form of a bag, this kind of packaging puts the desiccant in a small medicine bin on the bottle cap. This not only avoids the direct contact between the medicine and the desiccant, but also effectively prevents children from ingesting the desiccant by mistake.

Introduction of two caps for effervescent tablet packaging

 Effervescent tablet packaging is a packaging containing vitamin effervescent tablets or chewable tablets and other dosage forms. It has good moisture resistance. According to the different packaging requirements of pharmaceutical companies, this packaging contains two types of bottle caps.

caps for effervescent tube

Spring cap: This bottle cap is characterized by a spiral spring on the cap, this spring is made of LDPE raw materials, can play a role in compressing the tablets, and avoid being broken due to various external forces during transportation. It also reduces unnecessary losses for pharmaceutical companies. The LDPE material has good flexibility. The use of this material as a coil spring will neither crush the fragmentation agent due to the too hard texture, nor cause the medicine to be poorly fixed due to the too soft texture and too small pressure. It can give full play to the spring design. The advantages. In addition, this kind of bottle cap also has a feature that it has a desiccant. Unlike ordinary medicine bottles, the effervescent tablet packaging puts the desiccant on the cap, saving space, and is a cap with moisture-proof function. .

effervescent tablet tube 84mm

Non-spring cap: This kind of bottle cap is different from the spring cap. There is no spring on the cap, but it also has a moisture-proof function. Generally, vitamin chewable tablets and small-dose candy tablets will choose this kind of cap, and some vitamin C effervescent tablet manufacturers will also use this kind of bottle cap.

The above are the two types of caps and their characteristics for effervescent tablet packaging. These two different types of caps meet the differentiated needs of pharmaceutical companies for packaging, and are also a manifestation of the continuous development and diversification of pharmaceutical packaging.

Easily Oxidized Detection of Tablet Medicine Bottle

 With the improvement of people's health awareness, the degree of attention to pharmaceutical packaging has also increased. Tablets and medicine bottles are commonly used to pack solid medicines such as tablets, pills, and capsules, and their quality is directly related to the safety of medicines. The country has also formulated corresponding standards for packaging quality to ensure drug safety. Among the quality standards, easy oxide detection is a very important one.

45ml plastic medicine bottle with CRC

50ml pharma desiccant bottle

Easily oxidized substances refer to substances that are prone to chemically react with oxygen in ordinary environments. The common ones are metals that are prone to rust. In the pharmaceutical packaging industry, they generally refer to substances that are prone to oxidation reactions with oxygen, such as organic matter, reducing agents, Sulfur, phosphorus, etc. The control of easy oxides is of great significance to ensure the quality of the drug within the validity period, prevent the chemical reaction between the precipitated reducing substances and the drug, and affect the efficacy and safety of the drug.

For the detection of easy oxides in tablet vials, there are detailed regulations in the quality standard of YBB00122002-2015 "Oral Solid Pharmaceutical High Density Polyethylene Bottles": precise measurement of 20ml of water for test solution, precise addition of potassium permanganate for titration 20ml of solution (0.002mol/L) and 1ml of dilute sulfuric acid, boil for 3 minutes, quickly cool, add 0.1g potassium iodide, place in a dark place for 5 minutes, titrate with sodium thiosulfate titrant (0.01mol/L), and titrate to the end point At the time, add 5 drops of starch indicator solution, continue titration until it is colorless, and receive the water blank solution in the same way. The difference between the two consumption of sodium thiosulfate titrant (0.01mol/L) shall not exceed 1.5ml.

The above is the test method for the easy oxides of the tablet vial in the domestic quality standards for pharmaceutical packaging materials. This test is only one of the quality standards. To meet the standard requirements, it needs to be in appearance, microbial limit, abnormal toxicity, and production environment. Comprehensive control and other aspects.

Application of plastic syringe for horse

 The syringe is a new type of packaging that is convenient to use and has a wide range of applications. It is more common in the application of horse nutrition ointment and medicine.

60ml horse syringe

The horse syringe is a new type of packaging that integrates the functions of drug storage and injection. It consists of a push rod, a protective cap, a piston, and a positioning ring. When in use, you only need to open the protective cap to directly administer the drug. The design of the positioning ring can also allow The dosage of the medicine is more precise, and it has the advantages of convenient use, reduced pollution, and avoidance of residues, which can meet the administration needs of horse oral paste drugs.
The application of the veterinary paste syringe in horse oral paste medicine is only one aspect of its application range. Thanks to the advantages of convenient use and less residue, it has also been used in the dairy farming industry, cockroach-killing drugs, pet nutrition ointment, etc. The universal application is favored by many veterinary drug companies.

Pay attention to these four points when sterile dosing syringe

 Dosing syringe is used for sterilization, generally using ethylene oxide sterilization, but if you do not pay attention to these points, it is easy to have hidden dangers or affect the sterilization effect.

30ml dial a dose syringe

1. The ethylene oxide sterilizer must be placed in a well-ventilated place. Do not place it near the fire source. In order to facilitate maintenance and regular maintenance, 51cm of space should be reserved on each side (including the top) of the ethylene oxide sterilizer. Special exhaust ducts should be installed and completely isolated from other exhaust ducts in the sterilization site.
2. Items that need to be sterilized must be thoroughly cleaned. Note that they cannot be cleaned with saline. There should be no water droplets or too much water on the sterilized items to avoid dilution and hydrolysis of ethylene oxide. If the packaging material is changed, it should be verified to ensure the reliability of the sterilization of the sterilized items.
3. There should be gaps on the top, bottom, left and right of the loaded items in the sterilization cabinet (the sterilized items cannot touch the cabinet wall), and the items should be placed in a metal mesh basket or on a metal net rack; the amount of items loaded should not exceed the total volume of the cabinet 80% of it.
4. Sterilization treatment: It should be carried out in accordance with the operating instructions of the manufacturer of the ethylene oxide sterilizer; select the appropriate sterilization parameters according to the type, packaging, loading volume and method of the plastic dosing syringe.
Different from sterilization methods such as high temperature and high pressure, there will be a certain amount of residue after ethylene oxide sterilization. The sterilized veteriary syringe needs to be placed for a period of time to release the residue and ensure the safety of dosing syringe and medicine.

USDA begins process to identify veterinary shortage areas

 State animal health officials have until November 8, 2021, to submit nominations for locations to be designated as U.S. Department of Agriculture (USDA) veterinary shortage areas in 2022.

Designated shortage areas become eligible for assistance through two USDA programs that help recruit veterinarians to work in them: the Veterinary Medicine Loan Repayment Program (VMLRP) and Veterinary Services Grant Program (VSGP).

Veterinarians and other veterinary professionals can work with their state veterinary associations and local animal health officials on these nominations. Information about the nomination process and how to apply can be found on USDA’s website.

injection vial

The VMLRP and VSGP programs help alleviate veterinary access gaps in rural, agricultural communities and public health veterinary practice. Before each fiscal year, USDA gathers veterinary shortage data from state animal health officials and uses the information to designate shortage areas to be mitigated through VMLRP and VSGP awards.

veterinary syringe

1000ml dispensing bottle

The list of shortage areas for 2022 is expected to be announced in February 2022, when the application window for these awards will open. In 2021, the USDA designated 221 veterinary shortage areas in 48 states.

The VMLRP awards for 2021 are expected to be announced later this year. In 2021, there were 78 VMLRP offers to veterinarians in 36 states. Under the VSGP program, NIFA has issued $3 million in grants to support 17 projects since September. These included 10 awards to support rural practice enhancement and seven to support education, extension, and training work in shortage areas.

As the leading champion of the VMLRP and VSGP programs, the AVMA is working with Congress to pass the VMLRP Enhancement Act, a bill that would extend the program’s ability to reach more communities in need of veterinary services. In the House of Representatives, AVMA’s sustained advocacy has so far expanded the number of cosponsors for the VMLRP Enhancement Act to 37. In the previous Congress, there were 29 cosponsors.

Individual voices from the veterinary community make a difference in helping lawmakers understand the importance of programs like VMLRP and the need to broaden its impact. The AVMA Congressional Advocacy Network makes it easy for you to contact your representatives in Congress to urge them to support this legislation.

Ethylene oxide sterilization process for veterinary syringes

 Veterinary syringes are commonly used as packaging for veterinary drugs, and their sterility is very important to the safety of drugs. The sterilization method is generally based on ethylene oxide sterilization, and the sterilization process is as follows:

30ml dial a dose syringe

1. The ethylene oxide sterilization procedure needs to include preheating, pre-wetting, vacuuming, injecting vaporized ethylene oxide to reach a predetermined concentration, maintaining the sterilization time, removing the ethylene oxide gas in the sterilization cabinet, and analyzing Remove ethylene oxide residues in sterilized items.
2. 100% pure ethylene oxide or mixed gas of ethylene oxide and carbon dioxide can be used for ethylene oxide sterilization. The use of Freon is prohibited.
3. The analysis can be continued in an ethylene oxide sterilizer, or it can be placed in a special fume hood, and natural ventilation should not be used. The repeatedly input air should be filtered with high efficiency, which can filter out more than 99.6% of particles ≥0.3um.
4. Ethylene oxide residues mainly refer to the ethylene oxide remaining in articles and packaging materials after ethylene oxide sterilization and its two by-products, ethanol ethane and ethylene glycol ethane; exposure to excessive ethylene oxide Alkane residues can cause animal burns and irritation. The amount of ethylene oxide residue is related to the material of the veterinary syringe, sterilization parameters, packaging materials and packaging size, loading capacity, analysis parameters, etc. When the polyvinyl chloride catheter is at 60℃, it is analyzed for 8h; when it is 50℃, it is analyzed for 12h. Some materials can shorten the resolution time, such as metal and glass can be used immediately, and some materials need to extend the resolution time, such as a built-in pacemaker.
The above is the veterinary syringe ethylene oxide sterilization process. Ethylene oxide is harmful to the human body. When sterilizing in this way, the relevant technical operating procedures must be strictly followed, and all links must be strictly controlled to ensure the safety of personnel and the environment.