Analysis of the causes of moisture inside the effervescent tube

 Effervescent tablets are a kind of pharmaceutical dosage forms containing disintegrants. There are many kinds of them, such as aspirin effervescent tablets for antipyretic and analgesic, Chinese patent medicine Jinlian Qingre effervescent tablets, multi-dimensional effervescent tablets for supplementing vitamins or trace elements, etc. As a special item, it has very strict requirements on packaging effervescent tubes. If it gets wet, it will easily lead to deterioration of medicines, affect the efficacy of medicines and even human health. In order to avoid this situation, we can avoid the effervescent tube from getting damp from the following aspects:

144mm*29mm effervescent tube packaging

caps for effervescent tube

1. Sealing: If the inside of the effervescent tube is damp, first consider whether the sealing of the effervescent tube is qualified. The factors affecting the sealing performance mainly depend on the precision of the mold and the strict control of each production link. The material of the effervescent tube generally has moisture resistance, which can block the external water molecules, but if the seal is not tight, it is easy to cause water vapor to enter the inside of the effervescent tube, causing the medicine to be damp and deteriorate.

2. Dosage of desiccant: The desiccant of the effervescent tube is mainly a mixture of silica gel and molecular sieve. If the inside of the effervescent tube is still damp when the overall sealing is good, it may be because the amount of desiccant is not enough to completely To absorb the moisture of the medicine itself, consider increasing the amount of desiccant.

3. External environment: The moisture inside the effervescent tube is also related to the external environment. If the storage environment is too humid, it is easy to get damp inside the effervescent tube, so try to choose a dry and ventilated place during storage.

If we encounter moisture in the effervescent tube later, we can try to analyze these aspects to avoid this situation and ensure our stability during drug storage.

What is a Pet Syringe Applicator

 There are many kinds of veterinary drugs, including liquid preparations, solid preparations, pastes, etc., and the types of packaging are also very diverse, such as plastic bottles/barrels, aluminum foil bags, droppers, etc. The pet nutrition cream syringe applicator is a great type of packaging. 

pet syringe

Ordinary plastic bottle packaging is generally only used to store medicines. The pet syringe applicator can store medicines and can also be used as a drug delivery tool. It consists of a tube sleeve, a push rod, a piston, a protective cap and a positioning ring. It is a drug storage container in a sealed state, and when we open the protective cap and push the push rod, it turns into a drug delivery Tool of.

30ml dial a dose syringe

The magic of this packaging is that it allows precise control of the dose administered. There is a standard scale printed on the push rod, slide the positioning ring to the corresponding scale, and then push the push rod to achieve precise drug delivery. Especially for pets, the control of nutritional cream dosage is very important for their health.

In general, the pet syringe applicator, based on the drug storage function, satisfies the market's precise control of drug dosage, and is a functionally outstanding package. It is also used in the packaging of cow mastitis medicine, cow endometritis medicine, horse oral paste, calf oral paste and other medicines.

Application of COP vial in high pH value drug

 The stability of pharmaceuticals is closely related to the properties of the packaging materials, such as hardness, transparency, dissolution, chemical resistance, etc., which is particularly important for pharmaceuticals in storage. COP vial is a commonly used packaging for high value-added drugs, and its "confidence" also comes from its own good characteristics.

 

5ml COP vial

100ml COP injection vial

Initially, high pH drugs will choose glass as the packaging form, but the main component of glass is silicon dioxide, which is easy to react with glass during drug storage, resulting in glass delamination, which has a significant impact on the safety of drugs, and even Pharmaceutical companies also have to bear high recall costs.

COP is a cyclic olefin polymer. This raw material has very high transparency. The tensile strength and elastic modulus of the material are higher than those of PC, and it has good mechanical properties. In terms of temperature resistance, COP finished products are stable in the environment of -196°C - +121°C. Excellent chemical resistance, can tolerate drugs with a pH value greater than 10, and will not be delaminated when filling alkaline drugs, which plays a crucial role in the safety of drugs. The safety of drugs in special environments such as cells can also be guaranteed. In addition, it also has low protein adsorption and water vapor barrier properties, which can reduce the impact of packaging and external environment on drugs.

COP vial can provide complete safety protection for drugs with high pH, protect the safety and stability of drugs within the validity period, and avoid packaging problems that affect drug effects.

The innovative design of oral liquid bottle cap

 The cap is an important part of the medicinal plastic bottle, which mainly plays the role of sealing. With the continuous changes in market demand, the functionality of the cap is also more diversified. For example, the oral liquid bottle cap adopts an innovative design on the basis of airtightness, so that it has the function of preventing children from opening, reducing the risk of children ingesting medicines by mistake.

 

28mm child resistant  cap for liquid medicine

Oral liquid is a sterile or semi-sterile oral liquid, which is based on traditional Chinese medicine decoction, extracts the active ingredients in the drug, adds flavoring agents, bacteriostatic agents and other additives, and is processed by filling and sealing injection ampoules. Liquid preparations. The packaging of such drugs is generally dominated by plastic bottles or glass bottles, and the lids are mostly ordinary plastic bottle caps. In order to improve the sealing performance, aluminum foil gaskets are used to seal.

Oral liquid tastes better and is easily accepted by patients, especially children. However, children are in the growth and development period and are full of curiosity about many things. It is easy to mistake the oral liquid for a drink, resulting in accidental ingestion. The press-and-screw oral liquid bottle cap adopts an inner and outer double-layer structure. It cannot be opened only by rotating the cap. It must be rotated while pressing down to open. Such an opening method involves the simultaneous application of force in two different directions, which is difficult for children, which can prevent them from easily opening the package in a short period of time and avoid accidental ingestion of medicines.

Rotational medicine caps are not only used in the packaging of liquid preparations, but are also widely used in solid pharmaceutical plastic bottles such as tablets and capsules. The functionality of the lid is well used.

Effervesent Tablet Tubes: FAQ Guide

 Effervescent table tubes is popular in pharmaceutcial packaging, this guide main contain more detials and questions you want to know.

144mm*29mm effervescent tube packaging

caps for effervescent tube

1. what is packaging requirement fo effervescent tablet?

   Moisture
   

2. what is effervescent tablet tube?
   

3. what is application of the effervescent tube?

   
   

4. what is standard size for effervescet tablet tube?

   There are 144mm*29mm and...

5. what is material of effervescent tube?

   PP and PE

6. what is inside the cap of effervescent vitamin c tablets?

   There are silica gel desiccant
   

7. How long is the shelf life of the desiccant of the effervescent tube?

    If the effervescent tube is not opened, the theoretical data of the internal desiccant shelf life experiment is two years
   

8. How to test the tightness of effervescent tubes?

9. Production environment requirements for effervescent tubes?

10. Do effervescent tubes maufacturer provide printing and labeling services?

    Screen printing and flexographic printing

11. What information should be included on the label of an effervescent tube?

    Label of effervescent tube contain more information
    

12. What is the desiccant for effervescent lids?

    Silica gel

Application of plastic veterinary syringes-Cat Lysine Paste

 Veterinary drug packaging should have more functionality, and plastic veterinary syringes are such a multifunctional package. The lysine paste commonly used by cat breeders is the packaging of choice.

Feline Lysine Paste is a feline nutritional supplement developed and formulated for cats infected with or with feline herpesvirus, the causative agent of feline rhinotracheitis (feline flu). Feline herpes virus relies on arginine, an essential amino acid without which the virus cannot replicate. L-Lysine is also an amino acid. If it is given to animals as a supplement, it can compete with arginine, resist the growth-promoting effect of arginine on the virus, and inhibit the replication of feline herpes virus.

30ml dial a dose syringe

The plastic syringe is composed of a tube sleeve, a push rod, a piston, a protective cap, and a positioning ring. When the protective cap is tightly closed, it is a veterinary drug package, but when the protective cap is removed and the push rod is pushed, it transforms into a become a drug delivery tool. There is a standard scale on the push rod, turn the positioning ring to the appropriate scale, push the push rod to achieve drug delivery, and the push rod will stop pushing when it reaches the positioning ring, so that the dosage of the drug is well controlled, which is conducive to better efficacy of the drug and the healthy growth of pets.

In addition to being used as a packaging for cat lysine paste, the plastic paste syringe has a very wide range of applications in dairy cow mastitis medicine, horse medicine, cockroach medicine, etc. It is a versatile packaging form.

Factors Affecting Moisture Resistance of Effervescent Tablet Tubes

 Effervescent tablet is a new type of preparation, which originated from abroad and has been widely used in China in recent years. Due to the complex and difficult production process and high production cost, this dosage form has very strict requirements on packaging. Then as an effervescent tube as a special packaging for effervescent tablets, in order to prevent the medicine from being damp, denatured, and invalidated, a desiccant is usually placed in the bottle.

144mm*29mm effervescent tube packaging

caps for effervescent tube

But we also need to pay attention to the fact that the desiccant in the effervescent tube is sealed by white cardboard. There are certain requirements for the thickness and moisture content of the cardboard. If the cardboard is too thick, it will enhance the barrier effect on the desiccant and affect its moisture resistance. If the moisture content is too high, the desiccant will apply more moisture absorption performance to the cardboard, reducing the overall moisture resistance of the packaging internal environment. The quality requirements for effervescent tubes are in accordance with the national standard YBB00172004-2015 "Oral Solid Medicinal Low-density Polyethylene Moisture-proof Composite Bottle Caps", in which the requirements for cardboard are as follows: the moisture content is less than 6%, the The lead shall not exceed 0.0005%, and the drug contact surface shall be inspected under the ultraviolet lamp with a wavelength of 365mm and 254mm, and there shall be no flake fluorescence. The thickness is recognized in the industry as 0.46-0.55mm pure high-quality wood pulp white cardboard.

To sum up, the whiteboard must strictly meet the standard requirements, so as to ensure the moisture-proof performance of the desiccant, and then ensure the overall moisture-proof function of the effervescent tablet tube, and protect the health of users.

Factors Affecting Moisture Resistance of Effervescent Tablet Tubes

 Effervescent tablet is a new type of preparation, which originated from abroad and has been widely used in China in recent years. Due to the complex and difficult production process and high production cost, this dosage form has very strict requirements on packaging. Then as an effervescent tube as a special packaging for effervescent tablets, in order to prevent the medicine from being damp, denatured, and invalidated, a desiccant is usually placed in the bottle.

144mm*29mm effervescent tube packaging

caps for effervescent tube

But we also need to pay attention to the fact that the desiccant in the effervescent tube is sealed by white cardboard. There are certain requirements for the thickness and moisture content of the cardboard. If the cardboard is too thick, it will enhance the barrier effect on the desiccant and affect its moisture resistance. If the moisture content is too high, the desiccant will apply more moisture absorption performance to the cardboard, reducing the overall moisture resistance of the packaging internal environment. The quality requirements for effervescent tubes are in accordance with the national standard YBB00172004-2015 "Oral Solid Medicinal Low-density Polyethylene Moisture-proof Composite Bottle Caps", in which the requirements for cardboard are as follows: the moisture content is less than 6%, the The lead shall not exceed 0.0005%, and the drug contact surface shall be inspected under the ultraviolet lamp with a wavelength of 365mm and 254mm, and there shall be no flake fluorescence. The thickness is recognized in the industry as 0.46-0.55mm pure high-quality wood pulp white cardboard.

To sum up, the whiteboard must strictly meet the standard requirements, so as to ensure the moisture-proof performance of the desiccant, and then ensure the overall moisture-proof function of the effervescent tablet tube, and protect the health of users.

The innovative design of oral liquid bottle cap

 The cap is an important part of the medicinal plastic bottle, which mainly plays the role of sealing. With the continuous changes in market demand, the functionality of the cap is also more diversified. For example, the oral liquid bottle cap adopts an innovative design on the basis of airtightness, so that it has the function of preventing children from opening, reducing the risk of children ingesting medicines by mistake.

 

28mm child resistant  cap for liquid medicine

Oral liquid is a sterile or semi-sterile oral liquid, which is based on traditional Chinese medicine decoction, extracts the active ingredients in the drug, adds flavoring agents, bacteriostatic agents and other additives, and is processed by filling and sealing injection ampoules. Liquid preparations. The packaging of such drugs is generally dominated by plastic bottles or glass bottles, and the lids are mostly ordinary plastic bottle caps. In order to improve the sealing performance, aluminum foil gaskets are used to seal.

Oral liquid tastes better and is easily accepted by patients, especially children. However, children are in the growth and development period and are full of curiosity about many things. It is easy to mistake the oral liquid for a drink, resulting in accidental ingestion. The press-and-screw oral liquid bottle cap adopts an inner and outer double-layer structure. It cannot be opened only by rotating the cap. It must be rotated while pressing down to open. Such an opening method involves the simultaneous application of force in two different directions, which is difficult for children, which can prevent them from easily opening the package in a short period of time and avoid accidental ingestion of medicines.

Rotational medicine caps are not only used in the packaging of liquid preparations, but are also widely used in solid pharmaceutical plastic bottles such as tablets and capsules. The functionality of the lid is well used.

Microbial Limit Testing of Effervescent Tube Caps

 Effervescent tube is a kind of packaging form with special structure design. It consists of two parts: a cover and a tube body. It is mostly used for tablets, capsules and other drugs that need moisture-proof preservation. In the quality standard of packaging, the microbial limit is an important test item.

144mm*29mm effervescent tube packaging

caps for effervescent tube

The quality standard for effervescent tube caps is based on the "YBB00172004-2015" standard for oral solid medicinal low-density polyethylene moisture-proof combined bottle caps. The standard has a detailed description of the detection method of microbial limit, as follows:

Take a few pieces of this product, in a sterile environment, slightly dampen a sterile cotton swab with sodium chloride injection, wipe the bottle cap, wipe each bottle cap with 2 cotton swabs, and cut each cotton swab immediately after wiping (or Burn off), put it into a test tube containing 10ml of sodium chloride injection, shake and mix well, and then get the test solution. Take the test solution for membrane filtration and check according to the law (General Rules 1105 and 1106 of the Chinese Pharmacopoeia 2015 Edition). The cover cannot be detected.

The above is the microbial limit test of the lid of the effervescent tube. The main purpose of controlling this indicator is to prevent the microorganisms in the package from contaminating the drug and bringing the risk of medication to the patient.

Four Applications of Plastic Animal Health Syringes

 Veterinary packaging is taking on more and more functionality. Syringe is a new type of packaging that not only has the function of drug storage, but also can be used as a drug delivery tool. It is mainly used in the following aspects.

5ml syringe for cow mastitis

Dairy cow mastitis drugs: Dairy cow mastitis is an important disease that endangers the health of dairy cows, and most of its therapeutic drugs use syringes as packaging. The tip of the package is relatively thin, which can be directly administered to the cows, and the operation is convenient.

30ml dial a dose syringe

Horse medicine: mainly ointment for horses, medicine for horse gastroenteritis and other creamy or oily medicines. These medicines are all oral medicines for horses. It can be easily administered through packaging, reducing drug residues.

pet syringe

Pet nutrition cream: This type of medicine is mainly used to supplement the daily nutritional needs of pets. Ordinary packaging can easily be bitten by dogs and cats, resulting in excessive consumption. The syringe is made of polyethylene/polypropylene raw material, and the design of the positioning ring can also control the dosage to ensure the accuracy of the dosage.

cockroach syringe

Cockroach medicine: Cockroaches often appear in some narrow crevices, corners, etc. The slender tip of this syringe can reach various corners and easily complete the application.

The above are four common applications of syringes. It is not only convenient to operate, but also has less residue. Except for the packaging of drugs, some grease products will also choose this packaging form.

Two types of caps for effervescent tubes

 Effervescent tube is a kind of packaging with very good moisture-proof performance, which is mainly used to hold dosage forms such as VC effervescent tablets and chewable tablets. This packaging consists of a cap and a tube body. Depending on the properties of the drug, there are two different types of caps for effervescent tubes: spring caps and non-spring caps.

144mm*29mm effervescent tube packaging

caps for effervescent tube

Spring cover: This is a specially designed cover, which consists of four parts: desiccant, cardboard, coil spring, and anti-theft ring. There is a small medicine compartment on the top of the cover to store the desiccant, avoiding the direct contact between the medicine and the desiccant. touch. The spring is processed from soft LDPE raw materials, and its main function is to compress the tablet to avoid affecting the integrity of the drug due to various external forces during transportation. The anti-theft ring plays a vigilant role, and the cover will automatically fall off when it is opened. Spring caps are mainly used for drugs in larger dosage forms such as VC effervescent tubes.

Non-spring cover: The main difference with the spring cover is that it has no spring, but it also has the function of moisture resistance. Generally, vitamin chewable tablets and small-dose candy pressed tablets will choose this type of cap, and some VC effervescent tablet manufacturers will also use this type of cap.

The above are two types of effervescent tube caps, which meet the storage needs of different medicines and cater to market needs. In the future, with the continuous emergence of new drugs, the packaging will also be more diversified.

Application of 50ml 100ml veterinary vaccine bottles

 Animal vaccines play an important role in preventing infectious diseases and improving the economic benefits of farming. Veterinary vaccine bottles, as packaging containers for animal vaccines, are crucial to the safety and stability of vaccines. There are various types of animal vaccines, and different vaccines have different application of packaging specifications.

50ml PP INJECTION VIAL

100ml transparent PP vial

Foot-and-mouth disease inactivated vaccine: It is one of the most important weapons to prevent the occurrence and prevalence of foot-and-mouth disease. The vaccine should be an emulsion, allowing a small amount of oil phase precipitation or stratification of the emulsion column. If it encounters demulsification or exceeds the specified stratification (water phase exudation should not exceed 1/10 according to the regulations), it cannot be used. Vaccines should be stored at 2-8°C in the dark to prevent freezing. This vaccine mainly uses 50ml and 100ml veterinary vaccine bottles, and other piglets use 20ml or 50ml specifications.

The above is the application of different specifications of packaging in animal vaccines. In addition to being used as storage containers for inactivated vaccines, veterinary vaccine bottles can also be used to store vaccine diluents, and the specifications are mainly 20ml-50ml.