Oral Liquid Bottle Quality Standard

 Oral liquid bottles are mainly used to contain various oral liquid or syrup drugs, and the packaging directly contacts the drugs.

60ml amber PET bottle

100ml PET oral liquid syrup bottle

Oral liquid bottles are generally processed from polyester raw materials with additives. From the perspective of material properties, polyester has high transparency, good barrier properties, and is light in texture, not fragile, easy to process and shape, and has a high degree of automation. It is a good packaging material. In addition to being used in pharmaceutical packaging, it has a wide range of applications in food, beverages, and health products.

At present, the oral liquid bottles of polyester raw materials implement the YBB00102002-2015 "Oral Liquid Medicinal Polyester Bottles" quality standard, and the test items involved include appearance, material identification, tightness, oscillation test, water vapor transmission, and burning Residue, leachable test, microbial limit, abnormal toxicity and many other aspects. Each test is of extraordinary significance. For example, the appearance is to ensure the aesthetics of the package and give consumers a good impression; the tightness test is to ensure that the package does not leak, and that the chemical solution is not polluted by the external environment; The test is to test the compatibility of the drug with the packaging and ensure that the two do not react.

Effervescent Tube with Spiral Desiccant Closure

 The spiral desiccant closure or stoppers for our effervescent tablet tubes provide maximum protection while enhancing the shelf life of your product. Our spiral desiccant closure comes with an inbuilt tamper evident ring which can protect the integrity of your product while the spiral design of spiral desiccant cap helps in keeping the product in place during transportation.

spiral desiccant closure

As the industry level of misconduct and OTC drugs introduced the New Deal, industry demand for pharmaceutical packaging will be toward a more secure, more convenient, faster and more environmentally friendly direction. At present, the majority of drug packaging, quality generally unstable, with function of moisture-proof and deoxidizer function of medicinal plastic moisture proof cover less plastic bottles, nearly 7 compounds packaging are not up to international standards. Most domestic pharmaceutical packaging enterprise does not pay attention to technology and new materials research and development, still less investment in technology. Overall packaging materials of low value-added products, pharmaceutical packaging in the international market accounted for 30% of the value of the drug, compared with only 10% in China, far behind the international market.

effervescent packaging

As consumers purchasing trend gradually increase, medical market is more and more big, the pharmaceutical packaging market by the glass to plastic products, plastic pharmaceutical packaging more attention and concern. Pharmaceutical companies appearance of packaging, packaging design and packaging, quality promotes gradually, OTC drugs is more outstanding.

According to this situation, shijiazhuang Xinfuda Medical Packaging co., LTD., a new development with spiral desiccant closure has produced for oral solid pharmaceutical plastic bottles, desiccant cap is more security and prevent children open the auxiliary function, good sealing, in line with the national drug packaging materials and containers registration certificate, without aluminum foil sealing.

How to ensure the tightness of pharmaceutical bottle cap

 Tightness is a major function of pharmaceutical bottle caps, and it is also a very important test item in the quality standard of pharmaceutical packaging. If the sealability is not up to standard, the medicines in the package are easily polluted by the external environment or deteriorated by moisture, which endangers the health of patients. So, how does the lid ensure its tightness?

Child resistant cap

The sealing measures of medicinal bottle caps are mainly reflected in the sealing gaskets and sealing equipment. Generally, aluminum caps or plastic caps are mostly used for medicinal plastic bottles, and the matching gaskets include silicone gaskets and butyl gaskets. And aluminum foil gasket.

desiccant sprial cap

The silicone gasket has good chemical stability, pressure resistance, high temperature resistance, low temperature resistance, safety, environmental protection, no peculiar smell, insoluble in water and any solvents. It is a highly active green product, whether it is used in medicine or food grade. It is very safe and reliable. (2) Butyl gaskets: It is a type of gaskets that are more commonly used in the market, and butyl reclaimed rubber can replace butyl raw rubber to produce various medical sealing gaskets, reducing the cost of raw materials. (3) PE gasket has a single composition, non-toxic, tasteless, odorless, and has no independent bubbles. Good chemical stability, acid and alkali solvent resistance, using this gasket can increase the tightness of the bottle cap.

To enhance the sealing performance of pharmaceutical bottle caps, the above three types of gaskets are generally selected. In addition, to achieve good sealing performance, it is also necessary to control the size of the bottle cap and the mouth of the bottle. An interference fit between the two can ensure good drug storage.

Three main reasons for damp packaging of effervescent tablets

 Effervescent tablet packaging is a straight barreled packaging container, mainly used to store large tablets such as VC effervescent tablets. The main requirement for the packaging of this kind of drugs is moisture-proof. If the tablets are damp, they will easily decompose and deteriorate, which will endanger the safety of patients. If the packaging is found to be damp, the reasons can be analyzed from the following three aspects:

84mm effervescent tablet tube

144mm eff tablet tube supplier

1. Airtightness: If the inside of the effervescent tablet package is damp, first consider whether the airtightness of the package is qualified. The factors that affect the sealing performance mainly depend on the precision of the mold and the strict control of the brother's production process. Packaging materials generally have moisture barrier properties, which can block external water molecules, but if the seal is not tight, it is easy to cause water vapor to enter the package, causing the drug to be damp and deteriorate.

2. Dosage of desiccant: The desiccant inside the drug package is mainly a mixture of silica gel and molecular sieve. If the overall seal is good, the interior of the package still has moisture, it may be because the amount of desiccant is not enough to completely absorb the drug Consider increasing the amount of desiccant due to its own moisture.

3. External environment: The moisture inside the package is also related to the external environment. If the storage environment is too humid, it is easy to get moisture inside the package, so you should try to choose a dry and ventilated place during storage.

On the whole, if the inside of the effervescent tablet package is damp, you can analyze the above three aspects, and after finding the cause, formulate a specific solution to ensure the stability of the drug during storage.

Effervescent Tablet Tube with FDA

 Effervescent tablet tube with FDA as an important packaging for vitamin and chew in effervescent packaging, due to its excellent sealing and desiccant. Xinfuda effervescent tablet tube sizes from 84mm to 144mm with moisture proof tamper closure. The desiccant cap with spring can prevent the tablet shaking.

           

                       

 84mm effervescent tablet tube                                              144mm EFF Tab tube

The cap of effervescent tablet tube takes the important impact on the food or medicine. The tube can be used for vitamin, chew, test strip and so on. Test strip packaging also as a popular packaging in lab test equipment.

                         

spiral desiccant closures                                                       desiccant cap

Effervescent tablet tube is made of PP raw material, which has high hardness, acid and alkali corrosion, high . However its flexibility is lower than PE. Effervescent tablet tube with moisture proof tamper perform well in storing capsules and tablets which need dry condition.

Effervescent Tubes Manufacturer from China

 Effervescent tubes with spiral desiccant closure can be produced by Xinfuda Medical Packaging manufacturer, plastic tube with cap is usually used in effervescent tablet and test strip.

 

 

effervescent tube 

Effervescent tubes with cap are made of different sizes tube and desiccant cap with spiral, which can be more safe for tablets, there are five sizes including 84mm, 99mm, 96mm, 133mm and 144mm. 

Xinfuda Packaging as the best manufacturer in northern China, we have advanced technology and machine to offer healthy and wonderful products for customers.

What is plastic twin neck bottle?

 

1000ml dispensing bottle

The plastic twin neck bottle is one bottle with two neck, which is typically used to store liquids such as water, beverages, disinfector, pesticides, soaps, lubricants, concentrated cleaners and fuel. So this plastic twin neck bottle is used widely in the world, for example, drinks, disinfector, liquid medicine, fuel and so on.

The plastic twin neck bottle is made of HDPE and LDPE.

The twin neck bottle make dosing and dispensing simple and convenient! With just a single hand, users can measure and pour with ease.

To use these dispensing bottles, simply loosen cap from dispensing chamber. Gently squeeze the bottle to fill measuring chamber with required amount of liquid. Remove cap from dispensing chamber and easily pour measured fluid from the chamber.

How to choose the twin neck bottle?

choose the suitable capacity and dosing chamber

choose the suitable material LDPE or HDPE according to the liquid which you will fill in.

you need observe the surface of the twin neck bottle

Dosing syringes can make work easily for dogs paste

 

pets syringe

Pills and chewable medications are usually relatively easy to administer to dogs. Most dogs will readily eat a pill that is hidden in a small treat, such as a piece of cheese or a bit of peanut butter.

But if you want to give liquid or paste gel medicine to your dog, this way mybe not good. In such case, you can use tools to give medicine.The plastic prefilled dial a dose syringe is a easiest tool for you. Now I will tell you how to give liquid medicine to your dog with the injection syringe.

Liquid and gel paste can be given via a syringe into the rear of the dog’s mouth by inserting the tip of the veterinary syringe near the back teeth on either side. Holding the dog’s head pointing partially upward can help prevent spills.

How to produce effervescent table tube?

Effervescent Tubes with Desiccant and Stopper

 Usually effervescent tablets has two years expiration date, However it is used for 12-18 month in practical application. Two main desiccant are silica and molecular, and silica is the only one met demands of FDA. Desiccant and stopper caps make the vitamin and chew healthy and dry.

 

 

 84mm Effervescent tubes with desiccant and stopper

 

Silica of desiccant and stopper is a highly active adsorption material, It is hard, non-toxic, tasteless, non-corrosive, also strong chemical stability and thermal stability.

Silica has strong hydrophilia, at the same time has many holes with out eyes seeing on the surface of the silica gel desiccant cap, make its surface area has greatly increased, these characteristics of silica gel desiccant decided to become a good hygroscopicity of desiccant.

What should we pay more attention on choosing plastic pharma bottle

 Child resistant cap bottle mainly keep safe and prevent healthy people eatting by mistake, especially for children and psychopath. However desiccant bottle can offer dry condition for tablets. Today we talk something about plastic pharma bottle.

plastic pharma bottle with child resistant cap

Recently general plastic pharmaceutical packaging adopts the way of aluminum foil gasket seal to keep sealing. However after opening the gasket, sealing effect can not be get guarantee. The cap of tablets and capsules need to be opened frequently and the sealing is bad, which will cause drug absorption or oxidative deterioration. So there is a big hidden danger replying on gasket sealing. Second, when the cap is opened frequently, humidity will come into plastic bottle, and then speed up drug metamorphic. Especially for effervescent tablets, test strip and so on, it will be out of shape or go bad after moisture absorption. Excellent sealing bottle is important for tablets and capsules.

pharma desiccant bottle with CRC

So point of special child resistant cap bottle is having moisture proof, child resistant and desiccant cap can gurantee the drugs in the bottle can remain relatively sealed after opening, when using drugs. In order to prevent children opening and eating by mistake dangeriously. Recently the plastic pharma  bottle has applied for national patent.

The invention relates to the special structure of the bottle cap of the packaging bottle to achieve the purpose of the invention. The patent bottle cap is bilayer structure and equipped with child resistant cap, excellent sealing due to drug storehouse on the cap top, which can store desiccant and oxygen absorbent.

Take Care of Children, Starting with HDPE Child Resistant Cap Bottle

 HDPE bottle with push and down cap is a safe packaging  for children. It can be opened by double cover. In 2016, Center for drug evaluation and complete drug registration review and presented to the General Administration for approval for a total of 10060 pieces, 729 pieces of drug registration and complete review for reporting defects of applicants waiting for reply. There are so many kinds of drugs, but in terms of packaging, We only need material, compatibility and so on, External security and anti miseat in China now has no strong norms, promotion of high density polyethylene pressure screw cap bottle is also limited to the legal outside.

 

 

HDPE bottle with child resistant cap

In the United States, many tablets and capsules have been forced to use child resistant cap packaging. This package can not be said to prevent from the root of the eating event, but after 3 years of accumulated data comparison can be seen, the use of safe packaging after eating incident frequency dropped more than 36 percentage points before use.

 

 

75ml HDPE bottle with child proof cap  z007

 

Chinese pharmaceutical packaging appeals to tablet and capsule packaging using push and down cap packaging. In particular, mental, cardiovascular and cerebrovascular products try to use high-density polyethylene bottle, to protect life, from a bit start.

What Should We Pay More Attention On Choosing Child Proof Cap

 Child proof cap bottle mainly keep safe and prevent healthy people eatting by mistake, especially for children and psychopath. Today we talk something about child resistant cap.

 

 

pharma bottle with child proof cap

Recently general plastic bottle adopts the way of aluminum foil gasket seal to keep sealing. However after opening the gasket, sealing effect can not be get guarantee. The cap of tablets and capsules need to be opened frequently and the sealing is bad, which will cause drug absorption or oxidative deterioration. So there is a big hidden danger replying on gasket sealing. Second, when the cap is opened frequently, humidity will come into plastic bottle, and then speed up drug metamorphic. Especially for effervescent tablets, test strip and so on, it will be out of shape or go bad after moisture absorption. Excellent sealing bottle is important for tablets and capsules.

 

 

60ml plastic bottle with CRC

 

The invention relates to the special structure of the bottle cap of the pharmaceutical packaging bottle to achieve the purpose of the invention. The patent bottle cap is bilayer structure and equipped with child resistant cap, excellent sealing due to drug storehouse on the cap top, which can store desiccant and oxygen absorbent.

With the attention of drug safe, the using of patent child proof cap bottle.

What is Child Resistant Cap Bottle

 Child resistant cap bottle is aslo called CRC bottle, it is a necessary packaging for drug. It is safe for family who has children, especially for baby who can not distingwish anything. Children may eat tablets by mistake if open the pharma bottle.

pharma bottle with child resistant cap 

Pharmaceutical packagingchild resistant cap is contain with bottle and cap. The special design is the double cover, inner cap and thread of bottleneck connected, cover and inside links,it need external force to press the cover and turn to open. Which need people push down and turn can open the bottle. It adopts advanced injection blow molding which makes even bottleneck and uniform wall thickness. 

100ml child proof cap bottle

Excellent sealing and high security show the good quality. Child resistant cap is mainly used in medical and health care to prevent children eating pills or food by mistake.

Quality control point of vaccine vials

 Plastic bottles are widely used in many industries. Among them, our veterinary medicine industry also has a lot of applications. There are many types of injection vials, and the quality of products is also uneven. Manufacturers of vaccine vials need to control quality in many ways when producing bottles.

small injection vial

1. Capacity: Due to the particularity of drug packaging and medication, the shape is mostly round from a few milliliters to about 1,000 milliliters.

2. In order to ensure that the medicine is not affected by moisture and does not deteriorate during the validity period, the medical plastic bottle should have good sealing and barrier properties, and can prevent the effects of light, heat, water vapor, and oxygen on the medicine.

3. The inner wall of the oral liquid bottle is in direct contact with the drug. The bottle-making material must meet the requirements of the drug packaging to ensure the safety of the drug.

4. Oral liquid bottles belong to a class of packaging materials. It can be used for pharmaceutical packaging without cleaning and sterilization. Therefore, there are higher requirements for microbial limits, and the production environment and production process should meet the requirements of relevant regulations. 

5. The shape, size and structure of the oral liquid bottle should meet the requirements of various types of filling machines for pharmaceutical companies and the requirements of high-speed automatic filling machines.

Horse paste syringe appearance

 Our factory is a professional horse paste dispensing syringe manufacturer,we have our dial a dose syringe standard,and I will introduce the technical requirements from two aspects,one is sensory requirements,the other one is physical and chemical indicators.

veterinary syringe

I will introduce the appearance requirement of paste syringe.

1.Appearance,in natural light bright place,the syringe should have uniform colors,the surface should bright and clean,smooth,don't have obvious chromatic aberration.

2.The barrel of syringe is not crooked,the syringe don't have rags,deformation,cracks,sand hole,oil contamination,bubble;

3.The inside wall of barrel should be smoothness,don't have crinkle.

4.The syringe tip should be smooth

5.The syringe don't have defective printing which can influence of using

Introduction of two caps for effervescent tablet packaging

 Effervescent tablet packaging is a packaging containing vitamin effervescent tablets or chewable tablets and other dosage forms. It has good moisture resistance. According to the different packaging requirements of pharmaceutical companies, this packaging contains two types of bottle caps.

caps for effervescent tube

Spring cap: This bottle cap is characterized by a spiral spring on the cap, this spring is made of LDPE raw materials, can play a role in compressing the tablets, and avoid being broken due to various external forces during transportation. It also reduces unnecessary losses for pharmaceutical companies. The LDPE material has good flexibility. The use of this material as a coil spring will neither crush the fragmentation agent due to the too hard texture, nor cause the medicine to be poorly fixed due to the too soft texture and too small pressure. It can give full play to the spring design. The advantages. In addition, this kind of bottle cap also has a feature that it has a desiccant. Unlike ordinary medicine bottles, the effervescent tablet packaging puts the desiccant on the cap, saving space, and is a cap with moisture-proof function. .

effervescent tablet tube 84mm

Non-spring cap: This kind of bottle cap is different from the spring cap. There is no spring on the cap, but it also has a moisture-proof function. Generally, vitamin chewable tablets and small-dose candy tablets will choose this kind of cap, and some vitamin C effervescent tablet manufacturers will also use this kind of bottle cap.

The above are the two types of caps and their characteristics for effervescent tablet packaging. These two different types of caps meet the differentiated needs of pharmaceutical companies for packaging, and are also a manifestation of the continuous development and diversification of pharmaceutical packaging.

Pay attention to these four points when sterile dosing syringe

 Dosing syringe is used for sterilization, generally using ethylene oxide sterilization, but if you do not pay attention to these points, it is easy to have hidden dangers or affect the sterilization effect.

30ml dial a dose syringe

1. The ethylene oxide sterilizer must be placed in a well-ventilated place. Do not place it near the fire source. In order to facilitate maintenance and regular maintenance, 51cm of space should be reserved on each side (including the top) of the ethylene oxide sterilizer. Special exhaust ducts should be installed and completely isolated from other exhaust ducts in the sterilization site.
2. Items that need to be sterilized must be thoroughly cleaned. Note that they cannot be cleaned with saline. There should be no water droplets or too much water on the sterilized items to avoid dilution and hydrolysis of ethylene oxide. If the packaging material is changed, it should be verified to ensure the reliability of the sterilization of the sterilized items.
3. There should be gaps on the top, bottom, left and right of the loaded items in the sterilization cabinet (the sterilized items cannot touch the cabinet wall), and the items should be placed in a metal mesh basket or on a metal net rack; the amount of items loaded should not exceed the total volume of the cabinet 80% of it.
4. Sterilization treatment: It should be carried out in accordance with the operating instructions of the manufacturer of the ethylene oxide sterilizer; select the appropriate sterilization parameters according to the type, packaging, loading volume and method of the plastic dosing syringe.
Different from sterilization methods such as high temperature and high pressure, there will be a certain amount of residue after ethylene oxide sterilization. The sterilized veteriary syringe needs to be placed for a period of time to release the residue and ensure the safety of dosing syringe and medicine.

Packaging syringe for mastitis

Syringe for the packaging of products for the treatment of Mastitis. This type of packaging is commonly known as mastitis syringes in the veterinary environment, they are used by practically all veterinary pharmaceutical laboratories for the packaging of their products for the treatment, control and eradication of subclinical, clinical or chronic mastitis that occurs in dairy cattle, primarily, this condition is responsible for significant losses for dairy farms, especially those located in intensive production regions. Likewise, it is one of the main causes in making early dairy cow slaughter decisions, derived from the various and recurrent problems in the health of the mammary gland, about 27% of dairy cow slaughter is due to disorders associated with mastitis and loss of milk production.

5ml intramammary syringe

10ml udder injector

Therefore, the importance of having a suitable container for the application of pharmaceutical products for mastitis, which guarantees the useful life of the product in its transport, storage, shelf stays and especially in its due and correct application, all Syringe must meet at least the characteristics of tightness, seal, dimensions and measures available to its final use, whether it is the application of drugs for the control of mastitis or the application of dryers.
Other names by which it is known: Mastitis syringe, Intramammary syringe, Syringe with intramammary cannula, Syringe mastitis, Syringe with cannula for mastitis

Why eye drops bottle can only be used for four weeks after opening

 Eye drops occupies an important position in ophthalmic drugs and are a very common type of drug. Any medicine has a validity period. The validity period of eye drops is generally 1-3 years. If the eye drops bottle is opened, the validity period of the medicine is only four weeks.

eye dropper bottle

The 1-3 year validity period marked on the eye drop bottle packaging refers to the time when the package is unopened. The "People's Republic of China Pharmacopoeia" stipulates that "ophthalmic preparations can be used for up to 4 weeks after being used", even if the drug is still within the validity period. Inside, the eye drops can only be used for up to 4 weeks after opening.

This is because once the eye drops are opened, they are easy to come into contact with microorganisms and tears during storage and use, leading to drug contamination. Under normal circumstances, each eye drop will be available after opening in the manual [Precautions] Maximum time used. Some drugs can be used for less than 4 weeks after opening, and the specific instructions shall prevail. Patients are advised to indicate the opening time on the package after opening the eye drops to avoid expiration and deterioration.

Of course, there are some special cases. If it is a small package of eye drops without preservatives, it will not have any resistance to bacteria and viruses floating in the air after opening. Each small bottle is only used for one time. Open the eye drops bottle After that, it can only be used once, and it needs to be discarded after the medication is finished

Horse paste syringe appearance

 Our factory is a professional horse paste dispensing syringe manufacturer,we have our dial a dose syringe standard,and I will introduce the technical requirements from two aspects,one is sensory requirements,the other one is physical and chemical indicators.

veterinary syringe

I will introduce the appearance requirement of paste syringe.

1.Appearance,in natural light bright place,the syringe should have uniform colors,the surface should bright and clean,smooth,don't have obvious chromatic aberration.

2.The barrel of syringe is not crooked,the syringe don't have rags,deformation,cracks,sand hole,oil contamination,bubble;

3.The inside wall of barrel should be smoothness,don't have crinkle.

4.The syringe tip should be smooth

5.The syringe don't have defective printing which can influence of using                        

The importance of effervescent tablet packaging in protecting the safety of medicines

Vitamin C effervescent tablets contain disintegrants, which are easy to decompose when exposed to moisture. The packaging of effervescent tablets plays a vital role in protecting the safety of medicines.

1.The packaging of effervescent tablets has good airtightness to protect vitamin C effervescent tablets and keep them in a good storage environment. First of all, this packaging is generally processed from polyethylene or polypropylene raw materials, which is a barrel-shaped bottle. The diameter is slightly larger than the diameter of the tablet, which is convenient for filling and easy for patients to take out the medicine. The raw materials of the packaging have good barrier properties, which can isolate the intrusion of external impurities.

84mm effervescent tablet tube 

2. The packaging of effervescent tablets protects the safety of medicines. The medicines are unavoidably subjected to various external forces during transportation. There is a spiral spring on the packaging bottle cap. This spring is made of soft low-density polyethylene. Plays the role of compressing the tablet to prevent the drug from being damaged during transportation.

desiccant cap

3. Another important function of effervescent tablet packaging is moisture prevention. Unlike ordinary medicine bottles, which put the desiccant in the bottle in the form of a bag, this kind of packaging puts the desiccant in a small medicine bin on the bottle cap. This not only avoids the direct contact between the medicine and the desiccant, but also effectively prevents children from ingesting the desiccant by mistake.

Introduction of two caps for effervescent tablet packaging

 Effervescent tablet packaging is a packaging containing vitamin effervescent tablets or chewable tablets and other dosage forms. It has good moisture resistance. According to the different packaging requirements of pharmaceutical companies, this packaging contains two types of bottle caps.

caps for effervescent tube

Spring cap: This bottle cap is characterized by a spiral spring on the cap, this spring is made of LDPE raw materials, can play a role in compressing the tablets, and avoid being broken due to various external forces during transportation. It also reduces unnecessary losses for pharmaceutical companies. The LDPE material has good flexibility. The use of this material as a coil spring will neither crush the fragmentation agent due to the too hard texture, nor cause the medicine to be poorly fixed due to the too soft texture and too small pressure. It can give full play to the spring design. The advantages. In addition, this kind of bottle cap also has a feature that it has a desiccant. Unlike ordinary medicine bottles, the effervescent tablet packaging puts the desiccant on the cap, saving space, and is a cap with moisture-proof function. .

effervescent tablet tube 84mm

Non-spring cap: This kind of bottle cap is different from the spring cap. There is no spring on the cap, but it also has a moisture-proof function. Generally, vitamin chewable tablets and small-dose candy tablets will choose this kind of cap, and some vitamin C effervescent tablet manufacturers will also use this kind of bottle cap.

The above are the two types of caps and their characteristics for effervescent tablet packaging. These two different types of caps meet the differentiated needs of pharmaceutical companies for packaging, and are also a manifestation of the continuous development and diversification of pharmaceutical packaging.