Characteristics and future trends of veterinary vaccine bottles

 Veterinary vaccines play an important role in the prevention and control of animal diseases. As my country's animal husbandry has gradually transformed from decentralized breeding to large-scale breeding, the market demand for animal vaccines has expanded, which has driven the increase in sales of vaccine bottles. As a special packaging for veterinary vaccines, what are the characteristics of vaccine bottles? What direction will it develop in the future?

100 ml PP vaccine bottle

1. Material: In terms of the material of the vaccine bottle, it is mainly made of polyethylene or polypropylene. These two kinds of plastics are two commonly used raw materials for medicine packaging. They are non-toxic, tasteless, have good chemical properties, and are resistant to most acids. The erosion of alkali organic solvents and low prices help pharmaceutical companies control pharmaceutical costs.

2. Process: The vaccine bottle is mainly produced by the injection-blowing process. The bottle produced by this process is formed at one time, the bottle is stable in quality, comfortable in appearance, and the product has good sealing performance, which can effectively prevent leakage during vaccine transportation.

3. Specifications: Due to the particularity of veterinary vaccines, according to the general needs of most veterinary drug companies, the specifications of vaccine bottles range from a few milliliters to 500 milliliters, and the most commonly used ones are 20 milliliters to 250 milliliters.

4. Shape: The shape of the bottle is mostly round. On the one hand, the round shape is more in line with the aesthetics of most people, and it adapts to the characteristics of human mechanics and is convenient to grasp. On the other hand, the circular design can save raw material costs and reduce some costs.

The main features of the comprehensive vaccine bottle meet the needs of market development and practical application at the current stage. With the vigorous development of animal husbandry, veterinary medicine packaging is also facing more challenges. Vaccine bottles will also be affected by materials, production processes, shapes, etc. There are more explorations.

Microbial Limit Test of Eye Drop Bottle

 The microbial limit inspection method is a method to inspect the degree of microbial contamination of non-specified sterilized preparations and their raw materials and auxiliary materials. The inspection items include the number of bacteria, molds, yeasts and control bacteria. At present, most pharmaceutical packaging has specific regulations on microbial limits, and eye drop bottles used as eye medications are no exception. So, how to detect the microbial limit of the eye drop bottle? How is it required in relevant industry standards?

eye dropper bottle

The eye drop bottle consists of a bottle body, an inner stopper and a bottle cap. The specification is generally 5ml-100ml, and the material is mostly low-density polyethylene.

According to the relevant standards of "YBB20072012 Low Density Polyethylene Medical Eye Drop Bottles", the microbial limit detection follows the following methods and standards: Take several test bottles, add 1/2 nominal volume of sodium chloride injection, and tighten the cap , Shake for 1 minute to get the test solution. The test solution shall be tested in accordance with the law after membrane filtration (Chinese Pharmacopoeia 2010 Edition Two Appendix XIJ). Bacteria must not exceed 100cfu per bottle, molds and yeasts must not be detected, Staphylococcus aureus must not be detected, and Pseudomonas aeruginosa must not be detected. Check out.

Whether the microbial limit meets the standard is related to the quality of the eye drop bottle. If the unqualified product is used in the medicine, it will not only pollute the medicine, but also seriously affect the health of the patient. The importance of pharmaceutical packaging cannot be ignored, and pharmaceutical packaging material manufacturers should strictly control the quality to protect the safety of drugs.

Will the desiccant in the effervescent tube contaminate the medicine?

 Medicines are items that are kept at home, whether they are medicines or health care products, a large part of them are packaged in plastic pharmaceutica packaging. In order to prevent medicines from getting damp, denatured, and invalidated, a desiccant is generally placed in the bottle. Will the desiccant in the bottle contaminate the medicine? This article will take the effervescent tube packaging as an example to explain in detail.

144mm effervescent ablet tube

First of all, the medicinal desiccant itself is non-toxic and harmless, and has super moisture absorption properties. Before being applied to drugs, it must obtain the "Medicine Packaging Material Registration Certificate" issued by the State Drug Administration. The only desiccant that can be used in medicine is mainly made of silica gel desiccant. This kind of desiccant has stable chemical properties, high adsorption performance, good thermal stability, stable chemical properties, and high mechanical strength. Will cause pollution to medicines.

Secondly, the desiccant placement position of the effervescent tube is special. General drug desiccants are selected in bags and placed together with the drugs. Due to the particularity of effervescent tablets and the space in the bottle, the effervescent tube adopts a desiccant that is more in line with its own storage characteristics. Designed, there is a small medicine storehouse on the top of the bottle cap to store silica gel and molecular sieve. This method can avoid the contact between the desiccant and the medicine, maintain the dryness of the environment in the bottle, and effectively prevent children from eating the desiccant by mistake.

To sum up, unless the packaging of the desiccant in the effervescent tube is damaged, it will cause secondary pollution to the medicine. Under normal circumstances, the medicinal desiccant has less chance of chemical reaction with the common things in life, and the safety is very high.

Treatment of mastitis in dairy cows with plastic syringe

 Dairy cow mastitis is one of the most troublesome diseases for dairy farmers. It has the characteristics of high incidence and easy recurrence, and local administration to the diseased area of the breast through the plastic syringe is considered to be one of the more effective treatment methods. What should be paid attention to during the administration process?

5ml cow mastitis syringe

Dairy cow mastitis is different from other diseases, and the affected area is more special, so you should be more cautious when administering the drug through the intramammary syringe. The infusion should strictly follow the following procedures:

1. Squeeze the milk from the breast first, quickly bathe the nipple, and dry the liquid on the nipple with a sterile towel or paper towel;

2. Disinfect the nipple with an alcohol cotton ball, one cotton ball only disinfects one nipple, disinfect the outer pair of nipples first;

3. To infuse the medicine, start with a pair of nipples on the inner side. To avoid infection, one needle can only be used on one nipple;

4. Do not insert the nipple too deep into the nipple tube, just 6 cm, and massage the breast after infusion;

5. At the end of the perfusion, take a nipple bath again.

Special attention should be paid to the use of fingers to gently twist the nipple tube for a while during the perfusion massage, and hold the breast to gently massage upwards 10 times in order to force the liquid to rise slowly and fully contact the breast alveoli. In order to keep the medicine in the breast as long as possible, infusion can be performed after milking in the evening. But when the cow is suffering from fibrinous mastitis, purulent mastitis, hemorrhagic mastitis, cellulitis mastitis or breast abscess and necrosis, breast massage is strictly prohibited.

The use of a veterinary syringe for intramammary antibiotic treatment is a thorough chemical disinfection process. The drug can directly act on pathogens in the milk pond and has a significant therapeutic effect. It has become a simple and effective method commonly used in the treatment of cow mastitis at home and abroad. treatment method.

Why veterinary syringes are receiving more and more attention from veterinary drug companies

 The plastic syringe is a new type of veterinary packaging developed in the 1990s that has both the functions of preparation packaging and syringes. It is relatively common in the medical field. It can be stored as high-end pharmaceutical packaging and used directly for injection or in ophthalmology and otology. , Orthopedics and other surgical irrigation. With the continuous upgrading of packaging, many veterinary drug companies have also begun to use veterinary syringe packaging, especially for dairy cow mastitis and pet nutrition ointment drugs.

5ml  cow mastitis syringe

Veterinary pre-filling and filling device is generally made of plastic material, made by injection molding process. It is composed of tube sleeve, push rod, piston, positioning ring and protective cap. Its biggest feature is the pre-filling of the liquid medicine in the syringe. This can reduce intermediate links, effectively avoid contamination of the liquid medicine, and minimize liquid medicine residues. On the other hand, according to the specific needs of pharmaceutical companies, a scale can be marked on the push rod and matched with a positioning ring to achieve precise injection.

Technological innovation has allowed various new packaging to emerge in an endless stream, but the law of survival of the fittest in the market will not change. Good packaging must be a product that is generally recognized by the market in terms of functionality and applicability, and good products must be matched with good packaging to win market. The pre-filled perfusion device is favored by more and more veterinary drug companies, which is an inevitable trend for drug packaging technology innovation and pharmaceutical companies to improve product competitiveness.

Animal husbandry is a pillar industry that supports my country’s economic development. Various large-scale breeding policies have promoted the development of veterinary drug companies and pharmaceutical packaging material manufacturers to a certain extent, and have also put forward higher requirements for the development of the industry. The product in this market context. The market is changing rapidly, and perhaps in the near future there will be newer packaging to replace the pre-filled infusion device.

Principles of ethylene oxide sterilization for eye drop bottles

 Eye drops refer to sterile liquid preparations such as clear solutions or suspensions for eye drops made of medicines and excipients to prevent or diagnose eye diseases. As a kind of sterile medicine, its requirements for eye drop bottles are very strict. Whether the sterilization is thorough is of great significance to the efficacy of the medicine and the health of the patient.

10 ml eye dropper bottle

Among many sterilization methods, ethylene oxide sterilization is the most commonly used sterilization method for eye drop bottles. As a broad-spectrum sterilant, ethylene oxide can kill various microorganisms at room temperature, including spores, tubercle bacilli, bacteria, viruses, fungi, etc., mainly destroying the metabolic process of bacteria. This kind of sterilization method does not damage the sterilized items and has strong penetrating power. Most items that are not suitable for general methods can be sterilized and sterilized by ethylene oxide, such as electronic instruments, optical instruments, books, documents, Dialyzers and disposable medical supplies, etc.

Ethylene oxide can be sterilized with 100% pure ethylene oxide or a mixture of ethylene oxide and carbon dioxide, and the use of freon is prohibited. Excessive exposure to ethylene oxide can cause burns and irritation to the patient. Therefore, when using this sterilization method, the residue should also be investigated. The amount of the residue is related to the sterilized article materials, sterilization parameters, packaging materials and sizes, loading capacity, analytical parameters, etc. Related, the measurement method is based on YBB60202012.

Ethylene oxide sterilization is a widely used sterilization method for plastic pharmaceutical packaging materials. The sterilization method used for eye drop bottles depends on the properties of the drug and the specific needs of pharmaceutical companies.

Veterinary vaccines drive sales growth of vaccine bottles

 The prevention and control of animal diseases has always been the top priority of the development of animal husbandry. As my country's animal husbandry has gradually developed from small-scale farming to large-scale development, the domestic vaccine-based veterinary biological products industry has developed rapidly, and the vaccine market has been steadily The growth will definitely drive the growth of vaccine bottle sales.

At present, the sales scale of veterinary vaccines in my country is showing a steady growth trend. Relevant data shows that in 2018, the sales scale of veterinary vaccines in China was 12.196 billion yuan, and in 2019, the sales scale of veterinary vaccines in China was 11.724 billion yuan, a year-on-year decrease of 3.87%. Although the scale of the domestic vaccine market has declined due to the African swine fever epidemic, the market prospects for veterinary vaccines are still promising under the influence of the overall industry environment such as the continuous advancement of large-scale breeding in my country and the continuous improvement of modern biotechnology.

The steady development of any industry will drive the prosperity of related industrial chains. The veterinary vaccine market is in great demand and has a broad prospect, and the vaccine bottle market will also see an increase in market sales. High-quality vaccine vials can protect the vaccine from damage during transportation and are always in a good storage environment, which is of great significance for ensuring the immune effect of the vaccine.

Immunization can effectively reduce the incidence of animal diseases and control the spread of epidemics. Under the background of the overall improvement of the industry, vaccine bottle manufacturers will usher in new opportunities and challenges. The industry has obvious survival of the fittest effect, focusing on innovative research and development, stable product quality, Quality manufacturers with excellent strength and reputation will stand out.

Which sterilization method is more suitable for veterinary syringes

 The veterinary syringe is a kind of high-tech, practical, new type of injection packaging that is quietly emerging in recent years. This type of veterinary packaging originated from abroad and is mainly used in the packaging of drugs such as dairy cow mastitis and pet nutrition cream. Due to the dual functions of liquid medicine packaging and injection, prefilled syringes have high requirements for sterility. So which sterilization method is more suitable forveterinary syringes?

paste syringe

The sterilization methods of the yringe infusion device mainly include ethylene oxide and cobalt 60 irradiation sterilization, depending on the packaging material. Take sterilization adaptability as an example. Ethylene oxide sterilization requires materials to have sufficient air permeability to ensure that while steam permeates, there are fewer or no gas residues after sterilization; radiation sterilization does not require materials to have air permeability Performance, but gamma rays or high-energy electron beams may cause damage to polymer materials, making the materials brittle and easy to crack, so materials such as PP and PVC cannot generally be used. In terms of microbial barrier properties, air-permeable materials may lose their barrier capabilities under the long-term permeation of high-temperature steam, and qualified sterilization packaging materials must still maintain microbial barrier capabilities after sterilization.

With the vigorous development of the veterinary drug industry, the quality and functional requirements of packaging have also been continuously improved. Qualified prefilled infusion devices must meet the requirements of sterilization adaptability, microbial barrier properties, physical and chemical properties, etc. Packaging is not completely sterilized and is contaminated, causing unnecessary losses. Packaging manufacturers should also choose the most suitable sterilization method according to the material properties of the sterilization packaging.

Spring on the lid of the effervescent tube

 Effervescent tablets originate from abroad and are popular among young people for their diverse tastes and unique taste. Effervescent tablets contain disintegrating agents, which will produce a lot of carbon dioxide when placed in water. The effervescent tube containing the effervescent tablet is also special, mostly tubular. Many people may have noticed that there is a spiral spring on the lid of the package. So what is the magical effect of this cap spring?

spiral cap

The prescription of an effervescent tablet consists of the main drug, diluent, binder, disintegrant, lubricant and other auxiliary materials. The diluent, binder, lubricant and other auxiliary materials used are the same as ordinary tablets. The appropriate variety should be selected according to the preparation process. Due to the particularity of tablets, effervescent tablets packagingrequirements, and moisture resistance is the most basic requirement. In addition, the effervescent tube is specially designed on the lid. The spiral spring made of LDPE material can compress the tablets in the bottle to prevent them from being broken due to the impact of bumps during transportation, which reduces unnecessary loss. The LDPE material has good flexibility. The use of this material as a coil spring will neither crush the fragmentation agent due to the too hard texture, nor cause the medicine to be poorly fixed due to the too soft texture and too small pressure. The spring design can be maximized the advantages.

With the popularity of effervescent tablets at home and abroad, higher requirements have been placed on pharmaceutical packaging. Nothing is immutable, not only the coil spring, but the small medicine warehouse and anti-theft ring on the bottle cap are the products of industry innovation. With technological innovation and the continuous advent of various new materials, it is believed that the effervescent tube will have a greater improvement in function, and the safety and practicality of the product will be better reflected.

Veterinary syringe helps the healthy and steady growth of my country's dairy industry

 Recently, a press conference on the revitalization of the dairy industry in the Inner Mongolia Autonomous Region was held in Beijing. Ma Youxiang, Chief Livestock Pastor of the Ministry of Agriculture and Rural Affairs, introduced at the press conference that my country’s dairy industry has maintained a good momentum of development this year. Milk production in the first three quarters increased by 8.1% year-on-year, and the growth rate hit a five-year high. Fresh milk and dairy products in the first half of the year The sampling qualification rate is maintained above 99%.

veterinary syringe

Dairy products are a necessity for the daily consumption of urban and rural residents. Good milk comes from a good source of milk, and a good source of milk is inseparable from the meticulous management of pastures. It is particularly important to strengthen disease prevention and control, especially the prevention and treatment of cow mastitis. Cow mastitis is one of the most common diseases in the dairy industry. The disease has a high incidence and is easy to recur. It is the most difficult disease in the dairy farming process. Among the many treatment methods, drug delivery through a prefilled perfusion device is considered to be one of the faster effective methods.

The intramammary syringe is generally composed of a tube sleeve, a push rod, a piston, a positioning ring and a protective cap. It is a new type of packaging that integrates the functions of drug storage and infusion. It has the advantages of convenient use, precise medication, less drug residue, and can prevent Features such as secondary pollution. When using, open the protective cap and use the catheter to directly infuse the medicine into the diseased breast area, which can maintain a higher concentration of the medicine locally and achieve the purpose of treatment.

The dairy industry is an indispensable industry for a healthy China and a strong nation. Dairy cow mastitis can reduce milk production or stop milk production, affect milk quality and disturb the growth of dairy cows. Therefore, farms should make full use of the product advantages of pre-filled perfusion devices , Do a good job in the prevention and control of dairy cow epidemics, and promote the healthy and steady growth of my country's dairy industry.

The packaging ignores this, the effect of pet nutrition cream is halved

 As a health care product, pet nutrition cream has a significant effect on weak, elderly dogs and cats, dogs and cats recovering their physical fitness after surgery and illness, and pets who need to improve immunity. At present, pet nutrition cream has adopted a new type of pre-filled packaging. To ensure the maximum effect of the nutrition cream, the tightness of the package is very important.

15ml dosing syringe for pets

Tightness is an important indicator of veterinary packaging quality, related to the product quality and expiration date of the packaging contents, and is also a necessary guarantee for the product circulation environment. As a new type of drug packaging method, prefilling has the characteristics of convenient use and simple operation. Generally speaking, its tightness is mainly controlled by the following points:

First, the sealing member. The use of sealing components that comply with internationally accepted standards is the basis for ensuring the tightness of the package;

Second, the necessary verification. When the components of the sealing system or the potting system are changed, the impact on the sealing system should be evaluated in time, and the sealing integrity should be verified again when necessary;

Third, meet the test requirements. The verification of tightness requirements shall meet the requirements of bacteria intrusion test and saturated salt water test;

Fourth, other experimental evidence. In addition to the conventional experimental methods for prefilled syringes, influencing factor experiments and accelerated experiments should also be carried out to ensure that its sealing performance during the validity period meets user requirements.

The airtightness of the veterinary syringe is of great significance to the efficacy of pet nutrition cream. If the airtightness of the packaging is not good, it will have a certain impact on the brand image of the pharmaceutical company. Therefore, when choosing a packaging manufacturer, the pharmaceutical company should do the packaging performance Comprehensive assessment.

Ранняя профилактика птичьего гриппа-это ключ к успеху

 Зима-сезон высокой заболеваемости птичьим гриппом. По данным CCTV News, с конца ноября прошлого года по 2 января высокопатогенный птичий грипп распространился на 42 фермы Южной Кореи более чем за месяц, и его распространение ускоряется. До сих пор, чтобы предотвратить распространение эпидемии птичьего гриппа, Южная Корея выбраковала более 11,5 миллиона птиц на более чем 200 фермах. Не только Южная Корея, но и европейские страны, такие как Бельгия, Дания, Франция и Германия, сообщили о более чем 300 случаях птичьего гриппа.

100 мл бутылка PE впрыски

Общественная информация показывает, что вирус птичьего гриппа очень заразен среди домашней птицы и имеет очень высокий уровень смертности. Птицы, зараженные этим вирусом, обычно страдают от затрудненного дыхания, анорексии, апатии и, в конечном счете, смерти из-за повреждения нервной системы. В настоящее время вакцинация домашней птицы является самым быстрым и эффективным способом борьбы с птичьим гриппом. При введении вакцины против птичьего гриппа обратите внимание на следующее:

1. время инъекции: вообще говоря, наиболее целесообразно вводить вакцину против птичьего гриппа в течение одного-двух месяцев до начала эпидемии гриппа. Антитела будут вырабатываться в организме примерно через 10-15 дней после инъекции.

2. хранение вакцин: инактивированные вакцины обычно хранятся в бутылках с вакцинами и должны быть охлаждены при температуре 2 ~ 8°C в темноте и не должны быть заморожены или перегреты. Вакцина не может быть использована, если замечено, что флакон с вакциной поврежден, деэмульгирован, слоист и изменился в цвете перед использованием.

3. использование вакцин: инактивированные вакцины должны быть привиты путем инъекций, которые могут быть привиты внутримышечно или подкожно. Шприц должен быть строго стерилизован перед использованием. Самый простой способ-это сварить его. Флаконы с вакциной следует использовать в течение 24 часов после вскрытия, чтобы избежать местных или системных побочных реакций после того, как вакцина загрязняет бактерии и размножается в больших количествах, а также прививает птицу.

4. оставшиеся пустые флаконы с вакциной и оборудование для вакцинации должны быть продезинфицированы после вакцинации. При использовании у бройлеров запрещается использовать его в течение 21 дня до убоя. При использовании на других цыплятах запрещается использовать его в течение 42 дней до убоя.

Заблаговременная профилактика заболеваний птицы путем вакцинации позволяет минимизировать заболеваемость и снизить экономические потери хозяйства, что имеет большое значение для развития современной отрасли животноводства.

Increased demand for ophthalmic treatment

 The eye is one of the important sensory organs of the human body. With the changes in technology and lifestyle, the incidence of various eye diseases is gradually increasing. Relevant data shows that the number of myopia in Chinese adolescents is estimated to be about 100 million, the number of adult myopia is 450 million, and the number of macular fundus diseases is about 64 million. The incidence of various eye diseases such as cataract, glaucoma, and dry eye is increasing year by year. The sharp increase in demand for treatment has led to rapid growth in the ophthalmology market.

eye dropper bottles

According to statistics from the China Commercial Industry Research Institute, the scale of China's ophthalmology market has grown from 46.77 billion yuan in 2013 to 97.97 billion yuan in 2018, with a compound annual growth rate of 17%. With the upgrading of high-tech, consumption upgrades, increased ocular morbidity and increased patient self-diagnosis awareness, it is estimated that the size of the Chinese ophthalmology market has exceeded 100 billion yuan, and the compound annual growth rate of the market size in the next five years is expected to remain at 13%- Around 15%. The most common medicine to treat eye diseases is eye drops, and the large-scale growth of the ophthalmology market will inevitably stimulate the development of the packaging industry chain for eye medicines such as eye drop bottles.

The pharmaceutical packaging of medicines is an important means of competition for medicines, especially OTC products, especially for eye drop bottles. The overall appearance and practicality of the eye drop bottle will affect the sales of the drug. The scale of the ophthalmology market of hundreds of billions is both an opportunity and a challenge. How to seize the industry opportunities and occupy a place in the fierce market competition is worthy of consideration by many pharmaceutical companies.

Early prevention of bird flu is the key

 Winter is the season of high incidence of bird flu. According to CCTV News, from the end of November last year to January 2nd, highly pathogenic bird flu has spread to 42 farms in South Korea in more than a month, and the spread has been accelerating. So far, in order to prevent the spread of the bird flu epidemic, South Korea has culled more than 11.5 million poultry on more than 200 farms. Not only South Korea, but also European countries such as Belgium, Denmark, France, and Germany have reported more than 300 cases of bird flu.

100 ml PE vaccine bottle with rubber stopper 

Public information shows that the avian influenza virus is highly contagious among poultry and has a very high fatality rate. Birds infected with this virus usually suffer from breathing difficulties, anorexia, listlessness, and eventually death due to damage to the nervous system. At present, vaccinating poultry is the fastest and most effective way to control bird flu. Note the following when injecting bird flu vaccine:

1. Injection time: Generally speaking, it is most appropriate to inject the avian flu vaccine within one to two months before the flu epidemic. Antibodies will be produced in the body about 10 to 15 days after the injection.

2. Vaccine storage: Inactivated vaccines are generally stored in vaccine bottles, and should be refrigerated at 2～8°C in the dark and should not be frozen or overheated. The vaccine cannot be used if it is observed that the vaccine bottle is damaged, demulsified, layered, and changed in color before use.

3. Use of vaccines: Inactivated vaccines must be inoculated by injection, which can be inoculated intramuscularly or subcutaneously. The syringe must be strictly sterilized before use. The easiest way is to boil it. Vaccine bottles should be used up within 24 hours after being unsealed to avoid local or systemic adverse reactions after the vaccine contaminates bacteria and multiplies in large numbers and inoculates poultry.

4. The remaining empty vaccine bottles and vaccination equipment should be disinfected after vaccination. When used in broilers, it is forbidden to use it within 21 days before slaughter. When used in other chickens, it is forbidden to use it within 42 days before slaughter.

The advance prevention of poultry diseases through vaccination can minimize the incidence of diseases and reduce the economic losses of the farm, which is of great significance to the development of the current breeding industry.

Тест на растворение полипропиленовой бутылки

 Тест на растворение полипропиленовой бутылки:

Приготовление тестового раствора: возьмите внутреннюю поверхность плоской части этого изделия площадью 600см2 (разделите на куски длиной 5 см и шириной 0,3 см), установите

Добавьте соответствующее количество воды в коническую колбу, встряхните и промойте мелкие кусочки, выбросьте воду и повторите операцию дважды. После высыхания при температуре 30~40℃ используйте воду (70℃±2℃),

После замачивания в 200 мл в течение 24 часов выньте его и дайте ему остыть до комнатной температуры, используйте ту же порцию тестового растворителя, чтобы составить исходный объем, что и тестовый раствор, и используйте ту же порцию воды в качестве заготовки.

Жидкость, выполните следующие испытания:

флакон вакцины

6.9.1 изменение рН

Возьмите по 20 мл каждого тестового раствора и водного пустого раствора, добавьте 1,0 мл раствора хлорида калия (1→1000) соответственно, в соответствии с методом измерения рН.

В общих принципах ветеринарной Фармакопеи Китайской Народной Республики 2015 года Общим регламентом для второго отдела (0631) определено, что разница между ними не превышает 1,0.

6.9.2 тяжелые металлы

Точно возьмите 20 мл воды для тестового раствора, добавьте 2 мл ацетатного буфера (рН 3,5), проверьте в соответствии с законом ("ветеринарная фармакопея Китайской Народной Республики")

Издание 2015 года общих принципов Второго департамента (0821, 

6.9.4 номера-летучих веществ

Точно возьмите по 50 мл каждого тестового раствора и пустого раствора в испарительную посуду постоянного веса, выпарите на водяной бане, высушите при 105℃ в течение 2 часов и охладите

После точного определения разница между остатком нелетучей воды и остатком ее чистого раствора не должна превышать 12,0 мг.

6.9.5 ясность

Возьмите воду для тестового раствора и проверьте его в соответствии с законом ("общие правила ветеринарной Фармакопеи Китайской Народной Республики 2015" Часть вторая), раствор должен быть прозрачным, если он мутный,

По сравнению со стандартным раствором мутности № 2 он не должен быть толще.

6.9.6 поглощение

Возьмите соответствующ

Plastic vaccine vials compared with glass vials

 Many veterinary vaccine medicine is packed by glass vials now, and also more and more animal health factory begin to choose plastic vials to instead of glass vials, the follwing is a compare between two vials.

First, plastic vaccine vial is unbreakable duringe transportation process

Second, Plastic vaccine vial don’t need to clean, dry and finish the bottle before filling, which can reduce costs and save time.

Third, produced in GMP workshop

Fourth, vacuum typesetting packaging

Fifth, excellent seal

Sixth, various sterilization methods, like EO or autoclaved from 100 degree to 120 degree before filling 30 minutes

Seventh, plastic vaccine vials are more light then glass

Eighth, offer invisible anti-counterfeiting to keep brand security

pharma bottle with child proof cap market

 In order to ensure the safety of children, the use of child proof cap bottles for pharmaceutical packaging has become the choice of more and more pharmaceutical companies.

plastic medicine bottle with child proof cap

The child proof cap bottle is a special form of pharmaceutical packaging, which has been enforced by legislation for many years abroad and is widely used. Its principle is to reduce the risk of accidentally ingesting medicines by making it more difficult for children to open the cap. The bottle cap generally adopts a double-layer structure, which requires the combined action of pressure and torsion to open. This opening method is very simple for adults, and it is often difficult for children to open the package in a short time.

In my country, there is no legislative mandatory for safety packaging, but many pharmaceutical companies have realized the importance of drug safety packaging to ensure the safety of children, and many prescription drugs for mental, chronic diseases, and cardiovascular drugs have begun to use safety packaging. Appropriate packaging must not only meet the storage requirements of the drug, but also have a higher cost performance. Special drugs should also consider the functional requirements of the packaging and the impact on the brand image. Imagine that if a child is harmed because of unsafe packaging of medicines, even if it is not because the products of the pharmaceutical company are damaged, it may also cause potential legal liability and reputation damage to the company.

Here we call on the majority of pharmaceutical companies to increase the scope of application of child proof cap bottle packaging, to establish a barrier to protect the safety of children, and to add a guarantee for a good corporate image.