Eye drop bottle purchase to control these points

 Eye drops are common drugs for the treatment of eye diseases. As packaging materials for direct contact with drugs, the quality of eye drops bottles is the focus of attention of pharmaceutical companies. At present, there are many types of pharmaceutical packaging materials. How to choose high-quality and suitable eye drop bottles has become the key to many pharmaceutical companies to improve their product competitiveness.

5ml eye dropper bottle

The eye drop bottle is composed of a bottle cap, a bottle body and a bottle mouth. Due to the high reusability, the torque of the bottle cap will directly affect the tightness of the package. Pharmaceutical companies should fully consider this factor when choosing eye drop bottles. . According to the regulations of "Low Density Polyethylene Medical Eye Drop Bottle", when the bottle cap is twisted at 55-80Ncm, the bottle mouth and cap should match properly, and the teeth should not be slippery.

Secondly, consider the tightness of the eye drop bottle. The detection method is as follows: take a few of this product, first open the bottle, and then tighten the cap (use a force wrench to tighten the bottle and cap with a torque of 55-80Ncm, and place it in Add a baffle to the container with an air extraction device, immerse it with water, and vacuum to a vacuum of 20kPa and maintain it for 2 minutes. There should be no water or bubbling in the bottle.

Eye drops are in direct contact with the eyes, which is a high-risk route of administration. Under certain conditions, plastic packaging will migrate some of the substances contained in it to the contents, which may trigger a reaction to the contents. Therefore, the eye drops bottle Non-volatiles detection is very important. Detection method: Precisely measure 50.0ml each of the test solution and the blank solution and place them in an evaporating dish with constant weight. After evaporating to dryness in a water bath, dry to constant weight at 105°C. The difference between the two should not exceed 5.0mg.

In summary, the quality of eye drop bottles is related to the effectiveness and safety of drugs. Cap torque, tightness, and non-volatile detection are several factors that pharmaceutical companies should focus on when choosing packaging. A powerful means to control packaging quality to ensure drug safety and improve product competitiveness.

The key to early immunity to chicken respiratory diseases

 Respiratory diseases are an important factor threatening the healthy production of poultry. Such diseases are infectious to a certain extent. Disease outbreaks in farms will affect the entire chicken flock and bring huge economic losses to farmers. How to prevent and control poultry diseases is a concern for many farms. It is the inescapable responsibility of many veterinary drug packaging companies to improve the quality of vaccine bottles, serve more pharmaceutical companies, and help the development of the breeding industry.

small injection vial

Common chicken respiratory diseases include Newcastle disease, mild avian influenza, spreading, rhinotracheal ornithosis, mycoplasmosis, etc. Because the cause is complex and easy to recur, poultry respiratory diseases should be treated with prevention as the primary supplement, supplemented by treatment, combined with prevention and treatment Comprehensive measures.

From the perspective of farm management, farmers should keep cold and warm according to climate change and reduce cold stress. Disinfect the breeding environment regularly, and treat sick and dead chickens in a harmless manner to ensure the environmental hygiene of the chicken house.

To effectively reduce the incidence of chicken respiratory diseases, we should start from the root cause, strengthen the pre-immunization work, and enhance the overall immunity of the flock. It should be noted that the tightness of the vaccine bottle is related to the immune effect of the vaccine. The integrity of the vaccine bottle should be confirmed before vaccination to ensure that the vaccine can achieve a good vaccination effect.

Winter and spring are the frequent seasons for chicken respiratory diseases. Doing a good job in disease prevention and control and improving the overall efficiency of the farm is the foundation of promoting the healthy and stable development of the aquaculture industry. It is also the common responsibility of pharmaceutical companies and vaccine bottle manufacturers.

China intramammary syringe

 For intramammary syringe of vet. med. pastes and gels, e.g. for mastitis treatment.

Xinfuda has mastered the production of a new product – syringe-injectors to be filled with preparations against mastitis. 

5ml syringe for cow mastitis

Syringes are manufactured on modern equipment and do not differ from analogues of European manufacturers neither in parameters nor in quality. 

The cannula of a syringe is very elastic and does not injure the teats of the udder.

The cap of a syringe seals the nozzle of the flask and the piston perfectly sits in the flask body leaving no chance to leakage of the substance.

The piston of a syringe ideally slides inside the flask due to the use of special polymer additives approved for contact with food, this feature allows more smooth injections. 

Viewing the special design of effervescent tube from the importance of medicine moisture prevention

 As a necessary product in our lives, medicine is mainly used to prevent, treat and diagnose various diseases. Because of its direct action on the human body, the safety and effectiveness of medicines are crucial. It is a common choice of many pharmaceutical companies to prevent the deterioration of medicines from moisture absorption through the design of moisture-proof packaging. The common effervescent tube makes good use of this function of packaging.

144mm eff tablet tube

Drugs are prone to deliquescence by absorbing water, especially for effervescent tablets. To achieve the function of moisture-proof, packaging materials are required to have high moisture resistance and low water vapor transmission rate, which can effectively prevent the intrusion of external water vapor and prevent the medicine from being damp.

desiccant cap

In addition, the moisture resistance inside the effervescent tube must also be considered. After the drug is taken, some water vapor may enter the package through the cap during the opening process. Therefore, most of the effervescent tubes are fully considered in the design. When it comes to the importance of moisture-proofing for medicines, a moisture-proof cover is used in the design of the effervescent tube. The moisture-proof cap is a new design that combines the desiccant and the bottle cap into one. There is a small medicine storehouse on the top of the bottle cap to store silica gel and molecular sieve, which can absorb the moisture in the effervescent tube and keep the medicine dry. This design saves space and avoids the risk of children accidentally ingesting the desiccant, and is suitable for test strips and tablet packaging with larger dosage forms.

The special moisture-proof cover design of the effervescent tube is an inevitable trend for pharmaceutical packaging companies to adapt to the changing market needs. We will wait and see what innovative designs for pharmaceutical packaging in the future.

China's pharmaceutical packaging industry is advancing under supervision

 In recent years, with the vigorous development of the pharmaceutical industry, the pharmaceutical packaging industry in its downstream industries has also ushered in a period of rapid development. The development of the industry is inseparable from the norms of the opening standards. Looking at the development history of the pharmaceutical packaging industry, it is actually the history of perfection of the industry's regulatory policies.

eye dropper bottle

Compared with developed countries, my country's pharmaceutical packaging industry started late, but the speed of development is amazing. In 1978, the former State Administration of Pharmaceutical Administration was established, which opened a new phase of unified management and standardized development of my country's pharmaceutical field. So far, the supervision of my country's pharmaceutical packaging industry has gone through three stages, from enterprise production licenses, product registration approvals, to the review and approval of drug preparation registration applications.

effervescent tablet tube

"Administrative Measures for Drug Packaging (Trial)", "Production License for Pharmaceutical Packaging Materials and Containers", "Administrative Measures on Packaging Materials and Containers Directly Contacting Drugs", "Opinions of the State Council on Reforming the Review and Approval System of Drugs and Medical Devices", Opinions on Deepening the Reform of the Review and Approval System and Encouraging the Innovation of Drugs and Medical Devices, "Announcement of the General Administration on Adjusting the Review and Approval Items of APIs, Excipients and Packaging Materials"... After more than 40 years of deepening reforms, the National Pharmaceutical The Drug Evaluation Center of the Supervision Bureau has established a registration information platform for APIs, pharmaceutical excipients and pharmaceutical packaging materials. Relevant enterprises or units can submit the registration data of APIs, pharmaceutical excipients and pharmaceutical packaging materials through the registration platform, and after obtaining the registration numbers of APIs, pharmaceutical excipients and pharmaceutical packaging materials, they can be reviewed together with the registration application for pharmaceutical preparations.

In addition, comprehensive market trends such as volume procurement, drug consistency evaluation, and various policies for the healthy development of the industry have greatly promoted the high-quality development of the pharmaceutical packaging industry. As the country continues to increase investment in the medical industry, the pharmaceutical packaging industry's own regulatory policies continue to improve, and the pharmaceutical packaging industry will usher in long-term development.

Veterinary medicine packaging helps livestock

 Animal diseases have always been the main factor restricting the healthy development of animal husbandry. Veterinary drugs play a key role in the prevention and control of animal diseases and safeguarding the healthy development of animal husbandry. The safety and effectiveness of veterinary drugs must be ensured to maximize their use in animal immunity. The efficacy of the drug requires high-quality packaging for veterinary drugs.

veterinary syringe

In recent years, with the continuous improvement of a series of regulatory policies such as the "Chinese Veterinary Pharmacopoeia" and "Veterinary Drug Production Quality Management Regulations", veterinary drugs have made phased progress in terms of production raw materials and production process control, and product quality. As the standards become more comprehensive and standardized, the veterinary drug packaging industry related to them is also gradually developing in a standardized direction. The quality of veterinary drug packaging is related to whether the drug can be stored well and the stability of the drug effect during the validity period. If pharmaceutical companies ignore this point when choosing veterinary drug packaging, it will easily cause the drug to become damp and deteriorate. The influx of deteriorated drugs into the market will not only give farmers Bringing losses will also cause a certain negative impact on veterinary drug manufacturers. Therefore, quality is essential when choosing pharmaceutical packaging.

vaccine bottle

The quality of veterinary drug packaging must first examine the qualification rate of the product in terms of product sealability, drop resistance, volatile matter, dissolution test, and microbial limit. Product qualification and compliance with standards are the most basic requirements. Secondly, it is necessary to conduct a compatibility test on the packaging according to the characteristics of the medicine to ensure that the medicine and the packaging will not react. Finally, it is necessary to comprehensively consider the production scale and various qualifications of the pharmaceutical packaging material supplier to ensure the timely delivery of orders and subsequent services.

plastic liquid bottle

To sum up, veterinary drugs and veterinary drug packaging are a closely connected industry chain, and the two complement each other to jointly help the prevention and control of animal diseases and the healthy development of animal husbandry.

Why are effervescent tablets contaminated and deteriorated

 Effervescent tablets are a new type of preparation that originated from abroad and has also been widely used in China in recent years. Due to the complex production process, high difficulty and high production cost, this formulation has very strict requirements on packaging. The effervescent tube must not only meet the basic moisture-proof and sealing requirements, but also consider the impact of various impact forces on the tablet during transportation.

effervescent tablet tube

The effervescent tube is a necessary part of the effervescent tablet to enter the market. If the effervescent tablet is contaminated and deteriorated, it is generally related to these factors of the effervescent tube. First of all, it depends on whether the effervescent tube is completely sealed. If the seal is not complete, external water vapor will invade the inside of the package, and the effervescent tablet has the characteristics of moisture absorption, which can easily cause deterioration of the preparation by moisture.

Secondly, the anti-drop performance of the packaging should be considered. This performance is mainly to prevent damage to the packaging and damage to the contents due to various external forces during the packaging, transportation, handling, and shelf circulation. The heavier the item, the higher the distance it falls, the higher the impact energy generated, and the higher the strength requirements of the packaging. The anti-drop performance of the effervescent tube can be tested as follows: the desiccant cap and bottle body are dropped at a height of 1 meter, the bottle cap is not broken, and the desiccant must not leak. Since the desiccant of the effervescent tube is generally placed in the cap, if the desiccant leaks, the silica gel and the molecular sieve will directly contact the drug, which will cause pollution to the effervescent tube.

Pharmaceutical packaging is a very rigorous industry, and any one of the packaging testing failures will have a certain impact on the drugs, and even affect the health of patients. When selecting effervescent tube suppliers, manufacturers of effervescent tablets should strictly examine their product quality and production qualifications to ensure drug safety.

Note on packaging selection of pet nutrition cream

 Pet nutrition cream is an easy-to-digest and practical quick-replenishing nutrient. It can help pets absorb the nutrients needed by the body more comprehensively and adequately, and is favored by pet owners. Scientific feeding promotes the healthy growth of pets. Key factor. A very important factor affecting scientific feeding is the packaging of pet nutrition cream. So how should pharmaceutical companies choose packaging?

15ml syringe for pets

Scientific feeding not only means that pets mainly take them to the hospital to check their bodies on a regular basis, prevent epidemics and deworming, but also pay attention to the amount of feeding when feeding pets, especially the fortified products such as pet nutrition cream. The health of pets has a certain impact. At present, the packaging of pet nutrition paste on the market mainly includes two forms of hose and perfusion. The hose packaging is a kind of packaging form similar to toothpaste. When using, squeeze the outer wall of the hose to squeeze it out, but this The packaging has certain defects. For example, the feeding amount of the nutrient cream has a great relationship with the user's hand strength, the feeding amount is not accurate, and this kind of packaging is prone to residues, which will cause waste. Packaging in the form of an infusion device will not have these problems. Compared with hose packaging, a pet syringe has the following advantages:

1. Easy to use, open the protective cap when using the plastic veterinary syringe and push the push rod to feed directly, easy to use;

2. Precise feeding, the infusion device can print scales on the push rod and use it with the positioning ring to make the feeding volume more accurate and scientific;

3. Reduce residues. The packaging in the form of a veterinary syringe uses push rods to feed, which can minimize the residue of nutritional cream and avoid waste.

Comprehensive advantages, pet nutrition ointment packaging in the form of a perfusion device has certain advantages in terms of usability, residue, and scientific feeding compared with tube packaging. Veterinary drug companies should closely follow the market demand and choose better applicability. The veterinary packaging can not only meet the scientific feeding needs of pet owners, but also win a good market reputation for the product.

What are the differences between domestic and foreign standards for medicinal eye drop bottles

 Pharmaceutical packaging is a powerful guarantee to ensure the quality of medicines and maintain their efficacy, and is an indispensable part of the circulation of medicines. As a container that directly contacts drugs, drug packaging requires industry standards to regulate its production quality, and eye drop bottles are no exception. Eye drops are a high-risk route of drug administration, and their packaging requirements are more stringent. So what are the differences between domestic and foreign standards for eye drop bottles?

eye dropper bottle

At present, the standards implemented for low-density polyethylene medical eye drops bottles are the national drug packaging (container) material standards promulgated by the State Food and Drug Administration, YBB00062000 and the 2015 version of the national drug packaging material standard YBB0062002-2015. This standard is only applicable For multi-dose eye drop bottles, the standard for single-dose eye drop bottles is mostly corporate standards. In the domestic standard, the appearance, tightness, dripping volume, dissolution test, clarity, clarity, easy oxidation, PH value change, heavy metals, non-volatile matter, ignition residue, and decolorization test of eye drop bottles , Microbial limits, etc. have specific requirements.

Although the United States Pharmacopoeia (USP) and European Pharmacopoeia (EP) do not directly stipulate the quality standards of eye drop bottles, there are relevant regulations for polyethylene plastic packaging materials in the general rules. Compared with China's eye drop bottle standards, the United States and European Pharmacopoeia have no special requirements on the amount of eye drop bottle dripping, pH change, and eye irritation test. However, there are no special requirements for aluminum, chromium, titanium, vanadium, zinc, and zirconium. The content has standard requirements, and other items are not much different.

Through the comparison of the quality standards of eye drop bottles at home and abroad, it is not difficult to see that the domestic packaging standards are already very standardized and can fully meet the packaging needs of the domestic pharmaceutical industry. Among them, there are many pharmaceutical packaging materials companies that are going to the international stage. It is believed that with the continuous innovation and improvement of my country's packaging processing technology, the domestic pharmaceutical packaging standards will be in line with international standards and help the internationalization of Chinese pharmaceutical companies' brands.

How to choose better veterinary drug packaging

 With the completion of the revision of the 2020 version of the "Chinese Veterinary Pharmacopoeia" and the "New GMP", the veterinary drug industry has entered an era of stricter supervision, and the related veterinary drug packaging industry will also face greater challenges. There are many veterinary drug packaging companies on the market, and the product quality levels are not uniform. How can veterinary drug companies choose better packaging?

intramammary syringe

Applicability refers to the characteristics of a product suitable for use. It is a broad concept, including material aspects, such as physical properties, chemical composition, etc.; it also includes operational aspects, such as whether the operation is reliable, safe, and convenient to use; time Aspects, such as service life, accuracy retention, reliability, etc.; appearance aspects, such as beautiful appearance, packaging quality, etc.

100ml PP vaccine bottle

The applicability of veterinary drug packaging is mainly considered from the aspects of product material, functionality, convenience and overall appearance. Common materials currently used for packaging of veterinary drugs include polyethylene, polypropylene, polyester and other materials. Choose suitable materials according to the specific needs of pharmaceutical companies. If terminal sterilization is required, polypropylene materials can be selected. If packaging transparency is required , Can choose polyester material... In terms of functionality, it can be confirmed by communicating with the manufacturer of the drug packaging material according to the needs of the drug; secondly, the convenience of the farmers in the drug delivery process should be considered, especially for the more frequent use Medicines, such as seasonal vaccines, are easier to cultivate the user's habits; the last thing to look at is the overall appearance of the packaging. A comfortable appearance will add points to the sales of medicines.

With the strengthening of the supervision of the veterinary drug industry, the importance of veterinary drug packaging has become more and more prominent. Pharmaceutical companies should fully consider the importance of packaging when choosing veterinary drug packaging.

Pharmaceutical packaging industry reshuffle

 The General Office of the State Council issued a document requesting to promote the normalization and institutionalization of centralized drug procurement, guide drug prices to return to a reasonable level, and reduce the burden of drug use by the masses. Data shows that as of 2020, the actual procurement volume of centralized drug procurement has reached 2.4 times the agreed procurement volume, and the overall cost savings have exceeded 100 billion yuan.

effervescent tablet tube

Procurement with quantity means that the required quantity of procurement will be announced in the bidding announcement. In the bidding process, in addition to the price, you must also consider whether you can afford the corresponding production energy. In the past, drug bidding only focused on price, not quantity. The winning bidder still needed to work in hospitals to promote the use of medicines; while for volume procurement, the sales of medicines were promised at the same time as the bidding to ensure that they would be used up within a few months. This procurement method can achieve the effect of volume-for-price through market-based bidding among enterprises and reduce the price of drugs purchased.

child proof bottle

For pharmaceutical companies, if the market share is not too high before winning the bid, the shortlisted purchase list can quickly increase sales, and sales will also increase simultaneously, which has the effect of trading price for volume. But if the market share was already high before, the increase in volume may not be enough to make up for the price loss. On the whole, mass procurement has had a huge impact on the entire industry chain of drug research and development, production, circulation, and use. With the continuous deepening and improvement of mass procurement in the pharmaceutical industry, the pharmaceutical market is about to face a major industry reshuffle.

eye dropper bottle

The pharmaceutical industry has started a big wave of sand-washing mode. As a direct contact with drugs, the pharmaceutical packaging industry, which has an important impact on drug quality and drug safety, will also be affected. Good pharmaceutical packaging is critical in meeting regulatory requirements, increasing brand effect, and helping patients comply with medication regulations. Only pharmaceutical packaging can be used as a carrier to enter the circulation market. The market effect of the survival of the fittest in the pharmaceutical industry will inevitably lead to a new round of integration in the pharmaceutical packaging industry, and pharmaceutical packaging material manufacturers without strength will be eliminated.

Drugs to treat cow mastitis

 Dairy cow mastitis is one of the most troublesome diseases for dairy farmers. It has the characteristics of high incidence and easy recurrence, and local administration to the diseased area of the breast through the intramammary syringe is considered to be one of the more effective treatment methods. What should be paid attention to during the administration process?

5 ml cow mastitis syringe

Dairy cow mastitis is different from other diseases, and the affected area is more special, so you should be more cautious when administering the drug through the veterinary syringe. The infusion should strictly follow the following procedures:

1. Squeeze the milk from the breast first, quickly bathe the nipple, and dry the liquid on the nipple with a sterile towel or paper towel;

2. Disinfect the nipple with an alcohol cotton ball, one cotton ball only disinfects one nipple, disinfect the outer pair of nipples first;

3. To infuse the medicine, start with a pair of nipples on the inner side. To avoid infection, one needle can only be used on one nipple;

4. Do not insert the nipple too deep into the nipple tube, just 6 cm, and massage the breast after infusion;

5. At the end of the perfusion, take a nipple bath again.

Special attention should be paid to the use of fingers to gently twist the nipple tube for a while during the perfusion massage, and hold the breast to gently massage upwards 10 times in order to force the liquid to rise slowly and fully contact the breast alveoli. In order to keep the medicine in the breast as long as possible, infusion can be performed after milking in the evening. But when the cow is suffering from fibrinous mastitis, purulent mastitis, hemorrhagic mastitis, cellulitis mastitis or breast abscess and necrosis, breast massage is strictly prohibited.

The use of a perfusion device for intramammary antibiotic treatment is a thorough chemical disinfection process. The drug can directly act on pathogens in the milk pond and has a significant therapeutic effect. It has become a simple and effective method commonly used in the treatment of cow mastitis at home and abroad. treatment method.

Will the desiccant in the effervescent tube contaminate the medicine?

 Medicines are items that are kept at home, whether they are medicines or health care products, a large part of them are packaged in plastic bottles. In order to prevent medicines from getting damp, denatured, and invalidated, a desiccant is generally placed in the bottle. Will the desiccant in the bottle contaminate the medicine? This article will take the effervescent tube packaging as an example to explain in detail.

84mm*29mm effervescent tablet tube

First of all, the medicinal desiccant itself is non-toxic and harmless, and has super moisture absorption properties. Before being used in medicines, it must obtain the "Medicine Packaging Material Registration Certificate" issued by the State Drug Administration. The only desiccant that can be used in medicine is mainly made of silica gel desiccant. This kind of desiccant has stable chemical properties, high adsorption performance, good thermal stability, stable chemical properties, and high mechanical strength. Will cause pollution to medicines.

Secondly, the desiccant placement position of the effervescent tube is special. General drug desiccants are selected in bags and placed together with the drugs. Due to the particularity of effervescent tablets and the space in the bottle, the effervescent tube adopts a desiccant that is more in line with its own storage characteristics. Designed, there is a small medicine storehouse on the top of the bottle cap to store silica gel and molecular sieve. This method can avoid the contact between the desiccant and the medicine, maintain the dryness of the environment in the bottle, and effectively prevent children from eating the desiccant by mistake.

To sum up, unless the pharmaceutical packaging of the desiccant in the effervescent tube is damaged, it will cause secondary pollution to the medicine. Under normal circumstances, the medicinal desiccant has less chance of chemical reaction with common things in life, and the safety is very high.

The future prospects of child proof bottles

 Counting from the birth of the first plastic product celluloid, the plastics industry has a history of more than 150 years so far. Its development process can be divided into the natural polymer processing stage, the synthetic resin stage and the big development stage. After a hundred years of development, plastic products have been seen everywhere in our lives, and have grown at an alarming rate, gradually replacing glass products. HDPE bottles are a typical representative of plastic applications, mainly used for oral solid or liquid pharmaceutical packaging.  Is one of the most common pharmaceutical packaging materials in current pharmaceutical packaging.

child proof bottle

The natural polymer processing stage is mainly characterized by the modification and processing of cellulose. During this period, some chemists synthesized a variety of polymers in the laboratory, such as novolac resin, polymethyl methacrylate, and polychloride. Ethylene, etc., laid the foundation for the later development of the plastic industry.

The synthetic resin stage is characterized by the production of synthetic resin as the basic raw material. As the first colorless resin, urea-formaldehyde resin was also born in this period. General materials such as polyethylene, polystyrene, and polyvinyl chloride have developed rapidly, and the raw materials have shifted from coal. It is mainly based on petroleum, which ensures the full application of polymer chemical raw materials.

The output of general plastics has expanded rapidly during the large-scale development stage. The application of new technologies such as reinforcement, compounding and blending has given the raw materials more excellent comprehensive properties and expanded their application scope. At present, the world volume of plastic-based synthetic materials has long exceeded the output of all metals.

Why plastic can develop so fast in just 100 years is mainly because it has a variety of incomparable advantages. Taking child proof bottles as an example, its advantages are as follows:

1. Non-toxic, tasteless, light texture, soft and tough;

2. Acid and alkali resistance, organic solvent resistance, excellent electrical insulation, and still maintain a certain degree of toughness at low temperatures;

3. Surface hardness, tensile strength, rigidity and other mechanical strength are higher than low density polyethylene.

The rapid development of plastics is the result of scientific and technological development. It has been applied to all aspects of life. High-density polyethylene bottles have also been widely used in pharmaceutical packaging, shampoos, cosmetics, etc. In the future, with the development of high technology, high Density polyethylene bottles will have more processing methods and product forms, which will play a greater role in people's production and life.